DK0889886T3 - Hidtil ukendte, i 6-stilling substituerede phenanthridiner - Google Patents

Hidtil ukendte, i 6-stilling substituerede phenanthridiner

Info

Publication number
DK0889886T3
DK0889886T3 DK97915422T DK97915422T DK0889886T3 DK 0889886 T3 DK0889886 T3 DK 0889886T3 DK 97915422 T DK97915422 T DK 97915422T DK 97915422 T DK97915422 T DK 97915422T DK 0889886 T3 DK0889886 T3 DK 0889886T3
Authority
DK
Denmark
Prior art keywords
novel
position substituted
phenanthridines
substituted phenanthridines
compounds
Prior art date
Application number
DK97915422T
Other languages
English (en)
Other versions
DK0889886T5 (da
Inventor
Hermann Amschler
Dieter Flockerzi
Armin Hatzelmann
Rolf Beume
Dietrich Haefner
Hans-Peter Kley
Beate Gutterer
Wolf-Ruediger Ulrich
Thomas Baer
Thomas Martin
Christian Schudt
Hildegard Boss
Original Assignee
Altana Pharma Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE1996113091 external-priority patent/DE19613091A1/de
Application filed by Altana Pharma Ag filed Critical Altana Pharma Ag
Publication of DK0889886T3 publication Critical patent/DK0889886T3/da
Application granted granted Critical
Publication of DK0889886T5 publication Critical patent/DK0889886T5/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/16—Central respiratory analeptics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/04—Ortho- or peri-condensed ring systems
    • C07D221/06—Ring systems of three rings
    • C07D221/10—Aza-phenanthrenes
    • C07D221/12—Phenanthridines
DK97915422T 1996-03-26 1997-03-24 Hidtil ukendte, i 6-stilling substituerede phenanthridiner DK0889886T5 (da)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
DE19611922 1996-03-26
EP96105038 1996-03-29
DE1996113091 DE19613091A1 (de) 1996-04-02 1996-04-02 6-Phenylphenanthridine
EP96105311 1996-04-03
PCT/EP1997/001487 WO1997035854A1 (de) 1996-03-26 1997-03-24 Neue in 6-position substituierte phenanthridine

Publications (2)

Publication Number Publication Date
DK0889886T3 true DK0889886T3 (da) 2003-01-20
DK0889886T5 DK0889886T5 (da) 2003-02-24

Family

ID=27438318

Family Applications (1)

Application Number Title Priority Date Filing Date
DK97915422T DK0889886T5 (da) 1996-03-26 1997-03-24 Hidtil ukendte, i 6-stilling substituerede phenanthridiner

Country Status (12)

