ATE487697T1 - Iminocyclitol-inhibitoren von hexoaminidase und glycosidase - Google Patents
Iminocyclitol-inhibitoren von hexoaminidase und glycosidaseInfo
- Publication number
- ATE487697T1 ATE487697T1 AT00930662T AT00930662T ATE487697T1 AT E487697 T1 ATE487697 T1 AT E487697T1 AT 00930662 T AT00930662 T AT 00930662T AT 00930662 T AT00930662 T AT 00930662T AT E487697 T1 ATE487697 T1 AT E487697T1
- Authority
- AT
- Austria
- Prior art keywords
- iminocyclitol
- hexoaminidase
- glycosidase
- inhibitors
- hexoaminidases
- Prior art date
Links
- 102000005744 Glycoside Hydrolases Human genes 0.000 title abstract 2
- 108010031186 Glycoside Hydrolases Proteins 0.000 title abstract 2
- NJOZFAFEQVQFJI-KVTDHHQDSA-N (2r,3r,4r,5r)-2-(aminomethyl)-5-(hydroxymethyl)pyrrolidine-3,4-diol Chemical compound NC[C@H]1N[C@H](CO)[C@@H](O)[C@@H]1O NJOZFAFEQVQFJI-KVTDHHQDSA-N 0.000 title 1
- 239000003112 inhibitor Substances 0.000 title 1
- 230000000694 effects Effects 0.000 abstract 1
- 230000005764 inhibitory process Effects 0.000 abstract 1
- 230000003389 potentiating effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/12—Oxygen or sulfur atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/4025—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil not condensed and containing further heterocyclic rings, e.g. cromakalim
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Rheumatology (AREA)
- Physical Education & Sports Medicine (AREA)
- Immunology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Enzymes And Modification Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Pyrrole Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US13354999P | 1999-05-11 | 1999-05-11 | |
| PCT/US2000/013048 WO2000068194A1 (en) | 1999-05-11 | 2000-05-11 | Iminocyclitol inhibitors of hexoaminidase and glycosidase |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE487697T1 true ATE487697T1 (de) | 2010-11-15 |
Family
ID=22459157
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT00930662T ATE487697T1 (de) | 1999-05-11 | 2000-05-11 | Iminocyclitol-inhibitoren von hexoaminidase und glycosidase |
Country Status (7)
| Country | Link |
|---|---|
| EP (1) | EP1181274B1 (de) |
| JP (1) | JP2002544191A (de) |
| AT (1) | ATE487697T1 (de) |
| AU (1) | AU779347B2 (de) |
| CA (1) | CA2373183C (de) |
| DE (1) | DE60045217D1 (de) |
| WO (1) | WO2000068194A1 (de) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP4363183B2 (ja) * | 2001-06-08 | 2009-11-11 | 三菱化学株式会社 | アザ糖化合物 |
| WO2005072268A2 (en) * | 2004-01-20 | 2005-08-11 | Optimer Pharmaceuticals, Inc. | Treatment of degeneraative cartilage conditions in a mammal with glycosidase inhibitors |
| EP2057171A4 (de) | 2006-08-31 | 2010-04-21 | Univ Fraser Simon | Selektive glykosidaseinhibitoren und anwendungen davon |
| CA2822493C (en) | 2010-12-23 | 2018-11-20 | Merck Sharp & Dohme Corp. | Selective glycosidase inhibitors and uses thereof |
| US9718854B2 (en) | 2011-03-31 | 2017-08-01 | Alectos Therapeutics Inc. | Selective glycosidase inhibitors and uses thereof |
| EP2726492B1 (de) | 2011-06-27 | 2017-11-01 | Alectos Therapeutics Inc. | Selektive glycosidasehemmer und ihre verwendung |
| EP2890676B1 (de) | 2012-08-31 | 2018-12-05 | Alectos Therapeutics Inc. | Glycosidasehemmer und verwendungen davon |
| EP2890675A4 (de) * | 2012-08-31 | 2016-01-13 | Alectos Therapeutics Inc | Glycosidasehemmer und verwendungen davon |
| US9695197B2 (en) | 2012-10-31 | 2017-07-04 | Alectos Therapeutics Inc. | Glycosidase inhibitors and uses thereof |
| EA201691603A1 (ru) * | 2014-02-12 | 2016-11-30 | Амикус Терапьютикс, Инк. | Производные сахаров, содержащие серосодержащие фрагменты, способы их получения и способы их применения для лечения mps iiic |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5250703A (en) * | 1992-09-29 | 1993-10-05 | Monsanto Company | Pyrrolidin-3,4-diol derivatives of heptitols and preparation thereof |
| US5451679A (en) * | 1994-03-08 | 1995-09-19 | G. D. Searle & Co. | 2-chloro and 2-bromo derivatives of 1,5-iminosugars |
-
2000
- 2000-05-11 AT AT00930662T patent/ATE487697T1/de not_active IP Right Cessation
- 2000-05-11 AU AU48444/00A patent/AU779347B2/en not_active Ceased
- 2000-05-11 WO PCT/US2000/013048 patent/WO2000068194A1/en not_active Ceased
- 2000-05-11 JP JP2000617175A patent/JP2002544191A/ja active Pending
- 2000-05-11 DE DE60045217T patent/DE60045217D1/de not_active Expired - Lifetime
- 2000-05-11 CA CA002373183A patent/CA2373183C/en not_active Expired - Fee Related
- 2000-05-11 EP EP00930662A patent/EP1181274B1/de not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| AU4844400A (en) | 2000-11-21 |
| CA2373183C (en) | 2009-12-08 |
| JP2002544191A (ja) | 2002-12-24 |
| DE60045217D1 (de) | 2010-12-23 |
| EP1181274A4 (de) | 2005-08-17 |
| EP1181274A1 (de) | 2002-02-27 |
| AU779347B2 (en) | 2005-01-20 |
| EP1181274B1 (de) | 2010-11-10 |
| CA2373183A1 (en) | 2000-11-16 |
| WO2000068194A1 (en) | 2000-11-16 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |