BR112018015690A2 - anticorpos tgfbeta 2 - Google Patents
anticorpos tgfbeta 2Info
- Publication number
- BR112018015690A2 BR112018015690A2 BR112018015690A BR112018015690A BR112018015690A2 BR 112018015690 A2 BR112018015690 A2 BR 112018015690A2 BR 112018015690 A BR112018015690 A BR 112018015690A BR 112018015690 A BR112018015690 A BR 112018015690A BR 112018015690 A2 BR112018015690 A2 BR 112018015690A2
- Authority
- BR
- Brazil
- Prior art keywords
- tgf
- antibodies
- human
- tgfbeta
- relates
- Prior art date
Links
- ZRKFYGHZFMAOKI-QMGMOQQFSA-N tgfbeta Chemical compound C([C@H](NC(=O)[C@H](C(C)C)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](N)CCSC)C(C)C)[C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](C)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N1[C@@H](CCC1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(O)=O)C1=CC=C(O)C=C1 ZRKFYGHZFMAOKI-QMGMOQQFSA-N 0.000 title 1
- 102000001708 Protein Isoforms Human genes 0.000 abstract 2
- 108010029485 Protein Isoforms Proteins 0.000 abstract 2
- 101500025614 Homo sapiens Transforming growth factor beta-1 Proteins 0.000 abstract 1
- 101500025624 Homo sapiens Transforming growth factor beta-2 Proteins 0.000 abstract 1
- 101500026551 Homo sapiens Transforming growth factor beta-3 Proteins 0.000 abstract 1
- 230000000417 anti-transforming effect Effects 0.000 abstract 1
- 229940072041 transforming growth factor beta 2 Drugs 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/22—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/10—Immunoglobulins specific features characterized by their source of isolation or production
- C07K2317/14—Specific host cells or culture conditions, e.g. components, pH or temperature
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/55—Fab or Fab'
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Physical Education & Sports Medicine (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Cardiology (AREA)
- Oncology (AREA)
- Dermatology (AREA)
- Rheumatology (AREA)
- Heart & Thoracic Surgery (AREA)
- Neurology (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662296282P | 2016-02-17 | 2016-02-17 | |
| PCT/IB2017/050917 WO2017141208A1 (en) | 2016-02-17 | 2017-02-17 | Tgfbeta 2 antibodies |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR112018015690A2 true BR112018015690A2 (pt) | 2018-12-26 |
Family
ID=58191507
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR112018015690A BR112018015690A2 (pt) | 2016-02-17 | 2017-02-17 | anticorpos tgfbeta 2 |
Country Status (21)
| Country | Link |
|---|---|
| US (1) | US11180546B2 (enExample) |
| EP (1) | EP3416982A1 (enExample) |
| JP (1) | JP2019511911A (enExample) |
| KR (1) | KR20180107151A (enExample) |
| CN (1) | CN108699142A (enExample) |
| AU (1) | AU2017219254B2 (enExample) |
| BR (1) | BR112018015690A2 (enExample) |
| CA (1) | CA3012294A1 (enExample) |
| CL (1) | CL2018001941A1 (enExample) |
| CO (1) | CO2018008590A2 (enExample) |
| CU (1) | CU20180088A7 (enExample) |
| EA (1) | EA201891724A1 (enExample) |
| EC (1) | ECSP18064646A (enExample) |
| HK (1) | HK1257455A1 (enExample) |
| IL (1) | IL261065A (enExample) |
| MA (1) | MA44236A (enExample) |
| MX (1) | MX2018010021A (enExample) |
| PH (1) | PH12018501525A1 (enExample) |
| RU (1) | RU2018131123A (enExample) |
| SG (1) | SG11201805941WA (enExample) |
| WO (1) | WO2017141208A1 (enExample) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB201610044D0 (en) | 2016-06-08 | 2016-07-20 | Ucb Biopharma Sprl | Antibodies |
| MA53125A (fr) | 2018-07-11 | 2021-05-19 | Scholar Rock Inc | Inhibiteurs de tgf?1 sélectifs selon l'isoforme à affinité élevée |
| WO2020047333A1 (en) | 2018-08-30 | 2020-03-05 | HCW Biologics, Inc. | Single-chain chimeric polypeptides and uses thereof |
| SG11202101779RA (en) | 2018-08-30 | 2021-03-30 | Hcw Biologics Inc | Multi-chain chimeric polypeptides and uses thereof |
| WO2020095104A1 (en) * | 2018-11-05 | 2020-05-14 | Ludwig Institute For Cancer Research Ltd. | HUMANIZED AND VARIANT TGF-β3 SPECIFIC ANTIBODIES AND METHODS AND USES THEREOF |
| CN114269903B (zh) | 2019-06-21 | 2025-11-25 | 免疫生物公司 | 多链嵌合多肽和其用途 |
| CA3152371A1 (en) | 2019-08-01 | 2021-02-04 | Vaccinex, Inc. | Combined inhibition of semaphorin-4d and tgf.beta. and compositions therefor |
