CN104797706B - 涉及突变型艰难梭菌毒素的组合物和方法 - Google Patents
涉及突变型艰难梭菌毒素的组合物和方法 Download PDFInfo
- Publication number
- CN104797706B CN104797706B CN201380054635.3A CN201380054635A CN104797706B CN 104797706 B CN104797706 B CN 104797706B CN 201380054635 A CN201380054635 A CN 201380054635A CN 104797706 B CN104797706 B CN 104797706B
- Authority
- CN
- China
- Prior art keywords
- clostridium difficile
- seq
- toxin
- amino acid
- mutant
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Images
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/1048—Glycosyltransferases (2.4)
- C12N9/1051—Hexosyltransferases (2.4.1)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/20—Bacteria; Culture media therefor
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/08—Clostridium, e.g. Clostridium tetani
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/33—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Clostridium (G)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/20—Bacteria; Culture media therefor
- C12N1/205—Bacterial isolates
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/38—Chemical stimulation of growth or activity by addition of chemical compounds which are not essential growth factors; Stimulation of growth by removal of a chemical compound
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2330/00—Production
- C12N2330/50—Biochemical production, i.e. in a transformed host cell
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2510/00—Genetically modified cells
- C12N2510/02—Cells for production
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
- C12R2001/00—Microorganisms ; Processes using microorganisms
- C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
- C12R2001/145—Clostridium
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- Biotechnology (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- General Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Virology (AREA)
- Biophysics (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- General Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Mycology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810000818.1A CN108004286B (zh) | 2012-10-21 | 2013-10-07 | 涉及突变型艰难梭菌毒素的组合物和方法 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261716605P | 2012-10-21 | 2012-10-21 | |
| US61/716,605 | 2012-10-21 | ||
| PCT/IB2013/059183 WO2014060898A2 (en) | 2012-10-21 | 2013-10-07 | Compositions and methods relating to a mutant clostridium difficile toxin |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201810000818.1A Division CN108004286B (zh) | 2012-10-21 | 2013-10-07 | 涉及突变型艰难梭菌毒素的组合物和方法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN104797706A CN104797706A (zh) | 2015-07-22 |
| CN104797706B true CN104797706B (zh) | 2020-05-26 |
Family
ID=49546596
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201810000818.1A Active CN108004286B (zh) | 2012-10-21 | 2013-10-07 | 涉及突变型艰难梭菌毒素的组合物和方法 |
| CN201380054635.3A Active CN104797706B (zh) | 2012-10-21 | 2013-10-07 | 涉及突变型艰难梭菌毒素的组合物和方法 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201810000818.1A Active CN108004286B (zh) | 2012-10-21 | 2013-10-07 | 涉及突变型艰难梭菌毒素的组合物和方法 |
Country Status (19)
| Country | Link |
|---|---|
| US (5) | US10787652B2 (enExample) |
