JP2014501740A5 - - Google Patents

Download PDF

Info

Publication number
JP2014501740A5
JP2014501740A5 JP2013544980A JP2013544980A JP2014501740A5 JP 2014501740 A5 JP2014501740 A5 JP 2014501740A5 JP 2013544980 A JP2013544980 A JP 2013544980A JP 2013544980 A JP2013544980 A JP 2013544980A JP 2014501740 A5 JP2014501740 A5 JP 2014501740A5
Authority
JP
Japan
Prior art keywords
pharmaceutically acceptable
acceptable salt
effective amount
medicament
compound
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2013544980A
Other languages
English (en)
Japanese (ja)
Other versions
JP2014501740A (ja
JP5861194B2 (ja
Filing date
Publication date
Priority claimed from PCT/CN2011/074569 external-priority patent/WO2012159262A1/en
Application filed filed Critical
Priority claimed from PCT/CA2011/001397 external-priority patent/WO2012083435A1/en
Publication of JP2014501740A publication Critical patent/JP2014501740A/ja
Publication of JP2014501740A5 publication Critical patent/JP2014501740A5/ja
Application granted granted Critical
Publication of JP5861194B2 publication Critical patent/JP5861194B2/ja
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

JP2013544980A 2010-12-23 2011-12-21 選択的グルコシダーゼインヒビターおよびその使用 Expired - Fee Related JP5861194B2 (ja)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201061426773P 2010-12-23 2010-12-23
US61/426,773 2010-12-23
CNPCT/CN2011/074569 2011-05-24
PCT/CN2011/074569 WO2012159262A1 (en) 2011-05-24 2011-05-24 Selective glycosidase inhibitors and uses thereof
US201161507684P 2011-07-14 2011-07-14
US61/507,684 2011-07-14
PCT/CA2011/001397 WO2012083435A1 (en) 2010-12-23 2011-12-21 Selective glycosidase inhibitors and uses thereof

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2015230912A Division JP6322177B2 (ja) 2010-12-23 2015-11-26 選択的グルコシダーゼインヒビターおよびその使用

Publications (3)

Publication Number Publication Date
JP2014501740A JP2014501740A (ja) 2014-01-23
JP2014501740A5 true JP2014501740A5 (cg-RX-API-DMAC7.html) 2015-10-15
JP5861194B2 JP5861194B2 (ja) 2016-02-16

Family

ID=46312954

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2013544980A Expired - Fee Related JP5861194B2 (ja) 2010-12-23 2011-12-21 選択的グルコシダーゼインヒビターおよびその使用
JP2015230912A Active JP6322177B2 (ja) 2010-12-23 2015-11-26 選択的グルコシダーゼインヒビターおよびその使用

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2015230912A Active JP6322177B2 (ja) 2010-12-23 2015-11-26 選択的グルコシダーゼインヒビターおよびその使用

Country Status (26)

