IL261065A - Tgfbeta 2 antibodies - Google Patents
Tgfbeta 2 antibodiesInfo
- Publication number
- IL261065A IL261065A IL261065A IL26106518A IL261065A IL 261065 A IL261065 A IL 261065A IL 261065 A IL261065 A IL 261065A IL 26106518 A IL26106518 A IL 26106518A IL 261065 A IL261065 A IL 261065A
- Authority
- IL
- Israel
- Prior art keywords
- tgfbeta
- antibodies
- Prior art date
Links
- ZRKFYGHZFMAOKI-QMGMOQQFSA-N tgfbeta Chemical compound C([C@H](NC(=O)[C@H](C(C)C)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](N)CCSC)C(C)C)[C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](C)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N1[C@@H](CCC1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(O)=O)C1=CC=C(O)C=C1 ZRKFYGHZFMAOKI-QMGMOQQFSA-N 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/22—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/10—Immunoglobulins specific features characterized by their source of isolation or production
- C07K2317/14—Specific host cells or culture conditions, e.g. components, pH or temperature
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/55—Fab or Fab'
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Physical Education & Sports Medicine (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Neurology (AREA)
- Rheumatology (AREA)
- Dermatology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Oncology (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662296282P | 2016-02-17 | 2016-02-17 | |
| PCT/IB2017/050917 WO2017141208A1 (en) | 2016-02-17 | 2017-02-17 | Tgfbeta 2 antibodies |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IL261065A true IL261065A (en) | 2018-10-31 |
Family
ID=58191507
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL261065A IL261065A (en) | 2016-02-17 | 2018-08-08 | Tgfbeta 2 antibodies |
Country Status (21)
| Country | Link |
|---|---|
| US (1) | US11180546B2 (enExample) |
| EP (1) | EP3416982A1 (enExample) |
| JP (1) | JP2019511911A (enExample) |
| KR (1) | KR20180107151A (enExample) |
| CN (1) | CN108699142A (enExample) |
| AU (1) | AU2017219254B2 (enExample) |
| BR (1) | BR112018015690A2 (enExample) |
| CA (1) | CA3012294A1 (enExample) |
| CL (1) | CL2018001941A1 (enExample) |
| CO (1) | CO2018008590A2 (enExample) |
| CU (1) | CU20180088A7 (enExample) |
| EA (1) | EA201891724A1 (enExample) |
| EC (1) | ECSP18064646A (enExample) |
| HK (1) | HK1257455A1 (enExample) |
| IL (1) | IL261065A (enExample) |
| MA (1) | MA44236A (enExample) |
| MX (1) | MX2018010021A (enExample) |
| PH (1) | PH12018501525A1 (enExample) |
| RU (1) | RU2018131123A (enExample) |
| SG (1) | SG11201805941WA (enExample) |
| WO (1) | WO2017141208A1 (enExample) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB201610044D0 (en) | 2016-06-08 | 2016-07-20 | Ucb Biopharma Sprl | Antibodies |
| EP3820508A1 (en) | 2018-07-11 | 2021-05-19 | Scholar Rock, Inc. | High-affinity, isoform-selective tgf?1 inhibitors and use thereof |
| CN113365663B (zh) | 2018-08-30 | 2025-11-21 | 免疫生物公司 | 单链嵌合多肽和其用途 |
| KR20250160211A (ko) | 2018-08-30 | 2025-11-11 | 이뮤니티바이오, 인크. | 다중-사슬 키메라 폴리펩타이드 및 이의 용도 |
| CA3118027A1 (en) * | 2018-11-05 | 2020-05-14 | Ludwig Institute For Cancer Research Ltd. | Humanized and variant tgf-.beta.3 specific antibodies and methods and uses thereof |
| US11738052B2 (en) | 2019-06-21 | 2023-08-29 | HCW Biologics, Inc. | Multi-chain chimeric polypeptides and uses thereof |
| CA3152371A1 (en) | 2019-08-01 | 2021-02-04 | Vaccinex, Inc. | Combined inhibition of semaphorin-4d and tgf.beta. and compositions therefor |
| KR20220140535A (ko) | 2020-02-11 | 2022-10-18 | 에이치씨더블유 바이올로직스, 인크. | 크로마토그래피 수지 및 이의 용도 |
| WO2021163298A1 (en) | 2020-02-11 | 2021-08-19 | HCW Biologics, Inc. | Methods of activating regulatory t cells |
