JP2014113150A5 - - Google Patents
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- JP2014113150A5 JP2014113150A5 JP2013272028A JP2013272028A JP2014113150A5 JP 2014113150 A5 JP2014113150 A5 JP 2014113150A5 JP 2013272028 A JP2013272028 A JP 2013272028A JP 2013272028 A JP2013272028 A JP 2013272028A JP 2014113150 A5 JP2014113150 A5 JP 2014113150A5
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- seq
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- amino acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 125000003275 alpha amino acid group Chemical group 0.000 claims 37
- 108090000765 processed proteins & peptides Proteins 0.000 claims 37
- 229920001184 polypeptide Polymers 0.000 claims 32
- 102000004196 processed proteins & peptides Human genes 0.000 claims 32
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 27
- 108010087914 epidermal growth factor receptor VIII Proteins 0.000 claims 18
- 108090000623 proteins and genes Proteins 0.000 claims 12
- 102000004169 proteins and genes Human genes 0.000 claims 11
- 238000009739 binding Methods 0.000 claims 8
- 102000017420 CD3 protein, epsilon/gamma/delta subunit Human genes 0.000 claims 7
- 230000027455 binding Effects 0.000 claims 7
- 210000004027 cell Anatomy 0.000 claims 5
- 238000003149 assay kit Methods 0.000 claims 4
- 238000000034 method Methods 0.000 claims 4
- 102000004190 Enzymes Human genes 0.000 claims 3
- 108090000790 Enzymes Proteins 0.000 claims 3
- 102000008394 Immunoglobulin Fragments Human genes 0.000 claims 3
- 108010021625 Immunoglobulin Fragments Proteins 0.000 claims 3
- 241000124008 Mammalia Species 0.000 claims 3
- 206010028980 Neoplasm Diseases 0.000 claims 3
- 210000001744 T-lymphocyte Anatomy 0.000 claims 3
- 201000011510 cancer Diseases 0.000 claims 3
- 239000007850 fluorescent dye Substances 0.000 claims 3
- 210000004408 hybridoma Anatomy 0.000 claims 3
- 102000002260 Alkaline Phosphatase Human genes 0.000 claims 2
- 108020004774 Alkaline Phosphatase Proteins 0.000 claims 2
- 108010001336 Horseradish Peroxidase Proteins 0.000 claims 2
- 108060001084 Luciferase Proteins 0.000 claims 2
- 239000005089 Luciferase Substances 0.000 claims 2
- OAICVXFJPJFONN-UHFFFAOYSA-N Phosphorus Chemical compound [P] OAICVXFJPJFONN-UHFFFAOYSA-N 0.000 claims 2
- 150000001413 amino acids Chemical class 0.000 claims 2
- 102000005936 beta-Galactosidase Human genes 0.000 claims 2
- 108010005774 beta-Galactosidase Proteins 0.000 claims 2
- 125000004057 biotinyl group Chemical group [H]N1C(=O)N([H])[C@]2([H])[C@@]([H])(SC([H])([H])[C@]12[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C(*)=O 0.000 claims 2
- 102000052116 epidermal growth factor receptor activity proteins Human genes 0.000 claims 2
- 108700015053 epidermal growth factor receptor activity proteins Proteins 0.000 claims 2
- MHMNJMPURVTYEJ-UHFFFAOYSA-N fluorescein-5-isothiocyanate Chemical compound O1C(=O)C2=CC(N=C=S)=CC=C2C21C1=CC=C(O)C=C1OC1=CC(O)=CC=C21 MHMNJMPURVTYEJ-UHFFFAOYSA-N 0.000 claims 2
- 208000005017 glioblastoma Diseases 0.000 claims 2