| EP (2) | EP2909307B1 (enExample) |
| JP (4) | JP6527661B2 (enExample) |
| KR (5) | KR101940939B1 (enExample) |
| CN (2) | CN108004286B (enExample) |
| AU (5) | AU2013333532C1 (enExample) |
| BR (2) | BR122016023101B1 (enExample) |
| CA (2) | CA2887891C (enExample) |
| DK (1) | DK2909307T3 (enExample) |
| ES (1) | ES2878551T3 (enExample) |
| HR (1) | HRP20211170T1 (enExample) |
| HU (1) | HUE055594T2 (enExample) |
| IL (3) | IL237792B (enExample) |
| MX (2) | MX369289B (enExample) |
| PL (1) | PL2909307T3 (enExample) |
| PT (1) | PT2909307T (enExample) |
| RU (1) | RU2630671C2 (enExample) |
| SI (1) | SI2909307T1 (enExample) |
| WO (1) | WO2014060898A2 (enExample) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HUE047085T2 (hu) * | 2011-04-22 | 2020-04-28 | Wyeth Llc | Clostridium difficile mutáns toxinjához kapcsolódó készítmények és eljárásai |
| BR122016023101B1 (pt) * | 2012-10-21 | 2022-03-22 | Pfizer Inc | Polipeptídeo, composição imunogênica que o compreende, bem como célula recombinante derivada de clostridium difficile |
| WO2014144292A2 (en) | 2013-03-15 | 2014-09-18 | Sanofi Pasteur Biologics , Llc | Antibodies against clostridium difficile toxins and methods of using the same |
| CA2976976C (en) * | 2015-02-19 | 2023-02-28 | Immune Biosolutions Inc. | Clostridium difficile toxins a and/or b antigen and epitope antibody, and pharmaceutical uses thereof |
| KR101729251B1 (ko) | 2015-04-28 | 2017-04-21 | 주식회사 대웅 | 보툴리눔 독소의 제조를 위한 배지 조성물 |
| KR101723167B1 (ko) | 2015-04-28 | 2017-04-05 | 주식회사 대웅 | 보툴리눔 독소의 제조를 위한 배지 조성물 |
| WO2017040885A1 (en) * | 2015-09-03 | 2017-03-09 | The Board Of Regents Of The University Of Oklahoma | Peptide inhibitors of clostridium difficile tcdb toxin |
| EP4467565A3 (en) | 2016-12-21 | 2025-03-12 | Amgen Inc. | Anti-tnf alpha antibody formulations |
| CN106801077A (zh) * | 2017-02-13 | 2017-06-06 | 江南大学 | 一种高效杀灭滴虫等医学原虫的细菌培养上清液的制备方法和及其利用 |
| MX2020003756A (es) * | 2017-09-28 | 2020-07-29 | Pfizer | Composiciones y metodos para obtener una respuesta inmune contra clostridium difficile. |
| WO2020201985A1 (en) | 2019-04-01 | 2020-10-08 | Pfizer Inc. | Compositions and methods for eliciting an immune response against clostridium difficile |
| EP3972638A4 (en) * | 2019-05-21 | 2023-09-13 | The Regents Of The University Of California | VACCINE COMPOSITION FOR CLOSTRIDIUM DIFFICILE |
| AU2021267172A1 (en) * | 2020-05-06 | 2022-12-08 | Albert Einstein College Of Medicine | Agents to prevent tissue damage from clostridium difficile infections by inhibition of the gut-damaging bacterial toxins TcdA and TcdB |
| EP4168032A2 (en) | 2020-06-19 | 2023-04-26 | Pfizer Inc. | Immunogenic compositions against clostridioides (clostridium) difficile and methods thereof |
| KR20240159001A (ko) | 2022-03-14 | 2024-11-05 | 화이자 인코포레이티드 | 보조제의 제조 방법 |
| KR20250120405A (ko) | 2022-12-13 | 2025-08-08 | 화이자 인코포레이티드 | 클로스트리디오이데스 (클로스트리디움) 디피실레에 대한 면역 반응을 도출하기 위한 면역원성 조성물 및 방법 |
| WO2025057058A1 (en) | 2023-09-13 | 2025-03-20 | Pfizer Inc. | Methods for producing an adjuvant |
| WO2025257712A1 (en) | 2024-06-12 | 2025-12-18 | Pfizer Inc. | Immunogenic compositions and methods for eliciting an immune response against clostridioides (clostridium) difficile |
