PL3844189T3 - Strategia dawkowania, która łagodzi zespół uwalniania cytokin, dla przeciwciał dwuswoistych cd3/cd20 - Google Patents

Strategia dawkowania, która łagodzi zespół uwalniania cytokin, dla przeciwciał dwuswoistych cd3/cd20

Info

Publication number
PL3844189T3
PL3844189T3 PL19782800.7T PL19782800T PL3844189T3 PL 3844189 T3 PL3844189 T3 PL 3844189T3 PL 19782800 T PL19782800 T PL 19782800T PL 3844189 T3 PL3844189 T3 PL 3844189T3
Authority
PL
Poland
Prior art keywords
mitigates
bispecific antibodies
cytokine release
release syndrome
dosing strategy
Prior art date
Application number
PL19782800.7T
Other languages
English (en)
Inventor
Carrie BROWNSTEIN
Israel Lowy
Lieve Lucille ADRIAENS
Original Assignee
Regeneron Pharmaceuticals, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Regeneron Pharmaceuticals, Inc. filed Critical Regeneron Pharmaceuticals, Inc.
Publication of PL3844189T3 publication Critical patent/PL3844189T3/pl

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    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
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    • A61K31/33—Heterocyclic compounds
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    • A61K31/365—Lactones
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    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
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PL19782800.7T 2018-08-31 2019-08-30 Strategia dawkowania, która łagodzi zespół uwalniania cytokin, dla przeciwciał dwuswoistych cd3/cd20 PL3844189T3 (pl)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201862726137P 2018-08-31 2018-08-31
US201862774019P 2018-11-30 2018-11-30
US201962861100P 2019-06-13 2019-06-13
PCT/US2019/049027 WO2020047389A1 (en) 2018-08-31 2019-08-30 Dosing strategy that mitigates cytokine release syndrome for cd3/c20 bispecific antibodies

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PL3844189T3 true PL3844189T3 (pl) 2025-03-31

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US (2) US11590223B2 (pl)
EP (2) EP3844189B1 (pl)
JP (2) JP7605734B2 (pl)
KR (1) KR20210054528A (pl)
CN (1) CN112771077B (pl)
AU (1) AU2019331024B2 (pl)
CA (1) CA3110513A1 (pl)
DK (1) DK3844189T3 (pl)
ES (1) ES3009025T3 (pl)
FI (1) FI3844189T3 (pl)
HR (1) HRP20250234T1 (pl)
HU (1) HUE070384T2 (pl)
IL (1) IL280875B2 (pl)
LT (1) LT3844189T (pl)
MA (1) MA53495A (pl)
MX (1) MX2021002190A (pl)
PL (1) PL3844189T3 (pl)
PT (1) PT3844189T (pl)
RS (1) RS66543B1 (pl)
SI (1) SI3844189T1 (pl)
WO (1) WO2020047389A1 (pl)

Families Citing this family (19)

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Publication number Priority date Publication date Assignee Title
TWI701042B (zh) * 2014-03-19 2020-08-11 美商再生元醫藥公司 用於腫瘤治療之方法及抗體組成物
US10556952B2 (en) 2015-03-30 2020-02-11 Regeneron Pharmaceuticals, Inc. Heavy chain constant regions with reduced binding to Fc gamma receptors
TWI784917B (zh) 2015-09-23 2022-11-21 美商再生元醫藥公司 最優化抗ｃｄ３雙特異性抗體及其用途
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