HRP20161079T1 - Selektivni inhibitori glikozidaze i njihove uporabe - Google Patents
Selektivni inhibitori glikozidaze i njihove uporabe Download PDFInfo
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- HRP20161079T1 HRP20161079T1 HRP20161079TT HRP20161079T HRP20161079T1 HR P20161079 T1 HRP20161079 T1 HR P20161079T1 HR P20161079T T HRP20161079T T HR P20161079TT HR P20161079 T HRP20161079 T HR P20161079T HR P20161079 T1 HRP20161079 T1 HR P20161079T1
- Authority
- HR
- Croatia
- Prior art keywords
- pyrano
- tetrahydro
- thiazol
- diol
- fluoro
- Prior art date
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- 239000003316 glycosidase inhibitor Substances 0.000 title 1
- 150000001875 compounds Chemical class 0.000 claims 24
- 150000003839 salts Chemical class 0.000 claims 9
- 201000011240 Frontotemporal dementia Diseases 0.000 claims 5
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 5
- 201000002212 progressive supranuclear palsy Diseases 0.000 claims 5
- KFTTUHTWIAVGRH-IECVIRLLSA-N (3ar,5r,6r,7s,7ar)-7-fluoro-5-(hydroxymethyl)-2-(methylamino)-5,6,7,7a-tetrahydro-3ah-pyrano[3,2-d][1,3]thiazol-6-ol Chemical compound S1C(NC)=N[C@H]2[C@@H]1O[C@H](CO)[C@@H](O)[C@H]2F KFTTUHTWIAVGRH-IECVIRLLSA-N 0.000 claims 4
- ZMLWGEHWECDGGA-SDDMPLOYSA-N (3ar,5s,6r,7s,7ar)-5-(difluoromethyl)-7-fluoro-2-(methylamino)-5,6,7,7a-tetrahydro-3ah-pyrano[3,2-d][1,3]thiazol-6-ol Chemical compound S1C(NC)=N[C@H]2[C@@H]1O[C@H](C(F)F)[C@@H](O)[C@H]2F ZMLWGEHWECDGGA-SDDMPLOYSA-N 0.000 claims 4
- KBXUKXMJHZMGPE-KYGLGHNPSA-N (3ar,5s,6s,7r,7ar)-5-(difluoromethyl)-2-(dimethylamino)-5,6,7,7a-tetrahydro-3ah-pyrano[3,2-d][1,3]thiazole-6,7-diol Chemical compound S1C(N(C)C)=N[C@H]2[C@@H]1O[C@H](C(F)F)[C@@H](O)[C@@H]2O KBXUKXMJHZMGPE-KYGLGHNPSA-N 0.000 claims 4
- UDQTXCHQKHIQMH-KYGLGHNPSA-N (3ar,5s,6s,7r,7ar)-5-(difluoromethyl)-2-(ethylamino)-5,6,7,7a-tetrahydro-3ah-pyrano[3,2-d][1,3]thiazole-6,7-diol Chemical compound S1C(NCC)=N[C@H]2[C@@H]1O[C@H](C(F)F)[C@@H](O)[C@@H]2O UDQTXCHQKHIQMH-KYGLGHNPSA-N 0.000 claims 4
- NXPIDVOWIZXECG-RLZVPWTLSA-N (3ar,5s,6s,7r,7ar)-5-(difluoromethyl)-2-(methylamino)-5,6,7,7a-tetrahydro-3ah-pyrano[3,2-d][1,3]thiazole-6,7-diol Chemical compound S1C(NC)=N[C@H]2[C@@H]1O[C@H](C(F)F)[C@@H](O)[C@@H]2O NXPIDVOWIZXECG-RLZVPWTLSA-N 0.000 claims 4
- DJQLZCGDQCJIBK-NYMZXIIRSA-N (3ar,5s,6s,7r,7ar)-5-(fluoromethyl)-2-(methylamino)-5,6,7,7a-tetrahydro-3ah-pyrano[3,2-d][1,3]thiazole-6,7-diol Chemical compound S1C(NC)=N[C@H]2[C@@H]1O[C@H](CF)[C@@H](O)[C@@H]2O DJQLZCGDQCJIBK-NYMZXIIRSA-N 0.000 claims 4
- 208000003407 Creutzfeldt-Jakob Syndrome Diseases 0.000 claims 4
- 125000003342 alkenyl group Chemical group 0.000 claims 4
- 125000000217 alkyl group Chemical group 0.000 claims 4
- 125000000304 alkynyl group Chemical group 0.000 claims 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 4
- 125000001153 fluoro group Chemical group F* 0.000 claims 4
- 125000001424 substituent group Chemical group 0.000 claims 4
- 208000024827 Alzheimer disease Diseases 0.000 claims 3
- 208000020446 Cardiac disease Diseases 0.000 claims 3
- 208000029523 Interstitial Lung disease Diseases 0.000 claims 3
- 206010052779 Transplant rejections Diseases 0.000 claims 3
- 206010002026 amyotrophic lateral sclerosis Diseases 0.000 claims 3
- 208000010877 cognitive disease Diseases 0.000 claims 3
- 201000010099 disease Diseases 0.000 claims 3
- 208000019622 heart disease Diseases 0.000 claims 3
- JOKKFZJLPKIPOS-FMDGEEDCSA-N (3ar,5r,6r,7r,7ar)-2-(dimethylamino)-7-fluoro-5-(hydroxymethyl)-5,6,7,7a-tetrahydro-3ah-pyrano[3,2-d][1,3]thiazol-6-ol Chemical compound S1C(N(C)C)=N[C@H]2[C@@H]1O[C@H](CO)[C@@H](O)[C@@H]2F JOKKFZJLPKIPOS-FMDGEEDCSA-N 0.000 claims 2
- ICJGJSLPQBWFGV-FMDGEEDCSA-N (3ar,5r,6r,7r,7ar)-2-(ethylamino)-7-fluoro-5-(hydroxymethyl)-5,6,7,7a-tetrahydro-3ah-pyrano[3,2-d][1,3]thiazol-6-ol Chemical compound S1C(NCC)=N[C@H]2[C@@H]1O[C@H](CO)[C@@H](O)[C@@H]2F ICJGJSLPQBWFGV-FMDGEEDCSA-N 0.000 claims 2
