|
JPS58216123A
(ja)
|
1982-06-10 |
1983-12-15 |
Kazue Ueno |
抗血清
|
|
US4530833A
(en)
*
|
1982-09-13 |
1985-07-23 |
Wilkins Tracy D |
Toxins and antibodies of C. difficile
|
|
US4689299A
(en)
|
1982-09-30 |
1987-08-25 |
University Of Rochester |
Human monoclonal antibodies against bacterial toxins
|
|
EP0154064A1
(en)
*
|
1984-03-02 |
1985-09-11 |
Tracy Dale Wilkins |
Toxins and antibodies of C. difficile
|
|
US4713240A
(en)
|
1985-04-04 |
1987-12-15 |
Research Corporation |
Vaccines based on insoluble supports
|
|
US5358868A
(en)
|
1987-11-24 |
1994-10-25 |
Connaught Laboratories Limited |
Genetic detoxification of pertussis toxin
|
|
US4912094B1
(en)
|
1988-06-29 |
1994-02-15 |
Ribi Immunochem Research Inc. |
Modified lipopolysaccharides and process of preparation
|
|
US5530101A
(en)
|
1988-12-28 |
1996-06-25 |
Protein Design Labs, Inc. |
Humanized immunoglobulins
|
|
US5919665A
(en)
|
1989-10-31 |
1999-07-06 |
Ophidian Pharmaceuticals, Inc. |
Vaccine for clostridium botulinum neurotoxin
|
|
US5601823A
(en)
|
1989-10-31 |
1997-02-11 |
Ophidian Pharmaceuticals, Inc. |
Avian antitoxins to clostridium difficle toxin A
|
|
US5599539A
(en)
|
1989-10-31 |
1997-02-04 |
Ophidian Pharmaceuticals, Inc. |
Therapy for clostridial botulinum toxin
|
|
US5578308A
(en)
|
1990-02-12 |
1996-11-26 |
Capiau; Carine |
Glutaraldehyde and formalin detoxified bordetella toxin vaccine
|
|
US5231003A
(en)
|
1990-05-11 |
1993-07-27 |
Cambridge Bioscience Corporation |
Monoclonal antibodies specific for toxin b of clostridium difficile
|
|
JPH06509866A
(ja)
|
1991-04-22 |
1994-11-02 |
マサチューセッツ ヘルス リサーチ インスティチュート,インコーポレーテッド |
呼吸系ウイルスに対する有効な抗体力価用の血漿試料をスクリーニングする方法
|
|
US6221363B1
(en)
|
1991-07-11 |
2001-04-24 |
Baxter Aktiengesellschaft |
Vaccine for the prevention of lyme disease
|
|
JP4129544B2
(ja)
|
1993-03-29 |
2008-08-06 |
ファイザー・インク |
サポニンアジュバント使用の多成分系クロストリジウム・ワクチン
|
|
NZ291659A
(en)
|
1994-09-06 |
2001-04-27 |
Galagen Inc |
Use in the manufacture of a medicament of an antibody having specific activity against Clostridium difficile, and pharmaceutical compositions comprising Anti-Clostridium difficile bovine immunoglobulin concentrate; for treating diseases associated with Clostridium difficile
|
|
BR9509903A
(pt)
|
1994-10-24 |
1997-11-25 |
Ophidian Pharm Inc |
Proteína de fusão proteína de fus o solúvel composição de matéria célula hospedeira processo para gerar uma antiotoxina neutralizante dirigida contra toxina tipo a de clostridium botulinum anticorpo processo para purificar uma proteina de fusão recombinante derivada de uma toxina tipo a de clostridium botulinum processo para gerar uma antitoxina neutralizante dirigida contra toxina tipo b de clostridium difficile anticorpo processo de tratemento processo para gerar uma antitoxina neutralizante dirigida contra toxina tipo a de clostridium difficile composição processo para vacinar um individuo para produzir antitoxina neutralizante dirigida contra toxina de clostridium difficile processo a detecção de antigenos de clostridium difficile em uma amosta processo de purificação de toxinas de clostridium difficile de uma cultura e processo de generação de uma forma dosagem sólida de uma antitoxina de ave dirigida contra uma proteina de toxina clostridial
|
|
US6743430B1
(en)
|
1995-03-29 |
2004-06-01 |
Richard E. Parizek |
Multicomponent vaccine containing clostridial and non-clostridial organisms in a low dose
|
|
US5610023A
(en)
|
1995-03-31 |
1997-03-11 |
Lee Laboratories, Inc. |
Method of purification of clostridium difficile toxin A and production of mono-specific antibodies
|
|
US5919463A
(en)
|
1995-07-07 |
1999-07-06 |
Oravax, Inc. |
Clostridium difficle toxins as mucosal adjuvants
|
|
DE69610106D1
(de)
|
1995-07-07 |
2000-10-05 |
Oravax Inc |
Toxine und toxoide von clostridium difficile als schleimhautadjuvans
|
|
JPH11510793A
(ja)
|
1995-07-07 |
1999-09-21 |
オラバックス インク. |
胃腸病に対する鼻腔内ワクチン接種
|
|
CA2232001C
(en)
|
1995-09-15 |
2002-12-10 |
Dale N. Gerding |
Methods and compositions for prevention and treatment of clostridium difficile-associated diseases
|
|
ATE272409T1
(de)
|
1996-09-30 |
2004-08-15 |
Univ Arkansas |
Verfahren zur erzeugung aktiver immunität durch vakzinkonjugate
|
|
US20100267012A1
(en)
|
1997-11-04 |
2010-10-21 |
Bergeron Michel G |
Highly conserved genes and their use to generate probes and primers for detection of microorganisms
|
|
EP2172216A3
(en)
|
1997-03-10 |
2010-11-24 |
Ottawa Hospital Research Institute |
Use of nucleic acids containing unmethylated CpG dinucleotide as an adjuvant
|
|
US6299881B1
(en)
|
1997-03-24 |
2001-10-09 |
Henry M. Jackson Foundation For The Advancement Of Military Medicine |
Uronium salts for activating hydroxyls, carboxyls, and polysaccharides, and conjugate vaccines, immunogens, and other useful immunological reagents produced using uronium salts
|
|
US20050106157A1
(en)
|
1997-05-27 |
2005-05-19 |
Deckers Harm M. |
Immunogenic formulations comprising oil bodies
|
|
EP1000155A1
(en)
|
1997-06-20 |
2000-05-17 |
QUEEN MARY & WESTFIELD COLLEGE |
Immunogenic fragments of toxin a of clostridium difficile
|
|
DE19739685A1
(de)
|
1997-09-10 |
1999-03-11 |
Eichel Streiber Christoph Von |
Monoklonale Antikörper zur Therapie und Prophylaxe von Erkrankungen durch Clostridium difficile
|
|
EP1568378B1
(en)
|
1997-10-20 |
2016-03-16 |
Sanofi Pasteur Biologics, LLC |
Immunization against Clostridium difficile disease
|
|
US6214341B1
(en)
|
1997-10-20 |
2001-04-10 |
Oravax |
Passive immunization against Clostridium difficile disease
|
|
US6969520B2
(en)
|
1997-10-20 |
2005-11-29 |
Acambis Inc. |
Active immunization against clostridium difficile disease
|
|
US6733760B1
(en)
|
1999-04-09 |
2004-05-11 |
Techlab, Inc. |
Recombinant toxin A/toxin B vaccine against Clostridium difficile
|
|
EP1169456B1
(en)
|
1999-04-09 |
2012-07-11 |
Intercell USA, Inc. |
Recombinant production of Clostridium difficile Toxin A or Toxin B
|
|
JP2002541808A
(ja)
*
|
1999-04-09 |
2002-12-10 |
テクラブ, インコーポレイテッド |
ポリサッカリド結合体ワクチンのための組換えトキシンaタンパク質キャリア
|
|
TR200103018T2
(tr)
|
1999-04-19 |
2002-02-21 |
Beecham Biologicals S.A. Smithkline |
İmmünostimülatör oligonükleotid ve saponin içeren katkı bileşikleri.
