JP2012503993A5 - - Google Patents
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- JP2012503993A5 JP2012503993A5 JP2011529364A JP2011529364A JP2012503993A5 JP 2012503993 A5 JP2012503993 A5 JP 2012503993A5 JP 2011529364 A JP2011529364 A JP 2011529364A JP 2011529364 A JP2011529364 A JP 2011529364A JP 2012503993 A5 JP2012503993 A5 JP 2012503993A5
- Authority
- JP
- Japan
- Prior art keywords
- dhad
- host cell
- sequence
- enzyme
- microbial host
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 210000004027 cell Anatomy 0.000 claims 22
- 101100452478 Arabidopsis thaliana DHAD gene Proteins 0.000 claims 18
- KKZJGLLVHKMTCM-UHFFFAOYSA-N mitoxantrone Chemical compound O=C1C2=C(O)C=CC(O)=C2C(=O)C2=C1C(NCCNCCO)=CC=C2NCCNCCO KKZJGLLVHKMTCM-UHFFFAOYSA-N 0.000 claims 18
- 108090000790 Enzymes Proteins 0.000 claims 12
- 102000004190 Enzymes Human genes 0.000 claims 12
- 230000000813 microbial effect Effects 0.000 claims 11
- ZXEKIIBDNHEJCQ-UHFFFAOYSA-N isobutanol Chemical compound CC(C)CO ZXEKIIBDNHEJCQ-UHFFFAOYSA-N 0.000 claims 8
- 235000018102 proteins Nutrition 0.000 claims 8
- 102000004169 proteins and genes Human genes 0.000 claims 8
- 108090000623 proteins and genes Proteins 0.000 claims 8
- 150000001413 amino acids Chemical group 0.000 claims 6
- 238000000034 method Methods 0.000 claims 6
- 230000001580 bacterial effect Effects 0.000 claims 5
- JTEYKUFKXGDTEU-UHFFFAOYSA-N 2,3-dihydroxy-3-methylbutanoic acid Chemical compound CC(C)(O)C(O)C(O)=O JTEYKUFKXGDTEU-UHFFFAOYSA-N 0.000 claims 3
- DCXYFEDJOCDNAF-UHFFFAOYSA-N Asparagine Natural products OC(=O)C(N)CC(N)=O DCXYFEDJOCDNAF-UHFFFAOYSA-N 0.000 claims 3
- 241000194019 Streptococcus mutans Species 0.000 claims 3
- 229960001230 asparagine Drugs 0.000 claims 3
- 235000009582 asparagine Nutrition 0.000 claims 3
- 230000000694 effects Effects 0.000 claims 3
- QHKABHOOEWYVLI-UHFFFAOYSA-N 3-methyl-2-oxobutanoic acid Chemical compound CC(C)C(=O)C(O)=O QHKABHOOEWYVLI-UHFFFAOYSA-N 0.000 claims 2
- 238000004435 EPR spectroscopy Methods 0.000 claims 2
- DCXYFEDJOCDNAF-REOHCLBHSA-N L-asparagine Chemical compound OC(=O)[C@@H](N)CC(N)=O DCXYFEDJOCDNAF-REOHCLBHSA-N 0.000 claims 2
- 241000192001 Pediococcus Species 0.000 claims 2
- 241000194017 Streptococcus Species 0.000 claims 2
- 230000006696 biosynthetic metabolic pathway Effects 0.000 claims 2
- 229920001184 polypeptide Polymers 0.000 claims 2
- 102000004196 processed proteins & peptides Human genes 0.000 claims 2
- 108090000765 processed proteins & peptides Proteins 0.000 claims 2
- 210000005253 yeast cell Anatomy 0.000 claims 2
- 241000588986 Alcaligenes Species 0.000 claims 1
- 239000004475 Arginine Substances 0.000 claims 1
- 241000894006 Bacteria Species 0.000 claims 1
- 241000186146 Brevibacterium Species 0.000 claims 1
- 241000222120 Candida <Saccharomycetales> Species 0.000 claims 1
- 241000193403 Clostridium Species 0.000 claims 1
- 108700016168 Dihydroxy-acid dehydratases Proteins 0.000 claims 1
- 241000194033 Enterococcus Species 0.000 claims 1
- 241001058146 Erium Species 0.000 claims 1
