JP2019511911A5 - - Google Patents
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- JP2019511911A5 JP2019511911A5 JP2018543390A JP2018543390A JP2019511911A5 JP 2019511911 A5 JP2019511911 A5 JP 2019511911A5 JP 2018543390 A JP2018543390 A JP 2018543390A JP 2018543390 A JP2018543390 A JP 2018543390A JP 2019511911 A5 JP2019511911 A5 JP 2019511911A5
- Authority
- JP
- Japan
- Prior art keywords
- seq
- variable region
- chain variable
- heavy chain
- light chain
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
- 239000012634 fragment Substances 0.000 claims description 31
- 239000008194 pharmaceutical composition Substances 0.000 claims description 12
- 208000023178 Musculoskeletal disease Diseases 0.000 claims description 8
- 102000011117 Transforming Growth Factor beta2 Human genes 0.000 claims description 8
- 101800000304 Transforming growth factor beta-2 Proteins 0.000 claims description 8
- 108090000097 Transforming growth factor beta-3 Proteins 0.000 claims description 8
- 102000056172 Transforming growth factor beta-3 Human genes 0.000 claims description 8
- 201000010099 disease Diseases 0.000 claims description 7
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 7
- 108010029485 Protein Isoforms Proteins 0.000 claims description 6
- 102000001708 Protein Isoforms Human genes 0.000 claims description 6
- 102000046299 Transforming Growth Factor beta1 Human genes 0.000 claims description 6
- 101800002279 Transforming growth factor beta-1 Proteins 0.000 claims description 6
- 102000040430 polynucleotide Human genes 0.000 claims description 6
- 108091033319 polynucleotide Proteins 0.000 claims description 6
- 239000002157 polynucleotide Substances 0.000 claims description 6
- 238000000034 method Methods 0.000 claims description 5
- 208000001708 Dupuytren contracture Diseases 0.000 claims description 4
- 206010014989 Epidermolysis bullosa Diseases 0.000 claims description 4
- 101500025624 Homo sapiens Transforming growth factor beta-2 Proteins 0.000 claims description 4
- 201000009594 Systemic Scleroderma Diseases 0.000 claims description 4
- 206010042953 Systemic sclerosis Diseases 0.000 claims description 4
- 208000017445 musculoskeletal system disease Diseases 0.000 claims description 4
- 208000011580 syndromic disease Diseases 0.000 claims description 4
- 239000013543 active substance Substances 0.000 claims description 3
- 230000001419 dependent effect Effects 0.000 claims description 3
- 239000003085 diluting agent Substances 0.000 claims description 3
- 238000004519 manufacturing process Methods 0.000 claims description 3
- 238000003571 reporter gene assay Methods 0.000 claims description 3
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims description 2
- 101500025614 Homo sapiens Transforming growth factor beta-1 Proteins 0.000 claims description 2
- 238000010367 cloning Methods 0.000 claims description 2
- 239000013599 cloning vector Substances 0.000 claims description 2
- 238000012258 culturing Methods 0.000 claims description 2
- 238000010494 dissociation reaction Methods 0.000 claims description 2
- 230000005593 dissociations Effects 0.000 claims description 2
- 239000013604 expression vector Substances 0.000 claims description 2
- 230000002401 inhibitory effect Effects 0.000 claims description 2
- 239000013598 vector Substances 0.000 claims description 2
- 125000003275 alpha amino acid group Chemical group 0.000 description 8
- 239000003814 drug Substances 0.000 description 3
- 229920001184 polypeptide Polymers 0.000 description 2
- 102000004196 processed proteins & peptides Human genes 0.000 description 2
- 108090000765 processed proteins & peptides Proteins 0.000 description 2
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- 229940126523 co-drug Drugs 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 239000012636 effector Substances 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 230000035772 mutation Effects 0.000 description 1
- 238000006386 neutralization reaction Methods 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662296282P | 2016-02-17 | 2016-02-17 | |
| US62/296,282 | 2016-02-17 | ||
| PCT/IB2017/050917 WO2017141208A1 (en) | 2016-02-17 | 2017-02-17 | Tgfbeta 2 antibodies |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2019511911A JP2019511911A (ja) | 2019-05-09 |
| JP2019511911A5 true JP2019511911A5 (enExample) | 2020-03-26 |
Family
ID=58191507
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018543390A Ceased JP2019511911A (ja) | 2016-02-17 | 2017-02-17 | Ｔｇｆベータ２抗体 |
Country Status (21)
| Country | Link |
|---|---|
| US (1) | US11180546B2 (enExample) |
| EP (1) | EP3416982A1 (enExample) |
| JP (1) | JP2019511911A (enExample) |
| KR (1) | KR20180107151A (enExample) |
| CN (1) | CN108699142A (enExample) |
| AU (1) | AU2017219254B2 (enExample) |
| BR (1) | BR112018015690A2 (enExample) |
| CA (1) | CA3012294A1 (enExample) |
| CL (1) | CL2018001941A1 (enExample) |
| CO (1) | CO2018008590A2 (enExample) |
| CU (1) | CU20180088A7 (enExample) |
| EA (1) | EA201891724A1 (enExample) |
| EC (1) | ECSP18064646A (enExample) |
| HK (1) | HK1257455A1 (enExample) |
| IL (1) | IL261065A (enExample) |
| MA (1) | MA44236A (enExample) |
| MX (1) | MX2018010021A (enExample) |
| PH (1) | PH12018501525A1 (enExample) |
| RU (1) | RU2018131123A (enExample) |
| SG (1) | SG11201805941WA (enExample) |
| WO (1) | WO2017141208A1 (enExample) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB201610044D0 (en) | 2016-06-08 | 2016-07-20 | Ucb Biopharma Sprl | Antibodies |
| JP7540994B2 (ja) | 2018-07-11 | 2024-08-27 | スカラー ロック インコーポレイテッド | 高親和性のアイソフォーム選択的ＴＧＦβ１阻害剤、およびその使用 |
| NZ772550A (en) | 2018-08-30 | 2025-08-29 | Immunitybio Inc | Multi-chain chimeric polypeptides and uses thereof |
| CN120535649A (zh) | 2018-08-30 | 2025-08-26 | 免疫生物公司 | 单链嵌合多肽和其用途 |
| US20210388074A1 (en) * | 2018-11-05 | 2021-12-16 | Ludwig Institute For Cancer Research Ltd. | Humanized and variant tgf-beta3 specific antibodies and methods and uses thereof |
| KR20220035394A (ko) | 2019-06-21 | 2022-03-22 | 에이치씨더블유 바이올로직스, 인크. | 다중-사슬 키메라 폴리펩티드 및 이의 용도 |
| US20210032322A1 (en) | 2019-08-01 | 2021-02-04 | Vaccinex, Inc. | Combined inhibition of semaphorin-4d and tgf-beta and compositions therefor |
| AU2021220870A1 (en) | 2020-02-11 | 2022-08-04 | Immunitybio, Inc. | Methods of treating age-related and inflammatory diseases |
| WO2021163298A1 (en) | 2020-02-11 | 2021-08-19 | HCW Biologics, Inc. | Methods of activating regulatory t cells |
| KR20220140535A (ko) | 2020-02-11 | 2022-10-18 | 에이치씨더블유 바이올로직스, 인크. | 크로마토그래피 수지 및 이의 용도 |
| TWI867190B (zh) * | 2020-03-19 | 2024-12-21 | 美商建南德克公司 | 同功型選擇性抗-TGF-β抗體及其使用方法 |
| US12024545B2 (en) | 2020-06-01 | 2024-07-02 | HCW Biologics, Inc. | Methods of treating aging-related disorders |
| KR20230146032A (ko) | 2021-02-15 | 2023-10-18 | 다케다 야쿠힌 고교 가부시키가이샤 | Tgf-b 신호전달을 조절하기 위한 세포 치료 조성물 및 방법 |
| CN112940119B (zh) * | 2021-04-26 | 2022-05-20 | 北京芳渟阳生生物科技有限公司 | 一种单克隆抗体及其与间充质干细胞外泌体的联合应用 |
| KR20250004747A (ko) | 2022-04-13 | 2025-01-08 | 이뮤니티바이오, 인크. | 생체 시계 유전자 장애의 치료에 사용하기 위한 다중-사슬 키메라 폴리펩티드 |
| KR20250004757A (ko) | 2022-04-13 | 2025-01-08 | 이뮤니티바이오, 인크. | 신경염증성 장애의 치료에 사용하기 위한 다중-사슬 키메라 폴리펩티드 |
| CN119213034A (zh) | 2022-05-17 | 2024-12-27 | 苏州创胜医药集团有限公司 | 双功能蛋白质及其制剂和用途 |
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-
2017
- 2017-02-17 SG SG11201805941WA patent/SG11201805941WA/en unknown
- 2017-02-17 MA MA044236A patent/MA44236A/fr unknown
- 2017-02-17 CN CN201780011724.8A patent/CN108699142A/zh active Pending
- 2017-02-17 HK HK18116690.9A patent/HK1257455A1/zh unknown
- 2017-02-17 CU CU2018000088A patent/CU20180088A7/es unknown
- 2017-02-17 AU AU2017219254A patent/AU2017219254B2/en not_active Ceased
- 2017-02-17 BR BR112018015690A patent/BR112018015690A2/pt not_active IP Right Cessation
- 2017-02-17 CA CA3012294A patent/CA3012294A1/en not_active Abandoned
- 2017-02-17 EP EP17707960.5A patent/EP3416982A1/en not_active Withdrawn
- 2017-02-17 US US15/999,368 patent/US11180546B2/en active Active
- 2017-02-17 EA EA201891724A patent/EA201891724A1/ru unknown
- 2017-02-17 JP JP2018543390A patent/JP2019511911A/ja not_active Ceased
- 2017-02-17 KR KR1020187023260A patent/KR20180107151A/ko not_active Withdrawn
- 2017-02-17 RU RU2018131123A patent/RU2018131123A/ru not_active Application Discontinuation
- 2017-02-17 WO PCT/IB2017/050917 patent/WO2017141208A1/en not_active Ceased
- 2017-02-17 MX MX2018010021A patent/MX2018010021A/es unknown
-
2018
- 2018-07-16 PH PH12018501525A patent/PH12018501525A1/en unknown
- 2018-07-18 CL CL2018001941A patent/CL2018001941A1/es unknown
- 2018-08-08 IL IL261065A patent/IL261065A/en unknown
- 2018-08-15 CO CONC2018/0008590A patent/CO2018008590A2/es unknown
- 2018-08-27 EC ECSENADI201864646A patent/ECSP18064646A/es unknown
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