Family Cites Families (109)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS58216123A (ja) | 1982-06-10 | 1983-12-15 | Kazue Ueno | 抗血清 |
| US4530833A (en) * | 1982-09-13 | 1985-07-23 | Wilkins Tracy D | Toxins and antibodies of C. difficile |
| US4689299A (en) | 1982-09-30 | 1987-08-25 | University Of Rochester | Human monoclonal antibodies against bacterial toxins |
| EP0154064A1 (en) * | 1984-03-02 | 1985-09-11 | Tracy Dale Wilkins | Toxins and antibodies of C. difficile |
| US4713240A (en) | 1985-04-04 | 1987-12-15 | Research Corporation | Vaccines based on insoluble supports |
| US5358868A (en) | 1987-11-24 | 1994-10-25 | Connaught Laboratories Limited | Genetic detoxification of pertussis toxin |
| US4912094B1 (en) | 1988-06-29 | 1994-02-15 | Ribi Immunochem Research Inc. | Modified lipopolysaccharides and process of preparation |
| US5530101A (en) | 1988-12-28 | 1996-06-25 | Protein Design Labs, Inc. | Humanized immunoglobulins |
| US5601823A (en) | 1989-10-31 | 1997-02-11 | Ophidian Pharmaceuticals, Inc. | Avian antitoxins to clostridium difficle toxin A |
| US5919665A (en) | 1989-10-31 | 1999-07-06 | Ophidian Pharmaceuticals, Inc. | Vaccine for clostridium botulinum neurotoxin |
| US5599539A (en) | 1989-10-31 | 1997-02-04 | Ophidian Pharmaceuticals, Inc. | Therapy for clostridial botulinum toxin |
| US5578308A (en) | 1990-02-12 | 1996-11-26 | Capiau; Carine | Glutaraldehyde and formalin detoxified bordetella toxin vaccine |
| US5231003A (en) | 1990-05-11 | 1993-07-27 | Cambridge Bioscience Corporation | Monoclonal antibodies specific for toxin b of clostridium difficile |
| WO1992018652A1 (en) | 1991-04-22 | 1992-10-29 | Massachusetts Health Research Institute, Inc. | Process of screening plasma samples for effective antibody titers against respiratory viruses |
| US6221363B1 (en) | 1991-07-11 | 2001-04-24 | Baxter Aktiengesellschaft | Vaccine for the prevention of lyme disease |
| CA2158651C (en) | 1993-03-29 | 2009-09-01 | David S. Roberts | Multicomponent clostridial vaccines using saponin adjuvants |
| JPH10505358A (ja) | 1994-09-06 | 1998-05-26 | ギャラゲン・インコーポレイテッド | クロストリジウム・ディフィシル関連疾患の治療処置 |
| CZ296806B6 (cs) | 1994-10-24 | 2006-06-14 | Allergan, Inc. | Rozpustný fúzní protein a zpusob výroby rozpustného rekombinantního botulinového toxinu |
| US6743430B1 (en) | 1995-03-29 | 2004-06-01 | Richard E. Parizek | Multicomponent vaccine containing clostridial and non-clostridial organisms in a low dose |
| US5610023A (en) | 1995-03-31 | 1997-03-11 | Lee Laboratories, Inc. | Method of purification of clostridium difficile toxin A and production of mono-specific antibodies |
| CN1195993A (zh) | 1995-07-07 | 1998-10-14 | 奥拉瓦克斯有限公司 | 抗胃肠疾病的鼻内接种 |
| ATE195878T1 (de) | 1995-07-07 | 2000-09-15 | Oravax Inc | Toxine und toxoide von clostridium difficile als schleimhautadjuvans |
| US5919463A (en) | 1995-07-07 | 1999-07-06 | Oravax, Inc. | Clostridium difficle toxins as mucosal adjuvants |
| ES2248822T3 (es) | 1995-09-15 | 2006-03-16 | Dale N. Gerding | Procedimientos y composiciones para la prevencion y el tratamiento de enfermedades asociadas al clostridium difficile. |
| AU715555B2 (en) | 1996-09-30 | 2000-02-03 | University Of Arkansas, The | Method of producing active immunity with vaccine conjugate |