|
|
GB0008682D0
(en)
|
2000-04-07 |
2000-05-31 |
Microbiological Res Authority |
Transformation of clostridium difficile
|
|
PL365453A1
(en)
|
2000-05-04 |
2005-01-10 |
President And Fellows Of Harvard College |
Compounds and methods for the treatment and prevention of bacterial infection
|
|
DE60217107T2
(de)
|
2001-06-20 |
2007-08-23 |
Ramot At Tel Aviv University Ltd. |
Mehrantigenisches peptid enthaltend mehrere kopien eines epitopes von einem ablagerungsformenden polypeptid und dessen verwendung
|
|
US20040029129A1
(en)
|
2001-10-25 |
2004-02-12 |
Liangsu Wang |
Identification of essential genes in microorganisms
|
|
WO2003104453A1
(ja)
|
2002-06-05 |
2003-12-18 |
中外製薬株式会社 |
抗体作製方法
|
|
WO2004041857A2
(en)
|
2002-06-17 |
2004-05-21 |
Ballard Jimmy D |
Mutant of clostridium difficile toxin b and methods of use
|
|
US20040235139A1
(en)
*
|
2002-12-23 |
2004-11-25 |
Demain Arnold L. |
Clostridium difficile culture and toxin production methods
|
|
US20050020506A1
(en)
|
2003-07-25 |
2005-01-27 |
Drapeau Susan J. |
Crosslinked compositions comprising collagen and demineralized bone matrix, methods of making and methods of use
|
|
PL1709170T3
(pl)
|
2004-01-16 |
2018-06-29 |
Pfenex Inc. |
Ekspresja białek ssaczych w Pseudomonas fluorescens
|
|
NZ530709A
(en)
*
|
2004-01-21 |
2006-07-28 |
Agres Ltd |
Improved IGA production method
|
|
JP4588763B2
(ja)
|
2004-02-06 |
2010-12-01 |
ユニバーシティー オブ マサチューセッツ |
クロストリジウム・ディフィシル(Clostridiumdifficile)毒素に対する抗体およびその使用
|
|
WO2006071877A2
(en)
|
2004-12-27 |
2006-07-06 |
Progenics Pharmaceuticals (Nevada), Inc. |
Orally deliverable and anti-toxin antibodies and methods for making and using them
|
|
MXPA06009853A
(es)
*
|
2005-03-03 |
2007-03-29 |
Allergan Inc |
Medios para bacteria de clostridium y procesos para obtener una toxina clostridial.
|
|
WO2006130925A1
(en)
|
2005-06-10 |
2006-12-14 |
Monash University |
Genetic manipulation of clostridium difficile
|
|
GB0512751D0
(en)
*
|
2005-06-22 |
2005-07-27 |
Glaxo Group Ltd |
New adjuvant
|
|
WO2007090126A2
(en)
|
2006-01-30 |
2007-08-09 |
Invitrogen Corporation |
Compositions and methods for detecting and quantifying toxic substances in disease states
|
|
GB0612301D0
(en)
|
2006-06-21 |
2006-08-02 |
Morvus Technology Ltd |
DNA molecules and methods
|
|
US20080206819A1
(en)
|
2006-08-21 |
2008-08-28 |
Mary Tsao |
Intensified Perfusion Production Method
|
|
EP2813144A1
(en)
*
|
2006-10-09 |
2014-12-17 |
Charleston Laboratories, Inc. |
Analgesic compositions comprising an antihistamine
|
|
US9023352B2
(en)
|
2007-02-20 |
2015-05-05 |
Tufts University |
Methods, compositions and kits for treating a subject using a recombinant heteromultimeric neutralizing binding protein
|
|
EP2014760A1
(en)
|
2007-06-13 |
2009-01-14 |
CMC Biopharmaceuticals A/S |
A method for producing a biopolymer (e.g. polypeptide) in a continuous fermentation process
|
|
US9096638B2
(en)
|
2007-09-06 |
2015-08-04 |
Geneohm Sciences Canada, Inc. |
Detection of toxigenic strains of Clostridium difficile
|
|
CN101855336B
(zh)
|
2007-09-14 |
2019-07-30 |
赛诺菲巴斯德生物制剂有限责任公司 |
含艰难梭菌类毒素a和b的药物组合物
|
|
WO2009132082A2
(en)
|
2008-04-22 |
2009-10-29 |
Medical College Of Georgia Research Institute, Inc. |
Immunogenic compositions containing ceramide and methods of use thereof
|
|
US8206940B2
(en)
|
2008-05-15 |
2012-06-26 |
Tufts University |
Methods for diagnosis of Clostridium difficile and methods and vectors for recombinant toxin expression
|
|
WO2009156852A1
(en)
|
2008-06-25 |
2009-12-30 |
Novartis Ag |
Rapid responses to delayed booster immunisations
|
|
EP2146490A1
(en)
|
2008-07-18 |
2010-01-20 |
Alcatel, Lucent |
User device for gesture based exchange of information, methods for gesture based exchange of information between a plurality of user devices, and related devices and systems
