JP2011512144A - γ−アミノ酪酸の生産方法 - Google Patents

γ−アミノ酪酸の生産方法 Download PDF

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Publication number
JP2011512144A
JP2011512144A JP2010547114A JP2010547114A JP2011512144A JP 2011512144 A JP2011512144 A JP 2011512144A JP 2010547114 A JP2010547114 A JP 2010547114A JP 2010547114 A JP2010547114 A JP 2010547114A JP 2011512144 A JP2011512144 A JP 2011512144A
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Prior art keywords
glutamate decarboxylase
sequence
nucleic acid
gaba
seq
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JP2011512144A5 (enExample
Inventor
ゼルダー，オスカー
ジョン，ウォル，キュウ
クロップロッゲ，コリンナ
ヘロルト，アンドレア
シュレーダー，ハルトヴィッヒ
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BASF SE
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BASF SE
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/005—Amino acids other than alpha- or beta amino acids, e.g. gamma amino acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52—Genes encoding for enzymes or proenzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/74—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/88—Lyases (4.)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/02—Amides, e.g. chloramphenicol or polyamides; Imides or polyimides; Urethanes, i.e. compounds comprising N-C=O structural element or polyurethanes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y401/00—Carbon-carbon lyases (4.1)
    • C12Y401/01—Carboxy-lyases (4.1.1)
    • C12Y401/01015—Glutamate decarboxylase (4.1.1.15)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
    • C12R2001/15—Corynebacterium

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Polyamides (AREA)
JP2010547114A 2008-02-21 2009-02-20 γ−アミノ酪酸の生産方法 Pending JP2011512144A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP08151744 2008-02-21
PCT/EP2009/001225 WO2009103547A1 (en) 2008-02-21 2009-02-20 Process for the production of gamma-aminobutyric acid

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2015000040A Division JP2015119707A (ja) 2008-02-21 2015-01-05 γ−アミノ酪酸の生産方法

Publications (2)

Publication Number Publication Date
JP2011512144A true JP2011512144A (ja) 2011-04-21
JP2011512144A5 JP2011512144A5 (enExample) 2013-06-13

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Family Applications (2)

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JP2010547114A Pending JP2011512144A (ja) 2008-02-21 2009-02-20 γ−アミノ酪酸の生産方法
JP2015000040A Pending JP2015119707A (ja) 2008-02-21 2015-01-05 γ−アミノ酪酸の生産方法

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JP2015000040A Pending JP2015119707A (ja) 2008-02-21 2015-01-05 γ−アミノ酪酸の生産方法

Country Status (6)

Country Link
US (2) US8771998B2 (enExample)
EP (1) EP2247724A1 (enExample)
JP (2) JP2011512144A (enExample)
KR (1) KR20110004368A (enExample)
CN (2) CN101945997B (enExample)
WO (1) WO2009103547A1 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2020065946A (ja) * 2018-10-19 2020-04-30 水澤化学工業株式会社 γ−アミノ酪酸捕集剤

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2505637B1 (en) * 2007-08-17 2019-10-09 Basf Se Novel microbial succinic acid producer
CN101945997B (zh) * 2008-02-21 2014-12-03 巴斯夫欧洲公司 产生γ-氨基丁酸的方法
EP2204443B1 (en) * 2008-12-23 2015-11-25 Basf Se Bacterial cells exhibiting formate dehydrogenase activity for the manufacture of suc-cinic acid
ES2559385T3 (es) * 2008-12-23 2016-02-11 Basf Se Células bacterianas que tienen una derivación de glioxilato para la fabricación de ácido succínico
CN102317438A (zh) 2009-02-16 2012-01-11 巴斯夫欧洲公司 琥珀酸的新型微生物生产者和琥珀酸的纯化
WO2011137369A1 (en) * 2010-04-29 2011-11-03 The Regents Of The University Of California Production of gamma-aminobutyric acid by recombinant microorganisms
US8728775B2 (en) * 2010-09-30 2014-05-20 Daesang Corporation Method for preparing 2-pyrrolidone using a microorganism containing glutamate decarboxylase
CN102154393A (zh) * 2011-01-18 2011-08-17 江南大学 一种γ-氨基丁酸的生产方法及其生产菌株
PE20141569A1 (es) 2011-11-11 2014-11-08 Ajinomoto Kk Metodo para producir una sustancia diana mediante fermentacion
CN102864190A (zh) * 2012-10-10 2013-01-09 山东金城钟化生物药业有限公司 γ-氨基丁酸的生产方法
CN103555779B (zh) * 2013-08-01 2015-08-19 江南大学 一种发酵生产γ-氨基丁酸的方法
CN103555647B (zh) * 2013-11-06 2015-05-27 南京工业大学 一种高产γ-氨基丁酸的重组谷氨酸棒杆菌及构建方法和应用
WO2015092599A1 (en) * 2013-12-17 2015-06-25 Basf Se Improved process for the production of gamma-aminobutyric acid (gaba)
WO2015092576A1 (en) * 2013-12-17 2015-06-25 Basf Se Improved process for the production of gamma-aminobutyric acid (gaba)
CN104099366B (zh) * 2014-07-11 2017-01-18 苏州凯祥生物科技有限公司 一种谷氨酸脱羧酶重组质粒及其构建方法和应用
CN105647912B (zh) * 2014-12-01 2025-09-19 清华大学 抗酸表达盒及其筛选方法
KR20160077272A (ko) 2014-12-22 2016-07-04 한국광기술원 Led를 이용한 안구 피로회복 장치
CN104558589A (zh) 2015-01-08 2015-04-29 华东理工大学 一种绿色尼龙聚丁内酰胺的制备方法
CN104830886B (zh) * 2015-05-07 2017-09-22 福建师范大学 产γ‑氨基丁酸的重组菌及其构建方法与应用
CN105296456B (zh) * 2015-11-23 2018-08-07 江南大学 一种pH稳定性提高的谷氨酸脱羧酶突变体及其应用
CN111378611B (zh) * 2018-12-29 2022-02-22 杭州唯铂莱生物科技有限公司 一种谷氨酸脱羧酶重组菌及其构建方法和应用
CN110951664B (zh) * 2019-12-27 2021-09-24 江南大学 一种重组谷氨酸棒杆菌及其在生产2-吡咯烷酮中的应用
CN111635898B (zh) * 2020-06-17 2022-04-29 中国科学院天津工业生物技术研究所 谷氨酸脱羧酶突变体及其在制备γ-氨基丁酸中的应用
CN114752544B (zh) * 2022-06-16 2022-09-06 森瑞斯生物科技(深圳)有限公司 一步法生产γ-氨基丁酸的方法及其菌株构建
CN115927278B (zh) * 2022-12-23 2024-05-03 山西农业大学 一种与甘薯γ-氨基丁酸代谢相关的蛋白及其编码基因和应用
CN116286578B (zh) * 2023-03-06 2024-12-20 华南理工大学 一种能够合成gaba的酪丁酸梭菌基因工程菌及其构建方法与应用