| CA3169231A1 (en) | 2020-02-11 | 2021-08-19 | HCW Biologics, Inc. | Methods of treating age-related and inflammatory diseases |
| US11919948B2 (en) | 2020-03-19 | 2024-03-05 | Genentech, Inc. | Isoform-selective anti-TGFβ antibodies and methods of use |
| JP7734693B2 (ja) | 2020-04-29 | 2025-09-05 | イミュニティーバイオ インコーポレイテッド | 抗ｃｄ２６タンパク質及びそれらの使用法 |
| US12024545B2 (en) | 2020-06-01 | 2024-07-02 | HCW Biologics, Inc. | Methods of treating aging-related disorders |
| US20240226295A9 (en) | 2021-02-15 | 2024-07-11 | Takeda Pharmaceutical Company Limited | Cell therapy compositions and methods for modulating tgf-b signaling |
| CN112940119B (zh) * | 2021-04-26 | 2022-05-20 | 北京芳渟阳生生物科技有限公司 | 一种单克隆抗体及其与间充质干细胞外泌体的联合应用 |
| JP2025513831A (ja) | 2022-04-13 | 2025-04-30 | イミュニティバイオ，インコーポレーテッド | 神経炎症性障害の処置における使用のための多重鎖キメラポリペプチド |
| KR20250004747A (ko) | 2022-04-13 | 2025-01-08 | 이뮤니티바이오, 인크. | 생체 시계 유전자 장애의 치료에 사용하기 위한 다중-사슬 키메라 폴리펩티드 |
| TWI866210B (zh) | 2022-05-17 | 2024-12-11 | 大陸商蘇州創勝醫藥集團有限公司 | 雙功能蛋白質及其製劑和用途 |
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| TWI681969B (zh) | 2014-01-23 | 2020-01-11 | 美商再生元醫藥公司 | 針對ｐｄ-１的人類抗體 |
| JOP20200094A1 (ar) | 2014-01-24 | 2017-06-16 | Dana Farber Cancer Inst Inc | جزيئات جسم مضاد لـ pd-1 واستخداماتها |
| TWI693232B (zh) | 2014-06-26 | 2020-05-11 | 美商宏觀基因股份有限公司 | 與pd-1和lag-3具有免疫反應性的共價結合的雙抗體和其使用方法 |
| TWI595006B (zh) | 2014-12-09 | 2017-08-11 | 禮納特神經系統科學公司 | 抗ｐｄ－１抗體類和使用彼等之方法 |
-
2017
- 2017-02-17 US US15/999,368 patent/US11180546B2/en active Active
- 2017-02-17 RU RU2018131123A patent/RU2018131123A/ru not_active Application Discontinuation
- 2017-02-17 JP JP2018543390A patent/JP2019511911A/ja not_active Ceased
- 2017-02-17 CU CU2018000088A patent/CU20180088A7/es unknown
- 2017-02-17 SG SG11201805941WA patent/SG11201805941WA/en unknown
- 2017-02-17 MX MX2018010021A patent/MX2018010021A/es unknown
- 2017-02-17 HK HK18116690.9A patent/HK1257455A1/zh unknown
- 2017-02-17 BR BR112018015690A patent/BR112018015690A2/pt not_active IP Right Cessation
- 2017-02-17 MA MA044236A patent/MA44236A/fr unknown
- 2017-02-17 WO PCT/IB2017/050917 patent/WO2017141208A1/en not_active Ceased
- 2017-02-17 CN CN201780011724.8A patent/CN108699142A/zh active Pending
- 2017-02-17 KR KR1020187023260A patent/KR20180107151A/ko not_active Withdrawn
- 2017-02-17 EA EA201891724A patent/EA201891724A1/ru unknown
- 2017-02-17 CA CA3012294A patent/CA3012294A1/en not_active Abandoned
- 2017-02-17 EP EP17707960.5A patent/EP3416982A1/en not_active Withdrawn
- 2017-02-17 AU AU2017219254A patent/AU2017219254B2/en not_active Ceased
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2018
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- 2018-08-08 IL IL261065A patent/IL261065A/en unknown
- 2018-08-15 CO CONC2018/0008590A patent/CO2018008590A2/es unknown
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Also Published As
| Publication number | Publication date |
|---|---|
| JP2019511911A (ja) | 2019-05-09 |
| CO2018008590A2 (es) | 2018-08-21 |
| AU2017219254B2 (en) | 2019-12-12 |
| CL2018001941A1 (es) | 2018-09-07 |
| US11180546B2 (en) | 2021-11-23 |
| PH12018501525A1 (en) | 2019-03-18 |
| CU20180088A7 (es) | 2019-05-03 |
| SG11201805941WA (en) | 2018-09-27 |
| WO2017141208A1 (en) | 2017-08-24 |
| CN108699142A (zh) | 2018-10-23 |
| AU2017219254A1 (en) | 2018-08-02 |
| US20190092846A1 (en) | 2019-03-28 |
| RU2018131123A (ru) | 2020-03-17 |
| EP3416982A1 (en) | 2018-12-26 |
| HK1257455A1 (zh) | 2019-10-18 |
| ECSP18064646A (es) | 2018-09-30 |
| MA44236A (fr) | 2018-12-26 |
| CA3012294A1 (en) | 2017-08-24 |
| BR112018015690A2 (pt) | 2018-12-26 |
| MX2018010021A (es) | 2018-11-09 |
| RU2018131123A3 (enExample) | 2020-07-09 |
| EA201891724A1 (ru) | 2019-01-31 |
| KR20180107151A (ko) | 2018-10-01 |
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