|
|
US20120020996A1
(en)
*
|
2008-08-06 |
2012-01-26 |
Jonathan Lewis Telfer |
Vaccines against clostridium difficile and methods of use
|
|
US9115347B2
(en)
*
|
2008-09-24 |
2015-08-25 |
Sanofi Pasteur Biologies, LLC |
Methods and compositions for increasing toxin production
|
|
US8444996B2
(en)
*
|
2008-10-01 |
2013-05-21 |
The United States Of America, As Represented By The Secretary, Department Of Health And Human Services |
Multicomponent vaccine for malaria providing long-lasting immune responses against plasmodia
|
|
WO2010037402A1
(en)
|
2008-10-02 |
2010-04-08 |
Dako Denmark A/S |
Molecular vaccines for infectious disease
|
|
SG171934A1
(en)
|
2008-12-03 |
2011-07-28 |
Boehringer Ingelheim Vetmed |
Process for production of vaccines
|
|
EP2376107B1
(en)
|
2008-12-09 |
2014-05-21 |
Coley Pharmaceutical Group, Inc. |
Immunostimulatory oligonucleotides
|
|
GB0901001D0
(en)
|
2009-01-22 |
2009-03-04 |
Univ Nottingham |
Methods
|
|
EP2405940B1
(en)
|
2009-02-20 |
2021-08-04 |
Secretary of State for Health and Social Care |
Antibodies to clostridium difficile toxins
|
|
EP2470664A4
(en)
|
2009-08-27 |
2013-01-16 |
Synaptic Res Llc |
NEW PROTEIN RELEASE SYSTEM FOR GENERATING INDUCED PLURIPOTENTAL STEM CELLS OR TISSUE-SPECIFIC CELLS
|
|
WO2011060431A2
(en)
|
2009-11-16 |
2011-05-19 |
University Of Maryland Baltimore |
Multivalent live vector vaccine against clostridium difficile-associated disease
|
|
AU2010325992A1
(en)
|
2009-12-02 |
2012-05-31 |
Tufts University |
Atoxic recombinant holotoxins of Clostridium difficile as immunogens
|
|
GB0921288D0
(en)
|
2009-12-04 |
2010-01-20 |
Health Prot Agency |
Therapies for preventing or suppressing clostridium difficile infection
|
|
TW201136603A
(en)
|
2010-02-09 |
2011-11-01 |
Merck Sharp & Amp Dohme Corp |
15-valent pneumococcal polysaccharide-protein conjugate vaccine composition
|
|
US8530171B2
(en)
*
|
2010-03-30 |
2013-09-10 |
Pfenex Inc. |
High level expression of recombinant toxin proteins
|
|
US8765399B2
(en)
*
|
2010-05-18 |
2014-07-01 |
Montefiore Medical Center |
Cultures and protocols for diagnosis of toxigenic Clostridium difficile
|
|
WO2012028418A1
(en)
*
|
2010-09-02 |
2012-03-08 |
Novacem Limited |
Integrated process for producing compositions containing magnesium
|
|
JP6121421B2
(ja)
*
|
2010-09-03 |
2017-04-26 |
バルネバ オーストリア ジーエムビーエイチ |
C.ディフィシルの毒素aおよび毒素bタンパク質の単離ポリペプチドならびにその使用
|
|
GB201016742D0
(en)
*
|
2010-10-05 |
2010-11-17 |
Health Prot Agency |
Clostridium difficile antigens
|
|
WO2012078313A2
(en)
|
2010-11-12 |
2012-06-14 |
Reflexion Pharmaceuticals, Inc. |
Gb1 peptidic libraries and compounds, and methods of screening the same
|
|
CN102533867A
(zh)
*
|
2010-12-10 |
2012-07-04 |
西北民族大学 |
一种艰难梭菌a毒素的类毒素的制备方法
|
|
AU2012245904B2
(en)
|
2011-04-22 |
2016-04-21 |
Wyeth Llc |
Compositions relating to a mutant Clostridium difficile toxin and methods thereof
|
|
US9290565B2
(en)
*
|
2011-05-27 |
2016-03-22 |
Glaxosmithkline Biologicals, S.A. |
Immunogenic composition
|
|
WO2012166991A1
(en)
|
2011-05-31 |
2012-12-06 |
The Board Of Regents Of The University Of Texas Systeem |
S-nitrosylation of glucosylating toxins and uses therefor
|
|
WO2013082298A2
(en)
*
|
2011-11-30 |
2013-06-06 |
Board Of Trustees Of Michigan State University |
Immunological composition for clostridium difficile
|
|
CN103974718A
(zh)
*
|
2011-12-08 |
2014-08-06 |
诺华股份有限公司 |
基于艰难梭菌毒素的疫苗
|
|
AR089797A1
(es)
|
2012-01-27 |
2014-09-17 |
Merck Sharp & Dohme |
Vacunas contra clostridum difficile que comprenden toxinas recombinantes
|
|
MX2015002485A
(es)
*
|
2012-09-19 |
2015-06-05 |
Novartis Ag |
Polipeptidos de clostridium difficile como vacuna.
