DK0889886T3 - Novel, 6-position substituted phenanthridines - Google Patents
Novel, 6-position substituted phenanthridinesInfo
- Publication number
- DK0889886T3 DK0889886T3 DK97915422T DK97915422T DK0889886T3 DK 0889886 T3 DK0889886 T3 DK 0889886T3 DK 97915422 T DK97915422 T DK 97915422T DK 97915422 T DK97915422 T DK 97915422T DK 0889886 T3 DK0889886 T3 DK 0889886T3
- Authority
- DK
- Denmark
- Prior art keywords
- novel
- position substituted
- phenanthridines
- substituted phenanthridines
- compounds
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/16—Central respiratory analeptics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
- C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
- C07D221/04—Ortho- or peri-condensed ring systems
- C07D221/06—Ring systems of three rings
- C07D221/10—Aza-phenanthrenes
- C07D221/12—Phenanthridines
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pulmonology (AREA)
- Immunology (AREA)
- Rheumatology (AREA)
- Physical Education & Sports Medicine (AREA)
- Cardiology (AREA)
- Pain & Pain Management (AREA)
- Heart & Thoracic Surgery (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Urology & Nephrology (AREA)
- Dermatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Pyridine Compounds (AREA)
Abstract
Compounds of formula (I) in which R1, R2, R3, R31, R4, R5, R51 and R6 have the meanings given in the description, are novel effective bronchial therapeutic agents.
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19611922 | 1996-03-26 | ||
EP96105038 | 1996-03-29 | ||
DE1996113091 DE19613091A1 (en) | 1996-04-02 | 1996-04-02 | New 6-substituted phenanthridine derivatives |
EP96105311 | 1996-04-03 | ||
PCT/EP1997/001487 WO1997035854A1 (en) | 1996-03-26 | 1997-03-24 | Novel phenanthridines substituted in the 6 position |
Publications (2)
Publication Number | Publication Date |
---|---|
DK0889886T3 true DK0889886T3 (en) | 2003-01-20 |
DK0889886T5 DK0889886T5 (en) | 2003-02-24 |
Family
ID=27438318
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK97915422T DK0889886T5 (en) | 1996-03-26 | 1997-03-24 | Novel, 6-position substituted phenanthridines |
Country Status (12)
Country | Link |
---|---|
EP (1) | EP0889886B1 (en) |
JP (1) | JP4141501B2 (en) |
AT (1) | ATE224386T1 (en) |
AU (1) | AU718752B2 (en) |
CA (1) | CA2250569C (en) |
CY (1) | CY2431B1 (en) |
DE (1) | DE59708265D1 (en) |
DK (1) | DK0889886T5 (en) |
ES (1) | ES2184077T3 (en) |
PT (1) | PT889886E (en) |
SI (1) | SI0889886T1 (en) |
WO (1) | WO1997035854A1 (en) |
Families Citing this family (29)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EE04189B1 (en) * | 1997-07-25 | 2003-12-15 | Byk Gulden Lomberg Chemische Fabrik Gmbh | Substituted 6-phenylphenanthridines |
ATE260899T1 (en) * | 1997-07-25 | 2004-03-15 | Altana Pharma Ag | NEW TETRAZOLE DERIVATIVES |
AR015966A1 (en) * | 1997-10-17 | 2001-05-30 | Smithkline Beecham Corp | USE OF A PDE4 INHIBITOR COMPOUND FOR THE PREPARATION OF A USEFUL MEDICINAL PRODUCT FOR PRURITE TREATMENT |
IT1296985B1 (en) | 1997-12-19 | 1999-08-03 | Zambon Spa | BENZAZINIC DERIVATIVES INHIBITORS OF PHOSPHODIESTERASE 4 |
ATE315029T1 (en) * | 1999-01-15 | 2006-02-15 | Altana Pharma Ag | 6-ARYLPHENANTHRIDINE WITH PDE-IV INHIBITING EFFECT |
SI1147087T1 (en) * | 1999-01-15 | 2005-10-31 | Altana Pharma Ag | Phenanthridine-n-oxides with pde-iv inhibiting activity |
CA2360386A1 (en) * | 1999-01-15 | 2000-07-20 | Beate Gutterer | Polysubstituted 6-phenylphenanthridines with pde-iv inhibiting activity |
WO2000042034A1 (en) * | 1999-01-15 | 2000-07-20 | Byk Gulden | Phenanthridine-n-oxides with pde-iv inhibiting activity |
EP1147089B1 (en) * | 1999-01-15 | 2005-12-07 | ALTANA Pharma AG | Phenylphenanthridines with pde-iv inhibiting activity |
PT1212089E (en) | 1999-08-21 | 2006-08-31 | Altana Pharma Ag | ROFLUMILAST AND SALMETEROL SYNERGY COMBINATION |
EP1250325B1 (en) * | 2000-01-11 | 2008-05-07 | Nycomed GmbH | Phenanthridine-n-oxides |
AU2001267589A1 (en) * | 2000-07-14 | 2002-01-30 | Byk Gulden Lomberg Chemische Fabrik G.M.B.H. | Cycloalkyl - or cycloalkylmethyl-substituted 6-phenylphenanthridines |
