HRP20211170T1 - Pripravci i postupci koji se odnose na mutantni toksin iz bakterije clostridium difficile - Google Patents
Pripravci i postupci koji se odnose na mutantni toksin iz bakterije clostridium difficile Download PDFInfo
- Publication number
- HRP20211170T1 HRP20211170T1 HRP20211170TT HRP20211170T HRP20211170T1 HR P20211170 T1 HRP20211170 T1 HR P20211170T1 HR P20211170T T HRP20211170T T HR P20211170TT HR P20211170 T HRP20211170 T HR P20211170T HR P20211170 T1 HRP20211170 T1 HR P20211170T1
- Authority
- HR
- Croatia
- Prior art keywords
- bacterium
- medium
- difficile
- toxin
- mutant toxin
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/1048—Glycosyltransferases (2.4)
- C12N9/1051—Hexosyltransferases (2.4.1)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/08—Clostridium, e.g. Clostridium tetani
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/33—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Clostridium (G)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/20—Bacteria; Culture media therefor
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/20—Bacteria; Culture media therefor
- C12N1/205—Bacterial isolates
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/38—Chemical stimulation of growth or activity by addition of chemical compounds which are not essential growth factors; Stimulation of growth by removal of a chemical compound
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2330/00—Production
- C12N2330/50—Biochemical production, i.e. in a transformed host cell
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2510/00—Genetically modified cells
- C12N2510/02—Cells for production
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
- C12R2001/00—Microorganisms ; Processes using microorganisms
- C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
- C12R2001/145—Clostridium
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Zoology (AREA)
- Biotechnology (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- Biomedical Technology (AREA)
- General Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Virology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Gastroenterology & Hepatology (AREA)
- General Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Mycology (AREA)
- Immunology (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261716605P | 2012-10-21 | 2012-10-21 | |
| PCT/IB2013/059183 WO2014060898A2 (en) | 2012-10-21 | 2013-10-07 | Compositions and methods relating to a mutant clostridium difficile toxin |
| EP13786535.8A EP2909307B1 (en) | 2012-10-21 | 2013-10-07 | Compositions and methods relating to a mutant clostridium difficile toxin |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HRP20211170T1 true HRP20211170T1 (hr) | 2021-11-12 |
Family
ID=49546596
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HRP20211170TT HRP20211170T1 (hr) | 2012-10-21 | 2013-10-07 | Pripravci i postupci koji se odnose na mutantni toksin iz bakterije clostridium difficile |
Country Status (19)
| Country | Link |
|---|---|
| US (5) | US10787652B2 (enExample) |
| EP (2) | EP3912990A1 (enExample) |
| JP (4) | JP6527661B2 (enExample) |
| KR (5) | KR101940939B1 (enExample) |
| CN (2) | CN104797706B (enExample) |
| AU (5) | AU2013333532C1 (enExample) |
| BR (2) | BR122016023101B1 (enExample) |
| CA (2) | CA2887891C (enExample) |
| DK (1) | DK2909307T3 (enExample) |
| ES (1) | ES2878551T3 (enExample) |
| HR (1) | HRP20211170T1 (enExample) |