Country Link
US (2) US9243020B2 (cg-RX-API-DMAC7.html)
EP (1) EP2655388B1 (cg-RX-API-DMAC7.html)
JP (2) JP5861194B2 (cg-RX-API-DMAC7.html)
KR (1) KR101979036B1 (cg-RX-API-DMAC7.html)
CN (1) CN103339138B (cg-RX-API-DMAC7.html)
AR (1) AR085004A1 (cg-RX-API-DMAC7.html)
AU (1) AU2011349021B2 (cg-RX-API-DMAC7.html)
BR (1) BR112013016179A2 (cg-RX-API-DMAC7.html)
CA (1) CA2822493C (cg-RX-API-DMAC7.html)
CO (1) CO6821931A2 (cg-RX-API-DMAC7.html)
CY (1) CY1118157T1 (cg-RX-API-DMAC7.html)
DK (1) DK2655388T3 (cg-RX-API-DMAC7.html)
ES (1) ES2589164T3 (cg-RX-API-DMAC7.html)
HR (1) HRP20161079T1 (cg-RX-API-DMAC7.html)
HU (1) HUE030624T2 (cg-RX-API-DMAC7.html)
IL (1) IL227055A (cg-RX-API-DMAC7.html)
LT (1) LT2655388T (cg-RX-API-DMAC7.html)
MX (1) MX343822B (cg-RX-API-DMAC7.html)
MY (1) MY165728A (cg-RX-API-DMAC7.html)
NZ (1) NZ612703A (cg-RX-API-DMAC7.html)
PL (1) PL2655388T3 (cg-RX-API-DMAC7.html)
PT (1) PT2655388T (cg-RX-API-DMAC7.html)
RU (1) RU2609210C2 (cg-RX-API-DMAC7.html)
TW (1) TWI572609B (cg-RX-API-DMAC7.html)
WO (1) WO2012083435A1 (cg-RX-API-DMAC7.html)
ZA (1) ZA201305531B (cg-RX-API-DMAC7.html)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20080287375A1 (en) * 2005-03-01 2008-11-20 Simon Fraser University Selective Glycosidase Inhibitors, Methods of Making Inhibitors, and Uses Thereof
JP5380293B2 (ja) 2006-08-31 2014-01-08 サイモン・フレーザー・ユニバーシティ 選択的グリコシダーゼ阻害剤およびその使用
AU2009276223B2 (en) * 2008-08-01 2015-04-02 Simon Fraser University Selective glycosidase inhibitors and uses thereof
EP2569291B1 (en) 2010-05-11 2016-04-06 Simon Fraser University Selective glycosidase inhibitors and uses thereof
EP2638052B1 (en) * 2010-11-08 2017-03-22 Alectos Therapeutics, Inc. Selective glycosidase inhibitors and uses thereof
BR112013016179A2 (pt) * 2010-12-23 2018-07-10 Alectos Therapeutics Inc inibidores seletivos da glicosidase e usos dos mesmos.
WO2012126091A1 (en) 2011-03-24 2012-09-27 Alectos Therapeutics Inc. Selective glycosidase inhibitors and uses thereof
WO2012129651A1 (en) 2011-03-31 2012-10-04 Alectos Therapeutics Inc. Selective glycosidase inhibitors and uses thereof
WO2013000084A1 (en) * 2011-06-27 2013-01-03 Alectos Therapeutics Inc. Selective glycosidase inhibitors and uses thereof
WO2013000086A1 (en) 2011-06-27 2013-01-03 Alectos Therapeutics Inc. Selective glycosidase inhibitors and uses thereof
US9199949B2 (en) 2011-06-27 2015-12-01 Alectos Therapeutics Inc. Selective glycosidase inhibitors and uses thereof
CA2845149C (en) 2011-08-25 2019-12-31 Merck Patent Gmbh Pyrano[3,2-d] [1,3]thiazole as glycosidase inhibitors
EP2890676B1 (en) 2012-08-31 2018-12-05 Alectos Therapeutics Inc. Glycosidase inhibitors and uses thereof
US9809537B2 (en) 2012-08-31 2017-11-07 Alectos Therapeutics Inc. Glycosidase inhibitors and uses thereof
JP2015534991A (ja) * 2012-10-31 2015-12-07 アレクトス・セラピューティクス・インコーポレイテッド グリコシダーゼ阻害剤およびその使用
WO2014100934A1 (en) * 2012-12-24 2014-07-03 Merck Sharp & Dohme Corp. Glycosidase inhibitors and uses thereof
CA2958966C (en) 2014-08-28 2020-01-14 Asceneuron Sa Substituted cyclic amines as glucosidase inhibitors
KR101777164B1 (ko) 2015-07-20 2017-09-11 순천향대학교 산학협력단 O-GlcNAc 트랜스퍼레즈 억제제용 UDP-GlcNAc의 C1-포스포네이트 유도체
AR106977A1 (es) * 2015-12-14 2018-03-07 Amicus Therapeutics Inc Compuestos para el tratamiento de la enfermedad de alzheimer y/o la angiopatía amiloide cerebral
WO2017144637A1 (en) 2016-02-25 2017-08-31 Asceneuron S. A. Acid addition salts of piperazine derivatives
CA3012624A1 (en) 2016-02-25 2017-08-31 Asceneuron S.A. Glycosidase inhibitors
US11261183B2 (en) 2016-02-25 2022-03-01 Asceneuron Sa Sulfoximine glycosidase inhibitors
WO2017144633A1 (en) 2016-02-25 2017-08-31 Asceneuron S. A. Glycosidase inhibitors
EP3672959A1 (en) 2017-08-24 2020-07-01 Asceneuron SA Linear glycosidase inhibitors
CN107814773B (zh) * 2017-11-13 2020-05-22 西安交通大学 含有喹唑啉酮的二芳基脲类化合物及其制备方法和应用
US20210115040A1 (en) * 2018-06-20 2021-04-22 Janssen Pharmaceutica Nv Oga inhibitor compounds
WO2020039029A1 (en) 2018-08-22 2020-02-27 Asceneuron S. A. Spiro compounds as glycosidase inhibitors
MX2021002111A (es) * 2018-08-22 2021-07-16 Asceneuron S A Sales de adición de ácido de succinato y fumarato de derivados de piperazina útiles como inhibidores de glucosidasa.
US11795165B2 (en) 2018-08-22 2023-10-24 Asceneuron Sa Tetrahydro-benzoazepine glycosidase inhibitors
WO2020039027A1 (en) 2018-08-22 2020-02-27 Asceneuron S. A. Pyrrolidine glycosidase inhibitors
CN114174263B (zh) * 2019-05-10 2025-01-10 阿勒克图治疗公司 非溶酶体葡糖神经酰胺酶抑制剂及其用途
CN111956656B (zh) * 2020-08-28 2021-10-15 河北大学 Oga抑制剂在制备抗肿瘤药物中的应用
WO2024083820A1 (en) 2022-10-18 2024-04-25 Institut National de la Santé et de la Recherche Médicale Method and composition for determining the level of o-glcnacylation in horses