| US20100267012A1 (en) | 1997-11-04 | 2010-10-21 | Bergeron Michel G | Highly conserved genes and their use to generate probes and primers for detection of microorganisms |
| ATE441432T1 (de) | 1997-03-10 | 2009-09-15 | Ottawa Hospital Res Inst | Verwendung von nicht-methyliertem cpg dinukleotid in kombination mit aluminium als adjuvantien |
| US6299881B1 (en) | 1997-03-24 | 2001-10-09 | Henry M. Jackson Foundation For The Advancement Of Military Medicine | Uronium salts for activating hydroxyls, carboxyls, and polysaccharides, and conjugate vaccines, immunogens, and other useful immunological reagents produced using uronium salts |
| US20050106157A1 (en) | 1997-05-27 | 2005-05-19 | Deckers Harm M. | Immunogenic formulations comprising oil bodies |
| WO1998059053A1 (en) | 1997-06-20 | 1998-12-30 | Queen Mary & Westfield College | Immonogenic fragments of toxin a of clostridium difficile |
| DE19739685A1 (de) | 1997-09-10 | 1999-03-11 | Eichel Streiber Christoph Von | Monoklonale Antikörper zur Therapie und Prophylaxe von Erkrankungen durch Clostridium difficile |
| US6969520B2 (en) | 1997-10-20 | 2005-11-29 | Acambis Inc. | Active immunization against clostridium difficile disease |
| US6214341B1 (en) | 1997-10-20 | 2001-04-10 | Oravax | Passive immunization against Clostridium difficile disease |
| EP1568378B1 (en) | 1997-10-20 | 2016-03-16 | Sanofi Pasteur Biologics, LLC | Immunization against Clostridium difficile disease |
| US6733760B1 (en) | 1999-04-09 | 2004-05-11 | Techlab, Inc. | Recombinant toxin A/toxin B vaccine against Clostridium difficile |
| CA2365914A1 (en) | 1999-04-09 | 2000-10-19 | Techlab, Inc. | Recombinant clostridium toxin a protein carrier for polysaccharide conjugate vaccines |
| JP2002542169A (ja) | 1999-04-09 | 2002-12-10 | テクラブ, インコーポレイテッド | Clostridiumdifficileに対する、組換え毒素A/毒素Bワクチン |
| PL203951B1 (pl) | 1999-04-19 | 2009-11-30 | Smithkline Beecham Biolog | Kompozycja adiuwantowa, kompozycja szczepionki oraz sposób jej wytwarzania, szczepionka oraz zastosowanie |
| GB0008682D0 (en) | 2000-04-07 | 2000-05-31 | Microbiological Res Authority | Transformation of clostridium difficile |
| PL365453A1 (en) | 2000-05-04 | 2005-01-10 | President And Fellows Of Harvard College | Compounds and methods for the treatment and prevention of bacterial infection |
| ES2279869T3 (es) | 2001-06-20 | 2007-09-01 | Ramot At Tel Aviv University Ltd. | Peptido antigenico comprendido por mulitples copias de un epitope de un polipeptido implicado en enfermedades de formacion de placas y los procedimientos de uso correspondientes. |
| US20040029129A1 (en) | 2001-10-25 | 2004-02-12 | Liangsu Wang | Identification of essential genes in microorganisms |
| AU2003242024A1 (en) | 2002-06-05 | 2003-12-22 | Chugai Seiyaku Kabushiki Kaisha | Method of constructing antibody |
| AU2003299527A1 (en) | 2002-06-17 | 2004-06-07 | Jimmy D. Ballard | Mutant of clostridium difficile toxin b and methods of use |
| US20040235139A1 (en) * | 2002-12-23 | 2004-11-25 | Demain Arnold L. | Clostridium difficile culture and toxin production methods |
| US20050020506A1 (en) | 2003-07-25 | 2005-01-27 | Drapeau Susan J. | Crosslinked compositions comprising collagen and demineralized bone matrix, methods of making and methods of use |