| HU (1) | HUE055594T2 (enExample) |
| IL (3) | IL237792B (enExample) |
| MX (2) | MX369289B (enExample) |
| PL (1) | PL2909307T3 (enExample) |
| PT (1) | PT2909307T (enExample) |
| RU (1) | RU2630671C2 (enExample) |
| SI (1) | SI2909307T1 (enExample) |
| WO (1) | WO2014060898A2 (enExample) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2012245904B2 (en) | 2011-04-22 | 2016-04-21 | Wyeth Llc | Compositions relating to a mutant Clostridium difficile toxin and methods thereof |
| BR122016023101B1 (pt) | 2012-10-21 | 2022-03-22 | Pfizer Inc | Polipeptídeo, composição imunogênica que o compreende, bem como célula recombinante derivada de clostridium difficile |
| WO2014144292A2 (en) | 2013-03-15 | 2014-09-18 | Sanofi Pasteur Biologics , Llc | Antibodies against clostridium difficile toxins and methods of using the same |
| WO2016131157A1 (en) * | 2015-02-19 | 2016-08-25 | Immune Biosolutions Inc | Clostridium difficile toxins a and/or b antigen and epitope antibody, and pharmaceutical uses thereof |
| KR101723167B1 (ko) * | 2015-04-28 | 2017-04-05 | 주식회사 대웅 | 보툴리눔 독소의 제조를 위한 배지 조성물 |
| KR101729251B1 (ko) * | 2015-04-28 | 2017-04-21 | 주식회사 대웅 | 보툴리눔 독소의 제조를 위한 배지 조성물 |
| WO2017040885A1 (en) * | 2015-09-03 | 2017-03-09 | The Board Of Regents Of The University Of Oklahoma | Peptide inhibitors of clostridium difficile tcdb toxin |
| EP3558363A1 (en) | 2016-12-21 | 2019-10-30 | Amgen Inc. | Anti-tnf alpha antibody formulations |
| CN106801077A (zh) * | 2017-02-13 | 2017-06-06 | 江南大学 | 一种高效杀灭滴虫等医学原虫的细菌培养上清液的制备方法和及其利用 |
| IL320444A (en) * | 2017-09-28 | 2025-06-01 | Pfizer | Compositions and methods for stimulating an immune response against Clostridium difficile |
| WO2020201985A1 (en) | 2019-04-01 | 2020-10-08 | Pfizer Inc. | Compositions and methods for eliciting an immune response against clostridium difficile |
| MX2021014097A (es) * | 2019-05-21 | 2022-03-11 | Univ California | Composiciones de vacunas para clostridium difficile. |
| EP4146200A4 (en) * | 2020-05-06 | 2024-05-15 | Albert Einstein College of Medicine | AGENTS FOR PREVENTING TISSUE DAMAGE RELATED TO CLOSTRIDIUM DIFFICILE INFECTIONS BY INHIBITING THE BACTERIAL TOXINS TCDA AND TCDB DAMAGED THE INTESTIN |
| WO2021255690A2 (en) | 2020-06-19 | 2021-12-23 | Pfizer Inc. | Immunogenic compositions against clostridioides (clostridium) difficile and methods thereof |
| CA3254452A1 (en) | 2022-03-14 | 2023-09-21 | Pfizer Inc. | ADJUVANT PRODUCTION PROCESSES |
| CN120475988A (zh) | 2022-12-13 | 2025-08-12 | 辉瑞公司 | 免疫原性组合物及引发针对艰难梭菌的免疫应答的方法 |
| WO2025057058A1 (en) | 2023-09-13 | 2025-03-20 | Pfizer Inc. | Methods for producing an adjuvant |
| WO2025257712A1 (en) | 2024-06-12 | 2025-12-18 | Pfizer Inc. | Immunogenic compositions and methods for eliciting an immune response against clostridioides (clostridium) difficile |
Family Cites Families (109)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS58216123A (ja) | 1982-06-10 | 1983-12-15 | Kazue Ueno | 抗血清 |
| US4530833A (en) * | 1982-09-13 | 1985-07-23 | Wilkins Tracy D | Toxins and antibodies of C. difficile |
| US4689299A (en) | 1982-09-30 | 1987-08-25 | University Of Rochester | Human monoclonal antibodies against bacterial toxins |
| EP0154064A1 (en) * | 1984-03-02 | 1985-09-11 | Tracy Dale Wilkins | Toxins and antibodies of C. difficile |
| US4713240A (en) | 1985-04-04 | 1987-12-15 | Research Corporation | Vaccines based on insoluble supports |