- 241000588722 Escherichia Species 0.000 claims 1
- 241000588748 Klebsiella Species 0.000 claims 1
- ODKSFYDXXFIFQN-BYPYZUCNSA-P L-argininium(2+) Chemical compound NC(=[NH2+])NCCC[C@H]([NH3+])C(O)=O ODKSFYDXXFIFQN-BYPYZUCNSA-P 0.000 claims 1
- ROHFNLRQFUQHCH-YFKPBYRVSA-N L-leucine Chemical compound CC(C)C[C@H](N)C(O)=O ROHFNLRQFUQHCH-YFKPBYRVSA-N 0.000 claims 1
- 241000186660 Lactobacillus Species 0.000 claims 1
- 241000194036 Lactococcus Species 0.000 claims 1
- 241000194035 Lactococcus lactis Species 0.000 claims 1
- ROHFNLRQFUQHCH-UHFFFAOYSA-N Leucine Natural products CC(C)CC(N)C(O)=O ROHFNLRQFUQHCH-UHFFFAOYSA-N 0.000 claims 1
- 241000192132 Leuconostoc Species 0.000 claims 1
- 241000202223 Oenococcus Species 0.000 claims 1
- 241000179039 Paenibacillus Species 0.000 claims 1
- 241000235648 Pichia Species 0.000 claims 1
- 241000589516 Pseudomonas Species 0.000 claims 1
- 241000316848 Rhodococcus <scale insect> Species 0.000 claims 1
- 241000235070 Saccharomyces Species 0.000 claims 1
- 240000004808 Saccharomyces cerevisiae Species 0.000 claims 1
- 241000607142 Salmonella Species 0.000 claims 1
- 241000235346 Schizosaccharomyces Species 0.000 claims 1
- 235000014897 Streptococcus lactis Nutrition 0.000 claims 1
- 241000235013 Yarrowia Species 0.000 claims 1
- 241000588901 Zymomonas Species 0.000 claims 1
- 239000002253 acid Substances 0.000 claims 1
- 235000001014 amino acid Nutrition 0.000 claims 1
- 229940024606 amino acid Drugs 0.000 claims 1
- 238000004458 analytical method Methods 0.000 claims 1
- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 claims 1
- 125000000613 asparagine group Chemical group N[C@@H](CC(N)=O)C(=O)* 0.000 claims 1
- 235000018417 cysteine Nutrition 0.000 claims 1
- 125000000151 cysteine group Chemical class N[C@@H](CS)C(=O)* 0.000 claims 1
- 229940039696 lactobacillus Drugs 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US10079208P | 2008-09-29 | 2008-09-29 | |
| US61/100,792 | 2008-09-29 | ||
| PCT/US2009/058827 WO2010037112A1 (en) | 2008-09-29 | 2009-09-29 | IDENTIFICATION AND USE OF BACTERIAL [2Fe-2S] DIHYDROXY-ACID DEHYDRATASES |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2012503993A JP2012503993A (ja) | 2012-02-16 |
| JP2012503993A5 true JP2012503993A5 (enExample) | 2012-11-15 |
| JP5846912B2 JP5846912B2 (ja) | 2016-01-20 |
Family
ID=41402186
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011529364A Active JP5846912B2 (ja) | 2008-09-29 | 2009-09-29 | 細菌性［２Ｆｅ−２Ｓ］ジヒドロキシ酸デヒドラターゼの同定および使用 |
Country Status (13)
| Country | Link |
|---|---|
| US (3) | US20100081154A1 (enExample) |
| EP (2) | EP2821484B1 (enExample) |
| JP (1) | JP5846912B2 (enExample) |
| KR (1) | KR101659101B1 (enExample) |
| CN (1) | CN102186973B (enExample) |
| AU (1) | AU2009296225B2 (enExample) |
| BR (1) | BRPI0913682A2 (enExample) |
| CA (1) | CA2735690A1 (enExample) |
| ES (1) | ES2521675T3 (enExample) |
| MX (1) | MX2011003238A (enExample) |
| NZ (1) | NZ591244A (enExample) |
| WO (1) | WO2010037112A1 (enExample) |
| ZA (2) | ZA201101367B (enExample) |
