|
JPS58216123A
(ja)
|
1982-06-10 |
1983-12-15 |
Kazue Ueno |
抗血清
|
|
US4530833A
(en)
*
|
1982-09-13 |
1985-07-23 |
Wilkins Tracy D |
Toxins and antibodies of C. difficile
|
|
US4689299A
(en)
|
1982-09-30 |
1987-08-25 |
University Of Rochester |
Human monoclonal antibodies against bacterial toxins
|
|
EP0154064A1
(en)
*
|
1984-03-02 |
1985-09-11 |
Tracy Dale Wilkins |
Toxins and antibodies of C. difficile
|
|
US4713240A
(en)
|
1985-04-04 |
1987-12-15 |
Research Corporation |
Vaccines based on insoluble supports
|
|
US5358868A
(en)
|
1987-11-24 |
1994-10-25 |
Connaught Laboratories Limited |
Genetic detoxification of pertussis toxin
|
|
US4912094B1
(en)
|
1988-06-29 |
1994-02-15 |
Ribi Immunochem Research Inc. |
Modified lipopolysaccharides and process of preparation
|
|
US5530101A
(en)
|
1988-12-28 |
1996-06-25 |
Protein Design Labs, Inc. |
Humanized immunoglobulins
|
|
US5919665A
(en)
|
1989-10-31 |
1999-07-06 |
Ophidian Pharmaceuticals, Inc. |
Vaccine for clostridium botulinum neurotoxin
|
|
US5601823A
(en)
|
1989-10-31 |
1997-02-11 |
Ophidian Pharmaceuticals, Inc. |
Avian antitoxins to clostridium difficle toxin A
|
|
US5599539A
(en)
|
1989-10-31 |
1997-02-04 |
Ophidian Pharmaceuticals, Inc. |
Therapy for clostridial botulinum toxin
|
|
US5578308A
(en)
|
1990-02-12 |
1996-11-26 |
Capiau; Carine |
Glutaraldehyde and formalin detoxified bordetella toxin vaccine
|
|
US5231003A
(en)
|
1990-05-11 |
1993-07-27 |
Cambridge Bioscience Corporation |
Monoclonal antibodies specific for toxin b of clostridium difficile
|
|
EP0581882B1
(en)
|
1991-04-22 |
1998-01-07 |
Massachusetts Health Research Institute, Inc. (Mhri) |
Process of screening plasma samples for effective antibody titers against respiratory viruses
|
|
US6221363B1
(en)
|
1991-07-11 |
2001-04-24 |
Baxter Aktiengesellschaft |
Vaccine for the prevention of lyme disease
|
|
PT692974E
(pt)
|
1993-03-29 |
2003-09-30 |
Pfizer |
Vacinas clostridiais com multiplos componentes usando adjuvantes de saponina
|
|
WO1996007430A1
(en)
|
1994-09-06 |
1996-03-14 |
Galagen, Inc. |
Therapeutic treatment of clostridium difficile associated diseases
|
|
JP2002514886A
(ja)
|
1994-10-24 |
2002-05-21 |
プロメガ コーポレーション |
クロストリジウム・ディフィシル疾患の治療及び予防のためのワクチン及び抗トキシン
|
|
US6743430B1
(en)
|
1995-03-29 |
2004-06-01 |
Richard E. Parizek |
Multicomponent vaccine containing clostridial and non-clostridial organisms in a low dose
|
|
US5610023A
(en)
|
1995-03-31 |
1997-03-11 |
Lee Laboratories, Inc. |
Method of purification of clostridium difficile toxin A and production of mono-specific antibodies
|
|
US5919463A
(en)
|
1995-07-07 |
1999-07-06 |
Oravax, Inc. |
Clostridium difficle toxins as mucosal adjuvants
|
|
CA2226339A1
(en)
|
1995-07-07 |
1997-01-30 |
Oravax, Inc. |
Clostridium difficile toxins as mucosal adjuvants
|
|
JPH11510793A
(ja)
|
1995-07-07 |
1999-09-21 |
オラバックス インク． |
胃腸病に対する鼻腔内ワクチン接種
|
|
EP0952773B1
(en)
|
1995-09-15 |
2005-11-23 |
Dale N. Gerding |
Methods and compositions for prevention and treatment of clostridium difficile-associated diseases
|
|
IL128014A
(en)
|
1996-09-30 |
2003-11-23 |
Univ Arkansas |
Method of producing active immunity with vaccine conjugate, a vaccine preparation useful for the production of said vaccine conjugate and a process for the manufacture of said vaccine
|
|
US20100267012A1
(en)
|
1997-11-04 |
2010-10-21 |
Bergeron Michel G |
Highly conserved genes and their use to generate probes and primers for detection of microorganisms