| US5358868A (en) | 1987-11-24 | 1994-10-25 | Connaught Laboratories Limited | Genetic detoxification of pertussis toxin |
| US4912094B1 (en) | 1988-06-29 | 1994-02-15 | Ribi Immunochem Research Inc. | Modified lipopolysaccharides and process of preparation |
| US5530101A (en) | 1988-12-28 | 1996-06-25 | Protein Design Labs, Inc. | Humanized immunoglobulins |
| US5919665A (en) | 1989-10-31 | 1999-07-06 | Ophidian Pharmaceuticals, Inc. | Vaccine for clostridium botulinum neurotoxin |
| US5601823A (en) | 1989-10-31 | 1997-02-11 | Ophidian Pharmaceuticals, Inc. | Avian antitoxins to clostridium difficle toxin A |
| US5599539A (en) | 1989-10-31 | 1997-02-04 | Ophidian Pharmaceuticals, Inc. | Therapy for clostridial botulinum toxin |
| US5578308A (en) | 1990-02-12 | 1996-11-26 | Capiau; Carine | Glutaraldehyde and formalin detoxified bordetella toxin vaccine |
| US5231003A (en) | 1990-05-11 | 1993-07-27 | Cambridge Bioscience Corporation | Monoclonal antibodies specific for toxin b of clostridium difficile |
| JPH06509866A (ja) | 1991-04-22 | 1994-11-02 | マサチューセッツ ヘルス リサーチ インスティチュート,インコーポレーテッド | 呼吸系ウイルスに対する有効な抗体力価用の血漿試料をスクリーニングする方法 |
| US6221363B1 (en) | 1991-07-11 | 2001-04-24 | Baxter Aktiengesellschaft | Vaccine for the prevention of lyme disease |
| JP4129544B2 (ja) | 1993-03-29 | 2008-08-06 | ファイザー・インク | サポニンアジュバント使用の多成分系クロストリジウム・ワクチン |
| NZ291659A (en) | 1994-09-06 | 2001-04-27 | Galagen Inc | Use in the manufacture of a medicament of an antibody having specific activity against Clostridium difficile, and pharmaceutical compositions comprising Anti-Clostridium difficile bovine immunoglobulin concentrate; for treating diseases associated with Clostridium difficile |
| BR9509903A (pt) | 1994-10-24 | 1997-11-25 | Ophidian Pharm Inc | Proteína de fusão proteína de fus o solúvel composição de matéria célula hospedeira processo para gerar uma antiotoxina neutralizante dirigida contra toxina tipo a de clostridium botulinum anticorpo processo para purificar uma proteina de fusão recombinante derivada de uma toxina tipo a de clostridium botulinum processo para gerar uma antitoxina neutralizante dirigida contra toxina tipo b de clostridium difficile anticorpo processo de tratemento processo para gerar uma antitoxina neutralizante dirigida contra toxina tipo a de clostridium difficile composição processo para vacinar um individuo para produzir antitoxina neutralizante dirigida contra toxina de clostridium difficile processo a detecção de antigenos de clostridium difficile em uma amosta processo de purificação de toxinas de clostridium difficile de uma cultura e processo de generação de uma forma dosagem sólida de uma antitoxina de ave dirigida contra uma proteina de toxina clostridial |
| US6743430B1 (en) | 1995-03-29 | 2004-06-01 | Richard E. Parizek | Multicomponent vaccine containing clostridial and non-clostridial organisms in a low dose |
| US5610023A (en) | 1995-03-31 | 1997-03-11 | Lee Laboratories, Inc. | Method of purification of clostridium difficile toxin A and production of mono-specific antibodies |
| US5919463A (en) | 1995-07-07 | 1999-07-06 | Oravax, Inc. | Clostridium difficle toxins as mucosal adjuvants |
| DE69610106D1 (de) | 1995-07-07 | 2000-10-05 | Oravax Inc | Toxine und toxoide von clostridium difficile als schleimhautadjuvans |
| JPH11510793A (ja) | 1995-07-07 | 1999-09-21 | オラバックス インク. | 胃腸病に対する鼻腔内ワクチン接種 |
