AU2011349021B2 - Selective glycosidase inhibitors and uses thereof - Google Patents
Selective glycosidase inhibitors and uses thereof Download PDFInfo
- Publication number
- AU2011349021B2 AU2011349021B2 AU2011349021A AU2011349021A AU2011349021B2 AU 2011349021 B2 AU2011349021 B2 AU 2011349021B2 AU 2011349021 A AU2011349021 A AU 2011349021A AU 2011349021 A AU2011349021 A AU 2011349021A AU 2011349021 B2 AU2011349021 B2 AU 2011349021B2
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- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H9/00—Compounds containing a hetero ring sharing at least two hetero atoms with a saccharide radical
- C07H9/06—Compounds containing a hetero ring sharing at least two hetero atoms with a saccharide radical the hetero ring containing nitrogen as ring hetero atoms
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/429—Thiazoles condensed with heterocyclic ring systems
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- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/7056—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing five-membered rings with nitrogen as a ring hetero atom
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
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- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
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- C07H9/00—Compounds containing a hetero ring sharing at least two hetero atoms with a saccharide radical
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
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- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
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- G01N2333/914—Hydrolases (3)
- G01N2333/924—Hydrolases (3) acting on glycosyl compounds (3.2)
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- General Health & Medical Sciences (AREA)
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- Molecular Biology (AREA)
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- Zoology (AREA)
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Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201061426773P | 2010-12-23 | 2010-12-23 | |
| US61/426,773 | 2010-12-23 | ||
| PCT/CN2011/074569 WO2012159262A1 (en) | 2011-05-24 | 2011-05-24 | Selective glycosidase inhibitors and uses thereof |
| AUPCT/CN2011/074569 | 2011-05-24 | ||
| US201161507684P | 2011-07-14 | 2011-07-14 | |
| US61/507,684 | 2011-07-14 | ||
| PCT/CA2011/001397 WO2012083435A1 (en) | 2010-12-23 | 2011-12-21 | Selective glycosidase inhibitors and uses thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| AU2011349021A1 AU2011349021A1 (en) | 2013-08-08 |
| AU2011349021B2 true AU2011349021B2 (en) | 2016-12-22 |
Family
ID=46312954
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2011349021A Ceased AU2011349021B2 (en) | 2010-12-23 | 2011-12-21 | Selective glycosidase inhibitors and uses thereof |
Country Status (26)
Families Citing this family (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2599843C (en) * | 2005-03-01 | 2013-08-27 | Simon Fraser University | Selective glycosidase inhibitors, methods of making inhibitors, and uses thereof |
| US8334310B2 (en) | 2006-08-31 | 2012-12-18 | Simon Fraser University | Selective glycosidase inhibitors and uses thereof |
| CA2732336A1 (en) * | 2008-08-01 | 2010-02-04 | Simon Fraser University | Selective glycosidase inhibitors and uses thereof |
| EP2569291B1 (en) | 2010-05-11 | 2016-04-06 | Simon Fraser University | Selective glycosidase inhibitors and uses thereof |
| US8933040B2 (en) | 2010-11-08 | 2015-01-13 | Craig A. Coburn | Selective glycosidase inhibitors and uses thereof |
| US9243020B2 (en) | 2010-12-23 | 2016-01-26 | Alectos Therapeutics Inc. | Selective glycosidase inhibitors and uses thereof |
| EP2688899B1 (en) | 2011-03-24 | 2017-02-22 | Alectos Therapeutics Inc. | Selective glycosidase inhibitors and uses thereof |
| EP2691407B1 (en) | 2011-03-31 | 2017-02-22 | Alectos Therapeutics Inc. | Selective glycosidase inhibitors and uses thereof |
| WO2013000086A1 (en) | 2011-06-27 | 2013-01-03 | Alectos Therapeutics Inc. | Selective glycosidase inhibitors and uses thereof |