- KFTTUHTWIAVGRH-NYMZXIIRSA-N (3ar,5r,6r,7r,7ar)-7-fluoro-5-(hydroxymethyl)-2-(methylamino)-5,6,7,7a-tetrahydro-3ah-pyrano[3,2-d][1,3]thiazol-6-ol Chemical compound S1C(NC)=N[C@H]2[C@@H]1O[C@H](CO)[C@@H](O)[C@@H]2F KFTTUHTWIAVGRH-NYMZXIIRSA-N 0.000 claims 2
- VKALMUKKLOGDPG-JGKVKWKGSA-N (3ar,5r,6r,7r,7ar)-7-fluoro-5-(hydroxymethyl)-2-(propylamino)-5,6,7,7a-tetrahydro-3ah-pyrano[3,2-d][1,3]thiazol-6-ol Chemical compound S1C(NCCC)=N[C@H]2[C@@H]1O[C@H](CO)[C@@H](O)[C@@H]2F VKALMUKKLOGDPG-JGKVKWKGSA-N 0.000 claims 2
- JOKKFZJLPKIPOS-OZRXBMAMSA-N (3ar,5r,6r,7s,7ar)-2-(dimethylamino)-7-fluoro-5-(hydroxymethyl)-5,6,7,7a-tetrahydro-3ah-pyrano[3,2-d][1,3]thiazol-6-ol Chemical compound S1C(N(C)C)=N[C@H]2[C@@H]1O[C@H](CO)[C@@H](O)[C@H]2F JOKKFZJLPKIPOS-OZRXBMAMSA-N 0.000 claims 2
- ICJGJSLPQBWFGV-OZRXBMAMSA-N (3ar,5r,6r,7s,7ar)-2-(ethylamino)-7-fluoro-5-(hydroxymethyl)-5,6,7,7a-tetrahydro-3ah-pyrano[3,2-d][1,3]thiazol-6-ol Chemical compound S1C(NCC)=N[C@H]2[C@@H]1O[C@H](CO)[C@@H](O)[C@H]2F ICJGJSLPQBWFGV-OZRXBMAMSA-N 0.000 claims 2
- LOVCSZKKDWCJOT-JDDHQFAOSA-N (3ar,5r,6r,7s,7ar)-7-fluoro-5-(hydroxymethyl)-2-(2-methylpropylamino)-5,6,7,7a-tetrahydro-3ah-pyrano[3,2-d][1,3]thiazol-6-ol Chemical compound S1C(NCC(C)C)=N[C@H]2[C@@H]1O[C@H](CO)[C@@H](O)[C@H]2F LOVCSZKKDWCJOT-JDDHQFAOSA-N 0.000 claims 2
- VKALMUKKLOGDPG-ANZWQOBJSA-N (3ar,5r,6r,7s,7ar)-7-fluoro-5-(hydroxymethyl)-2-(propylamino)-5,6,7,7a-tetrahydro-3ah-pyrano[3,2-d][1,3]thiazol-6-ol Chemical compound S1C(NCCC)=N[C@H]2[C@@H]1O[C@H](CO)[C@@H](O)[C@H]2F VKALMUKKLOGDPG-ANZWQOBJSA-N 0.000 claims 2
- AMTGNXFFSFQYJA-ULAWRXDQSA-N (3ar,5r,6s,7ar)-2-(dimethylamino)-5-(hydroxymethyl)-5,6,7,7a-tetrahydro-3ah-pyrano[3,2-d][1,3]thiazol-6-ol Chemical compound C1[C@H](O)[C@@H](CO)O[C@@H]2SC(N(C)C)=N[C@@H]21 AMTGNXFFSFQYJA-ULAWRXDQSA-N 0.000 claims 2
- WYAROEYZBMXNIZ-ULAWRXDQSA-N (3ar,5r,6s,7ar)-2-(ethylamino)-5-(hydroxymethyl)-5,6,7,7a-tetrahydro-3ah-pyrano[3,2-d][1,3]thiazol-6-ol Chemical compound C1[C@H](O)[C@@H](CO)O[C@@H]2SC(NCC)=N[C@@H]21 WYAROEYZBMXNIZ-ULAWRXDQSA-N 0.000 claims 2
- VYBSQCAXXNKUFN-JGWLITMVSA-N (3ar,5r,6s,7ar)-2-amino-5-(hydroxymethyl)-5,6,7,7a-tetrahydro-3ah-pyrano[3,2-d][1,3]thiazol-6-ol Chemical compound C1[C@H](O)[C@@H](CO)O[C@@H]2SC(N)=N[C@@H]21 VYBSQCAXXNKUFN-JGWLITMVSA-N 0.000 claims 2
- UMXYJFMLLLIFPW-XZBKPIIZSA-N (3ar,5r,6s,7ar)-5-(hydroxymethyl)-2-(methylamino)-5,6,7,7a-tetrahydro-3ah-pyrano[3,2-d][1,3]thiazol-6-ol Chemical compound C1[C@H](O)[C@@H](CO)O[C@@H]2SC(NC)=N[C@@H]21 UMXYJFMLLLIFPW-XZBKPIIZSA-N 0.000 claims 2
- CMTNETCUCXXJBO-BZNPZCIMSA-N (3ar,5r,6s,7ar)-5-(hydroxymethyl)-2-(propylamino)-5,6,7,7a-tetrahydro-3ah-pyrano[3,2-d][1,3]thiazol-6-ol Chemical compound C1[C@H](O)[C@@H](CO)O[C@@H]2SC(NCCC)=N[C@@H]21 CMTNETCUCXXJBO-BZNPZCIMSA-N 0.000 claims 2
- KFTTUHTWIAVGRH-BNWJMWRWSA-N (3ar,5r,6s,7r,7ar)-7-fluoro-5-(hydroxymethyl)-2-(methylamino)-5,6,7,7a-tetrahydro-3ah-pyrano[3,2-d][1,3]thiazol-6-ol Chemical compound S1C(NC)=N[C@H]2[C@@H]1O[C@H](CO)[C@H](O)[C@@H]2F KFTTUHTWIAVGRH-BNWJMWRWSA-N 0.000 claims 2
- JIFVRMLZBUOEDL-RZUNNTJFSA-N (3ar,5r,6s,7s,7ar)-2-(3,3-difluoroazetidin-1-yl)-7-fluoro-5-methyl-5,6,7,7a-tetrahydro-3ah-pyrano[3,2-d][1,3]thiazol-6-ol Chemical compound S([C@H]1O[C@@H]([C@@H]([C@@H](F)[C@H]1N=1)O)C)C=1N1CC(F)(F)C1 JIFVRMLZBUOEDL-RZUNNTJFSA-N 0.000 claims 2
- UDQTXCHQKHIQMH-HRJVDPJDSA-N (3ar,5s,6r,7r,7ar)-5-(difluoromethyl)-2-(ethylamino)-5,6,7,7a-tetrahydro-3ah-pyrano[3,2-d][1,3]thiazole-6,7-diol Chemical compound S1C(NCC)=N[C@H]2[C@@H]1O[C@H](C(F)F)[C@H](O)[C@@H]2O UDQTXCHQKHIQMH-HRJVDPJDSA-N 0.000 claims 2
- ZMLWGEHWECDGGA-RLZVPWTLSA-N (3ar,5s,6r,7r,7ar)-5-(difluoromethyl)-7-fluoro-2-(methylamino)-5,6,7,7a-tetrahydro-3ah-pyrano[3,2-d][1,3]thiazol-6-ol Chemical compound S1C(NC)=N[C@H]2[C@@H]1O[C@H](C(F)F)[C@@H](O)[C@@H]2F ZMLWGEHWECDGGA-RLZVPWTLSA-N 0.000 claims 2
- XFEVUYIVNQYKSO-NYMZXIIRSA-N (3ar,5s,6r,7r,7ar)-7-fluoro-5-(fluoromethyl)-2-(methylamino)-5,6,7,7a-tetrahydro-3ah-pyrano[3,2-d][1,3]thiazol-6-ol Chemical compound S1C(NC)=N[C@H]2[C@@H]1O[C@H](CF)[C@@H](O)[C@@H]2F XFEVUYIVNQYKSO-NYMZXIIRSA-N 0.000 claims 2