| CA2232001C (en) | 1995-09-15 | 2002-12-10 | Dale N. Gerding | Methods and compositions for prevention and treatment of clostridium difficile-associated diseases |
| ATE272409T1 (de) | 1996-09-30 | 2004-08-15 | Univ Arkansas | Verfahren zur erzeugung aktiver immunität durch vakzinkonjugate |
| US20100267012A1 (en) | 1997-11-04 | 2010-10-21 | Bergeron Michel G | Highly conserved genes and their use to generate probes and primers for detection of microorganisms |
| EP2172216A3 (en) | 1997-03-10 | 2010-11-24 | Ottawa Hospital Research Institute | Use of nucleic acids containing unmethylated CpG dinucleotide as an adjuvant |
| US6299881B1 (en) | 1997-03-24 | 2001-10-09 | Henry M. Jackson Foundation For The Advancement Of Military Medicine | Uronium salts for activating hydroxyls, carboxyls, and polysaccharides, and conjugate vaccines, immunogens, and other useful immunological reagents produced using uronium salts |
| US20050106157A1 (en) | 1997-05-27 | 2005-05-19 | Deckers Harm M. | Immunogenic formulations comprising oil bodies |
| EP1000155A1 (en) | 1997-06-20 | 2000-05-17 | QUEEN MARY & WESTFIELD COLLEGE | Immunogenic fragments of toxin a of clostridium difficile |
| DE19739685A1 (de) | 1997-09-10 | 1999-03-11 | Eichel Streiber Christoph Von | Monoklonale Antikörper zur Therapie und Prophylaxe von Erkrankungen durch Clostridium difficile |
| EP1568378B1 (en) | 1997-10-20 | 2016-03-16 | Sanofi Pasteur Biologics, LLC | Immunization against Clostridium difficile disease |
| US6214341B1 (en) | 1997-10-20 | 2001-04-10 | Oravax | Passive immunization against Clostridium difficile disease |
| US6969520B2 (en) | 1997-10-20 | 2005-11-29 | Acambis Inc. | Active immunization against clostridium difficile disease |
| US6733760B1 (en) | 1999-04-09 | 2004-05-11 | Techlab, Inc. | Recombinant toxin A/toxin B vaccine against Clostridium difficile |
| EP1169456B1 (en) | 1999-04-09 | 2012-07-11 | Intercell USA, Inc. | Recombinant production of Clostridium difficile Toxin A or Toxin B |
| JP2002541808A (ja) * | 1999-04-09 | 2002-12-10 | テクラブ, インコーポレイテッド | ポリサッカリド結合体ワクチンのための組換えトキシンaタンパク質キャリア |
| TR200103018T2 (tr) | 1999-04-19 | 2002-02-21 | Beecham Biologicals S.A. Smithkline | İmmünostimülatör oligonükleotid ve saponin içeren katkı bileşikleri. |
| GB0008682D0 (en) | 2000-04-07 | 2000-05-31 | Microbiological Res Authority | Transformation of clostridium difficile |
| PL365453A1 (en) | 2000-05-04 | 2005-01-10 | President And Fellows Of Harvard College | Compounds and methods for the treatment and prevention of bacterial infection |
| DE60217107T2 (de) | 2001-06-20 | 2007-08-23 | Ramot At Tel Aviv University Ltd. | Mehrantigenisches peptid enthaltend mehrere kopien eines epitopes von einem ablagerungsformenden polypeptid und dessen verwendung |
| US20040029129A1 (en) | 2001-10-25 | 2004-02-12 | Liangsu Wang | Identification of essential genes in microorganisms |
| WO2003104453A1 (ja) | 2002-06-05 | 2003-12-18 | 中外製薬株式会社 | 抗体作製方法 |
| WO2004041857A2 (en) | 2002-06-17 | 2004-05-21 | Ballard Jimmy D | Mutant of clostridium difficile toxin b and methods of use |
| US20040235139A1 (en) * | 2002-12-23 | 2004-11-25 | Demain Arnold L. | Clostridium difficile culture and toxin production methods |
| US20050020506A1 (en) | 2003-07-25 | 2005-01-27 | Drapeau Susan J. | Crosslinked compositions comprising collagen and demineralized bone matrix, methods of making and methods of use |
| PL1709170T3 (pl) | 2004-01-16 | 2018-06-29 | Pfenex Inc. | Ekspresja białek ssaczych w Pseudomonas fluorescens |