Family Cites Families (78)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS423500Y1 (cg-RX-API-DMAC7.html) 1964-02-29 1967-03-01
DE2632243C3 (de) 1976-07-17 1979-08-30 Heidelberger Druckmaschinen Ag, 6900 Heidelberg Auf variable Bogenlängen einstellbare Umführtrommel für Druckmaschinen
DE3620645A1 (de) 1985-12-20 1987-07-02 Bayer Ag 3-amino-4,5-dihydroxypiperidine, verfahren zu ihrer herstellung und ihre verwendung
EP0243686B1 (en) 1986-03-27 1992-07-15 Sumitomo Pharmaceuticals Company, Limited Beta-lactam compounds, and their production
SU1441749A1 (ru) * 1987-03-16 1996-01-10 Институт Тонкой Органической Химии Им.А.Л.Мнджояна 2-АМИНО-5,5-ДИМЕТИЛ-4,5-ДИГИДРО-7Н-ПИРАНО [4,3-d] ТИАЗОЛ, ОБЛАДАЮЩИЙ ТРАНКВИЛИЗИРУЮЩЕЙ АКТИВНОСТЬЮ
JPS6461459A (en) 1987-08-28 1989-03-08 Nippon Shinyaku Co Ltd Moranoline derivative
JPH01180894A (ja) 1988-01-07 1989-07-18 Wako Pure Chem Ind Ltd アミノ糖誘導体の新規な製造法
GB8900719D0 (en) 1989-01-13 1989-03-08 Nycomed As Compounds
US5079254A (en) 1990-06-04 1992-01-07 Merrell Dow Pharmaceuticals Inc. Derivatives of 6-aminooctahydroindolizinetriol
WO1992003415A1 (en) 1990-08-14 1992-03-05 Nova Pharmaceutical Corporation Protein kinase c modulators
US5276120A (en) 1991-05-30 1994-01-04 The Scripps Research Institute Process for forming omega-deuxy-azasugars
US6291657B1 (en) 1993-05-13 2001-09-18 Monsanto Company Deoxygalactonojirimycin derivatives
US5451679A (en) 1994-03-08 1995-09-19 G. D. Searle & Co. 2-chloro and 2-bromo derivatives of 1,5-iminosugars
JPH07316178A (ja) 1994-05-25 1995-12-05 Sankyo Co Ltd 糖アミノオキサゾリン類
CN1131672A (zh) 1994-11-22 1996-09-25 生化学工业株式会社 氨基环戊烷衍生物
CA2235415A1 (en) 1995-09-08 1997-03-13 Novo Nordisk A/S 2-alkylpyrrolidines
CZ120398A3 (cs) 1995-09-08 1998-12-16 Novo Nordisk A/S Použití 2-alkylpyrrolidinových derivátů pro přípravu léčiva pro léčbu diabetu, 2-alkylpyrrolidiné deriváty
JPH09132585A (ja) 1995-11-10 1997-05-20 Shin Etsu Chem Co Ltd 新規アミノ糖及びキトオリゴ糖又はその類似オリゴ糖の製造方法
US6407103B2 (en) 1998-04-21 2002-06-18 Bristol-Myers Squibb Pharma Company Indeno [1,2-c] pyrazol-4-ones and their uses
JPH11349541A (ja) 1998-06-08 1999-12-21 Sankyo Co Ltd アロサミゾリン誘導体の新規な中間体
GB9818732D0 (en) 1998-08-27 1998-10-21 Univ Portsmouth Collection of compounds
US6774140B1 (en) 1999-05-11 2004-08-10 The Scripps Research Institute Iminocyclitol inhibitors of hexoaminidase and glycosidase
DE60045217D1 (de) 1999-05-11 2010-12-23 Scripps Research Inst Iminocyclitol-inhibitoren von hexoaminidase und glycosidase
FR2817472B1 (fr) 2000-12-06 2003-01-03 Oreal Composition de teinture d'oxydation a base de 1-(4-aminophenyl)pyrrolidines substituees au moins en position 2 et 3 et procede de teinture de mise en oeuvre
ATE509117T1 (de) 2001-03-14 2011-05-15 Denki Kagaku Kogyo Kk Herstellungsverfahren für hyaluronsäure oder ihre derivate
JP4233262B2 (ja) 2001-03-14 2009-03-04 生化学工業株式会社 カルバ糖アミン誘導体及びそれを用いるグリコシダーゼ阻害剤
WO2003008379A1 (en) 2001-06-08 2003-01-30 Mitsubishi Chemical Corporation Azasugar compounds