Families Citing this family (65)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8956850B2 (en) * | 2008-06-05 | 2015-02-17 | Butamax Advanced Biofuels Llc | Enhanced pyruvate to acetolactate conversion in yeast |
| US9303225B2 (en) | 2005-10-26 | 2016-04-05 | Butamax Advanced Biofuels Llc | Method for the production of isobutanol by recombinant yeast |
| US8945899B2 (en) | 2007-12-20 | 2015-02-03 | Butamax Advanced Biofuels Llc | Ketol-acid reductoisomerase using NADH |
| JP5582576B2 (ja) | 2007-04-18 | 2014-09-03 | ビュータマックス・アドバンスド・バイオフューエルズ・エルエルシー | 活性の高いケトール酸レダクトイソメラーゼ酵素を用いたイソブタノールの発酵生成 |
| US8188250B2 (en) | 2008-04-28 | 2012-05-29 | Butamax(Tm) Advanced Biofuels Llc | Butanol dehydrogenase enzyme from the bacterium Achromobacter xylosoxidans |
| WO2010037112A1 (en) | 2008-09-29 | 2010-04-01 | Butamax™ Advanced Biofuels LLC | IDENTIFICATION AND USE OF BACTERIAL [2Fe-2S] DIHYDROXY-ACID DEHYDRATASES |
| KR20110063576A (ko) | 2008-09-29 | 2011-06-10 | 부타맥스 어드밴스드 바이오퓨얼스 엘엘씨 | 효모에서 증가된 이종성 Ｆｅ-Ｓ 효소 활성 |
| US20160222370A1 (en) * | 2008-09-29 | 2016-08-04 | Butamax Advanced Biofuels Llc | Recombinant Yeast Host Cell With Fe-S Cluster Proteins And Methods Of Using Thereof |
| EP2331683A1 (en) * | 2008-09-29 | 2011-06-15 | Butamax Advanced Biofuels Llc | Enhanced dihydroxy-acid dehydratase activity in lactic acid bacteria |
| BRPI0913547A2 (pt) | 2008-09-29 | 2020-08-18 | Butamax Advanced Biofuels Llc | célula bacteriana ácido-lática recombinante, método para a produção de 2-butanol e método para a produção de 2-butanona |
| US8465964B2 (en) | 2008-11-13 | 2013-06-18 | Butamax (TM) Advanced Biofules LLC | Increased production of isobutanol in yeast with reduced mitochondrial amino acid biosynthesis |
| US8614085B2 (en) * | 2009-02-27 | 2013-12-24 | Butamax(Tm) Advanced Biofuels Llc | Yeast with increased butanol tolerance involving a multidrug efflux pump gene |
| WO2010119339A2 (en) | 2009-04-13 | 2010-10-21 | Butamax™ Advanced Biofuels LLC | Method for producing butanol using extractive fermentation |
| WO2011019894A1 (en) * | 2009-08-12 | 2011-02-17 | Gevo, Inc. | Cytosolic isobutanol pathway localization for the production of isobutanol |
| WO2011041426A1 (en) | 2009-09-29 | 2011-04-07 | Butamax(Tm) Advanced Biofuels Llc | Improved yeast production host cells |
| IN2012DN02227A (enExample) | 2009-09-29 | 2015-08-21 | Butamax Tm Advanced Biofuels | |
| US20110195505A1 (en) * | 2009-10-08 | 2011-08-11 | Butamax(Tm) Advanced Biofuels Llc | Bacterial strains for butanol production |
| BR112012012219A2 (pt) | 2009-11-23 | 2021-02-02 | Butamax (Tm) Advanced Biofuels Llc. | método para recuperar butanol, métodos para produzir butanol e composição |
| JP2013511284A (ja) | 2009-11-23 | 2013-04-04 | ビュータマックス・アドバンスド・バイオフューエルズ・エルエルシー | オスモライトの添加を伴う抽出発酵を用いたブタノールの生成方法 |
| MY156003A (en) | 2009-11-24 | 2015-12-31 | Gevo Inc | Methods of increasing dihydroxy acid dehydratase activity to improve production of fuels, chemicals, and amino acids |