| NZ530709A (en) * | 2004-01-21 | 2006-07-28 | Agres Ltd | Improved IGA production method |
| JP4588763B2 (ja) | 2004-02-06 | 2010-12-01 | ユニバーシティー オブ マサチューセッツ | クロストリジウム・ディフィシル(Clostridiumdifficile)毒素に対する抗体およびその使用 |
| WO2006071877A2 (en) | 2004-12-27 | 2006-07-06 | Progenics Pharmaceuticals (Nevada), Inc. | Orally deliverable and anti-toxin antibodies and methods for making and using them |
| MXPA06009853A (es) * | 2005-03-03 | 2007-03-29 | Allergan Inc | Medios para bacteria de clostridium y procesos para obtener una toxina clostridial. |
| WO2006130925A1 (en) | 2005-06-10 | 2006-12-14 | Monash University | Genetic manipulation of clostridium difficile |
| GB0512751D0 (en) * | 2005-06-22 | 2005-07-27 | Glaxo Group Ltd | New adjuvant |
| WO2007090126A2 (en) | 2006-01-30 | 2007-08-09 | Invitrogen Corporation | Compositions and methods for detecting and quantifying toxic substances in disease states |
| GB0612301D0 (en) | 2006-06-21 | 2006-08-02 | Morvus Technology Ltd | DNA molecules and methods |
| US20080206819A1 (en) | 2006-08-21 | 2008-08-28 | Mary Tsao | Intensified Perfusion Production Method |
| EP2813144A1 (en) * | 2006-10-09 | 2014-12-17 | Charleston Laboratories, Inc. | Analgesic compositions comprising an antihistamine |
| US9023352B2 (en) | 2007-02-20 | 2015-05-05 | Tufts University | Methods, compositions and kits for treating a subject using a recombinant heteromultimeric neutralizing binding protein |
| EP2014760A1 (en) | 2007-06-13 | 2009-01-14 | CMC Biopharmaceuticals A/S | A method for producing a biopolymer (e.g. polypeptide) in a continuous fermentation process |
| US9096638B2 (en) | 2007-09-06 | 2015-08-04 | Geneohm Sciences Canada, Inc. | Detection of toxigenic strains of Clostridium difficile |
| CN101855336B (zh) | 2007-09-14 | 2019-07-30 | 赛诺菲巴斯德生物制剂有限责任公司 | 含艰难梭菌类毒素a和b的药物组合物 |
| WO2009132082A2 (en) | 2008-04-22 | 2009-10-29 | Medical College Of Georgia Research Institute, Inc. | Immunogenic compositions containing ceramide and methods of use thereof |
| US8206940B2 (en) | 2008-05-15 | 2012-06-26 | Tufts University | Methods for diagnosis of Clostridium difficile and methods and vectors for recombinant toxin expression |
| WO2009156852A1 (en) | 2008-06-25 | 2009-12-30 | Novartis Ag | Rapid responses to delayed booster immunisations |
| EP2146490A1 (en) | 2008-07-18 | 2010-01-20 | Alcatel, Lucent | User device for gesture based exchange of information, methods for gesture based exchange of information between a plurality of user devices, and related devices and systems |
| US20120020996A1 (en) * | 2008-08-06 | 2012-01-26 | Jonathan Lewis Telfer | Vaccines against clostridium difficile and methods of use |
| US9115347B2 (en) * | 2008-09-24 | 2015-08-25 | Sanofi Pasteur Biologies, LLC | Methods and compositions for increasing toxin production |
| US8444996B2 (en) * | 2008-10-01 | 2013-05-21 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Multicomponent vaccine for malaria providing long-lasting immune responses against plasmodia |
| WO2010037402A1 (en) | 2008-10-02 | 2010-04-08 | Dako Denmark A/S | Molecular vaccines for infectious disease |
| SG171934A1 (en) | 2008-12-03 | 2011-07-28 | Boehringer Ingelheim Vetmed | Process for production of vaccines |
| EP2376107B1 (en) | 2008-12-09 | 2014-05-21 | Coley Pharmaceutical Group, Inc. | Immunostimulatory oligonucleotides |
| GB0901001D0 (en) | 2009-01-22 | 2009-03-04 | Univ Nottingham | Methods |