- PEVYBPQPNQWIRR-ANZWQOBJSA-N (3ar,5s,6r,7s,7ar)-7-fluoro-2-(3-fluoroazetidin-1-yl)-5-(fluoromethyl)-5,6,7,7a-tetrahydro-3ah-pyrano[3,2-d][1,3]thiazol-6-ol Chemical compound S([C@H]1O[C@H](CF)[C@H]([C@H]([C@H]1N=1)F)O)C=1N1CC(F)C1 PEVYBPQPNQWIRR-ANZWQOBJSA-N 0.000 claims 2
- KSQFLUCUWOSBDR-LSSCIPKCSA-N (3ar,5s,6s,7ar)-2-[2,2-difluoroethoxy(methyl)amino]-5-(difluoromethyl)-5,6,7,7a-tetrahydro-3ah-pyrano[3,2-d][1,3]thiazol-6-ol Chemical compound C1[C@H](O)[C@@H](C(F)F)O[C@@H]2SC(N(OCC(F)F)C)=N[C@@H]21 KSQFLUCUWOSBDR-LSSCIPKCSA-N 0.000 claims 2
- PGGPTJXWYICMCH-FZGKIIIMSA-N (3ar,5s,6s,7ar)-5-(difluoromethyl)-2-(dimethylamino)-5,6,7,7a-tetrahydro-3ah-pyrano[3,2-d][1,3]thiazol-6-ol Chemical compound C1[C@H](O)[C@@H](C(F)F)O[C@@H]2SC(N(C)C)=N[C@@H]21 PGGPTJXWYICMCH-FZGKIIIMSA-N 0.000 claims 2
- INFUQWHUNQRCMN-UELCQGJWSA-N (3ar,5s,6s,7ar)-5-(difluoromethyl)-2-(methylamino)-5,6,7,7a-tetrahydro-3ah-pyrano[3,2-d][1,3]thiazol-6-ol Chemical compound C1[C@H](O)[C@@H](C(F)F)O[C@@H]2SC(NC)=N[C@@H]21 INFUQWHUNQRCMN-UELCQGJWSA-N 0.000 claims 2
- QGBWBARJAAJENQ-CRYJZLASSA-N (3ar,5s,6s,7r,7ar)-2-(azetidin-1-yl)-5-(difluoromethyl)-5,6,7,7a-tetrahydro-3ah-pyrano[3,2-d][1,3]thiazole-6,7-diol Chemical compound N([C@@H]1[C@H]([C@@H]([C@@H](C(F)F)O[C@@H]1S1)O)O)=C1N1CCC1 QGBWBARJAAJENQ-CRYJZLASSA-N 0.000 claims 2
- SDGWDCUMNQRMGT-JGKVKWKGSA-N (3ar,5s,6s,7r,7ar)-2-(azetidin-1-yl)-5-(fluoromethyl)-5,6,7,7a-tetrahydro-3ah-pyrano[3,2-d][1,3]thiazole-6,7-diol Chemical compound N([C@@H]1[C@H]([C@@H]([C@@H](CF)O[C@@H]1S1)O)O)=C1N1CCC1 SDGWDCUMNQRMGT-JGKVKWKGSA-N 0.000 claims 2
- XAJQQTRAFMBOMC-FMDGEEDCSA-N (3ar,5s,6s,7r,7ar)-2-(dimethylamino)-5-(fluoromethyl)-5,6,7,7a-tetrahydro-3ah-pyrano[3,2-d][1,3]thiazole-6,7-diol Chemical compound S1C(N(C)C)=N[C@H]2[C@@H]1O[C@H](CF)[C@@H](O)[C@@H]2O XAJQQTRAFMBOMC-FMDGEEDCSA-N 0.000 claims 2
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- SXPPQYRVMAWUCR-CRYJZLASSA-N (3ar,5s,6s,7r,7ar)-5-(difluoromethyl)-2-(prop-2-ynylamino)-5,6,7,7a-tetrahydro-3ah-pyrano[3,2-d][1,3]thiazole-6,7-diol Chemical compound O1[C@H](C(F)F)[C@@H](O)[C@H](O)[C@H]2N=C(NCC#C)S[C@H]21 SXPPQYRVMAWUCR-CRYJZLASSA-N 0.000 claims 2
- FGOIZZGWQQYNNF-CRYJZLASSA-N (3ar,5s,6s,7r,7ar)-5-(difluoromethyl)-2-(propylamino)-5,6,7,7a-tetrahydro-3ah-pyrano[3,2-d][1,3]thiazole-6,7-diol Chemical compound S1C(NCCC)=N[C@H]2[C@@H]1O[C@H](C(F)F)[C@@H](O)[C@@H]2O FGOIZZGWQQYNNF-CRYJZLASSA-N 0.000 claims 2
- JPYVPVFKUIIADM-VVULQXIFSA-N (3ar,5s,6s,7r,7ar)-5-(fluoromethyl)-2-(4-hydroxybut-2-ynylamino)-5,6,7,7a-tetrahydro-3ah-pyrano[3,2-d][1,3]thiazole-6,7-diol Chemical compound S1C(NCC#CCO)=N[C@H]2[C@@H]1O[C@H](CF)[C@@H](O)[C@@H]2O JPYVPVFKUIIADM-VVULQXIFSA-N 0.000 claims 2
- XCVBKZPSKQHUMO-JGKVKWKGSA-N (3ar,5s,6s,7r,7ar)-5-(fluoromethyl)-2-(propylamino)-5,6,7,7a-tetrahydro-3ah-pyrano[3,2-d][1,3]thiazole-6,7-diol Chemical compound S1C(NCCC)=N[C@H]2[C@@H]1O[C@H](CF)[C@@H](O)[C@@H]2O XCVBKZPSKQHUMO-JGKVKWKGSA-N 0.000 claims 2
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- 208000010668 atopic eczema Diseases 0.000 claims 1
- 125000004566 azetidin-1-yl group Chemical group N1(CCC1)* 0.000 claims 1
- 230000000740 bleeding effect Effects 0.000 claims 1
- 210000004556 brain Anatomy 0.000 claims 1
- 201000011510 cancer Diseases 0.000 claims 1
- 210000000349 chromosome Anatomy 0.000 claims 1
- 208000017004 dementia pugilistica Diseases 0.000 claims 1
- 201000001981 dermatomyositis Diseases 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 230000002327 eosinophilic effect Effects 0.000 claims 1
- 201000009580 eosinophilic pneumonia Diseases 0.000 claims 1
- 206010015037 epilepsy Diseases 0.000 claims 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 1
- 201000001155 extrinsic allergic alveolitis Diseases 0.000 claims 1
- 201000006061 fatal familial insomnia Diseases 0.000 claims 1
- 239000003527 fibrinolytic agent Substances 0.000 claims 1
- 230000003480 fibrinolytic effect Effects 0.000 claims 1
- 230000007387 gliosis Effects 0.000 claims 1
- 208000024908 graft versus host disease Diseases 0.000 claims 1
- 239000008187 granular material Substances 0.000 claims 1
- 208000022098 hypersensitivity pneumonitis Diseases 0.000 claims 1
