AR106977A1 - Compuestos para el tratamiento de la enfermedad de alzheimer y/o la angiopatía amiloide cerebral - Google Patents
Compuestos para el tratamiento de la enfermedad de alzheimer y/o la angiopatía amiloide cerebralInfo
- Publication number
- AR106977A1 AR106977A1 ARP160103818A ARP160103818A AR106977A1 AR 106977 A1 AR106977 A1 AR 106977A1 AR P160103818 A ARP160103818 A AR P160103818A AR P160103818 A ARP160103818 A AR P160103818A AR 106977 A1 AR106977 A1 AR 106977A1
- Authority
- AR
- Argentina
- Prior art keywords
- amylooid
- angiopathy
- cerebral
- alzheimer
- disease
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 3
- 208000024827 Alzheimer disease Diseases 0.000 title 1
- 206010059245 Angiopathy Diseases 0.000 title 1
- 230000002490 cerebral effect Effects 0.000 title 1
- 125000004209 (C1-C8) alkyl group Chemical group 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- GBRAQQUMMCVTAV-UHFFFAOYSA-N n-[4,5-dihydroxy-6-(hydroxymethyl)piperidin-3-yl]acetamide Chemical compound CC(=O)NC1CNC(CO)C(O)C1O GBRAQQUMMCVTAV-UHFFFAOYSA-N 0.000 abstract 1
- 229940002612 prodrug Drugs 0.000 abstract 1
- 239000000651 prodrug Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000012453 solvate Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/56—Nitrogen atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hospice & Palliative Care (AREA)
- Cardiology (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
Reivindicación 1: Un compuesto que tiene una estructura representada por la fórmula (1) ó (2), donde: R¹, R², R⁴ se seleccionan independientemente entre H, alquilo C₁₋₈, arilo, (CH₂)ₙ-arilo, (CH₂)ₙ-heteroarilo; n = 0 - 8; X¹, X² se seleccionan independientemente entre CO, SO, SO₂, -CONH-, SO₂NH-, SONH-; y A¹, A², B¹, B², C¹, C² se seleccionan independientemente entre H, OR⁴, F, con la salvedad de que el compuesto no es 2-acetamido-1,2-didesoxinojirimicina o 2-acetamido-1,2-didesoxigalactonojirimicina, o una de sus sales, solvatos o profármacos farmacéuticamente aceptables.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562266760P | 2015-12-14 | 2015-12-14 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR106977A1 true AR106977A1 (es) | 2018-03-07 |
Family
ID=59018347
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP160103818A AR106977A1 (es) | 2015-12-14 | 2016-12-13 | Compuestos para el tratamiento de la enfermedad de alzheimer y/o la angiopatía amiloide cerebral |
Country Status (9)
| Country | Link |
|---|---|
| US (3) | US9994589B2 (es) |
| EP (1) | EP3390408A1 (es) |
| JP (1) | JP2019502679A (es) |
| CN (1) | CN108368131A (es) |
| AR (1) | AR106977A1 (es) |
| AU (1) | AU2016371917A1 (es) |
| CA (1) | CA3008266A1 (es) |
| TW (1) | TW201725197A (es) |
| WO (1) | WO2017106288A1 (es) |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3722788A1 (de) * | 1987-07-10 | 1989-01-19 | Bayer Ag | Chirale 6-hydroxymethylenverzweigte 3-amino-4,5-dihydroxypiperidine, zwischenprodukte zu ihrer herstellung, verfahren zu ihrer herstellung und ihre verwendung |
| US5206251A (en) * | 1992-04-01 | 1993-04-27 | G. D. Searle & Co. | 2- and 3- amino and azido derivatives of 1,5-iminosugars |
| WO2010015816A2 (en) | 2008-08-06 | 2010-02-11 | Summit Corporation Plc | Treatment of lysosomal storage disorders and other proteostatic diseases |
| PL2490712T3 (pl) | 2009-10-19 | 2015-12-31 | Amicus Therapeutics Inc | Sposób leczenia choroby Alzheimera przy zastosowaniu chaperonów farmakologicznych dla zwiększenia aktywności gangliozydaz |
| CA2822493C (en) * | 2010-12-23 | 2018-11-20 | Merck Sharp & Dohme Corp. | Selective glycosidase inhibitors and uses thereof |
| WO2012159262A1 (en) * | 2011-05-24 | 2012-11-29 | Alectos Therapeutics Inc. | Selective glycosidase inhibitors and uses thereof |
| JP6147737B2 (ja) * | 2011-06-27 | 2017-06-14 | アレクトス・セラピューティクス・インコーポレイテッド | 選択的グリコシダーゼ阻害剤およびその使用 |
| US9522883B2 (en) * | 2012-08-31 | 2016-12-20 | Alectos Therapeutics Inc. | Glycosidase inhibitors and uses thereof |
| US9675627B2 (en) | 2014-04-14 | 2017-06-13 | Amicus Therapeutics, Inc. | Dosing regimens for treating and/or preventing cerebral amyloidoses |
-
2016
- 2016-12-13 US US15/377,437 patent/US9994589B2/en active Active
- 2016-12-13 AR ARP160103818A patent/AR106977A1/es unknown
- 2016-12-14 AU AU2016371917A patent/AU2016371917A1/en not_active Abandoned
- 2016-12-14 JP JP2018530696A patent/JP2019502679A/ja active Pending
- 2016-12-14 TW TW105141335A patent/TW201725197A/zh unknown
- 2016-12-14 WO PCT/US2016/066572 patent/WO2017106288A1/en not_active Ceased
- 2016-12-14 CN CN201680073527.4A patent/CN108368131A/zh active Pending
- 2016-12-14 EP EP16820502.9A patent/EP3390408A1/en not_active Withdrawn
- 2016-12-14 CA CA3008266A patent/CA3008266A1/en active Pending
-
2018
- 2018-06-11 US US16/004,723 patent/US10174054B2/en active Active
-
2019
- 2019-01-07 US US16/241,215 patent/US10793583B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| US20190135832A1 (en) | 2019-05-09 |
| TW201725197A (zh) | 2017-07-16 |
| US20180291037A1 (en) | 2018-10-11 |
| EP3390408A1 (en) | 2018-10-24 |
| WO2017106288A1 (en) | 2017-06-22 |
| US9994589B2 (en) | 2018-06-12 |
| US10793583B2 (en) | 2020-10-06 |
| CA3008266A1 (en) | 2017-06-22 |
| AU2016371917A1 (en) | 2018-06-28 |
| US20170166588A1 (en) | 2017-06-15 |
| JP2019502679A (ja) | 2019-01-31 |
| CN108368131A (zh) | 2018-08-03 |
| US10174054B2 (en) | 2019-01-08 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FB | Suspension of granting procedure |