JP2011512144A5 - - Google Patents
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- Publication number
- JP2011512144A5 JP2011512144A5 JP2010547114A JP2010547114A JP2011512144A5 JP 2011512144 A5 JP2011512144 A5 JP 2011512144A5 JP 2010547114 A JP2010547114 A JP 2010547114A JP 2010547114 A JP2010547114 A JP 2010547114A JP 2011512144 A5 JP2011512144 A5 JP 2011512144A5
- Authority
- JP
- Japan
- Prior art keywords
- glutamate decarboxylase
- acid sequence
- heterologous
- gaba
- sequence
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 102000008214 Glutamate decarboxylase Human genes 0.000 claims 18
- 108091022930 Glutamate decarboxylase Proteins 0.000 claims 18
- 238000000034 method Methods 0.000 claims 17
- BTCSSZJGUNDROE-UHFFFAOYSA-N gamma-aminobutyric acid Chemical compound NCCCC(O)=O BTCSSZJGUNDROE-UHFFFAOYSA-N 0.000 claims 8
- 229960003692 gamma aminobutyric acid Drugs 0.000 claims 7
- 241000196324 Embryophyta Species 0.000 claims 5
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 5
- 150000001413 amino acids Chemical group 0.000 claims 5
- 150000007523 nucleic acids Chemical group 0.000 claims 5
- 244000061456 Solanum tuberosum Species 0.000 claims 4
- 235000002595 Solanum tuberosum Nutrition 0.000 claims 4
- 244000005700 microbiome Species 0.000 claims 4
- 108091026890 Coding region Proteins 0.000 claims 3
- WHUUTDBJXJRKMK-VKHMYHEASA-N L-glutamic acid Chemical compound OC(=O)[C@@H](N)CCC(O)=O WHUUTDBJXJRKMK-VKHMYHEASA-N 0.000 claims 3
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 2
- 241000186216 Corynebacterium Species 0.000 claims 2
- 241000186226 Corynebacterium glutamicum Species 0.000 claims 2
- 102000004190 Enzymes Human genes 0.000 claims 2
- 108090000790 Enzymes Proteins 0.000 claims 2
- WHUUTDBJXJRKMK-UHFFFAOYSA-N Glutamic acid Natural products OC(=O)C(N)CCC(O)=O WHUUTDBJXJRKMK-UHFFFAOYSA-N 0.000 claims 2
- 230000000694 effects Effects 0.000 claims 2
- 235000013922 glutamic acid Nutrition 0.000 claims 2
- 239000004220 glutamic acid Substances 0.000 claims 2
- OGNSCSPNOLGXSM-UHFFFAOYSA-N (+/-)-DABA Natural products NCCC(N)C(O)=O OGNSCSPNOLGXSM-UHFFFAOYSA-N 0.000 claims 1
- 241000894006 Bacteria Species 0.000 claims 1
- KXDHJXZQYSOELW-UHFFFAOYSA-N Carbamic acid Chemical class NC(O)=O KXDHJXZQYSOELW-UHFFFAOYSA-N 0.000 claims 1
- 102000004031 Carboxy-Lyases Human genes 0.000 claims 1
- 108090000489 Carboxy-Lyases Proteins 0.000 claims 1
- 108700010070 Codon Usage Proteins 0.000 claims 1
- 241000206602 Eukaryota Species 0.000 claims 1
- 239000004952 Polyamide Substances 0.000 claims 1
- 235000002634 Solanum Nutrition 0.000 claims 1
- 241000207763 Solanum Species 0.000 claims 1
- 240000003768 Solanum lycopersicum Species 0.000 claims 1
- 235000002560 Solanum lycopersicum Nutrition 0.000 claims 1
- BVKZGUZCCUSVTD-UHFFFAOYSA-N carbonic acid Chemical class OC(O)=O BVKZGUZCCUSVTD-UHFFFAOYSA-N 0.000 claims 1
- 238000012258 culturing Methods 0.000 claims 1
- 230000003831 deregulation Effects 0.000 claims 1
- 238000000855 fermentation Methods 0.000 claims 1
- 230000004151 fermentation Effects 0.000 claims 1
- 238000012262 fermentative production Methods 0.000 claims 1
- 229930195712 glutamate Natural products 0.000 claims 1
- 229920002647 polyamide Polymers 0.000 claims 1
- 230000000379 polymerizing effect Effects 0.000 claims 1
- 108090000623 proteins and genes Proteins 0.000 claims 1
- 230000001105 regulatory effect Effects 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP08151744 | 2008-02-21 | ||