| EP2405940B1 (en) | 2009-02-20 | 2021-08-04 | Secretary of State for Health and Social Care | Antibodies to clostridium difficile toxins |
| EP2470664A4 (en) | 2009-08-27 | 2013-01-16 | Synaptic Res Llc | NEW PROTEIN RELEASE SYSTEM FOR GENERATING INDUCED PLURIPOTENTAL STEM CELLS OR TISSUE-SPECIFIC CELLS |
| WO2011060431A2 (en) | 2009-11-16 | 2011-05-19 | University Of Maryland Baltimore | Multivalent live vector vaccine against clostridium difficile-associated disease |
| AU2010325992A1 (en) | 2009-12-02 | 2012-05-31 | Tufts University | Atoxic recombinant holotoxins of Clostridium difficile as immunogens |
| GB0921288D0 (en) | 2009-12-04 | 2010-01-20 | Health Prot Agency | Therapies for preventing or suppressing clostridium difficile infection |
| TW201136603A (en) | 2010-02-09 | 2011-11-01 | Merck Sharp & Amp Dohme Corp | 15-valent pneumococcal polysaccharide-protein conjugate vaccine composition |
| US8530171B2 (en) * | 2010-03-30 | 2013-09-10 | Pfenex Inc. | High level expression of recombinant toxin proteins |
| US8765399B2 (en) * | 2010-05-18 | 2014-07-01 | Montefiore Medical Center | Cultures and protocols for diagnosis of toxigenic Clostridium difficile |
| WO2012028418A1 (en) * | 2010-09-02 | 2012-03-08 | Novacem Limited | Integrated process for producing compositions containing magnesium |
| JP6121421B2 (ja) * | 2010-09-03 | 2017-04-26 | バルネバ オーストリア ジーエムビーエイチ | C.ディフィシルの毒素aおよび毒素bタンパク質の単離ポリペプチドならびにその使用 |
| GB201016742D0 (en) * | 2010-10-05 | 2010-11-17 | Health Prot Agency | Clostridium difficile antigens |
| WO2012078313A2 (en) | 2010-11-12 | 2012-06-14 | Reflexion Pharmaceuticals, Inc. | Gb1 peptidic libraries and compounds, and methods of screening the same |
| CN102533867A (zh) * | 2010-12-10 | 2012-07-04 | 西北民族大学 | 一种艰难梭菌a毒素的类毒素的制备方法 |
| AU2012245904B2 (en) | 2011-04-22 | 2016-04-21 | Wyeth Llc | Compositions relating to a mutant Clostridium difficile toxin and methods thereof |
| US9290565B2 (en) * | 2011-05-27 | 2016-03-22 | Glaxosmithkline Biologicals, S.A. | Immunogenic composition |
| WO2012166991A1 (en) | 2011-05-31 | 2012-12-06 | The Board Of Regents Of The University Of Texas Systeem | S-nitrosylation of glucosylating toxins and uses therefor |
| WO2013082298A2 (en) * | 2011-11-30 | 2013-06-06 | Board Of Trustees Of Michigan State University | Immunological composition for clostridium difficile |
| CN103974718A (zh) * | 2011-12-08 | 2014-08-06 | 诺华股份有限公司 | 基于艰难梭菌毒素的疫苗 |
| AR089797A1 (es) | 2012-01-27 | 2014-09-17 | Merck Sharp & Dohme | Vacunas contra clostridum difficile que comprenden toxinas recombinantes |
| MX2015002485A (es) * | 2012-09-19 | 2015-06-05 | Novartis Ag | Polipeptidos de clostridium difficile como vacuna. |
| BR122016023101B1 (pt) * | 2012-10-21 | 2022-03-22 | Pfizer Inc | Polipeptídeo, composição imunogênica que o compreende, bem como célula recombinante derivada de clostridium difficile |
| US10117933B2 (en) * | 2012-11-28 | 2018-11-06 | Emergent Biosolutions Canada Inc. | Antibodies against Clostridium difficile |
| LT2928489T (lt) * | 2012-12-05 | 2019-04-10 | Glaxosmithkline Biologicals S.A. | Imunogeninė kompozicija |
| GB201223342D0 (en) * | 2012-12-23 | 2013-02-06 | Glaxosmithkline Biolog Sa | Immunogenic composition |
| WO2014144292A2 (en) * | 2013-03-15 | 2014-09-18 | Sanofi Pasteur Biologics , Llc | Antibodies against clostridium difficile toxins and methods of using the same |