- 229910052747 lanthanoid Inorganic materials 0.000 claims 2
- 150000002602 lanthanoids Chemical class 0.000 claims 2
- YOHYSYJDKVYCJI-UHFFFAOYSA-N n-[3-[[6-[3-(trifluoromethyl)anilino]pyrimidin-4-yl]amino]phenyl]cyclopropanecarboxamide Chemical compound FC(F)(F)C1=CC=CC(NC=2N=CN=C(NC=3C=C(NC(=O)C4CC4)C=CC=3)C=2)=C1 YOHYSYJDKVYCJI-UHFFFAOYSA-N 0.000 claims 2
- 229910052698 phosphorus Inorganic materials 0.000 claims 2
- 239000011574 phosphorus Substances 0.000 claims 2
- PYWVYCXTNDRMGF-UHFFFAOYSA-N rhodamine B Chemical compound [Cl-].C=12C=CC(=[N+](CC)CC)C=C2OC2=CC(N(CC)CC)=CC=C2C=1C1=CC=CC=C1C(O)=O PYWVYCXTNDRMGF-UHFFFAOYSA-N 0.000 claims 2
- 206010006187 Breast cancer Diseases 0.000 claims 1
- 208000026310 Breast neoplasm Diseases 0.000 claims 1
- 206010009944 Colon cancer Diseases 0.000 claims 1
- 208000008839 Kidney Neoplasms Diseases 0.000 claims 1
- 206010058467 Lung neoplasm malignant Diseases 0.000 claims 1
- 239000004472 Lysine Substances 0.000 claims 1
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 claims 1
- 102000008300 Mutant Proteins Human genes 0.000 claims 1
- 108010021466 Mutant Proteins Proteins 0.000 claims 1
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 1
- 206010033128 Ovarian cancer Diseases 0.000 claims 1
- 206010061535 Ovarian neoplasm Diseases 0.000 claims 1
- 206010060862 Prostate cancer Diseases 0.000 claims 1
- 208000000236 Prostatic Neoplasms Diseases 0.000 claims 1
- 206010038389 Renal cancer Diseases 0.000 claims 1
- 208000005718 Stomach Neoplasms Diseases 0.000 claims 1
- 238000007792 addition Methods 0.000 claims 1
- 230000004663 cell proliferation Effects 0.000 claims 1
- 210000004978 chinese hamster ovary cell Anatomy 0.000 claims 1
- 208000029742 colonic neoplasm Diseases 0.000 claims 1
- 238000012217 deletion Methods 0.000 claims 1
- 230000037430 deletion Effects 0.000 claims 1
- 238000001514 detection method Methods 0.000 claims 1
- 230000008556 epithelial cell proliferation Effects 0.000 claims 1
- 206010017758 gastric cancer Diseases 0.000 claims 1
- 125000003630 glycyl group Chemical group [H]N([H])C([H])([H])C(*)=O 0.000 claims 1
- 238000001727 in vivo Methods 0.000 claims 1
- 230000002401 inhibitory effect Effects 0.000 claims 1
- 201000010982 kidney cancer Diseases 0.000 claims 1
- 201000005202 lung cancer Diseases 0.000 claims 1
- 208000020816 lung neoplasm Diseases 0.000 claims 1
- 239000003550 marker Substances 0.000 claims 1
- 230000009871 nonspecific binding Effects 0.000 claims 1
- 150000007523 nucleic acids Chemical group 0.000 claims 1
- 108020003175 receptors Proteins 0.000 claims 1
- 102000005962 receptors Human genes 0.000 claims 1
- 230000009870 specific binding Effects 0.000 claims 1
- 201000011549 stomach cancer Diseases 0.000 claims 1
- 239000000126 substance Substances 0.000 claims 1
- 238000006467 substitution reaction Methods 0.000 claims 1
- 210000001519 tissue Anatomy 0.000 claims 1