- 201000006362 hypersensitivity vasculitis Diseases 0.000 claims 1
- 208000027866 inflammatory disease Diseases 0.000 claims 1
- 230000002757 inflammatory effect Effects 0.000 claims 1
- 229910052742 iron Inorganic materials 0.000 claims 1
- 208000028867 ischemia Diseases 0.000 claims 1
- 210000003734 kidney Anatomy 0.000 claims 1
- 230000001404 mediated effect Effects 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 201000006417 multiple sclerosis Diseases 0.000 claims 1
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- 208000010125 myocardial infarction Diseases 0.000 claims 1
- 230000002956 necrotizing effect Effects 0.000 claims 1
- 208000015122 neurodegenerative disease Diseases 0.000 claims 1
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- 230000007823 neuropathy Effects 0.000 claims 1
- 230000004112 neuroprotection Effects 0.000 claims 1
- 210000000056 organ Anatomy 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 208000005987 polymyositis Diseases 0.000 claims 1
- 208000032207 progressive 1 supranuclear palsy Diseases 0.000 claims 1
- 230000000750 progressive effect Effects 0.000 claims 1
- 125000006412 propinylene group Chemical group [H]C#CC([H])([H])* 0.000 claims 1
- 201000009732 pulmonary eosinophilia Diseases 0.000 claims 1
- 201000000980 schizophrenia Diseases 0.000 claims 1
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- 239000007787 solid Substances 0.000 claims 1
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- 238000002560 therapeutic procedure Methods 0.000 claims 1
- 230000005951 type IV hypersensitivity Effects 0.000 claims 1
- 208000027930 type IV hypersensitivity disease Diseases 0.000 claims 1
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Claims (14)
1. Spoj formule (I) ili njegova farmaceutski prihvatljiva sol:
[image]
u kojem
R1 i R2 su H, ili R1 je H i R2 je F, ili R1 je F i R2 je H, ili R1 je OR3 i R2 je H;
svaki R3 je nezavisno H ili C1-6acil;
R4 je H i R5 je OR3, ili R4 je OR3 i R5 je H;
R6 je H, F ili OR3;
svaki R7 je nezavisno H ili F;
svaki R8 je nezavisno izabran iz grupe koja se sastoji od: H, C1-6 alkil, C3-6 alkenil, C3-6 alkinil i C1-6 alkoksi, gdje su C1-6 alkil, C3-6 alkenil, C3-6 alkinil ili C1-6 alkoksi izborno supstituirani od jednog do maksimalnog broja supstituenata sa jednim ili više od fluoro, OH, ili metil, ili
dvije R8 grupe su povezane sa atomom dušika za koji su vezane tako da formiraju prsten, pri čemu je navedeni prsten izborno nezavisno supstituiran od jednog do maksimalnog broja supstituenata sa jedim ili više od fluoro, OH ili metil,
uz uvjet da kada R6 je OR3, svaki R7 je H; i
uz uvjet da se R1 ili R6 razlikuje od OR3.
2. Spoj prema patentnom zahtjevu 1 u kojem:
(i) R1 i R2 su H, ili R1 je H i R2 je F, ili R1 je F i R2 je H, ili R1 je OH i R2 je H;
R4 je H;
R5 je OH;
R6 je H ili OH; i
svaki R8 je nezavisno izabran iz grupe koja se sastoji od: H, CH3, CH2CH3, (CH2)2CH3, CH2CH=CH2 i CH2C≡CH ili NR82 je azetidin-1-il,
uz uvjet da kada R6 je OH, svaki R7 je H;
uz uvjet da se R1 ili R6 razlikuje od OH; ili
(ii) najmanje jedan od R1, R2, R6 i R7 je F.
3. Spoj prema patentnom zahtjevu 1 naznačen time što spoj je spoj formule (Ia) ili njegova farmaceutski prihvatljiva sol:
[image]
gdje
R1 i R2 su H i R6 je F; ili R1 je H i R2 je F i R6 je H, F, ili OR3; ili R1 je F i R2 je H i R6 je H, F ili OR3; ili R1 je OR3 i R2 je H i R6 je F;
svaki R3 je nezavisno H ili C1-6 acil;
svaki R7 je nezavisno H ili F;
svaki R8 je nezavisno izabran iz grupe koja se sastoji od: H, C1-6 alkil, C3-6 alkenil, C3-6 alkinil i C1-6 alkoksi, gdje su C1-6 alkil, C3-6 alkenil, C3-6 alkinil ili C1-6 alkoksi izborno supstituirani sa od jednog do maksimalnog broja supstituenata sa jednim ili više od fluoro, OH ili metil, ili dvije R8 grupe su vezane zajedno sa atomom dušika za koji su vezane tako da formiraju prsten, pri čemu je navedeni prsten izborno nezavisno supstituiran sa od jednog do maksimalnog broja supstituenata sa jednim ili više od fluoro, OH ili metil,
uz uvjet da kada R6 je OR3, svaki R7 je H.