| PCT/EP2009/001225 WO2009103547A1 (en) | 2008-02-21 | 2009-02-20 | Process for the production of gamma-aminobutyric acid |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015000040A Division JP2015119707A (ja) | 2008-02-21 | 2015-01-05 | γ−アミノ酪酸の生産方法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2011512144A JP2011512144A (ja) | 2011-04-21 |
| JP2011512144A5 true JP2011512144A5 (enExample) | 2013-06-13 |
Family
ID=40578627
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010547114A Pending JP2011512144A (ja) | 2008-02-21 | 2009-02-20 | γ−アミノ酪酸の生産方法 |
| JP2015000040A Pending JP2015119707A (ja) | 2008-02-21 | 2015-01-05 | γ−アミノ酪酸の生産方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015000040A Pending JP2015119707A (ja) | 2008-02-21 | 2015-01-05 | γ−アミノ酪酸の生産方法 |
Country Status (6)
| Country | Link |
|---|---|
| US (2) | US8771998B2 (enExample) |
| EP (1) | EP2247724A1 (enExample) |
| JP (2) | JP2011512144A (enExample) |
| KR (1) | KR20110004368A (enExample) |
| CN (2) | CN101945997B (enExample) |
| WO (1) | WO2009103547A1 (enExample) |
Families Citing this family (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2505637B1 (en) * | 2007-08-17 | 2019-10-09 | Basf Se | Novel microbial succinic acid producer |
| CN101945997B (zh) * | 2008-02-21 | 2014-12-03 | 巴斯夫欧洲公司 | 产生γ-氨基丁酸的方法 |
| EP2204443B1 (en) * | 2008-12-23 | 2015-11-25 | Basf Se | Bacterial cells exhibiting formate dehydrogenase activity for the manufacture of suc-cinic acid |
| ES2559385T3 (es) * | 2008-12-23 | 2016-02-11 | Basf Se | Células bacterianas que tienen una derivación de glioxilato para la fabricación de ácido succínico |
| CN102317438A (zh) | 2009-02-16 | 2012-01-11 | 巴斯夫欧洲公司 | 琥珀酸的新型微生物生产者和琥珀酸的纯化 |
| WO2011137369A1 (en) * | 2010-04-29 | 2011-11-03 | The Regents Of The University Of California | Production of gamma-aminobutyric acid by recombinant microorganisms |
| US8728775B2 (en) * | 2010-09-30 | 2014-05-20 | Daesang Corporation | Method for preparing 2-pyrrolidone using a microorganism containing glutamate decarboxylase |
| CN102154393A (zh) * | 2011-01-18 | 2011-08-17 | 江南大学 | 一种γ-氨基丁酸的生产方法及其生产菌株 |
| PE20141569A1 (es) | 2011-11-11 | 2014-11-08 | Ajinomoto Kk | Metodo para producir una sustancia diana mediante fermentacion |
| CN102864190A (zh) * | 2012-10-10 | 2013-01-09 | 山东金城钟化生物药业有限公司 | γ-氨基丁酸的生产方法 |
| CN103555779B (zh) * | 2013-08-01 | 2015-08-19 | 江南大学 | 一种发酵生产γ-氨基丁酸的方法 |
| CN103555647B (zh) * | 2013-11-06 | 2015-05-27 | 南京工业大学 | 一种高产γ-氨基丁酸的重组谷氨酸棒杆菌及构建方法和应用 |
| WO2015092599A1 (en) * | 2013-12-17 | 2015-06-25 | Basf Se | Improved process for the production of gamma-aminobutyric acid (gaba) |
| WO2015092576A1 (en) * | 2013-12-17 | 2015-06-25 | Basf Se | Improved process for the production of gamma-aminobutyric acid (gaba) |
| CN104099366B (zh) * | 2014-07-11 | 2017-01-18 | 苏州凯祥生物科技有限公司 | 一种谷氨酸脱羧酶重组质粒及其构建方法和应用 |
| CN105647912B (zh) * | 2014-12-01 | 2025-09-19 | 清华大学 | 抗酸表达盒及其筛选方法 |
| KR20160077272A (ko) | 2014-12-22 | 2016-07-04 | 한국광기술원 | Led를 이용한 안구 피로회복 장치 |
| CN104558589A (zh) | 2015-01-08 | 2015-04-29 | 华东理工大学 | 一种绿色尼龙聚丁内酰胺的制备方法 |
| CN104830886B (zh) * | 2015-05-07 | 2017-09-22 | 福建师范大学 | 产γ‑氨基丁酸的重组菌及其构建方法与应用 |
| CN105296456B (zh) * | 2015-11-23 | 2018-08-07 | 江南大学 | 一种pH稳定性提高的谷氨酸脱羧酶突变体及其应用 |
| JP7113720B2 (ja) * | 2018-10-19 | 2022-08-05 | 水澤化学工業株式会社 | γ－アミノ酪酸捕集剤 |
| CN111378611B (zh) * | 2018-12-29 | 2022-02-22 | 杭州唯铂莱生物科技有限公司 | 一种谷氨酸脱羧酶重组菌及其构建方法和应用 |