- VBEQCZHXXJYVRD-GACYYNSASA-N uroanthelone Chemical compound C([C@@H](C(=O)N[C@H](C(=O)N[C@@H](CS)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CS)C(=O)N[C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)NCC(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(O)=O)C(C)C)[C@@H](C)O)NC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CC=1NC=NC=1)NC(=O)[C@H](CCSC)NC(=O)[C@H](CS)NC(=O)[C@@H](NC(=O)CNC(=O)CNC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CS)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)CNC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@H]1N(CCC1)C(=O)[C@H](CS)NC(=O)CNC(=O)[C@H]1N(CCC1)C(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC(N)=O)C(C)C)[C@@H](C)CC)C1=CC=C(O)C=C1 VBEQCZHXXJYVRD-GACYYNSASA-N 0.000 claims 1
Applications Claiming Priority (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US48314503P | 2003-06-27 | 2003-06-27 | |
| US60/483,145 | 2003-06-27 | ||
| US52557003P | 2003-11-26 | 2003-11-26 | |
| US60/525,570 | 2003-11-26 | ||
| US56245304P | 2004-04-15 | 2004-04-15 | |
| US60/562,453 | 2004-04-15 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010262796A Division JP5583560B2 (ja) | 2003-06-27 | 2010-11-25 | 上皮成長因子受容体の欠失型変異体を認識する抗体、およびそれらの使用 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017163089A Division JP2017210486A (ja) | 2003-06-27 | 2017-08-28 | 上皮成長因子受容体の欠失型変異体を認識する抗体、およびそれらの使用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2014113150A JP2014113150A (ja) | 2014-06-26 |
| JP2014113150A5 true JP2014113150A5 (OSRAM) | 2014-11-06 |
| JP6328928B2 JP6328928B2 (ja) | 2018-05-23 |
Family
ID=34108807
Family Applications (9)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006517700A Expired - Lifetime JP4800210B2 (ja) | 2003-06-27 | 2004-06-25 | 上皮成長因子受容体の欠失型変異体を認識する抗体、およびそれらの使用 |
| JP2006517620A Expired - Lifetime JP4808614B2 (ja) | 2003-06-27 | 2004-06-25 | 上皮成長因子受容体の欠失型変異体を認識する抗体、およびそれらの使用 |
| JP2010252825A Expired - Lifetime JP5583557B2 (ja) | 2003-06-27 | 2010-11-11 | 上皮成長因子受容体の欠失型変異体を認識する抗体、およびそれらの使用 |
| JP2010262796A Expired - Lifetime JP5583560B2 (ja) | 2003-06-27 | 2010-11-25 | 上皮成長因子受容体の欠失型変異体を認識する抗体、およびそれらの使用 |
| JP2013272029A Expired - Lifetime JP6328929B2 (ja) | 2003-06-27 | 2013-12-27 | 上皮成長因子受容体の欠失型変異体を認識する抗体、およびそれらの使用 |
| JP2013272028A Expired - Lifetime JP6328928B2 (ja) | 2003-06-27 | 2013-12-27 | 上皮成長因子受容体の欠失型変異体を認識する抗体、およびそれらの使用 |
| JP2017163089A Pending JP2017210486A (ja) | 2003-06-27 | 2017-08-28 | 上皮成長因子受容体の欠失型変異体を認識する抗体、およびそれらの使用 |
| JP2017175574A Pending JP2017222711A (ja) | 2003-06-27 | 2017-09-13 | 上皮成長因子受容体の欠失型変異体を認識する抗体、およびそれらの使用 |
| JP2019107945A Expired - Lifetime JP7062616B2 (ja) | 2003-06-27 | 2019-06-10 | 上皮成長因子受容体の欠失型変異体を認識する抗体、およびそれらの使用 |
Family Applications Before (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006517700A Expired - Lifetime JP4800210B2 (ja) | 2003-06-27 | 2004-06-25 | 上皮成長因子受容体の欠失型変異体を認識する抗体、およびそれらの使用 |
| JP2006517620A Expired - Lifetime JP4808614B2 (ja) | 2003-06-27 | 2004-06-25 | 上皮成長因子受容体の欠失型変異体を認識する抗体、およびそれらの使用 |
| JP2010252825A Expired - Lifetime JP5583557B2 (ja) | 2003-06-27 | 2010-11-11 | 上皮成長因子受容体の欠失型変異体を認識する抗体、およびそれらの使用 |