| AU2005206951B2 (en) | 2004-01-16 | 2010-08-19 | Pfenex Inc. | Expression of mammalian proteins in Pseudomonas fluorescens |
| NZ530709A (en) * | 2004-01-21 | 2006-07-28 | Agres Ltd | Improved IGA production method |
| JP4588763B2 (ja) * | 2004-02-06 | 2010-12-01 | ユニバーシティー オブ マサチューセッツ | クロストリジウム・ディフィシル(Clostridiumdifficile)毒素に対する抗体およびその使用 |
| AU2005321974B2 (en) | 2004-12-27 | 2011-11-17 | Progenics Pharmaceuticals (Nevada), Inc. | Orally deliverable and anti-toxin antibodies and methods for making and using them |
| KR20070116710A (ko) * | 2005-03-03 | 2007-12-11 | 알러간, 인코포레이티드 | 보툴리눔 독소를 정제하기 위한 동물 산물이 없는 시스템및 프로세스 |
| WO2006130925A1 (en) | 2005-06-10 | 2006-12-14 | Monash University | Genetic manipulation of clostridium difficile |
| GB0512751D0 (en) * | 2005-06-22 | 2005-07-27 | Glaxo Group Ltd | New adjuvant |
| WO2007090126A2 (en) | 2006-01-30 | 2007-08-09 | Invitrogen Corporation | Compositions and methods for detecting and quantifying toxic substances in disease states |
| GB0612301D0 (en) | 2006-06-21 | 2006-08-02 | Morvus Technology Ltd | DNA molecules and methods |
| WO2008024769A2 (en) | 2006-08-21 | 2008-02-28 | Raven Biotechnologies, Inc. | Intensified perfusion production method |
| EP2124556B1 (en) * | 2006-10-09 | 2014-09-03 | Charleston Laboratories, Inc. | Pharmaceutical compositions |
| US9023352B2 (en) | 2007-02-20 | 2015-05-05 | Tufts University | Methods, compositions and kits for treating a subject using a recombinant heteromultimeric neutralizing binding protein |
| EP2014760A1 (en) | 2007-06-13 | 2009-01-14 | CMC Biopharmaceuticals A/S | A method for producing a biopolymer (e.g. polypeptide) in a continuous fermentation process |
| US9096638B2 (en) | 2007-09-06 | 2015-08-04 | Geneohm Sciences Canada, Inc. | Detection of toxigenic strains of Clostridium difficile |
| JP5503543B2 (ja) | 2007-09-14 | 2014-05-28 | サノフィ パスツール バイオロジクス リミテッド ライアビリティ カンパニー | クロストリジウム・ディフィシレトキソイドaおよびbを含有する薬学的組成物 |
| WO2009132082A2 (en) | 2008-04-22 | 2009-10-29 | Medical College Of Georgia Research Institute, Inc. | Immunogenic compositions containing ceramide and methods of use thereof |
| EP2288719A4 (en) | 2008-05-15 | 2012-01-11 | Univ Tufts | METHOD FOR DIAGNOSIS OF CLOSTRIDIUM DIFFICILE AND METHOD AND VECTORS FOR RECOMBINANT TOXINEXPRESSION |
| US9421251B2 (en) | 2008-06-25 | 2016-08-23 | Novartis Ag | Rapid responses to delayed booster immunisations |
| EP2146490A1 (en) | 2008-07-18 | 2010-01-20 | Alcatel, Lucent | User device for gesture based exchange of information, methods for gesture based exchange of information between a plurality of user devices, and related devices and systems |
| US20120020996A1 (en) | 2008-08-06 | 2012-01-26 | Jonathan Lewis Telfer | Vaccines against clostridium difficile and methods of use |
| WO2010036826A1 (en) | 2008-09-24 | 2010-04-01 | Sanofi Pasteur Biologics Co. | Methods and compositions for increasing toxin production |
| EP2346523A4 (en) * | 2008-10-01 | 2014-12-31 | Us Health | MULTICOMPONENT VACCINE AGAINST MALARIA INDUCING SUSTAINABLE IMMUNE RESPONSES AGAINST PLASMODIUM |
| WO2010037402A1 (en) | 2008-10-02 | 2010-04-08 | Dako Denmark A/S | Molecular vaccines for infectious disease |
| MX2011005758A (es) | 2008-12-03 | 2011-06-28 | Boehringer Ingelheim Vetmed | Procedimiento para la produccion de vacunas. |