|
|
AU753688B2
(en)
|
1997-03-10 |
2002-10-24 |
Ottawa Civic Loeb Research Institute |
Use of nucleic acids containing unmethylated CpG dinucleotide as an adjuvant
|
|
US6299881B1
(en)
|
1997-03-24 |
2001-10-09 |
Henry M. Jackson Foundation For The Advancement Of Military Medicine |
Uronium salts for activating hydroxyls, carboxyls, and polysaccharides, and conjugate vaccines, immunogens, and other useful immunological reagents produced using uronium salts
|
|
US20050106157A1
(en)
|
1997-05-27 |
2005-05-19 |
Deckers Harm M. |
Immunogenic formulations comprising oil bodies
|
|
AU746859B2
(en)
|
1997-06-20 |
2002-05-02 |
Imperial College Of Science, Technology And Medicine |
Immonogenic fragments of toxin a of clostridium difficile
|
|
DE19739685A1
(de)
|
1997-09-10 |
1999-03-11 |
Eichel Streiber Christoph Von |
Monoklonale Antikörper zur Therapie und Prophylaxe von Erkrankungen durch Clostridium difficile
|
|
EP2305303A3
(en)
|
1997-10-20 |
2013-11-13 |
Sanofi Pasteur Biologics Co. |
Immunization against Clostridium difficile disease
|
|
US6969520B2
(en)
|
1997-10-20 |
2005-11-29 |
Acambis Inc. |
Active immunization against clostridium difficile disease
|
|
EP1568378B1
(en)
|
1997-10-20 |
2016-03-16 |
Sanofi Pasteur Biologics, LLC |
Immunization against Clostridium difficile disease
|
|
EP1169456B1
(en)
|
1999-04-09 |
2012-07-11 |
Intercell USA, Inc. |
Recombinant production of Clostridium difficile Toxin A or Toxin B
|
|
WO2000061761A2
(en)
*
|
1999-04-09 |
2000-10-19 |
Techlab, Inc. |
Recombinant clostridium toxin a protein carrier for polysaccharide conjugate vaccines
|
|
US6733760B1
(en)
|
1999-04-09 |
2004-05-11 |
Techlab, Inc. |
Recombinant toxin A/toxin B vaccine against Clostridium difficile
|
|
DK1187629T3
(da)
|
1999-04-19 |
2005-01-17 |
Glaxosmithkline Biolog Sa |
Adjuvanssammensætning omfattende saponin og et immunostimulerende oligonucleotid
|
|
GB0008682D0
(en)
|
2000-04-07 |
2000-05-31 |
Microbiological Res Authority |
Transformation of clostridium difficile
|
|
IL152553A0
(en)
|
2000-05-04 |
2003-05-29 |
Harvard College |
Compounds and methods for the treatment and prevention of bacterial infection
|
|
DE60217107T2
(de)
|
2001-06-20 |
2007-08-23 |
Ramot At Tel Aviv University Ltd. |
Mehrantigenisches peptid enthaltend mehrere kopien eines epitopes von einem ablagerungsformenden polypeptid und dessen verwendung
|
|
US20040029129A1
(en)
|
2001-10-25 |
2004-02-12 |
Liangsu Wang |
Identification of essential genes in microorganisms
|
|
AU2003242024A1
(en)
|
2002-06-05 |
2003-12-22 |
Chugai Seiyaku Kabushiki Kaisha |
Method of constructing antibody
|
|
AU2003299527A1
(en)
|
2002-06-17 |
2004-06-07 |
Jimmy D. Ballard |
Mutant of clostridium difficile toxin b and methods of use
|
|
US20040235139A1
(en)
*
|
2002-12-23 |
2004-11-25 |
Demain Arnold L. |
Clostridium difficile culture and toxin production methods
|
|
US20050020506A1
(en)
|
2003-07-25 |
2005-01-27 |
Drapeau Susan J. |
Crosslinked compositions comprising collagen and demineralized bone matrix, methods of making and methods of use
|
|
KR101183720B1
(ko)
|
2004-01-16 |
2012-09-17 |
다우 글로벌 테크놀로지스 엘엘씨 |
슈도모나스 플루오레센스에서의 포유류 단백질의 발현
|
|
NZ530709A
(en)
*
|
2004-01-21 |
2006-07-28 |
Agres Ltd |
Improved IGA production method
|
|
ES2366626T3
(es)
|
2004-02-06 |
2011-10-24 |
University Of Massachusetts |
Anticuerpos contra toxinas de clostridium difficile y usos de los mismos.
