DK0889886T3 - Novel, 6-position substituted phenanthridines - Google Patents

Novel, 6-position substituted phenanthridines

Info

Publication number
DK0889886T3
DK0889886T3 DK97915422T DK97915422T DK0889886T3 DK 0889886 T3 DK0889886 T3 DK 0889886T3 DK 97915422 T DK97915422 T DK 97915422T DK 97915422 T DK97915422 T DK 97915422T DK 0889886 T3 DK0889886 T3 DK 0889886T3
Authority
DK
Denmark
Prior art keywords
novel
position substituted
phenanthridines
substituted phenanthridines
compounds
Prior art date
Application number
DK97915422T
Other languages
Danish (da)
Other versions
DK0889886T5 (en
Inventor
Hermann Amschler
Dieter Flockerzi
Armin Hatzelmann
Rolf Beume
Dietrich Haefner
Hans-Peter Kley
Beate Gutterer
Wolf-Ruediger Ulrich
Thomas Baer
Thomas Martin
Christian Schudt
Hildegard Boss
Original Assignee
Altana Pharma Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE1996113091 external-priority patent/DE19613091A1/en
Application filed by Altana Pharma Ag filed Critical Altana Pharma Ag
Publication of DK0889886T3 publication Critical patent/DK0889886T3/en
Application granted granted Critical
Publication of DK0889886T5 publication Critical patent/DK0889886T5/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/16—Central respiratory analeptics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/04—Ortho- or peri-condensed ring systems
    • C07D221/06—Ring systems of three rings
    • C07D221/10—Aza-phenanthrenes
    • C07D221/12—Phenanthridines

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Rheumatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Dermatology (AREA)
  • Pain & Pain Management (AREA)
  • Urology & Nephrology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Pyridine Compounds (AREA)

Abstract

Compounds of formula (I) in which R1, R2, R3, R31, R4, R5, R51 and R6 have the meanings given in the description, are novel effective bronchial therapeutic agents.
DK97915422T 1996-03-26 1997-03-24 Novel, 6-position substituted phenanthridines DK0889886T5 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
DE19611922 1996-03-26
EP96105038 1996-03-29
DE1996113091 DE19613091A1 (en) 1996-04-02 1996-04-02 New 6-substituted phenanthridine derivatives
EP96105311 1996-04-03
PCT/EP1997/001487 WO1997035854A1 (en) 1996-03-26 1997-03-24 Novel phenanthridines substituted in the 6 position

Publications (2)

Publication Number Publication Date
DK0889886T3 true DK0889886T3 (en) 2003-01-20
DK0889886T5 DK0889886T5 (en) 2003-02-24

Family

ID=27438318

Family Applications (1)

Application Number Title Priority Date Filing Date
DK97915422T DK0889886T5 (en) 1996-03-26 1997-03-24 Novel, 6-position substituted phenanthridines

Country Status (12)

