CO2018008590A2 - Anticuerpos anti tgfbeta 2 - Google Patents

Anticuerpos anti tgfbeta 2

Info

Publication number
CO2018008590A2
CO2018008590A2 CONC2018/0008590A CO2018008590A CO2018008590A2 CO 2018008590 A2 CO2018008590 A2 CO 2018008590A2 CO 2018008590 A CO2018008590 A CO 2018008590A CO 2018008590 A2 CO2018008590 A2 CO 2018008590A2
Authority
CO
Colombia
Prior art keywords
antibodies
tgf
tgfbeta
human
isoforms
Prior art date
Application number
CONC2018/0008590A
Other languages
English (en)
Inventor
Chikwendu Ibebunjo
Carsten Jacobi
Angelika Meyer
Eveline Schaadt
Anne-Ulrike Trendelenburg
Mitina Olga Vladimirovna
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=58191507&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CO2018008590(A2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of CO2018008590A2 publication Critical patent/CO2018008590A2/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/22—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/10—Immunoglobulins specific features characterized by their source of isolation or production
    • C07K2317/14—Specific host cells or culture conditions, e.g. components, pH or temperature
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55—Fab or Fab'
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

Abstract

Esta invención se encuentra en el campo de los anticuerpos anti factor de crecimiento beta 2 transformante (TGF-β2). En particular, la invención proporciona anticuerpos monoclonales humanos que se unen a la isoforma TGF-β2 humana preferentemente sobre las isoformas TGF-β1 o TGF-β3 humanas.
CONC2018/0008590A 2016-02-17 2018-08-15 Anticuerpos anti tgfbeta 2 CO2018008590A2 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201662296282P 2016-02-17 2016-02-17
PCT/IB2017/050917 WO2017141208A1 (en) 2016-02-17 2017-02-17 Tgfbeta 2 antibodies

Publications (1)

Publication Number Publication Date
CO2018008590A2 true CO2018008590A2 (es) 2018-08-21

Family

ID=58191507

Family Applications (1)

Application Number Title Priority Date Filing Date
CONC2018/0008590A CO2018008590A2 (es) 2016-02-17 2018-08-15 Anticuerpos anti tgfbeta 2

Country Status (21)

Country Link
US (1) US11180546B2 (es)
EP (1) EP3416982A1 (es)
JP (1) JP2019511911A (es)
KR (1) KR20180107151A (es)
CN (1) CN108699142A (es)
AU (1) AU2017219254B2 (es)
BR (1) BR112018015690A2 (es)
CA (1) CA3012294A1 (es)
CL (1) CL2018001941A1 (es)
CO (1) CO2018008590A2 (es)
CU (1) CU20180088A7 (es)
EA (1) EA201891724A1 (es)
EC (1) ECSP18064646A (es)
HK (1) HK1257455A1 (es)
IL (1) IL261065A (es)
MA (1) MA44236A (es)
MX (1) MX2018010021A (es)
PH (1) PH12018501525A1 (es)
RU (1) RU2018131123A (es)
SG (1) SG11201805941WA (es)
WO (1) WO2017141208A1 (es)

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AU2022219373A1 (en) 2021-02-15 2023-08-24 Takeda Pharmaceutical Company Limited Cell therapy compositions and methods for modulating tgf-b signaling
CN112940119B (zh) * 2021-04-26 2022-05-20 北京芳渟阳生生物科技有限公司 一种单克隆抗体及其与间充质干细胞外泌体的联合应用
WO2023201310A1 (en) 2022-04-13 2023-10-19 HCW Biologics, Inc. Multi-chain chimeric polypeptide for use in the treatment of circardian clock gene disorder
WO2023201311A1 (en) 2022-04-13 2023-10-19 HCW Biologics, Inc. Multi-chain chimeric polypeptide for use in the treatment of treating neuroinflammatory disorder

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Also Published As

Publication number Publication date
HK1257455A1 (zh) 2019-10-18
KR20180107151A (ko) 2018-10-01
PH12018501525A1 (en) 2019-03-18
EP3416982A1 (en) 2018-12-26
JP2019511911A (ja) 2019-05-09
RU2018131123A3 (es) 2020-07-09
RU2018131123A (ru) 2020-03-17
WO2017141208A1 (en) 2017-08-24
CU20180088A7 (es) 2019-05-03
CA3012294A1 (en) 2017-08-24
ECSP18064646A (es) 2018-09-30
SG11201805941WA (en) 2018-09-27
BR112018015690A2 (pt) 2018-12-26
US20190092846A1 (en) 2019-03-28
CN108699142A (zh) 2018-10-23
CL2018001941A1 (es) 2018-09-07
MA44236A (fr) 2018-12-26
MX2018010021A (es) 2018-11-09
EA201891724A1 (ru) 2019-01-31
US11180546B2 (en) 2021-11-23
AU2017219254A1 (en) 2018-08-02
AU2017219254B2 (en) 2019-12-12
IL261065A (en) 2018-10-31

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