|
|
CA2592015A1
(en)
|
2004-12-27 |
2006-07-06 |
Progenics Pharmaceuticals (Nevada), Inc. |
Orally deliverable and anti-toxin antibodies and methods for making and using them
|
|
CN1930186A
(zh)
*
|
2005-03-03 |
2007-03-14 |
阿勒根公司 |
为获得梭菌毒素的梭菌细菌培养基及方法
|
|
WO2006130925A1
(en)
|
2005-06-10 |
2006-12-14 |
Monash University |
Genetic manipulation of clostridium difficile
|
|
GB0512751D0
(en)
*
|
2005-06-22 |
2005-07-27 |
Glaxo Group Ltd |
New adjuvant
|
|
US20080038761A1
(en)
|
2006-01-30 |
2008-02-14 |
Invitrogen Corporation |
Compositions and methods for detecting and quantifying toxic substances in disease states
|
|
GB0612301D0
(en)
|
2006-06-21 |
2006-08-02 |
Morvus Technology Ltd |
DNA molecules and methods
|
|
US20080206819A1
(en)
|
2006-08-21 |
2008-08-28 |
Mary Tsao |
Intensified Perfusion Production Method
|
|
US8653066B2
(en)
*
|
2006-10-09 |
2014-02-18 |
Charleston Laboratories, Inc. |
Pharmaceutical compositions
|
|
US9023352B2
(en)
|
2007-02-20 |
2015-05-05 |
Tufts University |
Methods, compositions and kits for treating a subject using a recombinant heteromultimeric neutralizing binding protein
|
|
EP2014760A1
(en)
|
2007-06-13 |
2009-01-14 |
CMC Biopharmaceuticals A/S |
A method for producing a biopolymer (e.g. polypeptide) in a continuous fermentation process
|
|
US9096638B2
(en)
|
2007-09-06 |
2015-08-04 |
Geneohm Sciences Canada, Inc. |
Detection of toxigenic strains of Clostridium difficile
|
|
AU2008299885C1
(en)
|
2007-09-14 |
2015-06-25 |
Sanofi Pasteur Biologics, Llc |
Pharmaceutical compositions containing clostridium difficile toxoids A and B
|
|
WO2009132082A2
(en)
|
2008-04-22 |
2009-10-29 |
Medical College Of Georgia Research Institute, Inc. |
Immunogenic compositions containing ceramide and methods of use thereof
|
|
WO2009139919A2
(en)
|
2008-05-15 |
2009-11-19 |
Tufts University |
Methods for diagnosis of clostridium diffcile and methods and vectors for recombinant toxin expression
|
|
EP2310045A1
(en)
|
2008-06-25 |
2011-04-20 |
Novartis AG |
Rapid responses to delayed booster immunisations
|
|
EP2146490A1
(en)
|
2008-07-18 |
2010-01-20 |
Alcatel, Lucent |
User device for gesture based exchange of information, methods for gesture based exchange of information between a plurality of user devices, and related devices and systems
|
|
WO2010017383A1
(en)
|
2008-08-06 |
2010-02-11 |
Emergent Product Development Uk Limited |
Vaccines against clostridium difficile and methods of use
|
|
WO2010036826A1
(en)
|
2008-09-24 |
2010-04-01 |
Sanofi Pasteur Biologics Co. |
Methods and compositions for increasing toxin production
|
|
EP2346523A4
(en)
*
|
2008-10-01 |
2014-12-31 |
Us Health |