JP4866515B2 (ja) 2001-07-02 2012-02-01 生化学工業株式会社 糖オキサゾリン誘導体の製造方法
WO2003009808A2 (en) 2001-07-24 2003-02-06 Yale University Methods, compositions and kits relating to chitinases and chitinase-like molecules and inflammatory disease
CA2526173A1 (en) 2003-05-22 2004-12-02 The Hospital For Sick Children Treatment of tay sachs or sandhoff diseases by enhancing hexosaminidase activity
CN1548053A (zh) 2003-05-23 2004-11-24 华晶基因技术有限公司 黄芩甙作为治疗焦虑症的药物的新用途
WO2005026156A1 (en) 2003-09-16 2005-03-24 Astrazeneca Ab Quinazoline derivatives
WO2005072268A2 (en) 2004-01-20 2005-08-11 Optimer Pharmaceuticals, Inc. Treatment of degeneraative cartilage conditions in a mammal with glycosidase inhibitors
US20080166323A1 (en) 2004-04-14 2008-07-10 Uab Research Foundation Activators of Hexosamine Biosynthesis as Inhibitors of Injury Induced by Ischemia or Hermorrhagic Shock
TW200602314A (en) 2004-05-28 2006-01-16 Tanabe Seiyaku Co A novel pyrrolidine compound and a process for preparing the same
WO2006008194A1 (en) 2004-07-23 2006-01-26 Bayer Cropscience Sa 3-pyridinylethylcarboxamide derivatives as fungicides
EP1789413A1 (en) 2004-09-13 2007-05-30 Amgen Inc. Vanilloid receptor ligands and their use in treatments
US7884115B2 (en) 2004-09-28 2011-02-08 Allergan, Inc. Methods and compositions for the treatment of pain and other neurological conditions
US20080287375A1 (en) 2005-03-01 2008-11-20 Simon Fraser University Selective Glycosidase Inhibitors, Methods of Making Inhibitors, and Uses Thereof
AT502145B1 (de) 2005-03-24 2012-01-15 Univ Graz Tech Glycosidase-hemmendes iminoalditol
US7820699B2 (en) 2005-04-27 2010-10-26 Hoffmann-La Roche Inc. Cyclic amines
US20070111981A1 (en) 2005-10-26 2007-05-17 Roth Gerald J New (hetero)aryl compounds with MCH antagonistic activity and medicaments comprising these compounds
WO2007067515A2 (en) 2005-12-05 2007-06-14 Academia Sinica Novel five-membered iminocyclitol derivatives as selective and potent glycosidase inhibitors: new structures for antivirals and osteoarthritis therapeutics
JP5380293B2 (ja) 2006-08-31 2014-01-08 サイモン・フレーザー・ユニバーシティ 選択的グリコシダーゼ阻害剤およびその使用
CN107253970A (zh) * 2006-08-31 2017-10-17 西蒙·弗雷瑟大学 选择性糖苷酶抑制剂及其用途
US8258307B2 (en) 2006-11-07 2012-09-04 University Of Tokyo Amide compound or salt thereof, and biofilm inhibitor, biofilm remover and disinfectant containing the same
CA2732335A1 (en) 2008-08-01 2010-02-04 Simon Fraser University Selective glycosidase inhibitors and uses thereof
AU2009276223B2 (en) 2008-08-01 2015-04-02 Simon Fraser University Selective glycosidase inhibitors and uses thereof
US20110195929A1 (en) 2008-08-05 2011-08-11 Summit Corporation Plc Compounds for the treatment of flaviviral infections
EP2323652A2 (en) 2008-08-06 2011-05-25 Summit Corporation Plc Treatment of lysosomal storage disorders and other proteostatic diseases
AU2009299073B2 (en) 2008-09-16 2015-04-02 Simon Fraser University Selective glycosidase inhibitors and uses thereof
WO2010049678A2 (en) 2008-10-31 2010-05-06 Summit Corporation Plc Treatment of energy utilization diseases