4. Spoj prema patentnom zahtjevu 1 naznačen time što spoj je:
(3aR,5R,6S,7R,7aR)-2-(etilamino)-5-metil-5,6,7,7a-tetrahidro-3aH-pirano[3,2-d]tiazol-6,7-diol;
(3aR,5R,6S,7aR)-2-(etilamino)-5-(hidroksimetil)-5,6,7,7a-tetrahidro-3aH-pirano[3,2-d]tiazol-6-ol;
(3aR,5R,6S,7aR)-5-(hidroksimetil)-2-(metilamino)-5,6,7,7a-tetrahidro-3aH-pirano[3,2-d]tiazol-6-ol;
(3aR,5R,6S,7aR)-2-(dimetilamino)-5-(hidroksimetil)-5,6,7,7a-tetrahidro-3aH-pirano[3,2-d]tiazol-6-ol;
(3aR,5R,6S,7aR)-2-amino-5-(hidroksimetil)-5,6,7,7a-tetrahidro-3aH-pirano[3,2-d]tiazol-6-ol;
(3aR,5R,6S,7aR)-5-(hidroksimetil)-2-(propilamino)-5,6,7,7a-tetrahidro-3aH-pirano[3,2-d]tiazol-6-ol;
(3aR,5R,6R,7R,7aR)-2-(etilamino)-7-fluoro-5-(hidroksimetil)-5,6,7,7a-tetrahidro-3aH-pirano[3,2-d]tiazol-6-ol;
(3aR,5R,6R,7R,7aR)-2-(dimetilamino)-7-fluoro-5-(hidroksimetil)-5,6,7,7a-tetrahidro-3aH-pirano [3,2-d]tiazol-6-ol;
(3aR,5R,6R,7R,7aR)-7-fluoro-5-(hidroksimetil)-2-(metilamino)-5,6,7,7a-tetrahidro-3aH-pirano[3,2-d]tiazol-6-ol;
(3aR,5R,6R,7R,7aR)-7-fluoro-5-(hidroksimetil)-2-(propilamino)-5,6,7,7a-tetrahidro-3aH-pirano[3,2-d]tiazol-6-ol;
(3aR,5R,6R,7S,7aR)-7-fluoro-5-(hidroksimetil)-2-(metilamino)-5,6,7,7a-tetrahidro-3aH-pirano[3,2-d]tiazol-6-ol;
(3aR,5S,6S,7R,7aR)-2-(etilamino)-5-(fluorometil)-5,6,7,7a-tetrahidro-3aH-pirano[3,2-d]tiazol-6,7-diol;
(3aR,5S,6S,7R,7aR)-2-(dimetilamino)-5-(fluorometil)-5,6,7,7a-tetrahidro-3aH-pirano[3,2-d]tiazol-6,7-diol;
(3aR,5S,6S,7R,7aR)-2-(alilamino)-5-(fluorometil)-5,6,7,7a-tetrahidro-3aH-pirano[3,2-d]tiazol-6,7-diol;
(3aR,5S,6S,7R,7aR)-2-amino-5-(fluorometil)-5,6,7,7a-tetrahidro-3aH-pirano[3,2-d]tiazol-6,7-diol;
(3aR,5S,6S,7R,7aR)-2-(azetidin-1-il)-5-(fluorometil)-5,6,7,7a-tetrahidro-3aH-pirano[3,2-d]tiazol-6,7-diol;
(3aR,5S,6S,7R,7aR)-5-(fluorometil)-2-(metilamino)-5,6,7,7a-tetrahidro-3aH-pirano[3,2-d]tiazol-6,7-diol;
(3aR,5S,6S,7R,7aR)-5-(fluorometil)-2-(propilamino)-5,6,7,7a-tetrahidro-3aH-pirano[3,2-d]tiazol-6,7-diol;
(3aR,5S,6S,7R,7aR)-5-(difluorometil)-2-(etilamino)-5,6,7,7a-tetrahidro-3aH-pirano[3,2-d]tiazol-6,7-diol;
(3aR,5S,6S,7R,7aR)-5-(difluorometil)-2-(dimetilamino)-5,6,7,7a-tetrahidro-3aH-pirano[3,2-d]tiazol-6,7-diol;
(3aR,5S,6S,7R,7aR)-2-(alilamino)-5-(difluorometil)-5,6,7,7a-tetrahidro-3aH-pirano[3,2-d]tiazol-6,7-diol;
(3aR,5S,6S,7R,7aR)-2-amino-5-(difluorometil)-5,6,7,7a-tetrahidro-3aH-pirano[3,2-d]tiazol-6,7-diol;
(3aR,5S,6S,7R,7aR)-5-(difluorometil)-2-(prop-2-yn-1-ilamino)-5,6,7,7a-tetrahidro-3aH-pirano[3,2-d]tiazol-6,7-diol;
(3aR,5S,6S,7R,7aR)-2-(azetidin-1-il)-5-(difluorometil)-5,6,7,7a-tetrahidro-3aH-pirano[3,2-d]tiazol-6,7-diol;
(3aR,5S,6S,7R,7aR)-5-(difluorometil)-2-(metilamino)-5,6,7,7a-tetrahidro-3aH-pirano[3,2-d]tiazol-6,7-diol;
(3aR,5S,6S,7R,7aR)-5-(difluorometil)-2-(propilamino)-5,6,7,7a-tetrahidro-3aH-pirano[3,2-d]tiazol-6,7-diol;
(3aR,5S,6S,7aR)-5-(difluorometil)-2-(metilamino)-5,6,7,7a-tetrahidro-3aH-pirano[3,2-d]tiazol-6-ol;
(3aR,5S,6S,7aR)-5-(difluorometil)-2-(dimetilamino)-5,6,7,7a-tetrahidro-3aH-pirano[3,2-d]tiazol-6-ol;
(3aR,5S,6R,7R,7aR)-5-(difluorometil)-2-(etilamino)-5,6,7,7a-tetrahidro-3aH-pirano[3,2-d]tiazol-6,7-diol;
(3aR,5R,6S,7R,7aR)-7-fluoro-5-(hidroksimetil)-2-(metilamino)-5,6,7,7a-tetrahidro-3aH-pirano[3,2-d]tiazol-6-ol;
(3aR,5S,6R,7R,7aR)-7-fluoro-5-(fluorometil)-2-(metilamino)-5,6,7,7a-tetrahidro-3aH-pirano[3,2-d]tiazol-6-ol;
(3aR,5S,6R,7R,7aR)-5-(difluorometil)-7-fluoro-2-(metilamino)-5,6,7,7a-tetrahidro-3aH-pirano[3,2-d]tiazol-6-ol;
(3aR,5S,6R,7S,7aR)-5-(difluorometil)-7-fluoro-2-(metilamino)-5,6,7,7a-tetrahidro-3aH-pirano[3,2-d]tiazol-6-ol;
(3aR,5R,6R,7S,7aR)-2-(etilamino)-7-fluoro-5-(hidroksimetil)-5,6,7,7a-tetrahidro-3aH-pirano[3,2-d]tiazol-6-ol;
(3aR,5R,6R,7S,7aR)-2-(dimetilamino)-7-fluoro-5-(hidroksimetil)-5,6,7,7a-tetrahidro-3aH-pirano[3,2-d]tiazol-6-ol;
(3aR,5R,6R,7S,7aR)-7-fluoro-5-(hidroksimetil)-2-(propilamino)-5,6,7,7a-tetrahidro-3aH-pirano[3,2-d]tiazol-6-ol;
(3aR,5R,6R,7S,7aR)-7-fluoro-5-(hidroksimetil)-2-(isobutilamino)-5,6,7,7a-tetrahidro-3aH-pirano [3,2-d]tiazol-6-ol;
(3aR,5S,6R,7R,7aR)-5-(difluorometil)-7-fluoro-2-(((E)-3-fluoro-2-metilalil)amino)-5,6,7,7a-tetrahidro-3aH-pirano[3,2-d]tiazol-6-ol;
(3aR,5S,6S,7R,7aR)-5-(fluorometil)-2-((4-hidroksibut-2-yn-1-il)amino)-5,6,7,7a-tetrahidro-3aH-pirano[3,2-d]tiazol-6,7-diol;
(3aR,5S,6S,7aR)-2-((2,2-difluoroetoksi)(metil)amino)-5-(difluorometil)-5,6,7,7a-tetrahidro-3aH-pirano[3,2-d]tiazol-6-ol;
(3aR,5S,6R,7S,7aR)-7-fluoro-2-(3-fluoroazetidin-1-il)-5-(fluorometil)-5,6,7,7a-tetrahidro-3aH-pirano[3,2-d]tiazol-6-ol; ili
(3aR,5R,6S,7S,7aR)-2-(3,3-difluoroazetidin-1-il)-7-fluoro-5-metil-5,6,7,7a-tetrahidro-3aH-pirano[3,2-d]tiazol-6-ol,
ili farmaceutski prihvatljiva sol bilo kojeg od gore navedenih spojeva.
