AR104415A1 - Compuestos antiestrogénicos derivados de cromeno - Google Patents

Compuestos antiestrogénicos derivados de cromeno

Info

Publication number
AR104415A1
AR104415A1 ARP160101179A ARP160101179A AR104415A1 AR 104415 A1 AR104415 A1 AR 104415A1 AR P160101179 A ARP160101179 A AR P160101179A AR P160101179 A ARP160101179 A AR P160101179A AR 104415 A1 AR104415 A1 AR 104415A1
Authority
AR
Argentina
Prior art keywords
hydrogen
halogen
hydroxy
chromene
alkyl
Prior art date
Application number
ARP160101179A
Other languages
English (en)
Inventor
C Myles David
J Kushner Peter
Carol Hodges Gallagher Leslie
L Harmon Cyrus
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of AR104415A1 publication Critical patent/AR104415A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/12—Drugs for genital or sexual disorders; Contraceptives for climacteric disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/30—Oestrogens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/32—Antioestrogens
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/10—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing aromatic rings

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Endocrinology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Reproductive Health (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Estos compuestos de 2H-cromeno son de utilidad para la modulación de trastornos mediados por estrógeno y otros trastornos. También composiciones farmacéuticas con contenido de los compuestos y a métodos de uso de los compuestos y las composiciones. Reivindicación 1: Un compuesto caracterizado por la fórmula (1) o una de sus sales farmacéuticamente aceptables, en donde X es CH₂, O, S, NH o N-(alquilo C₁₋₄); R¹ es -(C(Y¹)(Y²))ₘ-C((Y³)(Y⁴)(Y⁵)), en donde Y¹, Y², Y³, Y⁴ e Y⁵ son, de modo independiente, hidrógeno o flúor; m es 0 ó 1; R² es hidrógeno, halógeno, ciano o hidroxi; R³ es hidrógeno, halógeno, alquilo C₁₋₄, -CH₂F, -CHF₂ o -CF₃; R⁴ y R⁵ son cada uno, de modo independiente, hidrógeno, halógeno o hidroxi, siempre que R⁴ y R⁵ no sean ambos hidroxi; R⁶ y R⁷ son cada uno, de modo independiente, hidrógeno o halógeno; R⁸ es hidrógeno, halógeno, ciano, hidroxi o alquilo C₁₋₄; n es 1 ó 2; p es 1 ó 2; y q es 1.
ARP160101179A 2015-04-27 2016-04-26 Compuestos antiestrogénicos derivados de cromeno AR104415A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201562153097P 2015-04-27 2015-04-27

Publications (1)

Publication Number Publication Date
AR104415A1 true AR104415A1 (es) 2017-07-19

Family

ID=55863140

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP160101179A AR104415A1 (es) 2015-04-27 2016-04-26 Compuestos antiestrogénicos derivados de cromeno

Country Status (6)

Country Link
US (2) US20160311805A1 (es)
AR (1) AR104415A1 (es)
CA (1) CA2928060A1 (es)
TW (1) TW201710253A (es)
UY (1) UY36651A (es)
WO (1) WO2016174551A1 (es)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20180071274A (ko) * 2015-10-01 2018-06-27 올레마 파마슈티컬스 인코포레이티드 테트라히드로-1H-피리도[3,4-b]인돌 항에스트로겐 약물
MX2018007079A (es) 2015-12-09 2018-11-12 The Board Of Trustees Of Univ Of Illinois Reguladores a la baja del receptor de estrogeno selectivo de benzotiofeno.
TW201803870A (zh) 2016-04-20 2018-02-01 阿斯特捷利康公司 化學化合物
WO2018019793A1 (en) 2016-07-25 2018-02-01 Astrazeneca Ab N-(2-(4-((1r,3r)-3-methyl-2,3,4,9-tetrahydro-1h-pyrido[3,4-b]indol-1-yl)phenoxy)ethyl)propan-1-amine derivatives and related compounds as selective down-regulators of the estrogen receptor for treating cancer
US10131663B2 (en) 2016-10-24 2018-11-20 Astrazeneca Ab Chemical compounds
MX2019008158A (es) 2017-01-06 2019-12-09 G1 Therapeutics Inc Terapia de combinacion para el tratamiento del cancer.
WO2018138739A1 (en) 2017-01-27 2018-08-02 Sun Pharma Advanced Research Company Limited Novel antiestrogenic heterocyclic compounds
CA3050337A1 (en) 2017-01-30 2018-08-02 Astrazeneca Ab Estrogen receptor modulators
AU2019210129B2 (en) * 2018-01-22 2023-09-28 Radius Pharmaceuticals, Inc. Estrogen receptor-modulating compounds
JP2022523146A (ja) * 2019-02-06 2022-04-21 オレゴン ヘルス アンド サイエンス ユニバーシティ ビスホスホネート連結化合物
JP2022541938A (ja) 2019-07-22 2022-09-28 サン・ファーマ・アドバンスド・リサーチ・カンパニー・リミテッド 選択的エストロゲン受容体分解剤

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9540361B2 (en) * 2010-12-24 2017-01-10 Merck Sharp & Dohme B.V. N-substituted azetidine derivatives
BR112015030595A2 (pt) * 2013-06-19 2017-07-25 Seragon Pharmaceuticals Inc moduladores de receptor de estrogênio de azetidina e usos dos mesmos

Also Published As

Publication number Publication date
US20160311805A1 (en) 2016-10-27
US20170362210A1 (en) 2017-12-21
CA2928060A1 (en) 2016-10-27
TW201710253A (zh) 2017-03-16
WO2016174551A1 (en) 2016-11-03
UY36651A (es) 2016-11-30

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