| JP2016516721A (ja) * | 2013-03-15 | 2016-06-09 | サノフィ パストゥール インコーポレイテッド | トキソイド、組成物および関連方法 |
| US20170165375A1 (en) | 2013-04-02 | 2017-06-15 | Stc. Unm | Antibiotic protocells and related pharmaceutical formulations and methods of treatment |
| SG11201510166YA (en) | 2013-06-14 | 2016-01-28 | Sanofi Pasteur Inc | Compositions and methods of immunizing against c. difficile |
| EP3060246A4 (en) * | 2013-10-23 | 2017-08-16 | The Rockefeller University | Compositions and methods for prophylaxis and therapy of clostridium difficile infection |
| US11160855B2 (en) | 2014-01-21 | 2021-11-02 | Pfizer Inc. | Immunogenic compositions comprising conjugated capsular saccharide antigens and uses thereof |
| US10947494B2 (en) | 2015-11-17 | 2021-03-16 | Pfizer Inc. | Media and fermentation methods for producing polysaccharides in bacterial cell culture |
| US10813988B2 (en) * | 2016-02-16 | 2020-10-27 | President And Fellows Of Harvard College | Pathogen vaccines and methods of producing and using the same |
| IL269258B2 (en) | 2017-03-15 | 2023-09-01 | Novavax Inc | Methods and compositions for inducing immune responses against Clostridium difficile |
| CA3016351A1 (en) | 2017-09-05 | 2019-03-05 | Mcmaster University | Aptamers for clostridium difficile detection |
| IL320444A (en) | 2017-09-28 | 2025-06-01 | Pfizer | Compositions and methods for stimulating an immune response against Clostridium difficile |
| WO2020201985A1 (en) | 2019-04-01 | 2020-10-08 | Pfizer Inc. | Compositions and methods for eliciting an immune response against clostridium difficile |
| WO2021255690A2 (en) | 2020-06-19 | 2021-12-23 | Pfizer Inc. | Immunogenic compositions against clostridioides (clostridium) difficile and methods thereof |
-
2013
- 2013-10-01 BR BR122016023101-1A patent/BR122016023101B1/pt active IP Right Grant
- 2013-10-07 HU HUE13786535A patent/HUE055594T2/hu unknown
- 2013-10-07 KR KR1020177017169A patent/KR101940939B1/ko active Active
- 2013-10-07 CA CA2887891A patent/CA2887891C/en active Active
- 2013-10-07 SI SI201331900T patent/SI2909307T1/sl unknown
- 2013-10-07 ES ES13786535T patent/ES2878551T3/es active Active
- 2013-10-07 CN CN201380054635.3A patent/CN104797706B/zh active Active
- 2013-10-07 PT PT137865358T patent/PT2909307T/pt unknown
- 2013-10-07 HR HRP20211170TT patent/HRP20211170T1/hr unknown
- 2013-10-07 AU AU2013333532A patent/AU2013333532C1/en active Active
- 2013-10-07 CA CA3063892A patent/CA3063892C/en active Active
- 2013-10-07 WO PCT/IB2013/059183 patent/WO2014060898A2/en not_active Ceased
- 2013-10-07 EP EP21171606.3A patent/EP3912990A1/en active Pending
- 2013-10-07 KR KR1020197001177A patent/KR101990272B1/ko active Active
- 2013-10-07 KR KR1020157009888A patent/KR101751822B1/ko active Active
- 2013-10-07 MX MX2015004986A patent/MX369289B/es active IP Right Grant
- 2013-10-07 MX MX2019013075A patent/MX379863B/es unknown
- 2013-10-07 US US14/436,875 patent/US10787652B2/en active Active
- 2013-10-07 BR BR112015008844-9A patent/BR112015008844B1/pt active IP Right Grant
- 2013-10-07 CN CN201810000818.1A patent/CN108004286B/zh active Active
- 2013-10-07 EP EP13786535.8A patent/EP2909307B1/en active Active
- 2013-10-07 KR KR1020197016516A patent/KR102078517B1/ko active Active
- 2013-10-07 RU RU2015112079A patent/RU2630671C2/ru active
- 2013-10-07 KR KR1020207003847A patent/KR102169216B1/ko active Active
- 2013-10-07 DK DK13786535.8T patent/DK2909307T3/da active
- 2013-10-07 PL PL13786535.8T patent/PL2909307T3/pl unknown