|
|
BR122016023101B1
(pt)
*
|
2012-10-21 |
2022-03-22 |
Pfizer Inc |
Polipeptídeo, composição imunogênica que o compreende, bem como célula recombinante derivada de clostridium difficile
|
|
US10117933B2
(en)
*
|
2012-11-28 |
2018-11-06 |
Emergent Biosolutions Canada Inc. |
Antibodies against Clostridium difficile
|
|
LT2928489T
(lt)
*
|
2012-12-05 |
2019-04-10 |
Glaxosmithkline Biologicals S.A. |
Imunogeninė kompozicija
|
|
GB201223342D0
(en)
*
|
2012-12-23 |
2013-02-06 |
Glaxosmithkline Biolog Sa |
Immunogenic composition
|
|
WO2014144292A2
(en)
*
|
2013-03-15 |
2014-09-18 |
Sanofi Pasteur Biologics , Llc |
Antibodies against clostridium difficile toxins and methods of using the same
|
|
JP2016516721A
(ja)
*
|
2013-03-15 |
2016-06-09 |
サノフィ パストゥール インコーポレイテッド |
トキソイド、組成物および関連方法
|
|
US20170165375A1
(en)
|
2013-04-02 |
2017-06-15 |
Stc. Unm |
Antibiotic protocells and related pharmaceutical formulations and methods of treatment
|
|
SG11201510166YA
(en)
|
2013-06-14 |
2016-01-28 |
Sanofi Pasteur Inc |
Compositions and methods of immunizing against c. difficile
|
|
EP3060246A4
(en)
*
|
2013-10-23 |
2017-08-16 |
The Rockefeller University |
Compositions and methods for prophylaxis and therapy of clostridium difficile infection
|
|
US11160855B2
(en)
|
2014-01-21 |
2021-11-02 |
Pfizer Inc. |
Immunogenic compositions comprising conjugated capsular saccharide antigens and uses thereof
|
|
US10947494B2
(en)
|
2015-11-17 |
2021-03-16 |
Pfizer Inc. |
Media and fermentation methods for producing polysaccharides in bacterial cell culture
|
|
US10813988B2
(en)
*
|
2016-02-16 |
2020-10-27 |
President And Fellows Of Harvard College |
Pathogen vaccines and methods of producing and using the same
|
|
IL269258B2
(en)
|
2017-03-15 |
2023-09-01 |
Novavax Inc |
Methods and compositions for inducing immune responses against Clostridium difficile
|
|
CA3016351A1
(en)
|
2017-09-05 |
2019-03-05 |
Mcmaster University |
Aptamers for clostridium difficile detection
|
|
IL320444A
(en)
|
2017-09-28 |
2025-06-01 |
Pfizer |
Compositions and methods for stimulating an immune response against Clostridium difficile
|
|
WO2020201985A1
(en)
|
2019-04-01 |
2020-10-08 |
Pfizer Inc. |
Compositions and methods for eliciting an immune response against clostridium difficile
|
|
WO2021255690A2
(en)
|
2020-06-19 |
2021-12-23 |
Pfizer Inc. |
Immunogenic compositions against clostridioides (clostridium) difficile and methods thereof
|