5. Spoj prema patentnom zahtjevu 1 naznačen time što spoj je:
(3aR,5R,6R,7S,7aR)-7-fluoro-5-(hidroksimetil)-2-(metilamino)-5,6,7,7a-tetrahidro-3aH-pirano[3,2-d]tiazol-6-ol;
(3aR,5S,6S,7R,7aR)-5-(fluorometil)-2-(metilamino)-5,6,7,7a-tetrahidro-3aH-pirano[3,2-d]tiazol-6,7-diol;
(3aR,5S,6S,7R,7aR)-5-(difluorometil)-2-(etilamino)-5,6,7,7a-tetrahidro-3aH-pirano[3,2-d]tiazol-6,7-diol;
(3aR,5S,6S,7R,7aR)-5-(difluorometil)-2-(dimetilamino)-5,6,7,7a-tetrahidro-3aH-pirano[3,2-d]tiazol-6,7-diol;
(3aR,5S,6S,7R,7aR)-5-(difluorometil)-2-(metilamino)-5,6,7,7a-tetrahidro-3aH-pirano[3,2-d]tiazol-6,7-diol; ili
(3aR,5S,6R,7S,7aR)-5-(difluorometil)-7-fluoro-2-(metilamino)-5,6,7,7a-tetrahidro-3aH-pirano[3,2-d]tiazol-6-ol;
ili farmaceutski prihvatljiva sol bilo kojeg od gore navedenih spojeva.
6. Farmaceutska kompozicija koja sadrži spoj prema bilo kojem od patentnih zahtjeva 1 do 5 ili njegovu farmaceutski prihvatljivu sol u kombinaciji sa farmaceutski prihvatljivim nosačem.
7. Spoj formule (I) ili njegova farmaceutski prihvatljiva sol prema jednom ili više od patentnih zahtjeva 1 do 5 za uporabu u liječenju stanja koje je: inflamatorna bolest, alergija, astma, alergijski rinitis, bolesti hipersenzitivnosti pluća, hipersenzitivan pneumonitis, eozinofilne pneumonije, hipersenzitivnost odgođenog tipa, ateroskleroza, intersticijalna bolest pluća (ILD), idiopatska bolest pluća, ILD povezan sa reumatoidnim artritisom, sustavni lupus eritematodes, ankilozni spondilitis, sustavna skleroza, Sjogrenov sindrom, polimiozitis ili dermatomiozitis, sustavna anafilaksa ili odgovor hipersenzitivnosti, alergije na lijekove, alergija na ubod insekata, autoimuna bolest, reumatoidni artritis, psorijatski artritis, multipla skleroza, Guillain-Barré sindrom, sustavni lupus eritematodes, miastenija gravis, glomerulonefritis, autoimuni tiroiditis, odbacivanje transplanta, odbacivanje alo-transplanta, bolest transplanta protiv domaćina, inflamatorna bolest crijeva, Kronova bolest, ulcerozni kolitis, spondiloartropatija, skleroderma, psorijaza, T-stanično posredovana psorijaza, inflamatorni dermatozis, dermatitis, ekcem, atopijski dermatitis, alergijski kontaktni dermatitis, urtikarija, vaskulitis, nekrotizujući, kutani i hipersenzitivni vaskulitis, eozinofilni miotis, eozinofilni fasciitis, odbacivanje transplanta solidnog organa, odbacivanje transplanta srca, odbacivanje transplanta pluća, odbacivanje transplanta jetre, odbacivanje transplanta bubrega, odbacivanje transplanta pankreasa, alografta bubrega, alografta pluća, epilepsija, bol, fibromialgija, moždani udar ili neuroprotekcija.
8. Spoj formule (I) ili njegova farmaceutski prihvatljiva sol prema jednom ili više patentnih zahtjeva 1 do 5 za uporabu u liječenju stanja koje je izabrano iz grupe koja se sastoji od neurodegenerativne bolesti, tauopatije, kancera i stresa, kod subjekta kod kojeg postoji potreba za istim.
9. Spoj za upotrabu prema patentnom zahtjevu 8 gdje je stanje:
(i) Alzheimerova bolest, amiotrofna lateralna skleroza (ALS), amiotrofna lateralna skleroza sa kognitivnim oštećenjem (ALSci), demencija sa argirofilnim zrnima, Bluit-ova bolest, kortikobazalna degeneracija (CBD), Dementia pugilistica, difuzni neurofibrilarni čvorovi sa kalcifikacijom, Daunov sindrom, porodična britanska demencija, porodična danska demencija, frontotemporalna demencija sa parkinsonizmom povezanim za kromosomom 17 (FTDP-17), Gerstmann-Straussler-Scheinker-ova bolest, Guadeloupean-ov parkinsonizam, Hallevorden-Spatz-ova bolest (neurodegeneracija sa akumulacijom željeza u mozgu tipa 1), multipla sustavna atrofija, miotonična distrofija, Niemann-Pick-ova bolest (tip C), Palido-ponto-nigralna degeneracija, Guamov kompleks parkinsonizma-demencije, Pickova bolest (PiD), post-encefalitički parkinsonizam (PEP), Prionske bolesti (uključujući Creutzfeldt-Jakobovu bolest (CJD), varijantnu Creutzfeldt-Jakobovu bolest (vCJD), fatalnu porodičnu insomniju i kuru), progresivna superkortikalna glioza, progresivna supranuklearna paraliza (PSP), Richardson-ov sindrom, subakutni sklerotizujući panencefalitis, „tangle-only“ demencija, Huntington-ova bolest, Parkinson-ova bolest, šizofrenija, blago kognitivno oštećenje (MCI), neuropatija (uključujući perifernu neuropatiju, autonomnu neuropatiju, neuritis i dijabetičku neuropatiju) ili glaukom;
(ii) stres, gdje je stres srčani poremećaj;
(iii) stres, gdje je stres srčani poremećaj i gdje je srčani poremećaj: ishemija; krvarenje; hipovolemijski šok; infarkt miokarda; intervencijska kardiološka procedura; operacija srčanog bypass-a; fibrinolitička terapija; angioplastika; ili postavljanje stenta.