| JP2010262796A Expired - Lifetime JP5583560B2 (ja) | 2003-06-27 | 2010-11-25 | 上皮成長因子受容体の欠失型変異体を認識する抗体、およびそれらの使用 |
| JP2013272029A Expired - Lifetime JP6328929B2 (ja) | 2003-06-27 | 2013-12-27 | 上皮成長因子受容体の欠失型変異体を認識する抗体、およびそれらの使用 |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017163089A Pending JP2017210486A (ja) | 2003-06-27 | 2017-08-28 | 上皮成長因子受容体の欠失型変異体を認識する抗体、およびそれらの使用 |
| JP2017175574A Pending JP2017222711A (ja) | 2003-06-27 | 2017-09-13 | 上皮成長因子受容体の欠失型変異体を認識する抗体、およびそれらの使用 |
| JP2019107945A Expired - Lifetime JP7062616B2 (ja) | 2003-06-27 | 2019-06-10 | 上皮成長因子受容体の欠失型変異体を認識する抗体、およびそれらの使用 |
Country Status (12)
| Country | Link |
|---|---|
| US (9) | US7628986B2 (OSRAM) |
| EP (7) | EP3037105B1 (OSRAM) |
| JP (9) | JP4800210B2 (OSRAM) |
| KR (11) | KR101435167B1 (OSRAM) |
| CN (4) | CN102558352A (OSRAM) |
| AU (4) | AU2004260936B2 (OSRAM) |
| BR (2) | BRPI0411852A (OSRAM) |
| CA (2) | CA2530172A1 (OSRAM) |
| HK (2) | HK1201861A1 (OSRAM) |
| IN (1) | IN2012DN00313A (OSRAM) |
| MX (2) | MXPA05014155A (OSRAM) |
| WO (2) | WO2005012479A2 (OSRAM) |
Families Citing this family (163)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PT1392359E (pt) | 2001-05-11 | 2010-01-27 | Ludwig Inst For Cancer Res Ltd | Proteínas de ligação específica e suas utilizações |
| US20100056762A1 (en) | 2001-05-11 | 2010-03-04 | Old Lloyd J | Specific binding proteins and uses thereof |
| US20050271663A1 (en) * | 2001-06-28 | 2005-12-08 | Domantis Limited | Compositions and methods for treating inflammatory disorders |
| EP1399484B1 (en) * | 2001-06-28 | 2010-08-11 | Domantis Limited | Dual-specific ligand and its use |
| US7658924B2 (en) * | 2001-10-11 | 2010-02-09 | Amgen Inc. | Angiopoietin-2 specific binding agents |
| US9321832B2 (en) * | 2002-06-28 | 2016-04-26 | Domantis Limited | Ligand |
| US7696320B2 (en) | 2004-08-24 | 2010-04-13 | Domantis Limited | Ligands that have binding specificity for VEGF and/or EGFR and methods of use therefor |
| DE60305919T2 (de) * | 2002-06-28 | 2007-01-18 | Domantis Limited, Cambridge | Dual-specifische liganden mit erhöhter halbwertszeit |
| EP1578801A2 (en) * | 2002-12-27 | 2005-09-28 | Domantis Limited | Dual specific single domain antibodies specific for a ligand and for the receptor of the ligand |
| CA2517287C (en) * | 2003-02-28 | 2022-12-13 | The Johns Hopkins University | Regulation of t cells by lag-3 (cd223) |
| EP3037105B1 (en) * | 2003-06-27 | 2021-03-17 | Amgen Fremont Inc. | Antibodies directed to the deletion mutants of epidermal growth factor receptor and uses thereof |
| EP2305716B1 (en) * | 2004-11-30 | 2014-10-22 | Celldex Therapeutics, Inc. | Antibodies directed to gpnmb and uses thereof |
| US20110166319A1 (en) * | 2005-02-11 | 2011-07-07 | Immunogen, Inc. | Process for preparing purified drug conjugates |
| EP1739179A1 (en) * | 2005-06-30 | 2007-01-03 | Octapharma AG | Serum-free stable transfection and production of recombinant human proteins in human cell lines |
| NZ595430A (en) | 2005-08-24 | 2013-05-31 | Immunogen Inc | Process for preparing maytansinoid antibody conjugates |