| CN110951664B (zh) * | 2019-12-27 | 2021-09-24 | 江南大学 | 一种重组谷氨酸棒杆菌及其在生产2-吡咯烷酮中的应用 |
| CN111635898B (zh) * | 2020-06-17 | 2022-04-29 | 中国科学院天津工业生物技术研究所 | 谷氨酸脱羧酶突变体及其在制备γ-氨基丁酸中的应用 |
| CN114752544B (zh) * | 2022-06-16 | 2022-09-06 | 森瑞斯生物科技(深圳)有限公司 | 一步法生产γ-氨基丁酸的方法及其菌株构建 |
| CN115927278B (zh) * | 2022-12-23 | 2024-05-03 | 山西农业大学 | 一种与甘薯γ-氨基丁酸代谢相关的蛋白及其编码基因和应用 |
| CN116286578B (zh) * | 2023-03-06 | 2024-12-20 | 华南理工大学 | 一种能够合成gaba的酪丁酸梭菌基因工程菌及其构建方法与应用 |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP4178720B2 (ja) * | 1999-06-03 | 2008-11-12 | 味の素株式会社 | Ｌ−アルギニンの製造法 |
| JP4623825B2 (ja) | 1999-12-16 | 2011-02-02 | 協和発酵バイオ株式会社 | 新規ポリヌクレオチド |
| DE10031213B4 (de) | 2000-06-27 | 2005-10-20 | Silu Verwaltung Ag Meggen | Dichtungsband für Fugen |
| IL155768A0 (en) | 2000-11-07 | 2003-12-23 | Emerald Bioagriculture Corp | Methods for regulating plant gaba production |
| JP4560998B2 (ja) * | 2001-02-05 | 2010-10-13 | 味の素株式会社 | 発酵法によるｌ−グルタミンの製造法及びｌ−グルタミン生産菌 |
| US20030170653A1 (en) * | 2001-06-08 | 2003-09-11 | Damude Howard Glenn | Biological method for the production of tuliposide A and its intermediates |
| US20050108791A1 (en) * | 2001-12-04 | 2005-05-19 | Edgerton Michael D. | Transgenic plants with improved phenotypes |
| WO2006028298A2 (en) | 2004-09-10 | 2006-03-16 | Ajinomoto Co., Inc. | L-glutamic acid-producing microorganism and a method for producing l-glutamic acid |
| EP3078749B1 (en) * | 2004-12-21 | 2019-10-09 | Monsanto Technology LLC | Transgenic plants with enhanced agronomic traits |
| JP5343303B2 (ja) * | 2004-12-28 | 2013-11-13 | 味の素株式会社 | Ｌ−グルタミン酸生産菌及びｌ−グルタミン酸の製造方法 |
| BR122019024048B1 (pt) | 2004-12-28 | 2022-05-24 | Ajinomoto Co., Inc | Método para produzir ácido l-glutâmico |
| AU2006219823A1 (en) * | 2005-03-02 | 2006-09-08 | Metanomics Gmbh | Process for the production of fine chemicals |
| CN1276087C (zh) * | 2005-03-07 | 2006-09-20 | 浙江大学 | 一种生物合成γ－氨基丁酸的方法 |
| CA2610164A1 (en) * | 2005-05-31 | 2006-12-07 | Neurologix, Inc. | Novel glutamic acid decarboxylase (gad) chimera and methods of use |
| US20090318593A1 (en) * | 2005-09-28 | 2009-12-24 | Klaus Stoll | Process for Improving the Flow Properties of Polymer Melts |
| HUE030521T2 (en) * | 2006-03-30 | 2017-05-29 | Basf Se | A method for producing cadaverine |
| JP2007283565A (ja) * | 2006-04-14 | 2007-11-01 | Mitsubishi Plastics Ind Ltd | ガスバリア性フィルム、並びに該フィルムを用いた包装材及び包装体 |
| US8206970B2 (en) * | 2006-05-02 | 2012-06-26 | Butamax(Tm) Advanced Biofuels Llc | Production of 2-butanol and 2-butanone employing aminobutanol phosphate phospholyase |
| CN101945997B (zh) * | 2008-02-21 | 2014-12-03 | 巴斯夫欧洲公司 | 产生γ-氨基丁酸的方法 |
-
2009
- 2009-02-20 CN CN200980105702.3A patent/CN101945997B/zh not_active Expired - Fee Related
- 2009-02-20 JP JP2010547114A patent/JP2011512144A/ja active Pending
- 2009-02-20 EP EP09713039A patent/EP2247724A1/en not_active Withdrawn
- 2009-02-20 CN CN201410601958.6A patent/CN104357431A/zh active Pending
- 2009-02-20 US US12/918,241 patent/US8771998B2/en not_active Expired - Fee Related
- 2009-02-20 WO PCT/EP2009/001225 patent/WO2009103547A1/en not_active Ceased
- 2009-02-20 KR KR1020107021064A patent/KR20110004368A/ko not_active Withdrawn
-
2014
- 2014-05-29 US US14/289,731 patent/US20140256005A1/en not_active Abandoned
-
2015
- 2015-01-05 JP JP2015000040A patent/JP2015119707A/ja active Pending
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