Country Link
EP (1) EP0889886B1 (en)
JP (1) JP4141501B2 (en)
AT (1) ATE224386T1 (en)
AU (1) AU718752B2 (en)
CA (1) CA2250569C (en)
CY (1) CY2431B1 (en)
DE (1) DE59708265D1 (en)
DK (1) DK0889886T5 (en)
ES (1) ES2184077T3 (en)
PT (1) PT889886E (en)
SI (1) SI0889886T1 (en)
WO (1) WO1997035854A1 (en)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CZ293725B6 (en) * 1997-07-25 2004-07-14 Altana Pharma Ag Tetrazole derivatives
WO1999005113A1 (en) * 1997-07-25 1999-02-04 Byk Gulden Lomberg Chemische Fabrik Gmbh Substituted 6-phenylphenanthridines
AR015966A1 (en) * 1997-10-17 2001-05-30 Smithkline Beecham Corp USE OF A PDE4 INHIBITOR COMPOUND FOR THE PREPARATION OF A USEFUL MEDICINAL PRODUCT FOR PRURITE TREATMENT
IT1296985B1 (en) * 1997-12-19 1999-08-03 Zambon Spa BENZAZINIC DERIVATIVES INHIBITORS OF PHOSPHODIESTERASE 4
DK1147089T3 (en) * 1999-01-15 2006-04-10 Altana Pharma Ag Phenylphenanthridines with PDE-IV inhibitory effect
DK1147087T3 (en) * 1999-01-15 2005-09-05 Altana Pharma Ag Phenanthridine N-oxides with PDE-IV inhibitory activity
ATE356810T1 (en) * 1999-01-15 2007-04-15 Altana Pharma Ag POLYSUBSTITUTED 6-PHENYLPHENANTHRIDINES WITH PDE-IV INHIBITING EFFECT
JP2002534507A (en) * 1999-01-15 2002-10-15 ビイク グルデン ロンベルク ヒエーミツシエ フアブリーク ゲゼルシヤフト ミツト ベシユレンクテル ハフツング New 6-arylphenanthridine
CA2359449A1 (en) * 1999-01-15 2000-07-20 Beate Gutterer Phenanthridine-n-oxides with pde-iv inhibiting activity
PT1212089E (en) 1999-08-21 2006-08-31 Altana Pharma Ag ROFLUMILAST AND SALMETEROL SYNERGY COMBINATION
WO2001051470A1 (en) * 2000-01-11 2001-07-19 Byk Gulden Lomberg Chemische Fabrik Gmbh Phenanthridine-n-oxides
DK1303506T3 (en) 2000-07-14 2005-05-30 Altana Pharma Ag 6-heteroarylphenanthridines
AU2001267589A1 (en) * 2000-07-14 2002-01-30 Byk Gulden Lomberg Chemische Fabrik G.M.B.H. Cycloalkyl - or cycloalkylmethyl-substituted 6-phenylphenanthridines
WO2002005616A1 (en) * 2000-07-14 2002-01-24 Altana Pharma Ag Novel 6-phenylphenanthridines
AU2001269126A1 (en) * 2000-07-14 2002-01-30 Byk Gulden Lomberg Chemische Fabrik G.M.B.H. Phenanthridine n-oxides
ATE353217T1 (en) 2002-08-29 2007-02-15 Altana Pharma Ag 3-HYDROXY-6-PHENYLPHENANTHRIDINE AS PDE-4 INHIBITORS
JP4587294B2 (en) 2002-08-29 2010-11-24 ニコメッド ゲゼルシャフト ミット ベシュレンクテル ハフツング 2-hydroxy-6-phenylphenanthridine as PDE4 inhibitor
EP1658270A1 (en) * 2003-07-31 2006-05-24 ALTANA Pharma AG Novel 6-phenylphenantridines
CA2533636A1 (en) * 2003-07-31 2005-02-10 Altana Pharma Ag Novel 6-phenylphenanthridines
AU2005212857B2 (en) 2004-02-18 2011-04-28 Takeda Gmbh Novel guanidinyl-substituted hydroxy-6-phenylphenenthridines as effective phosphodiesterase (PDE) 4 inhibitors
CN104817534A (en) 2004-03-03 2015-08-05 塔科达有限责任公司 Novel hydroxy-6-heteroarylphenanthridines and their use as PDE4 inhibitors
EP1745025A2 (en) * 2004-03-09 2007-01-24 Altana Pharma AG Novel isoamido-substituted hydroxy-6-phenylphenanthridines and their use as pde4 inhibitors
EP1725532A1 (en) * 2004-03-10 2006-11-29 Altana Pharma AG Novel difluoroethoxy-substituted hydroxy-6-phenylphenanthridines and their use as pde4 inhibitors
CA2558390A1 (en) * 2004-03-10 2005-09-22 Altana Pharma Ag Novel thio-containing hydroxy-6-phenylphenanthridines and their use as pde4 inhibitors
EA200701626A1 (en) 2005-02-01 2008-06-30 Никомед Гмбх NEW 6-Pyridylphenanthrin
WO2006092422A1 (en) 2005-03-02 2006-09-08 Nycomed Gmbh Novel salts of 6-heterocyclyl substituted hexahydrophenanthridine derivatives
AU2006219862A1 (en) * 2005-03-02 2006-09-08 Nycomed Gmbh 6-Heteroaryl-1,2,3,4,4a, 10b-hexahydro-phenanthridines as PDE-4 inhibitors for the treatment of inflammatory disorders
WO2007027651A2 (en) * 2005-08-30 2007-03-08 Abbott Laboratories Pharmaceutical compositions as inhibitors of dipeptidyl peptidase-iv (dpp-iv)
UY35543A (en) * 2013-04-30 2014-11-28 Bayer Cropscience Ag N- (PHENYLCYCALALKYL) CARBOXAMIDS AND N- (PHENYLCICLOALKYL) NEMATICIDED THIOCARBOXAMIDS

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE786031A (en) * 1971-07-08 1973-01-08 Rhone Poulenc Sa NEW DERIVATIVES OF PHENANTHRIDIN, THEIR PREPARATION AND THE MEDICINAL COMPOSITIONS CONTAINING THEM
US4309545A (en) * 1980-07-28 1982-01-05 Pfizer Inc. Oximino-1-hydroxyoctahydrobenzo[c]quinolines and derivatives thereof

Also Published As

Publication number Publication date
AU718752B2 (en) 2000-04-20
JP4141501B2 (en) 2008-08-27
CY2431B1 (en) 2004-11-12
AU2291097A (en) 1997-10-17
CA2250569C (en) 2005-05-10
PT889886E (en) 2003-02-28
EP0889886A1 (en) 1999-01-13
EP0889886B1 (en) 2002-09-18
WO1997035854A1 (en) 1997-10-02
DE59708265D1 (en) 2002-10-24
CA2250569A1 (en) 1997-10-02
JP2000507256A (en) 2000-06-13
ES2184077T3 (en) 2003-04-01
ATE224386T1 (en) 2002-10-15
DK0889886T5 (en) 2003-02-24
SI0889886T1 (en) 2003-02-28

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