| EP2726468B1 (en) | 2011-06-27 | 2017-04-12 | Alectos Therapeutics Inc. | Selective glycosidase inhibitors and uses thereof |
| BR112013033098B8 (pt) | 2011-06-27 | 2021-03-23 | Alectos Therapeutics Inc | inibidores de glicosidade seletivos e usos dos mesmos |
| RS54773B1 (sr) | 2011-08-25 | 2016-10-31 | Merck Patent Gmbh | Pirano [3,2-d][1,3] tiazol kao inhibitor glukozidaze |
| EP2890676B1 (en) | 2012-08-31 | 2018-12-05 | Alectos Therapeutics Inc. | Glycosidase inhibitors and uses thereof |
| EP2890675A4 (en) | 2012-08-31 | 2016-01-13 | Alectos Therapeutics Inc | GLYCOSIDASE INHIBITORS AND USES THEREOF |
| BR112015009638A2 (pt) * | 2012-10-31 | 2017-07-04 | Alectos Therapeutics Inc | inibidores de glicosidase e usos dos mesmos |
| WO2014100934A1 (en) * | 2012-12-24 | 2014-07-03 | Merck Sharp & Dohme Corp. | Glycosidase inhibitors and uses thereof |
| CN107108601B (zh) | 2014-08-28 | 2021-08-20 | 阿森纽荣股份公司 | 糖苷酶抑制剂 |
| KR101777164B1 (ko) | 2015-07-20 | 2017-09-11 | 순천향대학교 산학협력단 | O-GlcNAc 트랜스퍼레즈 억제제용 UDP-GlcNAc의 C1-포스포네이트 유도체 |
| US9994589B2 (en) * | 2015-12-14 | 2018-06-12 | Amicus Therapeutics, Inc. | Compounds and methods for the treatment of alzheimer's disease and/or cerebral amyloid angiopathy |
| US11612599B2 (en) | 2016-02-25 | 2023-03-28 | Asceneuron Sa | Glycosidase inhibitors |
| CN108884078A (zh) | 2016-02-25 | 2018-11-23 | 阿森纽荣股份公司 | 糖苷酶抑制剂 |
| US11261183B2 (en) | 2016-02-25 | 2022-03-01 | Asceneuron Sa | Sulfoximine glycosidase inhibitors |
| WO2017144637A1 (en) | 2016-02-25 | 2017-08-31 | Asceneuron S. A. | Acid addition salts of piperazine derivatives |
| WO2019037860A1 (en) | 2017-08-24 | 2019-02-28 | Asceneuron S.A. | LINEAR INHIBITORS OF GLYCOSIDASE |
| CN107814773B (zh) * | 2017-11-13 | 2020-05-22 | 西安交通大学 | 含有喹唑啉酮的二芳基脲类化合物及其制备方法和应用 |
| US20210115040A1 (en) * | 2018-06-20 | 2021-04-22 | Janssen Pharmaceutica Nv | Oga inhibitor compounds |
| ES2954474T3 (es) | 2018-08-22 | 2023-11-22 | Asceneuron Sa | Sales de adición de ácido de succinato y fumarato de derivados de piperazina útiles como inhibidores de glucosidasa |
| WO2020039027A1 (en) | 2018-08-22 | 2020-02-27 | Asceneuron S. A. | Pyrrolidine glycosidase inhibitors |
| US11731972B2 (en) | 2018-08-22 | 2023-08-22 | Asceneuron Sa | Spiro compounds as glycosidase inhibitors |
| US11795165B2 (en) | 2018-08-22 | 2023-10-24 | Asceneuron Sa | Tetrahydro-benzoazepine glycosidase inhibitors |
| WO2020229968A1 (en) * | 2019-05-10 | 2020-11-19 | Alectos Therapeutics Inc. | Non-lysosomal glucosylceramidase inhibitors and uses thereof |
| CN111956656B (zh) * | 2020-08-28 | 2021-10-15 | 河北大学 | Oga抑制剂在制备抗肿瘤药物中的应用 |
| WO2024083820A1 (en) | 2022-10-18 | 2024-04-25 | Institut National de la Santé et de la Recherche Médicale | Method and composition for determining the level of o-glcnacylation in horses |
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| JPS423500Y1 (cg-RX-API-DMAC7.html) | 1964-02-29 | 1967-03-01 | ||
| DE2632243C3 (de) | 1976-07-17 | 1979-08-30 | Heidelberger Druckmaschinen Ag, 6900 Heidelberg | Auf variable Bogenlängen einstellbare Umführtrommel für Druckmaschinen |
| DE3620645A1 (de) | 1985-12-20 | 1987-07-02 | Bayer Ag | 3-amino-4,5-dihydroxypiperidine, verfahren zu ihrer herstellung und ihre verwendung |
| EP0243686B1 (en) | 1986-03-27 | 1992-07-15 | Sumitomo Pharmaceuticals Company, Limited | Beta-lactam compounds, and their production |
| SU1441749A1 (ru) * | 1987-03-16 | 1996-01-10 | Институт Тонкой Органической Химии Им.А.Л.Мнджояна | 2-АМИНО-5,5-ДИМЕТИЛ-4,5-ДИГИДРО-7Н-ПИРАНО [4,3-d] ТИАЗОЛ, ОБЛАДАЮЩИЙ ТРАНКВИЛИЗИРУЮЩЕЙ АКТИВНОСТЬЮ |
| JPS6461459A (en) | 1987-08-28 | 1989-03-08 | Nippon Shinyaku Co Ltd | Moranoline derivative |
| JPH01180894A (ja) | 1988-01-07 | 1989-07-18 | Wako Pure Chem Ind Ltd | アミノ糖誘導体の新規な製造法 |
| GB8900719D0 (en) | 1989-01-13 | 1989-03-08 | Nycomed As | Compounds |
| US5079254A (en) | 1990-06-04 | 1992-01-07 | Merrell Dow Pharmaceuticals Inc. | Derivatives of 6-aminooctahydroindolizinetriol |
| WO1992003415A1 (en) | 1990-08-14 | 1992-03-05 | Nova Pharmaceutical Corporation | Protein kinase c modulators |
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