| CN102333538B (zh) | 2008-12-09 | 2014-01-15 | 科勒制药集团有限公司 | 免疫刺激性寡核苷酸 |
| GB0901001D0 (en) | 2009-01-22 | 2009-03-04 | Univ Nottingham | Methods |
| WO2010094970A1 (en) | 2009-02-20 | 2010-08-26 | Health Protection Agency | Antibodies to clostridium difficile toxins |
| KR20120061053A (ko) | 2009-08-27 | 2012-06-12 | 시냅틱 리서치, 엘엘씨 | 유도 만능 줄기(iPS) 세포 또는 조직 특이적 세포를 생성하기 위한 신규한 단백질 전달 시스템 |
| WO2011060431A2 (en) | 2009-11-16 | 2011-05-19 | University Of Maryland Baltimore | Multivalent live vector vaccine against clostridium difficile-associated disease |
| EP2519257A4 (en) | 2009-12-02 | 2014-10-15 | Univ Tufts | ATOXIC RECOMBINANT HOLOTOXINS FROM CLOSTRIDIUM DIFFICILE AS IMMUNOGENESIS |
| GB0921288D0 (en) | 2009-12-04 | 2010-01-20 | Health Prot Agency | Therapies for preventing or suppressing clostridium difficile infection |
| TW201136603A (en) | 2010-02-09 | 2011-11-01 | Merck Sharp & Amp Dohme Corp | 15-valent pneumococcal polysaccharide-protein conjugate vaccine composition |
| MX343356B (es) * | 2010-03-30 | 2016-11-03 | Pfenex Inc * | Toxinas proteicas recombinantes de alto nivel de expresion. |
| US8765399B2 (en) * | 2010-05-18 | 2014-07-01 | Montefiore Medical Center | Cultures and protocols for diagnosis of toxigenic Clostridium difficile |
| WO2012028418A1 (en) * | 2010-09-02 | 2012-03-08 | Novacem Limited | Integrated process for producing compositions containing magnesium |
| HUE033342T2 (en) * | 2010-09-03 | 2017-11-28 | Valneva Austria Gmbh | Isolated polypeptide of the toxin a and toxin b proteins of c. difficile and uses thereof |
| GB201016742D0 (en) | 2010-10-05 | 2010-11-17 | Health Prot Agency | Clostridium difficile antigens |
| US9285372B2 (en) | 2010-11-12 | 2016-03-15 | Reflexion Pharmaceuticals, Inc. | Methods and compositions for identifying D-peptidic compounds that specifically bind target proteins |
| CN102533867A (zh) * | 2010-12-10 | 2012-07-04 | 西北民族大学 | 一种艰难梭菌a毒素的类毒素的制备方法 |
| HUE047085T2 (hu) * | 2011-04-22 | 2020-04-28 | Wyeth Llc | Clostridium difficile mutáns toxinjához kapcsolódó készítmények és eljárásai |
| DK2714910T3 (en) * | 2011-05-27 | 2018-02-05 | Glaxosmithkline Biologicals Sa | Immunogenic composition |
| US9770500B2 (en) | 2011-05-31 | 2017-09-26 | The Board Of Regents Of The University Of Texas System | S-nitrosylation of glucosylating toxins and uses therefor |
| US20150071958A1 (en) * | 2011-11-30 | 2015-03-12 | Board Of Trustees Of Michigan State University | Immunological composition for clostridium difficile |
| CA2858519A1 (en) | 2011-12-08 | 2013-06-13 | Novartis Ag | Clostridium difficile toxin-based vaccine |
| AR089797A1 (es) | 2012-01-27 | 2014-09-17 | Merck Sharp & Dohme | Vacunas contra clostridum difficile que comprenden toxinas recombinantes |
| CA2882620A1 (en) * | 2012-09-19 | 2014-03-27 | Novartis Ag | Clostridium difficile polypeptides as vaccine |
| BR122016023101B1 (pt) * | 2012-10-21 | 2022-03-22 | Pfizer Inc | Polipeptídeo, composição imunogênica que o compreende, bem como célula recombinante derivada de clostridium difficile |
| US10117933B2 (en) * | 2012-11-28 | 2018-11-06 | Emergent Biosolutions Canada Inc. | Antibodies against Clostridium difficile |
| DK2928489T3 (en) * | 2012-12-05 | 2019-04-23 | Glaxosmithkline Biologicals Sa | IMMUNOGENE COMPOSITION |