10. Spoj za uporabu prema patentnom zahtjevu 8 naznačen time što je stanje Alzheimerova bolest (AD).
11. Spoj za uporabu prema patentnom zahtjevu 8 naznačen time što je stanje progresivna supranuklearna paraliza (PSP).
12. Spoj za uporabu prema bilo kojem od patentnih zahtjeva 7 do 11 naznačen time što spoj je:
(3aR,5R,6S,7R,7aR)-2-(etilamino)-5-metil-5,6,7,7a-tetrahidro-3aH-pirano[3,2-d]tiazol-6,7-diol;
(3aR,5R,6S,7aR)-2-(etilamino)-5-(hidroksimetil)-5,6,7,7a-tetrahidro-3aH-pirano[3,2-d]tiazol-6-ol;
(3aR,5R,6S,7aR)-5-(hidroksimetil)-2-(metilamino)-5,6,7,7a-tetrahidro-3aH-pirano[3,2-d]tiazol-6-ol;
(3aR,5R,6S,7aR)-2-(dimetilamino)-5-(hidroksimetil)-5,6,7,7a-tetrahidro-3aH-pirano[3,2-d]tiazol-6-ol;
(3aR,5R,6S,7aR)-2-amino-5-(hidroksimetil)-5,6,7,7a-tetrahidro-3aH-pirano[3,2-d]tiazol-6-ol;
(3aR,5R,6S,7aR)-5-(hidroksimetil)-2-(propilamino)-5,6,7,7a-tetrahidro-3aH-pirano[3,2-d]tiazol-6-ol;
(3aR,5R,6R,7R,7aR)-2-(etilamino)-7-fluoro-5-(hidroksimetil)-5,6,7,7a-tetrahidro-3aH-pirano[3,2-d]tiazol-6-ol;
(3aR,5R,6R,7R,7aR)-2-(dimetilamino)-7-fluoro-5-(hidroksimetil)-5,6,7,7a-tetrahidro-3aH-pirano[3,2-d]tiazol-6-ol;
(3aR,5R,6R,7R,7aR)-7-fluoro-5-(hidroksimetil)-2-(metilamino)-5,6,7,7a-tetrahidro-3aH-pirano[3,2-d]tiazol-6-ol;
(3aR,5R,6R,7R,7aR)-7-fluoro-5-(hidroksimetil)-2-(propilamino)-5,6,7,7a-tetrahidro-3aH-pirano[3,2-d]tiazol-6-ol;
(3aR,5R,6R,7S,7aR)-7-fluoro-5-(hidroksimetil)-2-(metilamino)-5,6,7,7a-tetrahidro-3aH-pirano[3,2-d]tiazol-6-ol;
(3aR,5S,6S,7R,7aR)-2-(etilamino)-5-(fluorometil)-5,6,7,7a-tetrahidro-3aH-pirano[3,2-d]tiazol-6,7-diol;
(3aR,5S,6S,7R,7aR)-2-(dimetilamino)-5-(fluorometil)-5,6,7,7a-tetrahidro-3aH-pirano[3,2-d]tiazol-6,7-diol;
(3aR,5S,6S,7R,7aR)-2-(alilamino)-5-(fluorometil)-5,6,7,7a-tetrahidro-3aH-pirano[3,2-d]tiazol-6,7-diol;
(3aR,5S,6S,7R,7aR)-2-amino-5-(fluorometil)-5,6,7,7a-tetrahidro-3aH-pirano[3,2-d]tiazol-6,7-diol;
(3aR,5S,6S,7R,7aR)-2-(azetidin-1-il)-5-(fluorometil)-5,6,7,7a-tetrahidro-3aH-pirano[3,2-d]tiazol-6,7-diol;
(3aR,5S,6S,7R,7aR)-5-(fluorometil)-2-(metilamino)-5,6,7,7a-tetrahidro-3aH-pirano[3,2-d]tiazol-6,7-diol;
(3aR,5S,6S,7R,7aR)-5-(fluorometil)-2-(propilamino)-5,6,7,7a-tetrahidro-3aH-pirano[3,2-d]tiazol-6,7-diol;
(3aR,5S,6S,7R,7aR)-5-(difluorometil)-2-(etilamino)-5,6,7,7a-tetrahidro-3aH-pirano[3,2-d]tiazol-6,7-diol;
(3aR,5S,6S,7R,7aR)-5-(difluorometil)-2-(dimetilamino)-5,6,7,7a-tetrahidro-3aH-pirano[3,2-d]tiazol-6,7-diol;
(3aR,5S,6S,7R,7aR)-2-(alilamino)-5-(difluorometil)-5,6,7,7a-tetrahidro-3aH-pirano[3,2-d]tiazol-6,7-diol;
(3aR,5S,6S,7R,7aR)-2-amino-5-(difluorometil)-5,6,7,7a-tetrahidro-3aH-pirano[3,2-d]tiazol-6,7-diol;
(3aR,5S,6S,7R,7aR)-5-(difluorometil)-2-(prop-2-yn-1-ilamino)-5,6,7,7a-tetrahidro-3aH-pirano[3,2-d]tiazol-6,7-diol;
(3aR,5S,6S,7R,7aR)-2-(azetidin-1-il)-5-(difluorometil)-5,6,7,7a-tetrahidro-3aH-pirano[3,2-d]tiazol-6,7-diol;
(3aR,5S,6S,7R,7aR)-5-(difluorometil)-2-(metilamino)-5,6,7,7a-tetrahidro-3aH-pirano[3,2-d]tiazol-6,7-diol;
(3aR,5S,6S,7R,7aR)-5-(difluorometil)-2-(propilamino)-5,6,7,7a-tetrahidro-3aH-pirano[3,2-d]tiazol-6,7-diol;
(3aR,5S,6S,7aR)-5-(difluorometil)-2-(metilamino)-5,6,7,7a-tetrahidro-3aH-pirano[3,2-d]tiazol-6-ol;
(3aR,5S,6S,7aR)-5-(difluorometil)-2-(dimetilamino)-5,6,7,7a-tetrahidro-3aH-pirano[3,2-d]tiazol-6-ol;
(3aR,5S,6R,7R,7aR)-5-(difluorometil)-2-(etilamino)-5,6,7,7a-tetrahidro-3aH-pirano[3,2-d]tiazol-6,7-diol;
(3aR,5R,6S,7R,7aR)-7-fluoro-5-(hidroksimetil)-2-(metilamino)-5,6,7,7a-tetrahidro-3aH-pirano[3,2-d]tiazol-6-ol;
(3aR,5S,6R,7R,7aR)-7-fluoro-5-(fluorometil)-2-(metilamino)-5,6,7,7a-tetrahidro-3aH-pirano[3,2-d]tiazol-6-ol;
(3aR,5S,6R,7R,7aR)-5-(difluorometil)-7-fluoro-2-(metilamino)-5,6,7,7a-tetrahidro-3aH-pirano [3,2-d]tiazol-6-ol;
(3aR,5S,6R,7S,7aR)-5-(difluorometil)-7-fluoro-2-(metilamino)-5,6,7,7a-tetrahidro-3aH-pirano [3,2-d]tiazol-6-ol;
(3aR,5R,6R,7S,7aR)-2-(etilamino)-7-fluoro-5-(hidroksimetil)-5,6,7,7a-tetrahidro-3aH-pirano[3,2-d]tiazol-6-ol;
(3aR,5R,6R,7S,7aR)-2-(dimetilamino)-7-fluoro-5-(hidroksimetil)-5,6,7,7a-tetrahidro-3aH-pirano[3,2-d]tiazol-6-ol;
(3aR,5R,6R,7S,7aR)-7-fluoro-5-(hidroksimetil)-2-(propilamino)-5,6,7,7a-tetrahidro-3aH-pirano[3,2-d]tiazol-6-ol;
(3aR,5R,6R,7S,7aR)-7-fluoro-5-(hidroksimetil)-2-(isobutilamino)-5,6,7,7a-tetrahidro-3aH-pirano[3,2-d]tiazol-6-ol;
(3aR,5S,6R,7R,7aR)-5-(difluorometil)-7-fluoro-2-(((E)-3-fluoro-2-metilalil)amino)-5,6,7,7a-tetrahidro-3aH-pirano[3,2-d]tiazol-6-ol;
(3aR,5S,6S,7R,7aR)-5-(fluorometil)-2-((4-hidroksibut-2-yn-1-il)amino)-5,6,7,7a-tetrahidro-3aH-pirano[3,2-d]tiazol-6,7-diol;
(3aR,5S,6S,7aR)-2-((2,2-difluoroetoksi)(metil)amino)-5-(difluorometil)-5,6,7,7a-tetrahidro-3aH-pirano[3,2-d]tiazol-6-ol;
(3aR,5S,6R,7S,7aR)-7-fluoro-2-(3-fluoroazetidin-1-il)-5-(fluorometil)-5,6,7,7a-tetrahidro-3aH-pirano[3,2-d]tiazol-6-ol; ili
(3aR,5R,6S,7S,7aR)-2-(3,3-difluoroazetidin-1-il)-7-fluoro-5-metil-5,6,7,7a-tetrahidro-3aH-pirano[3,2-d]tiazol-6-ol,
ili farmaceutski prihvatljiva sol bilo kojeg od gore navedenih spojeva.
13. Spoj za uporabu prema bilo kojem od patentnih zahtjeva 7 do 11 naznačen time što spoj je:
(3aR,5R,6R,7S,7aR)-7-fluoro-5-(hidroksimetil)-2-(metilamino)-5,6,7,7a-tetrahidro-3aH-pirano[3,2-d]tiazol-6-ol;
(3aR,5S,6S,7R,7aR)-5-(fluorometil)-2-(metilamino)-5,6,7,7a-tetrahidro-3aH-pirano[3,2-d]tiazol-6,7-diol;
(3aR,5S,6S,7R,7aR)-5-(difluorometil)-2-(etilamino)-5,6,7,7a-tetrahidro-3aH-pirano[3,2-d]tiazol-6,7-diol;
(3aR,5S,6S,7R,7aR)-5-(difluorometil)-2-(dimetilamino)-5,6,7,7a-tetrahidro-3aH-pirano[3,2-d]tiazol-6,7-diol;
(3aR,5S,6S,7R,7aR)-5-(difluorometil)-2-(metilamino)-5,6,7,7a-tetrahidro-3aH-pirano[3,2-d]tiazol-6,7-diol; ili
(3aR,5S,6R,7S,7aR)-5-(difluorometil)-7-fluoro-2-(metilamino)-5,6,7,7a-tetrahidro-3aH-pirano[3,2-d]tiazol-6-ol;
ili farmaceutski prihvatljiva sol bilo kojeg od gore navedenih spojeva.
14. Spoj za uporabu prema bilo kojem od patentnih zahtjeva 7 do 13 naznačen time što subjekt je čovjek.
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PCT/CN2011/074569 WO2012159262A1 (en) | 2011-05-24 | 2011-05-24 | Selective glycosidase inhibitors and uses thereof |
US201161507684P | 2011-07-14 | 2011-07-14 | |
PCT/CA2011/001397 WO2012083435A1 (en) | 2010-12-23 | 2011-12-21 | Selective glycosidase inhibitors and uses thereof |
EP11850773.0A EP2655388B1 (en) | 2010-12-23 | 2011-12-21 | Selective glycosidase inhibitors and uses thereof |
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PL (1) | PL2655388T3 (hr) |
PT (1) | PT2655388T (hr) |
RU (1) | RU2609210C2 (hr) |
TW (1) | TWI572609B (hr) |
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AU2006220187B2 (en) * | 2005-03-01 | 2012-11-08 | Simon Fraser University | Selective glycosidase inhibitors, methods of making inhibitors, and uses thereof |
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WO2011140640A1 (en) | 2010-05-11 | 2011-11-17 | Simon Fraser University | Selective glycosidase inhibitors and uses thereof |
WO2012061927A1 (en) | 2010-11-08 | 2012-05-18 | Alectos Therapeutics, Inc. | Selective glycosidase inhibitors and uses thereof |
JP5861194B2 (ja) * | 2010-12-23 | 2016-02-16 | アレクトス・セラピューティクス・インコーポレイテッド | 選択的グルコシダーゼインヒビターおよびその使用 |
US8927507B2 (en) | 2011-03-24 | 2015-01-06 | Ernest J. McEachern | Selective glycosidase inhibitors and uses thereof |
EP2691407B1 (en) | 2011-03-31 | 2017-02-22 | Alectos Therapeutics Inc. | Selective glycosidase inhibitors and uses thereof |
BR112013033098B8 (pt) * | 2011-06-27 | 2021-03-23 | Alectos Therapeutics Inc | inibidores de glicosidade seletivos e usos dos mesmos |
US9199949B2 (en) | 2011-06-27 | 2015-12-01 | Alectos Therapeutics Inc. | Selective glycosidase inhibitors and uses thereof |
US9701693B2 (en) | 2011-06-27 | 2017-07-11 | Alectos Therapeutics Inc. | Selective glycosidase inhibitors and uses thereof |
US8884023B2 (en) | 2011-08-25 | 2014-11-11 | Merck Patent Gmbh | Pyrano [3,2-D][1,3]thiazole as glycosidase inhibitors |
WO2014032185A1 (en) | 2012-08-31 | 2014-03-06 | Alectos Therapeutics Inc. | Glycosidase inhibitors and uses thereof |
WO2014032188A1 (en) | 2012-08-31 | 2014-03-06 | Alectos Therapeutics Inc. | Glycosidase inhibitors and uses thereof |
US9695197B2 (en) | 2012-10-31 | 2017-07-04 | Alectos Therapeutics Inc. | Glycosidase inhibitors and uses thereof |
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MA53944A (fr) | 2014-08-28 | 2021-08-25 | Asceneuron Sa | Inhibiteurs de la glycosidase |
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US9994589B2 (en) * | 2015-12-14 | 2018-06-12 | Amicus Therapeutics, Inc. | Compounds and methods for the treatment of alzheimer's disease and/or cerebral amyloid angiopathy |
CN108884077A (zh) | 2016-02-25 | 2018-11-23 | 阿森纽荣股份公司 | 糖苷酶抑制剂 |
WO2017144639A1 (en) | 2016-02-25 | 2017-08-31 | Asceneuron S. A. | Glycosidase inhibitors |
EA201891438A1 (ru) | 2016-02-25 | 2019-01-31 | Асенейрон С. А. | Кислотно-аддитивные соли производных пиперазина |
US11261183B2 (en) | 2016-02-25 | 2022-03-01 | Asceneuron Sa | Sulfoximine glycosidase inhibitors |
EP3672959A1 (en) | 2017-08-24 | 2020-07-01 | Asceneuron SA | Linear glycosidase inhibitors |
CN107814773B (zh) * | 2017-11-13 | 2020-05-22 | 西安交通大学 | 含有喹唑啉酮的二芳基脲类化合物及其制备方法和应用 |
MA52936A (fr) * | 2018-06-20 | 2021-04-28 | Janssen Pharmaceutica Nv | Composés inhibiteurs d'oga |
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CN114174263A (zh) * | 2019-05-10 | 2022-03-11 | 阿勒克图治疗公司 | 非溶酶体葡糖神经酰胺酶抑制剂及其用途 |
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