| ATE461220T1 (de) * | 2005-11-12 | 2010-04-15 | Lilly Co Eli | Anti-egfr-antikörper |
| AU2006321364B2 (en) * | 2005-12-01 | 2011-11-10 | Domantis Limited | Noncompetitive domain antibody formats that bind Interleukin 1 Receptor type 1 |
| DOP2006000277A (es) * | 2005-12-12 | 2007-08-31 | Bayer Pharmaceuticals Corp | Anticuerpos anti mn y métodos para su utilización |
| AR059900A1 (es) * | 2006-03-17 | 2008-05-07 | Genentech Inc | Anticuerpos anti-tat226 e inmunoconjugados |
| CN101484807A (zh) * | 2006-03-31 | 2009-07-15 | 麻省理工学院 | 表达突变型egf受体的肿瘤的治疗 |
| EP2010568A1 (en) * | 2006-04-14 | 2009-01-07 | Ablynx N.V. | Dp-78-like nanobodies |
| CN101711284A (zh) | 2007-01-25 | 2010-05-19 | 达娜-法勃肿瘤研究所 | 抗egfr抗体在治疗egfr突变体介导的疾病中的用途 |
| US9340601B2 (en) * | 2007-03-01 | 2016-05-17 | The Board Of Trustees Of The Leland Stanford Junior University | Splice variants of the EGF receptor |
| JP5618549B2 (ja) | 2007-03-15 | 2014-11-05 | ルードヴィッヒ インスティテュート フォー キャンサーリサーチ リミテッド | Ｅｇｆｒ抗体及びｓｒｃ阻害剤を用いる治療方法及び関連製剤 |
| AU2008259513B2 (en) * | 2007-06-06 | 2014-07-24 | Domantis Limited | Polypeptides, antibody variable domains and antagonists |
| US20090011060A1 (en) * | 2007-07-06 | 2009-01-08 | Peter Koepke | Campsiandra angustifolia extract and methods of extracting and using such extract |
| US20090023199A1 (en) * | 2007-07-19 | 2009-01-22 | New England Clean Fuels, Inc. | Micro-organism production system and method |
| US8900816B2 (en) * | 2007-07-19 | 2014-12-02 | Duke University | Assay for anti-EGFRvIII antibodies |
| US20100120134A1 (en) * | 2007-07-19 | 2010-05-13 | Texas Clean Fuels, Inc. | Micro-organism production apparatus and system |
| EP2188311B1 (en) | 2007-08-14 | 2016-10-05 | Ludwig Institute for Cancer Research Ltd. | Monoclonal antibody 175 targeting the egf receptor and derivatives and uses thereof |
| US7879369B2 (en) | 2007-09-18 | 2011-02-01 | Selvamedica, Llc | Combretum laurifolium Mart. extract and methods of extracting and using such extract |
| CA2700723A1 (en) * | 2007-09-26 | 2009-04-02 | Amgen Inc. | Heparin-binding epidermal growth factor-like growth factor antigen binding proteins |
| JO2913B1 (en) | 2008-02-20 | 2015-09-15 | امجين إنك, | Antibodies directed towards angiopoietin-1 and angiopoietin-2 proteins and their uses |
| WO2009149094A2 (en) * | 2008-06-02 | 2009-12-10 | University Of Pittsburgh - Of The Commonwealth System Of Higher Education | Cytotoxic t cell defined egfr peptide and an optimized derivative peptide |
| KR101947176B1 (ko) | 2009-06-03 | 2019-02-12 | 이뮤노젠 아이엔씨 | 접합 방법 |
| JP5680087B2 (ja) * | 2009-09-22 | 2015-03-04 | シャンハイ・イージェー・バイオテクノロジー・カンパニー、リミテッドＳｈａｎｇｈａｉ Ｙｉｊｉｅ Ｂｉｏｔｅｃｈｎｏｌｏｇｙ Ｃｏ．，Ｌｔｄ | 特異的結合タンパク質およびその使用 |
| US20110076232A1 (en) * | 2009-09-29 | 2011-03-31 | Ludwig Institute For Cancer Research | Specific binding proteins and uses thereof |
| CA3031851C (en) * | 2009-10-23 | 2020-07-07 | Amgen British Columbia | Anti-gcc antibody molecules and related compositions and methods |