| GB201223342D0 (en) * | 2012-12-23 | 2013-02-06 | Glaxosmithkline Biolog Sa | Immunogenic composition |
| CN105338997A (zh) * | 2013-03-15 | 2016-02-17 | 圣诺菲·帕斯图尔公司 | 类毒素、组合物和相关的方法 |
| WO2014144292A2 (en) * | 2013-03-15 | 2014-09-18 | Sanofi Pasteur Biologics , Llc | Antibodies against clostridium difficile toxins and methods of using the same |
| EP2981611A4 (en) | 2013-04-02 | 2016-11-16 | Stc Unm | ANTIBIOTICUM PROTOCOLS AND PHARMACEUTICAL FORMULATIONS AND TREATMENT METHODS THEREWITH |
| SG11201510166YA (en) | 2013-06-14 | 2016-01-28 | Sanofi Pasteur Inc | Compositions and methods of immunizing against c. difficile |
| EP3060246A4 (en) * | 2013-10-23 | 2017-08-16 | The Rockefeller University | Compositions and methods for prophylaxis and therapy of clostridium difficile infection |
| US11160855B2 (en) | 2014-01-21 | 2021-11-02 | Pfizer Inc. | Immunogenic compositions comprising conjugated capsular saccharide antigens and uses thereof |
| CA3005308C (en) | 2015-11-17 | 2022-01-04 | Pfizer Inc. | Media and fermentation methods for producing polysaccharides in bacterial cell culture |
| US10813988B2 (en) * | 2016-02-16 | 2020-10-27 | President And Fellows Of Harvard College | Pathogen vaccines and methods of producing and using the same |
| CA3056090A1 (en) | 2017-03-15 | 2018-09-20 | Novavax, Inc. | Methods and compositions for inducing immune responses against clostridium difficile |
| CA3016351A1 (en) | 2017-09-05 | 2019-03-05 | Mcmaster University | Aptamers for clostridium difficile detection |
| MX2020003756A (es) | 2017-09-28 | 2020-07-29 | Pfizer | Composiciones y metodos para obtener una respuesta inmune contra clostridium difficile. |
| WO2020201985A1 (en) | 2019-04-01 | 2020-10-08 | Pfizer Inc. | Compositions and methods for eliciting an immune response against clostridium difficile |
| EP4168032A2 (en) | 2020-06-19 | 2023-04-26 | Pfizer Inc. | Immunogenic compositions against clostridioides (clostridium) difficile and methods thereof |
-
2013
- 2013-10-01 BR BR122016023101-1A patent/BR122016023101B1/pt active IP Right Grant
- 2013-10-07 WO PCT/IB2013/059183 patent/WO2014060898A2/en not_active Ceased
- 2013-10-07 SI SI201331900T patent/SI2909307T1/sl unknown
- 2013-10-07 KR KR1020177017169A patent/KR101940939B1/ko active Active
- 2013-10-07 HR HRP20211170TT patent/HRP20211170T1/hr unknown
- 2013-10-07 MX MX2015004986A patent/MX369289B/es active IP Right Grant
- 2013-10-07 KR KR1020207003847A patent/KR102169216B1/ko active Active
- 2013-10-07 DK DK13786535.8T patent/DK2909307T3/da active
- 2013-10-07 AU AU2013333532A patent/AU2013333532C1/en active Active
- 2013-10-07 EP EP13786535.8A patent/EP2909307B1/en active Active
- 2013-10-07 PL PL13786535.8T patent/PL2909307T3/pl unknown
- 2013-10-07 KR KR1020157009888A patent/KR101751822B1/ko active Active
- 2013-10-07 CA CA2887891A patent/CA2887891C/en active Active
- 2013-10-07 CA CA3063892A patent/CA3063892C/en active Active
- 2013-10-07 EP EP21171606.3A patent/EP3912990A1/en active Pending
- 2013-10-07 BR BR112015008844-9A patent/BR112015008844B1/pt active IP Right Grant
- 2013-10-07 RU RU2015112079A patent/RU2630671C2/ru active
- 2013-10-07 KR KR1020197016516A patent/KR102078517B1/ko active Active