| WO2011082248A1 (en) | 2009-12-29 | 2011-07-07 | Butamax(Tm) Advanced Biofuels Llc | Expression of hexose kinase in recombinant host cells |
| CA2784903A1 (en) | 2009-12-29 | 2011-07-28 | Butamax(Tm) Advanced Biofuels Llc | Alcohol dehydrogenases (adh) useful for fermentive production of lower alkyl alcohols |
| MX348605B (es) | 2010-02-17 | 2017-06-21 | Butamax(Tm) Advanced Biofuels Llc | Mejoramiento de la actividad de proteinas que requieren centros fe-s. |
| KR101778821B1 (ko) * | 2010-05-24 | 2017-09-14 | 질레코 인코포레이티드 | 바이오매스의 가공처리 |
| JP2013528398A (ja) | 2010-06-17 | 2013-07-11 | ビュータマックス・アドバンスド・バイオフューエルズ・エルエルシー | ブタノール産生用の酵母生産培養物 |
| KR20130116858A (ko) | 2010-06-18 | 2013-10-24 | 부타맥스 어드밴스드 바이오퓨얼스 엘엘씨 | 추출 발효에서 알코올 수거를 위한 오일 유래의 추출 용매 |
| US9040263B2 (en) | 2010-07-28 | 2015-05-26 | Butamax Advanced Biofuels Llc | Production of alcohol esters and in situ product removal during alcohol fermentation |
| US9012190B2 (en) | 2011-06-15 | 2015-04-21 | Butamax Advanced Biofuels Llc | Use of thiamine and nicotine adenine dinucleotide for butanol production |
| US8409834B2 (en) | 2010-06-18 | 2013-04-02 | Butamax(Tm) Advanced Biofuels Llc | Extraction solvents derived from oil for alcohol removal in extractive fermentation |
| US8871488B2 (en) | 2010-06-18 | 2014-10-28 | Butamax Advanced Biofuels Llc | Recombinant host cells comprising phosphoketolases |
| NZ722791A (en) | 2010-09-07 | 2018-12-21 | Butamax Tm Advanced Biofuels | Integration of a polynucleotide encoding a polypeptide that catalyzes pyruvate to acetolactate conversion |
| US20130040340A1 (en) | 2011-02-07 | 2013-02-14 | E. I. Du Pont De Nemours And Company | Production of alcohol esters in situ using alcohols and fatty acids produced by microorganisms |
| US8765425B2 (en) | 2011-03-23 | 2014-07-01 | Butamax Advanced Biofuels Llc | In situ expression of lipase for enzymatic production of alcohol esters during fermentation |
| US8759044B2 (en) | 2011-03-23 | 2014-06-24 | Butamax Advanced Biofuels Llc | In situ expression of lipase for enzymatic production of alcohol esters during fermentation |
| KR20140092759A (ko) | 2011-03-24 | 2014-07-24 | 부타맥스 어드밴스드 바이오퓨얼스 엘엘씨 | 숙주 세포 및 아이소부탄올의 제조 방법 |
| MX2013014327A (es) | 2011-06-17 | 2014-01-23 | Butamax Tm Advanced Biofuels | Coproductos de procesos de produccion de biocombustible y metodos para elaborarlos. |
| MX2014000966A (es) | 2011-07-28 | 2014-07-09 | Butamax Advanced Biofuels Llc | Enzimas cetoisovalerato descarboxilasa y metodos de uso de las mismas. |
| WO2013043801A1 (en) * | 2011-09-20 | 2013-03-28 | Gevo, Inc. | High-performance dihydroxy acid dehydratases |
| WO2013086222A2 (en) | 2011-12-09 | 2013-06-13 | Butamax(Tm) Advanced Biofuels Llc | Process to remove product alcohols from fermentation broth |
| JP2015503351A (ja) | 2011-12-30 | 2015-02-02 | ビュータマックス・アドバンスド・バイオフューエルズ・エルエルシー | ブタノール生産のための遺伝的スイッチ |
| CA2861613A1 (en) | 2011-12-30 | 2013-07-04 | Butamax Advanced Biofuels Llc | Fermentative production of alcohols |
| KR20140146616A (ko) | 2012-03-23 | 2014-12-26 | 부타맥스 어드밴스드 바이오퓨얼스 엘엘씨 | 부타놀로겐용 배지의 아세테이트 보충물 |