| DK2496698T3 (en) | 2009-11-03 | 2019-04-15 | Hope City | TRUNCATED EPIDERIMAL GROWTH FACTOR RECEPTOR (EGFRt) FOR TRUNCATED T-CELL SELECTION |
| NZ600978A (en) * | 2009-12-22 | 2014-08-29 | Celldex Therapeutics Inc | Vaccine compositions |
| WO2011156617A2 (en) | 2010-06-09 | 2011-12-15 | Aveo Pharmaceuticals, Inc. | Anti-egfr antibodies |
| CN103328505B (zh) | 2010-10-29 | 2015-12-02 | 伊缪诺金公司 | 非拮抗性egfr结合分子及其免疫偶联物 |
| EP2632490A4 (en) | 2010-10-29 | 2014-10-22 | Immunogen Inc | NOVEL MOLECULES BINDING TO THE EGF RECEPTOR AND IMMUNOCONJUGATES THEREOF |
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| US9315566B2 (en) * | 2011-01-24 | 2016-04-19 | National University Of Singapore | Pathogenic mycobacteria-derived mannose-capped lipoarabinomannan antigen binding proteins |
| WO2012135517A2 (en) | 2011-03-29 | 2012-10-04 | Immunogen, Inc. | Preparation of maytansinoid antibody conjugates by a one-step process |
| CA2831562A1 (en) * | 2011-03-29 | 2012-10-04 | Immunogen, Inc. | Process for manufacturing conjugates of improved homogeneity |
| EA201991268A3 (ru) | 2011-03-29 | 2020-01-31 | Иммуноджен, Инк. | Получение конъюгатов "майтансиноид-антитело" одностадийным способом |
| CA2832540C (en) * | 2011-04-08 | 2020-09-15 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Anti-epidermal growth factor receptor variant iii chimeric antigen receptors and use of same for the treatment of cancer |
| KR102023496B1 (ko) | 2011-04-21 | 2019-09-20 | 시애틀 지네틱스, 인크. | 신규 결합제-약물 콘주게이트 (adc) 및 그의 용도 |
| MX355877B (es) | 2011-09-30 | 2018-05-03 | Dana Farber Cancer Inst Inc | Peptidos terapeuticos. |
| US20140314667A1 (en) * | 2011-11-16 | 2014-10-23 | Amgen Inc. | Methods of treating epidermal growth factor deletion mutant viii related disorders |
| AU2012340686A1 (en) | 2011-11-21 | 2014-06-19 | Immunogen, Inc. | Method of treatment of tumors that are resistant to EGFR therapies by EGFR antibody cytotoxic agent conjugate |
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2010
- 2010-05-20 AU AU2010202054A patent/AU2010202054A1/en not_active Abandoned
- 2010-09-09 AU AU2010219363A patent/AU2010219363A1/en not_active Abandoned
- 2010-11-11 JP JP2010252825A patent/JP5583557B2/ja not_active Expired - Lifetime
- 2010-11-25 JP JP2010262796A patent/JP5583560B2/ja not_active Expired - Lifetime
-
2013
- 2013-12-27 JP JP2013272029A patent/JP6328929B2/ja not_active Expired - Lifetime
- 2013-12-27 JP JP2013272028A patent/JP6328928B2/ja not_active Expired - Lifetime
-
2015
- 2015-03-10 HK HK15102456.6A patent/HK1201861A1/xx unknown
- 2015-04-14 HK HK15103624.1A patent/HK1203205A1/xx unknown
- 2015-06-18 US US14/743,886 patent/US10508153B2/en not_active Expired - Lifetime
-
2017
- 2017-08-28 JP JP2017163089A patent/JP2017210486A/ja active Pending
- 2017-09-13 JP JP2017175574A patent/JP2017222711A/ja active Pending
-
2019
- 2019-06-10 JP JP2019107945A patent/JP7062616B2/ja not_active Expired - Lifetime
- 2019-11-04 US US16/673,234 patent/US11492411B2/en not_active Expired - Lifetime
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