- 2013-10-07 KR KR1020197001177A patent/KR101990272B1/ko active Active
- 2013-10-07 CN CN201810000818.1A patent/CN108004286B/zh active Active
- 2013-10-07 PT PT137865358T patent/PT2909307T/pt unknown
- 2013-10-07 CN CN201380054635.3A patent/CN104797706B/zh active Active
- 2013-10-07 HU HUE13786535A patent/HUE055594T2/hu unknown
- 2013-10-07 ES ES13786535T patent/ES2878551T3/es active Active
- 2013-10-07 MX MX2019013075A patent/MX379863B/es unknown
- 2013-10-07 US US14/436,875 patent/US10787652B2/en active Active
- 2013-10-17 JP JP2013216224A patent/JP6527661B2/ja active Active
-
2015
- 2015-03-16 IL IL237792A patent/IL237792B/en active IP Right Grant
-
2017
- 2017-02-22 AU AU2017201193A patent/AU2017201193C1/en active Active
-
2018
- 2018-08-19 US US16/104,938 patent/US10982198B2/en active Active
-
2019
- 2019-05-06 AU AU2019203159A patent/AU2019203159B2/en active Active
- 2019-05-13 JP JP2019090728A patent/JP6871969B2/ja active Active
- 2019-12-01 IL IL271064A patent/IL271064B/en unknown
- 2019-12-05 US US16/704,744 patent/US11208633B2/en active Active
-
2020
- 2020-05-25 AU AU2020203423A patent/AU2020203423A1/en not_active Abandoned
- 2020-07-07 US US16/922,952 patent/US11952597B2/en active Active
-
2021
- 2021-04-16 JP JP2021069760A patent/JP7208293B2/ja active Active
- 2021-07-04 IL IL284582A patent/IL284582B2/en unknown
- 2021-11-29 AU AU2021277590A patent/AU2021277590A1/en not_active Abandoned
-
2023
- 2023-01-05 JP JP2023000594A patent/JP7556987B2/ja active Active
-
2024
- 2024-03-01 US US18/593,348 patent/US20250002875A1/en active Pending
Non-Patent Citations (3)
| Title |
|---|
| Aiqi Fang 等.Production of Clostridium difficile toxin in a medium totally free of both animal and dairy proteins or digests..《PNAS》.2009,第106卷(第32期),第13225-13229页. * |
| John T. Heap等.The ClosTron: Mutagenesis in Clostridium refined and streamlined..《Journal of Microbiological Methods》.2009,第80卷第49-55页. * |
| Production of Clostridium difficile toxin in a medium totally free of both animal and dairy proteins or digests.;Aiqi Fang 等;《PNAS》;20090811;第106卷(第32期);第13225-13229页 * |
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US20250002875A1 (en) | Compositions and methods relating to a mutant clostridium difficile toxin | |
| CA2832712C (en) | Compositions relating to a mutant clostridium difficile toxin and methods thereof | |
| HK1254448B (en) | Compositions and methods relating to a mutant clostridium difficile toxin | |
| HK40035897A (en) | Compositions relating to a mutant clostridium difficile toxin and methods thereof | |
| HK1212385B (zh) | 涉及突变型艰难梭菌毒素的组合物和方法 | |
| HK1242375A1 (en) | Compositions relating to a mutant clostridium difficile toxin and methods thereof | |
| HK1195325B (en) | Compositions relating to a mutant clostridium difficile toxin and methods thereof | |
| HK1195325A (en) | Compositions relating to a mutant clostridium difficile toxin and methods thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| EXSB | Decision made by sipo to initiate substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| REG | Reference to a national code |
Ref country code: HK Ref legal event code: DE Ref document number: 1212385 Country of ref document: HK |
|
| GR01 | Patent grant | ||
| GR01 | Patent grant |