| NZ701099A (en) | 2012-05-11 | 2017-04-28 | Butamax Advanced Biofuels Llc | Ketol-acid reductoisomerase enzymes and methods of use |
| US20140024064A1 (en) | 2012-07-23 | 2014-01-23 | Butamax(Tm) Advanced Biofuels Llc | Processes and systems for the production of fermentative alcohols |
| BR112015003701A2 (pt) | 2012-08-22 | 2017-12-12 | Butamax Advanced Biofuels Llc | células hospedeiras recombinantes, método para aprimoramento, processo para a produção de um álcool, polinucleotídeo isolado, cassete de expressão e composição |
| MX2015003073A (es) | 2012-09-12 | 2015-07-14 | Butamax Advanced Biofuels Llc | Procesos y sistemas para la produccion de productos de fermentacion. |
| US9840724B2 (en) | 2012-09-21 | 2017-12-12 | Butamax Advanced Biofuels Llc | Production of renewable hydrocarbon compositions |
| CN105102616A (zh) | 2012-09-26 | 2015-11-25 | 布特马斯先进生物燃料有限责任公司 | 具有酮醇酸还原异构酶活性的多肽 |
| AU2013323396B2 (en) | 2012-09-28 | 2017-04-20 | Butamax Advanced Biofuels Llc | Production of fermentation products |
| US9273330B2 (en) | 2012-10-03 | 2016-03-01 | Butamax Advanced Biofuels Llc | Butanol tolerance in microorganisms |
| EP2906706B1 (en) | 2012-10-11 | 2020-02-26 | Butamax Advanced Biofuels LLC | Processes and systems for the production of fermentation products |
| US9650624B2 (en) | 2012-12-28 | 2017-05-16 | Butamax Advanced Biofuels Llc | DHAD variants for butanol production |
| WO2014105840A1 (en) | 2012-12-31 | 2014-07-03 | Butamax Advanced Biofuels Llc | Fermentative production of alcohols |
| US9523104B2 (en) | 2013-03-12 | 2016-12-20 | Butamax Advanced Biofuels Llc | Processes and systems for the production of alcohols |
| US9441250B2 (en) | 2013-03-14 | 2016-09-13 | Butamax Advanced Biofuels Llc | Glycerol 3- phosphate dehydrogenase for butanol production |
| CN105229156A (zh) | 2013-03-15 | 2016-01-06 | 布特马斯先进生物燃料有限责任公司 | 用于利用提取发酵生产丁醇的方法 |
| WO2014151645A1 (en) | 2013-03-15 | 2014-09-25 | Butamax Advanced Biofuels Llc | Process for maximizing biomass growth and butanol yield by feedback control |
| US9771602B2 (en) | 2013-03-15 | 2017-09-26 | Butamax Advanced Biofuels Llc | Competitive growth and/or production advantage for butanologen microorganism |
| US9580705B2 (en) | 2013-03-15 | 2017-02-28 | Butamax Advanced Biofuels Llc | DHAD variants and methods of screening |
| WO2014144643A1 (en) | 2013-03-15 | 2014-09-18 | Butamax Advanced Biofuels Llc | Method for producing butanol using extractive fermentation |
| US9663759B2 (en) | 2013-07-03 | 2017-05-30 | Butamax Advanced Biofuels Llc | Partial adaptation for butanol production |
| US10280438B2 (en) | 2014-08-11 | 2019-05-07 | Butamax Advanced Biofuels Llc | Method for the production of yeast |
| EP3589740A1 (en) | 2017-03-03 | 2020-01-08 | NMR - Bio | Cell-free synthesis of isotopic labelled proteins from amino-acids precursors |
| CN111893083A (zh) * | 2019-05-05 | 2020-11-06 | 中国科学院上海高等研究院 | 改造的克雷伯氏属细菌及其生产2,3-二羟基异戊酸的应用 |