AT507745B1 (de) 2008-12-16 2012-01-15 Forschungsholding Tu Graz Gmbh Fluorophile glykosidasehemmer
WO2011060397A1 (en) 2009-11-16 2011-05-19 Schering Corporation Substituted amino heterocycles useful as hiv antagonists
EP2569291B1 (en) 2010-05-11 2016-04-06 Simon Fraser University Selective glycosidase inhibitors and uses thereof
TW201249848A (en) 2010-11-08 2012-12-16 Merck Sharp & Dohme Selective glycosidase inhibitors and uses thereof
WO2012061971A1 (en) 2010-11-08 2012-05-18 Alectos Therapeutics Inc. Selective glycosidase inhibitors and uses thereof
US8901087B2 (en) 2010-11-08 2014-12-02 Merck Sharp & Dohme Corp. Selective glycosidase inhibitors and uses thereof
WO2012061972A1 (en) 2010-11-08 2012-05-18 Alectos Therapeutics Inc. Selective glycosidase inhibitors and uses thereof
EP2638052B1 (en) 2010-11-08 2017-03-22 Alectos Therapeutics, Inc. Selective glycosidase inhibitors and uses thereof
BR112013016179A2 (pt) * 2010-12-23 2018-07-10 Alectos Therapeutics Inc inibidores seletivos da glicosidase e usos dos mesmos.
GB201103526D0 (en) 2011-03-02 2011-04-13 Summit Corp Plc Selective glycosidase inhibitors and uses thereof
JP6277121B2 (ja) 2011-03-22 2018-02-07 アドヴィナス・セラピューティックス・リミテッド 置換された縮合三環式化合物、その組成物および医学的応用
WO2012126091A1 (en) 2011-03-24 2012-09-27 Alectos Therapeutics Inc. Selective glycosidase inhibitors and uses thereof
WO2012129802A1 (en) 2011-03-31 2012-10-04 Alectos Therapeutics Inc. Pyrano[3,2-d]thiazol derivatives and uses as selective glycosidase inhibitors thereof
WO2012129651A1 (en) 2011-03-31 2012-10-04 Alectos Therapeutics Inc. Selective glycosidase inhibitors and uses thereof
US9199949B2 (en) 2011-06-27 2015-12-01 Alectos Therapeutics Inc. Selective glycosidase inhibitors and uses thereof
WO2013000086A1 (en) 2011-06-27 2013-01-03 Alectos Therapeutics Inc. Selective glycosidase inhibitors and uses thereof
WO2013000084A1 (en) 2011-06-27 2013-01-03 Alectos Therapeutics Inc. Selective glycosidase inhibitors and uses thereof
EP2744338B1 (en) 2011-08-18 2016-04-27 Merck Sharp & Dohme Corp. Selective glycosidase inhibitors and uses thereof
CA2845149C (en) 2011-08-25 2019-12-31 Merck Patent Gmbh Pyrano[3,2-d] [1,3]thiazole as glycosidase inhibitors
EP2847199B1 (en) 2012-05-08 2017-10-25 Merck Sharp & Dohme Corp. Permeable glycosidase inhibitors and uses thereof
US9809537B2 (en) 2012-08-31 2017-11-07 Alectos Therapeutics Inc. Glycosidase inhibitors and uses thereof
EP2890676B1 (en) 2012-08-31 2018-12-05 Alectos Therapeutics Inc. Glycosidase inhibitors and uses thereof
US20150299122A1 (en) 2012-08-31 2015-10-22 Alectos Therapeutics Inc. Glycosidase inhibitors and uses thereof
US9522883B2 (en) 2012-08-31 2016-12-20 Alectos Therapeutics Inc. Glycosidase inhibitors and uses thereof
JP2015534991A (ja) 2012-10-31 2015-12-07 アレクトス・セラピューティクス・インコーポレイテッド グリコシダーゼ阻害剤およびその使用
WO2014100934A1 (en) 2012-12-24 2014-07-03 Merck Sharp & Dohme Corp. Glycosidase inhibitors and uses thereof