- 2013-10-17 JP JP2013216224A patent/JP6527661B2/ja active Active
-
2015
- 2015-03-16 IL IL237792A patent/IL237792B/en active IP Right Grant
-
2017
- 2017-02-22 AU AU2017201193A patent/AU2017201193C1/en active Active
-
2018
- 2018-08-19 US US16/104,938 patent/US10982198B2/en active Active
-
2019
- 2019-05-06 AU AU2019203159A patent/AU2019203159B2/en active Active
- 2019-05-13 JP JP2019090728A patent/JP6871969B2/ja active Active
- 2019-12-01 IL IL271064A patent/IL271064B/en unknown
- 2019-12-05 US US16/704,744 patent/US11208633B2/en active Active
-
2020
- 2020-05-25 AU AU2020203423A patent/AU2020203423A1/en not_active Abandoned
- 2020-07-07 US US16/922,952 patent/US11952597B2/en active Active
-
2021
- 2021-04-16 JP JP2021069760A patent/JP7208293B2/ja active Active
- 2021-07-04 IL IL284582A patent/IL284582B2/en unknown
- 2021-11-29 AU AU2021277590A patent/AU2021277590A1/en not_active Abandoned
-
2023
- 2023-01-05 JP JP2023000594A patent/JP7556987B2/ja active Active
-
2024
- 2024-03-01 US US18/593,348 patent/US20250002875A1/en active Pending
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| HRP20211170T1 (hr) | Pripravci i postupci koji se odnose na mutantni toksin iz bakterije clostridium difficile | |
| JP2014083054A5 (enExample) | ||
| MX2021010518A (es) | Medios y metodos de fermentacion para producir polisacarido en cultivo celular bacteriano. | |
| MX2020006117A (es) | Integracion dirigida de acidos nucleicos. | |
| HRP20231631T1 (hr) | Pripravci koji se odnose na mutantni toksin iz bakterije clostridium difficile i odgovarajući postupci | |
| MX2015016379A (es) | Produccion de diterpeno extracelular. | |
| WO2014022702A3 (en) | Methods and compositions for controlling gene expression by rna processing | |
| BR112018004377A2 (pt) | cepas de levedura para a expressão e secreção de proteínas heterólogas em temperaturas elevadas | |
| WO2010006312A3 (en) | Methods and compositions for producing carbon-based products in microorganisms | |
| IN2014DN03419A (enExample) | ||
| BR112017008108A2 (pt) | incorporação de aminoácidos não naturais em proteínas | |
| BR112012033404A2 (pt) | polipetídeo tendo ou auxiliando a atividade de degradação de material de carboidratos e uso dos mesmos. | |
| NZ609903A (en) | Expression vector for high level expression of recombinant proteins | |
| NZ733709A (en) | Clostridium histolyticum enzymes and methods for the use thereof | |
| BR112015000585A8 (pt) | método para preparar uma cepa mutante de mycoplasma hyopneumoniae, vetores, cepa mutante, vacina, kit de vacinação e usos do vetor e da cepa mutante | |
| WO2014150449A3 (en) | Constitutive soybean promoters | |
| AR090340A1 (es) | Operaciones de cosecha mejoradas para proteinas recombinadas | |
| IN2015DN03206A (enExample) | ||
| MX2017000014A (es) | Metodo para producir acido graso de cadena media con el uso de beta-cetoacil-proteina portadora de acilo (acp) sintasa. | |
| AR100605A1 (es) | Métodos para la producción de lipasas | |
| CO2017011431A2 (es) | Proteínas de fusión de receptor de factor de crecimiento epidermal variante iii - mesotelina | |
| BR112015031236A2 (pt) | Produção de proteína em plantas | |
| WO2011159092A3 (ko) | 신규 토양 미생물과 상기 토양 미생물로부터 분리된 신규한 산화환원효소, 상기 산화환원 효소를 암호화하는 유전자 및 이들을 이용한 비당체의 생산방법 | |
| BR112012033396A2 (pt) | Polipetídeo tendo atividade swollenin e seus usos. | |
| BR112016028185A2 (pt) | método para produzir um l-aminoácido. |