MULTIPLE VACCINE VACCINATE AGAINST MALARIA TO CREATE LONG-TERM IMMUNE RESPONSE AGAINST PLASMODIA
|
|
WO2010037402A1
(en)
|
2008-10-02 |
2010-04-08 |
Dako Denmark A/S |
Molecular vaccines for infectious disease
|
|
AU2009324180A1
(en)
*
|
2008-12-03 |
2010-06-10 |
Boehringer Ingelheim Vetmedica Gmbh |
Process for production of vaccines
|
|
KR101329374B1
(ko)
|
2008-12-09 |
2013-11-14 |
콜레이 파마시티컬 그룹, 인코포레이티드 |
면역자극성 올리고뉴클레오타이드
|
|
GB0901001D0
(en)
|
2009-01-22 |
2009-03-04 |
Univ Nottingham |
Methods
|
|
US8709428B2
(en)
|
2009-02-20 |
2014-04-29 |
Health Protection Agency |
Antibodies to Clostridium difficile toxins
|
|
EP2470664A4
(en)
|
2009-08-27 |
2013-01-16 |
Synaptic Res Llc |
NEW PROTEIN RELEASE SYSTEM FOR GENERATING INDUCED PLURIPOTENTAL STEM CELLS OR TISSUE-SPECIFIC CELLS
|
|
WO2011060431A2
(en)
|
2009-11-16 |
2011-05-19 |
University Of Maryland Baltimore |
Multivalent live vector vaccine against clostridium difficile-associated disease
|
|
JP2013512916A
(ja)
|
2009-12-02 |
2013-04-18 |
タフツ ユニバーシティー |
免疫原としてのＣｌｏｓｔｒｉｄｉｕｍｄｉｆｆｉｃｉｌｅの無毒の組換えホロトキシン
|
|
GB0921288D0
(en)
|
2009-12-04 |
2010-01-20 |
Health Prot Agency |
Therapies for preventing or suppressing clostridium difficile infection
|
|
TW201136603A
(en)
|
2010-02-09 |
2011-11-01 |
Merck Sharp & Amp Dohme Corp |
15-valent pneumococcal polysaccharide-protein conjugate vaccine composition
|
|
WO2011126811A2
(en)
*
|
2010-03-30 |
2011-10-13 |
Pfenex Inc. |
High level expression of recombinant toxin proteins
|
|
US8765399B2
(en)
*
|
2010-05-18 |
2014-07-01 |
Montefiore Medical Center |
Cultures and protocols for diagnosis of toxigenic Clostridium difficile
|
|
WO2012028418A1
(en)
*
|
2010-09-02 |
2012-03-08 |
Novacem Limited |
Integrated process for producing compositions containing magnesium
|
|
KR101907434B1
(ko)
|
2010-09-03 |
2018-10-12 |
발네바 오스트리아 게엠베하 |
C. 디피실의 a 독소 및 b 독소 단백질의 분리된 폴리펩타이드 및 이의 용도
|
|
GB201016742D0
(en)
*
|
2010-10-05 |
2010-11-17 |
Health Prot Agency |
Clostridium difficile antigens
|
|
EP2638063A4
(en)
|
2010-11-12 |
2014-04-23 |
Reflexion Pharmaceuticals Inc |
GB1 PEPTIDE LIBRARIES AND CONNECTIONS AND SCREENING METHOD THEREFOR
|
|
CN102533867A
(zh)
*
|
2010-12-10 |
2012-07-04 |
西北民族大学 |
一种艰难梭菌a毒素的类毒素的制备方法
|
|
AR086199A1
(es)
*
|
2011-04-22 |
2013-11-27 |
Wyeth Llc |
Composiciones relacionadas con una toxina de clostridium difficile mutante y sus metodos
|
|
US9290565B2
(en)
*
|
2011-05-27 |
2016-03-22 |
Glaxosmithkline Biologicals, S.A. |
Immunogenic composition
|
|
US9770500B2
(en)
|
2011-05-31 |
2017-09-26 |
The Board Of Regents Of The University Of Texas System |
S-nitrosylation of glucosylating toxins and uses therefor
|
|
WO2013082298A2
(en)
*
|
2011-11-30 |
2013-06-06 |