Country Link
EP (1) EP0889886B1 (da)
JP (1) JP4141501B2 (da)
AT (1) ATE224386T1 (da)
AU (1) AU718752B2 (da)
CA (1) CA2250569C (da)
CY (1) CY2431B1 (da)
DE (1) DE59708265D1 (da)
DK (1) DK0889886T5 (da)
ES (1) ES2184077T3 (da)
PT (1) PT889886E (da)
SI (1) SI0889886T1 (da)
WO (1) WO1997035854A1 (da)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6410551B1 (en) * 1997-07-25 2002-06-25 Byk Gulden Lomberg Chemische Fabrik Gmbh Tetrazole derivatives
EE04189B1 (et) * 1997-07-25 2003-12-15 Byk Gulden Lomberg Chemische Fabrik Gmbh Asendatud 6-fenüülfenantridiinid
AR015966A1 (es) * 1997-10-17 2001-05-30 Smithkline Beecham Corp Uso de un compuesto inhibidor de pde4 para la preparacion de un medicamento util para el tratamiento de prurito
IT1296985B1 (it) * 1997-12-19 1999-08-03 Zambon Spa Derivati benzazinici inibitori della fosfodiesterasi 4
EP1147088B1 (en) * 1999-01-15 2006-01-04 ALTANA Pharma AG 6-arylphenanthridines with pde-iv inhibiting activity
US6534518B1 (en) * 1999-01-15 2003-03-18 Altana Pharma Ag Polysubstituted 6-phenylphenanthridines with PDE-IV inhibiting activity
SI1147087T1 (en) * 1999-01-15 2005-10-31 Altana Pharma Ag Phenanthridine-n-oxides with pde-iv inhibiting activity
PT1147103E (pt) * 1999-01-15 2005-08-31 Altana Pharma Ag Fenantridina-n-oxidos com actividade inibitoria de pde-iv
IL144026A0 (en) * 1999-01-15 2002-04-21 Byk Gulden Lomberg Chem Fab Phenylphenanthridine derivatives and pharmaceutical compostions containing the same
SI1212089T1 (sl) 1999-08-21 2006-08-31 Altana Pharma Ag Sinergisticna kombinacija roflumilasta in salmeterola
AU782908B2 (en) * 2000-01-11 2005-09-08 Altana Pharma Ag Phenanthridine-N-oxides
WO2002006238A1 (en) * 2000-07-14 2002-01-24 Altana Pharma Ag Cycloalkyl - or cycloalkylmethyl-substituted 6-phenylphenanthridines
WO2002006239A1 (en) * 2000-07-14 2002-01-24 Altana Pharma Ag Phenanthridine n-oxides
EP1303506B1 (en) * 2000-07-14 2005-02-02 ALTANA Pharma AG 6-heteroarylphenanthridines
AU2001281965A1 (en) * 2000-07-14 2002-01-30 Byk Gulden Lomberg Chemische Fabrik G.M.B.H. Novel 6-phenylphenanthridines
AU2003273805B8 (en) 2002-08-29 2010-06-17 Takeda Gmbh 3-hydroxy-6-phenylphenanthridines as PDE-4 inhibitors
JP4587294B2 (ja) 2002-08-29 2010-11-24 ニコメッド ゲゼルシャフト ミット ベシュレンクテル ハフツング Ｐｄｅ４インヒビターとしての２−ヒドロキシ−６−フェニルフェナントリジン
EP1658270A1 (en) * 2003-07-31 2006-05-24 ALTANA Pharma AG Novel 6-phenylphenantridines
CA2533636A1 (en) * 2003-07-31 2005-02-10 Altana Pharma Ag Novel 6-phenylphenanthridines
ES2400823T3 (es) 2004-02-18 2013-04-12 Takeda Gmbh Nuevas hidroxi-6-fenilfenantridinas sustituidas con guanidinilo como inhibidores eficaces de fosfodiesterasa (PDE) 4
MXPA06009695A (es) * 2004-03-03 2007-03-26 Altana Pharma Ag Nuevas hidroxi-6-heteroarilfenantridinas y su uso como inhibidores de la fosfodiesterasa tipo 4 (pde4).
AU2005220034A1 (en) * 2004-03-09 2005-09-15 Nycomed Gmbh Novel isoamido-substituted hydroxy-6-phenylphenanthridines and their use as PDE4 inhibitors
CA2558532A1 (en) * 2004-03-10 2005-09-15 Altana Pharma Ag Novel difluoroethoxy-substituted hydroxy-6-phenylphenanthridines and their use as pde4 inhibitors
CA2558390A1 (en) * 2004-03-10 2005-09-22 Altana Pharma Ag Novel thio-containing hydroxy-6-phenylphenanthridines and their use as pde4 inhibitors
US20080119505A1 (en) 2005-02-01 2008-05-22 Altana Pharma Ag Novel 6-Pyridylphenanthridines
EP1856092A1 (en) * 2005-03-02 2007-11-21 Nycomed GmbH 6-heteroaryl-1,2,3,4,4a,10b-hexahydro-phenanthridines as pde-4 inhibitors for the treatment of inflammatory disorders
ATE450524T1 (de) 2005-03-02 2009-12-15 Nycomed Gmbh (2r,4ar,10br)-6-(2,6-dimethoxypyridin-3-yl)-9- ethoxy-8-methoxy-1,2,3,4,4a,10b- hexahydrophenanthridin-2-ol hydrochloridsalz
EP1919854B1 (en) * 2005-08-30 2013-09-18 AbbVie Inc. Pharmaceutical compositions as inhibitors of dipeptidyl peptidase-iv (dpp-iv)
UY35543A (es) * 2013-04-30 2014-11-28 Bayer Cropscience Ag N-(fenilcicloalquil)carboxamidas y n-(fenilcicloalquil)tiocarboxamidas nematicidas

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE786031A (fr) * 1971-07-08 1973-01-08 Rhone Poulenc Sa Nouveaux derives de la phenanthridine, leur preparation et les compositions medicinales qui les contiennent
US4309545A (en) * 1980-07-28 1982-01-05 Pfizer Inc. Oximino-1-hydroxyoctahydrobenzo[c]quinolines and derivatives thereof

Also Published As

Publication number Publication date
WO1997035854A1 (de) 1997-10-02
CY2431B1 (en) 2004-11-12
DE59708265D1 (de) 2002-10-24
ATE224386T1 (de) 2002-10-15
SI0889886T1 (en) 2003-02-28
CA2250569A1 (en) 1997-10-02
EP0889886B1 (de) 2002-09-18
ES2184077T3 (es) 2003-04-01
CA2250569C (en) 2005-05-10
JP2000507256A (ja) 2000-06-13
AU718752B2 (en) 2000-04-20
EP0889886A1 (de) 1999-01-13
AU2291097A (en) 1997-10-17
PT889886E (pt) 2003-02-28
DK0889886T5 (da) 2003-02-24
JP4141501B2 (ja) 2008-08-27

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