DE60045217D1 - Iminocyclitol-inhibitoren von hexoaminidase und glycosidase - Google Patents

Iminocyclitol-inhibitoren von hexoaminidase und glycosidase

Info

Publication number
DE60045217D1
DE60045217D1 DE60045217T DE60045217T DE60045217D1 DE 60045217 D1 DE60045217 D1 DE 60045217D1 DE 60045217 T DE60045217 T DE 60045217T DE 60045217 T DE60045217 T DE 60045217T DE 60045217 D1 DE60045217 D1 DE 60045217D1
Authority
DE
Germany
Prior art keywords
iminocyclitol
hexoaminidase
glycosidase
inhibitors
hexoaminidases
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60045217T
Other languages
English (en)
Inventor
Chi-Huey Wong
Jungie Liu
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Scripps Research Institute
Original Assignee
Scripps Research Institute
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Scripps Research Institute filed Critical Scripps Research Institute
Application granted granted Critical
Publication of DE60045217D1 publication Critical patent/DE60045217D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/12—Oxygen or sulfur atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/4025—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil not condensed and containing further heterocyclic rings, e.g. cromakalim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
DE60045217T 1999-05-11 2000-05-11 Iminocyclitol-inhibitoren von hexoaminidase und glycosidase Expired - Lifetime DE60045217D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US13354999P 1999-05-11 1999-05-11
PCT/US2000/013048 WO2000068194A1 (en) 1999-05-11 2000-05-11 Iminocyclitol inhibitors of hexoaminidase and glycosidase

Publications (1)

Publication Number Publication Date
DE60045217D1 true DE60045217D1 (de) 2010-12-23

Family

ID=22459157

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60045217T Expired - Lifetime DE60045217D1 (de) 1999-05-11 2000-05-11 Iminocyclitol-inhibitoren von hexoaminidase und glycosidase

Country Status (7)

Country Link
EP (1) EP1181274B1 (de)
JP (1) JP2002544191A (de)
AT (1) ATE487697T1 (de)
AU (1) AU779347B2 (de)
CA (1) CA2373183C (de)
DE (1) DE60045217D1 (de)
WO (1) WO2000068194A1 (de)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003008379A1 (fr) * 2001-06-08 2003-01-30 Mitsubishi Chemical Corporation Composes azasucre
WO2005072268A2 (en) * 2004-01-20 2005-08-11 Optimer Pharmaceuticals, Inc. Treatment of degeneraative cartilage conditions in a mammal with glycosidase inhibitors
EP2322529B1 (de) 2006-08-31 2017-12-06 Simon Fraser University Selektive Glykosidaseinhibitoren und Anwendungen davon
NZ612703A (en) 2010-12-23 2015-07-31 Merck Sharp & Dohme Selective glycosidase inhibitors and uses thereof
EP2691407B1 (de) 2011-03-31 2017-02-22 Alectos Therapeutics Inc. Selektive glycosidasehemmer und ihre verwendung
EP2726492B1 (de) 2011-06-27 2017-11-01 Alectos Therapeutics Inc. Selektive glycosidasehemmer und ihre verwendung
US9670195B2 (en) 2012-08-31 2017-06-06 Alectos Therapeutics Inc. Glycosidase inhibitors and uses thereof
EP2890675A4 (de) * 2012-08-31 2016-01-13 Alectos Therapeutics Inc Glycosidasehemmer und verwendungen davon
AU2013337570B2 (en) 2012-10-31 2018-01-18 Alectos Therapeutics Inc. Glycosidase inhibitors and uses thereof
ES2771849T3 (es) * 2014-02-12 2020-07-07 Amicus Therapeutics Inc Derivados de azúcares que comprenden restos que contienen azufre, métodos para prepararlos y métodos para emplearlos en el tratamiento de MPS IIIC

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5250703A (en) * 1992-09-29 1993-10-05 Monsanto Company Pyrrolidin-3,4-diol derivatives of heptitols and preparation thereof
US5451679A (en) * 1994-03-08 1995-09-19 G. D. Searle & Co. 2-chloro and 2-bromo derivatives of 1,5-iminosugars

Also Published As

Publication number Publication date
WO2000068194A1 (en) 2000-11-16
EP1181274B1 (de) 2010-11-10
JP2002544191A (ja) 2002-12-24
AU4844400A (en) 2000-11-21
EP1181274A4 (de) 2005-08-17
EP1181274A1 (de) 2002-02-27
ATE487697T1 (de) 2010-11-15
AU779347B2 (en) 2005-01-20
CA2373183C (en) 2009-12-08
CA2373183A1 (en) 2000-11-16

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