WO2002006239A1 (en) * | 2000-07-14 | 2002-01-24 | Altana Pharma Ag | Phenanthridine n-oxides |
WO2002005616A1 (en) * | 2000-07-14 | 2002-01-24 | Altana Pharma Ag | Novel 6-phenylphenanthridines |
WO2002006270A1 (en) * | 2000-07-14 | 2002-01-24 | Altana Pharma Ag | Novel 6-heteroarylphenanthridines |
CA2495827C (en) | 2002-08-29 | 2012-05-08 | Altana Pharma Ag | 2-hydroxy-6-phenylphenanthridines as pde-4 inhibitors |
EP1536798B1 (en) | 2002-08-29 | 2007-02-07 | ALTANA Pharma AG | 3-hydroxy-6-phenylphenanthridines as pde-4 inhibitors |
WO2005012252A1 (en) * | 2003-07-31 | 2005-02-10 | Altana Pharma Ag | Novel 6-phenylphenantridines |
EP1658271A1 (en) * | 2003-07-31 | 2006-05-24 | ALTANA Pharma AG | Novel 6-phenylphenanthridines |
ES2400823T3 (en) | 2004-02-18 | 2013-04-12 | Takeda Gmbh | New guanidinyl substituted hydroxy-6-phenylphenanthridines as effective phosphodiesterase (PDE) 4 inhibitors |
SG182194A1 (en) | 2004-03-03 | 2012-07-30 | Nycomed Gmbh | Novel hydroxy-6-heteroarylphenanthridines and their use as pde4 inhibitors |
EP1745025A2 (en) * | 2004-03-09 | 2007-01-24 | Altana Pharma AG | Novel isoamido-substituted hydroxy-6-phenylphenanthridines and their use as pde4 inhibitors |
BRPI0508473A (en) * | 2004-03-10 | 2007-07-31 | Altana Pharma Ag | thiol-containing hydroxy-6-phenylphenanthridines and their use as pde4 inhibitors |
BRPI0508471A8 (en) * | 2004-03-10 | 2019-01-15 | Altana Pharma Ag | difluoroethoxy substituted hydroxy-6-phenylphenantidines compounds, pharmaceutical composition and use for their production |
ATE461189T1 (en) | 2005-02-01 | 2010-04-15 | Nycomed Gmbh | NEW 6-PYRIDYLPHENANTHRIDINE |
JP2008531654A (en) * | 2005-03-02 | 2008-08-14 | ニコメッド ゲゼルシャフト ミット ベシュレンクテル ハフツング | 6-heteroaryl-1,2,3,4,4a, 10b-hexahydrophenanthridine as PDE4 inhibitor for the treatment of inflammatory diseases |
DK1856093T3 (en) | 2005-03-02 | 2010-03-15 | Nycomed Gmbh | (2R, 4aR, 10bR) -6- (2,6-dimethoxypyridin-3-yl) -9-ethoxy-8-methoxy-1,2,3,4,4a, 10b-hexahydrophenanthridin-2-ol, HCl salt |
EP1919854B1 (en) * | 2005-08-30 | 2013-09-18 | AbbVie Inc. | Pharmaceutical compositions as inhibitors of dipeptidyl peptidase-iv (dpp-iv) |
UY35543A (en) * | 2013-04-30 | 2014-11-28 | Bayer Cropscience Ag | N- (PHENYLCYCALALKYL) CARBOXAMIDS AND N- (PHENYLCICLOALKYL) NEMATICIDED THIOCARBOXAMIDS |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
BE786031A (en) * | 1971-07-08 | 1973-01-08 | Rhone Poulenc Sa | NEW DERIVATIVES OF PHENANTHRIDIN, THEIR PREPARATION AND THE MEDICINAL COMPOSITIONS CONTAINING THEM |
US4309545A (en) * | 1980-07-28 | 1982-01-05 | Pfizer Inc. | Oximino-1-hydroxyoctahydrobenzo[c]quinolines and derivatives thereof |
-
1997
- 1997-03-24 SI SI9730427T patent/SI0889886T1/en unknown
- 1997-03-24 PT PT97915422T patent/PT889886E/en unknown
- 1997-03-24 EP EP97915422A patent/EP0889886B1/en not_active Expired - Lifetime
- 1997-03-24 JP JP53403097A patent/JP4141501B2/en not_active Expired - Fee Related
- 1997-03-24 DK DK97915422T patent/DK0889886T5/en active
- 1997-03-24 DE DE59708265T patent/DE59708265D1/en not_active Expired - Lifetime
- 1997-03-24 CA CA002250569A patent/CA2250569C/en not_active Expired - Fee Related
- 1997-03-24 ES ES97915422T patent/ES2184077T3/en not_active Expired - Lifetime
- 1997-03-24 AT AT97915422T patent/ATE224386T1/en not_active IP Right Cessation
- 1997-03-24 WO PCT/EP1997/001487 patent/WO1997035854A1/en active IP Right Grant
- 1997-03-24 AU AU22910/97A patent/AU718752B2/en not_active Ceased
-
2004
- 2004-03-12 CY CY0400018A patent/CY2431B1/en unknown
Also Published As
Publication number | Publication date |
---|---|
AU2291097A (en) | 1997-10-17 |
DE59708265D1 (en) | 2002-10-24 |
JP4141501B2 (en) | 2008-08-27 |
WO1997035854A1 (en) | 1997-10-02 |
PT889886E (en) | 2003-02-28 |
CA2250569A1 (en) | 1997-10-02 |
EP0889886B1 (en) | 2002-09-18 |
CY2431B1 (en) | 2004-11-12 |
AU718752B2 (en) | 2000-04-20 |
ES2184077T3 (en) | 2003-04-01 |
ATE224386T1 (en) | 2002-10-15 |
DK0889886T5 (en) | 2003-02-24 |
CA2250569C (en) | 2005-05-10 |
EP0889886A1 (en) | 1999-01-13 |
SI0889886T1 (en) | 2003-02-28 |
JP2000507256A (en) | 2000-06-13 |
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