| AU2021219720B2 (en) | 2020-02-11 | 2025-10-02 | Immunitybio, Inc. | Chromatography resin and uses thereof |
| AU2021220870A1 (en) | 2020-02-11 | 2022-08-04 | Immunitybio, Inc. | Methods of treating age-related and inflammatory diseases |
| KR20220140572A (ko) | 2020-02-11 | 2022-10-18 | 에이치씨더블유 바이올로직스, 인크. | 조절 t 세포를 활성화시키는 방법 |
| EP4121163A1 (en) * | 2020-03-19 | 2023-01-25 | Genentech, Inc. | Isoform-selective anti-tgf-beta antibodies and methods of use |
| US12497462B2 (en) | 2020-04-29 | 2025-12-16 | Immunitybio, Inc. | Anti-CD26 proteins and uses thereof |
| US12024545B2 (en) | 2020-06-01 | 2024-07-02 | HCW Biologics, Inc. | Methods of treating aging-related disorders |
| AU2022219373A1 (en) | 2021-02-15 | 2023-08-24 | Takeda Pharmaceutical Company Limited | Cell therapy compositions and methods for modulating tgf-b signaling |
| CN112940119B (zh) * | 2021-04-26 | 2022-05-20 | 北京芳渟阳生生物科技有限公司 | 一种单克隆抗体及其与间充质干细胞外泌体的联合应用 |
| EP4507712A1 (en) | 2022-04-13 | 2025-02-19 | ImmunityBio, Inc. | Multi-chain chimeric polypeptide for use in the treatment of circardian clock gene disorder |
| WO2023201311A1 (en) | 2022-04-13 | 2023-10-19 | HCW Biologics, Inc. | Multi-chain chimeric polypeptide for use in the treatment of treating neuroinflammatory disorder |
| EP4527857A1 (en) | 2022-05-17 | 2025-03-26 | Suzhou Transcenta Therapeutics Co., Ltd. | Bifunctional protein, and preparation thereof and use thereof |
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| TWI681969B (zh) | 2014-01-23 | 2020-01-11 | 美商再生元醫藥公司 | 針對ｐｄ-１的人類抗體 |
| JOP20200094A1 (ar) | 2014-01-24 | 2017-06-16 | Dana Farber Cancer Inst Inc | جزيئات جسم مضاد لـ pd-1 واستخداماتها |
| TWI693232B (zh) | 2014-06-26 | 2020-05-11 | 美商宏觀基因股份有限公司 | 與pd-1和lag-3具有免疫反應性的共價結合的雙抗體和其使用方法 |
| TWI595006B (zh) | 2014-12-09 | 2017-08-11 | 禮納特神經系統科學公司 | 抗ｐｄ－１抗體類和使用彼等之方法 |
-
2017
- 2017-02-17 EA EA201891724A patent/EA201891724A1/ru unknown
- 2017-02-17 CN CN201780011724.8A patent/CN108699142A/zh active Pending
- 2017-02-17 CA CA3012294A patent/CA3012294A1/en not_active Abandoned
- 2017-02-17 EP EP17707960.5A patent/EP3416982A1/en not_active Withdrawn
- 2017-02-17 WO PCT/IB2017/050917 patent/WO2017141208A1/en not_active Ceased
- 2017-02-17 MX MX2018010021A patent/MX2018010021A/es unknown
- 2017-02-17 US US15/999,368 patent/US11180546B2/en active Active
- 2017-02-17 CU CU2018000088A patent/CU20180088A7/es unknown
- 2017-02-17 HK HK18116690.9A patent/HK1257455A1/zh unknown
- 2017-02-17 BR BR112018015690A patent/BR112018015690A2/pt not_active IP Right Cessation
- 2017-02-17 MA MA044236A patent/MA44236A/fr unknown
- 2017-02-17 RU RU2018131123A patent/RU2018131123A/ru not_active Application Discontinuation
- 2017-02-17 SG SG11201805941WA patent/SG11201805941WA/en unknown
- 2017-02-17 JP JP2018543390A patent/JP2019511911A/ja not_active Ceased
- 2017-02-17 KR KR1020187023260A patent/KR20180107151A/ko not_active Withdrawn
- 2017-02-17 AU AU2017219254A patent/AU2017219254B2/en not_active Ceased
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2018
- 2018-07-16 PH PH12018501525A patent/PH12018501525A1/en unknown
- 2018-07-18 CL CL2018001941A patent/CL2018001941A1/es unknown
- 2018-08-08 IL IL261065A patent/IL261065A/en unknown
- 2018-08-15 CO CONC2018/0008590A patent/CO2018008590A2/es unknown
- 2018-08-27 EC ECSENADI201864646A patent/ECSP18064646A/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| RU2018131123A3 (enExample) | 2020-07-09 |
| RU2018131123A (ru) | 2020-03-17 |
| CA3012294A1 (en) | 2017-08-24 |
| CU20180088A7 (es) | 2019-05-03 |
| AU2017219254B2 (en) | 2019-12-12 |
| EP3416982A1 (en) | 2018-12-26 |
| IL261065A (en) | 2018-10-31 |
| AU2017219254A1 (en) | 2018-08-02 |
| ECSP18064646A (es) | 2018-09-30 |
| CO2018008590A2 (es) | 2018-08-21 |
| MX2018010021A (es) | 2018-11-09 |
| CL2018001941A1 (es) | 2018-09-07 |
| CN108699142A (zh) | 2018-10-23 |
| HK1257455A1 (zh) | 2019-10-18 |
| US11180546B2 (en) | 2021-11-23 |
| KR20180107151A (ko) | 2018-10-01 |
| JP2019511911A (ja) | 2019-05-09 |
| MA44236A (fr) | 2018-12-26 |
| EA201891724A1 (ru) | 2019-01-31 |
| PH12018501525A1 (en) | 2019-03-18 |
| SG11201805941WA (en) | 2018-09-27 |
| US20190092846A1 (en) | 2019-03-28 |
| WO2017141208A1 (en) | 2017-08-24 |
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