Board Of Trustees Of Michigan State University |
Immunological composition for clostridium difficile
|
|
AU2012349753A1
(en)
|
2011-12-08 |
2014-06-19 |
Novartis Ag |
Clostridium difficile toxin-based vaccine
|
|
AR089797A1
(es)
|
2012-01-27 |
2014-09-17 |
Merck Sharp & Dohme |
Vacunas contra clostridum difficile que comprenden toxinas recombinantes
|
|
JP2015529677A
(ja)
*
|
2012-09-19 |
2015-10-08 |
ノバルティス アーゲー |
ワクチンとしてのＣｌｏｓｔｒｉｄｉｕｍｄｉｆｆｉｃｉｌｅポリペプチド
|
|
BR122016023101B1
(pt)
*
|
2012-10-21 |
2022-03-22 |
Pfizer Inc |
Polipeptídeo, composição imunogênica que o compreende, bem como célula recombinante derivada de clostridium difficile
|
|
JP2016501877A
(ja)
*
|
2012-11-28 |
2016-01-21 |
シーエヌジェー ホールディングス，インコーポレイテッド |
クロストリジウム・ディフィシルに対する抗体
|
|
EP2928489B1
(en)
*
|
2012-12-05 |
2019-02-27 |
GlaxoSmithKline Biologicals S.A. |
Immunogenic composition
|
|
GB201223342D0
(en)
*
|
2012-12-23 |
2013-02-06 |
Glaxosmithkline Biolog Sa |
Immunogenic composition
|
|
KR20150133770A
(ko)
*
|
2013-03-15 |
2015-11-30 |
사노피 파스퇴르 인코포레이티드 |
톡소이드, 조성물 및 관련 방법
|
|
WO2014144292A2
(en)
*
|
2013-03-15 |
2014-09-18 |
Sanofi Pasteur Biologics , Llc |
Antibodies against clostridium difficile toxins and methods of using the same
|
|
EP2981611A4
(en)
|
2013-04-02 |
2016-11-16 |
Stc Unm |
ANTIBIOTICUM PROTOCOLS AND PHARMACEUTICAL FORMULATIONS AND TREATMENT METHODS THEREWITH
|
|
SG11201510166YA
(en)
|
2013-06-14 |
2016-01-28 |
Sanofi Pasteur Inc |
Compositions and methods of immunizing against c. difficile
|
|
WO2015061529A1
(en)
*
|
2013-10-23 |
2015-04-30 |
The Rockefeller University |
Compositions and methods for prophylaxis and therapy of clostridium difficile infection
|
|
US11160855B2
(en)
|
2014-01-21 |
2021-11-02 |
Pfizer Inc. |
Immunogenic compositions comprising conjugated capsular saccharide antigens and uses thereof
|
|
IL259404B2
(en)
|
2015-11-17 |
2025-08-01 |
Pfizer |
Media and fermentation methods for producing polysaccharides in bacterial cell culture
|
|
CN117244049A
(zh)
*
|
2016-02-16 |
2023-12-19 |
哈佛学院院长等 |
病原体疫苗及其生产和使用方法
|
|
CN110691609B
(zh)
|
2017-03-15 |
2024-04-19 |
诺瓦瓦克斯股份有限公司 |
用于诱导针对艰难梭菌的免疫应答的方法和组合物
|
|
CA3016351A1
(en)
|
2017-09-05 |
2019-03-05 |
Mcmaster University |
Aptamers for clostridium difficile detection
|
|
MX2020003756A
(es)
|
2017-09-28 |
2020-07-29 |
Pfizer |
Composiciones y metodos para obtener una respuesta inmune contra clostridium difficile.
|
|
WO2020201985A1
(en)
|
2019-04-01 |
2020-10-08 |
Pfizer Inc. |
Compositions and methods for eliciting an immune response against clostridium difficile
|
|
WO2021255690A2
(en)
|
2020-06-19 |
2021-12-23 |
Pfizer Inc. |
Immunogenic compositions against clostridioides (clostridium) difficile and methods thereof
|