Similar Documents

Publication Publication Date Title
JP2014501740A5 (cg-RX-API-DMAC7.html)
JP2014524911A5 (cg-RX-API-DMAC7.html)
JP2015534991A5 (cg-RX-API-DMAC7.html)
RU2013134345A (ru) Селективные ингибиторы гликозидазы и их применение
JP2010501598A5 (cg-RX-API-DMAC7.html)
RU2014102232A (ru) Селективные ингибиторы гликозидазы и их применение
JP2012502884A5 (cg-RX-API-DMAC7.html)
JP2013541596A5 (cg-RX-API-DMAC7.html)
RU2015120556A (ru) Ингибиторы гликозидаз и их применения
JP6218260B2 (ja) Jak阻害剤としてのアミノピリミジニル化合物
JP2011529858A5 (cg-RX-API-DMAC7.html)
JP2011529857A5 (cg-RX-API-DMAC7.html)
WO2008025170B1 (en) Selective glycosidase inhibitors and uses thereof
JP6740354B2 (ja) オートファジーの流れ及びホスホリパーゼd及びタウを含むタンパク質凝集体のクリアランスの活性化剤ならびにタンパク質症の治療方法
SI2956452T1 (en) Heterocyclic amides as kinase inhibitors
TW200911254A (en) Oxadiazole derivatives and their use as metabotropic glutamate receptor potentiators-842
CN100475813C (zh) 4-氧代-1-(3-取代苯基)-1,4-二氢-1,8-萘啶-3-甲酰胺磷酸二酯酶-4抑制剂
JP2004505973A (ja) ブラジキニンアンタゴニストとしての1,4−ジヒドロピリジン類
KR102602998B1 (ko) 억제제 및 이의 사용
US10835624B2 (en) Compounds for imaging Tau protein aggregates
JP2017538753A5 (cg-RX-API-DMAC7.html)
US9464103B2 (en) Spirocyclic sulfones as gamma secretase inhibitors
JPWO2021262484A5 (cg-RX-API-DMAC7.html)
JP2018515536A (ja) カゼインキナーゼ1δ阻害剤
CA2601458A1 (en) Benzimidazolone derivatives as cb2 receptor ligands