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| EP2331683A1 (en) | 2008-09-29 | 2011-06-15 | Butamax Advanced Biofuels Llc | Enhanced dihydroxy-acid dehydratase activity in lactic acid bacteria |
| BRPI0913547A2 (pt) | 2008-09-29 | 2020-08-18 | Butamax Advanced Biofuels Llc | célula bacteriana ácido-lática recombinante, método para a produção de 2-butanol e método para a produção de 2-butanona |
| KR20110063576A (ko) * | 2008-09-29 | 2011-06-10 | 부타맥스 어드밴스드 바이오퓨얼스 엘엘씨 | 효모에서 증가된 이종성 Ｆｅ-Ｓ 효소 활성 |
| US20100081182A1 (en) | 2008-09-29 | 2010-04-01 | Butamax(Tm) Advanced Biofuels Llc | Enhanced iron-sulfur cluster formation for increased dihydroxy-acid dehydratase activity in lactic acid bacteria |
| WO2010037112A1 (en) | 2008-09-29 | 2010-04-01 | Butamax™ Advanced Biofuels LLC | IDENTIFICATION AND USE OF BACTERIAL [2Fe-2S] DIHYDROXY-ACID DEHYDRATASES |
| US8828694B2 (en) * | 2008-11-13 | 2014-09-09 | Butamax Advanced Biofuels Llc | Production of isobutanol in yeast mitochondria |
| WO2011019894A1 (en) * | 2009-08-12 | 2011-02-17 | Gevo, Inc. | Cytosolic isobutanol pathway localization for the production of isobutanol |
| IN2012DN02227A (enExample) * | 2009-09-29 | 2015-08-21 | Butamax Tm Advanced Biofuels | |
| WO2011041426A1 (en) * | 2009-09-29 | 2011-04-07 | Butamax(Tm) Advanced Biofuels Llc | Improved yeast production host cells |
| BR112012012219A2 (pt) * | 2009-11-23 | 2021-02-02 | Butamax (Tm) Advanced Biofuels Llc. | método para recuperar butanol, métodos para produzir butanol e composição |
| JP2013511284A (ja) * | 2009-11-23 | 2013-04-04 | ビュータマックス・アドバンスド・バイオフューエルズ・エルエルシー | オスモライトの添加を伴う抽出発酵を用いたブタノールの生成方法 |
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2009
- 2009-09-29 WO PCT/US2009/058827 patent/WO2010037112A1/en not_active Ceased
- 2009-09-29 AU AU2009296225A patent/AU2009296225B2/en active Active
- 2009-09-29 CN CN200980138542.2A patent/CN102186973B/zh not_active Expired - Fee Related
- 2009-09-29 US US12/569,636 patent/US20100081154A1/en not_active Abandoned
- 2009-09-29 BR BRPI0913682-7A patent/BRPI0913682A2/pt not_active Application Discontinuation
- 2009-09-29 JP JP2011529364A patent/JP5846912B2/ja active Active
- 2009-09-29 MX MX2011003238A patent/MX2011003238A/es not_active Application Discontinuation
- 2009-09-29 CA CA2735690A patent/CA2735690A1/en not_active Abandoned
- 2009-09-29 NZ NZ591244A patent/NZ591244A/xx not_active IP Right Cessation
- 2009-09-29 EP EP14180626.5A patent/EP2821484B1/en active Active
- 2009-09-29 KR KR1020117009692A patent/KR101659101B1/ko not_active Expired - Fee Related
- 2009-09-29 EP EP09793126.5A patent/EP2337851B1/en active Active
- 2009-09-29 ES ES09793126.5T patent/ES2521675T3/es active Active
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2011
- 2011-02-21 ZA ZA2011/01367A patent/ZA201101367B/en unknown
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2013
- 2013-03-15 US US13/838,570 patent/US20140051137A1/en not_active Abandoned
- 2013-03-15 US US13/838,508 patent/US8951937B2/en active Active
- 2013-12-20 ZA ZA2013/09658A patent/ZA201309658B/en unknown
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