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2001046082A (ja) * 1999-06-03 2001-02-20 Ajinomoto Co Inc Ｌ−アルギニンの製造法
JP2002300887A (ja) * 2001-02-05 2002-10-15 Ajinomoto Co Inc 発酵法によるｌ−グルタミンの製造法及びｌ−グルタミン生産菌
JP2005506034A (ja) * 2000-11-07 2005-03-03 エメラルド・バイオアグリカルチャー・コーポレーション 植物ｇａｂａ産生を調節する方法
JP2007097573A (ja) * 2004-12-28 2007-04-19 Ajinomoto Co Inc Ｌ−グルタミン酸生産菌及びｌ−グルタミン酸の製造方法
WO2007113127A1 (en) * 2006-03-30 2007-10-11 Basf Se Process for the production of cadaverine
JP2007283565A (ja) * 2006-04-14 2007-11-01 Mitsubishi Plastics Ind Ltd ガスバリア性フィルム、並びに該フィルムを用いた包装材及び包装体
WO2007130521A2 (en) * 2006-05-02 2007-11-15 E. I. Du Pont De Nemours And Company Fermentive production of four carbon alcohols

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4623825B2 (ja) 1999-12-16 2011-02-02 協和発酵バイオ株式会社 新規ポリヌクレオチド
DE10031213B4 (de) 2000-06-27 2005-10-20 Silu Verwaltung Ag Meggen Dichtungsband für Fugen
US20030170653A1 (en) * 2001-06-08 2003-09-11 Damude Howard Glenn Biological method for the production of tuliposide A and its intermediates
US20050108791A1 (en) * 2001-12-04 2005-05-19 Edgerton Michael D. Transgenic plants with improved phenotypes
WO2006028298A2 (en) 2004-09-10 2006-03-16 Ajinomoto Co., Inc. L-glutamic acid-producing microorganism and a method for producing l-glutamic acid
EP3078749B1 (en) * 2004-12-21 2019-10-09 Monsanto Technology LLC Transgenic plants with enhanced agronomic traits
BR122019024048B1 (pt) 2004-12-28 2022-05-24 Ajinomoto Co., Inc Método para produzir ácido l-glutâmico
AU2006219823A1 (en) * 2005-03-02 2006-09-08 Metanomics Gmbh Process for the production of fine chemicals
CN1276087C (zh) * 2005-03-07 2006-09-20 浙江大学 一种生物合成γ－氨基丁酸的方法
CA2610164A1 (en) * 2005-05-31 2006-12-07 Neurologix, Inc. Novel glutamic acid decarboxylase (gad) chimera and methods of use
US20090318593A1 (en) * 2005-09-28 2009-12-24 Klaus Stoll Process for Improving the Flow Properties of Polymer Melts
CN101945997B (zh) * 2008-02-21 2014-12-03 巴斯夫欧洲公司 产生γ-氨基丁酸的方法

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2001046082A (ja) * 1999-06-03 2001-02-20 Ajinomoto Co Inc Ｌ−アルギニンの製造法
JP2005506034A (ja) * 2000-11-07 2005-03-03 エメラルド・バイオアグリカルチャー・コーポレーション 植物ｇａｂａ産生を調節する方法
JP2002300887A (ja) * 2001-02-05 2002-10-15 Ajinomoto Co Inc 発酵法によるｌ−グルタミンの製造法及びｌ−グルタミン生産菌
JP2007097573A (ja) * 2004-12-28 2007-04-19 Ajinomoto Co Inc Ｌ−グルタミン酸生産菌及びｌ−グルタミン酸の製造方法
WO2007113127A1 (en) * 2006-03-30 2007-10-11 Basf Se Process for the production of cadaverine
JP2007283565A (ja) * 2006-04-14 2007-11-01 Mitsubishi Plastics Ind Ltd ガスバリア性フィルム、並びに該フィルムを用いた包装材及び包装体
WO2007130521A2 (en) * 2006-05-02 2007-11-15 E. I. Du Pont De Nemours And Company Fermentive production of four carbon alcohols

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
JPN6013041680; Ｂｉｏｔｅｃｈｎｏｌｏｇｙ　Ｌｅｔｔｅｒｓ ｖｏｌ．２７, 2005, ｐ．１６８１-１６８４ *

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2020065946A (ja) * 2018-10-19 2020-04-30 水澤化学工業株式会社 γ−アミノ酪酸捕集剤
JP7113720B2 (ja) 2018-10-19 2022-08-05 水澤化学工業株式会社 γ－アミノ酪酸捕集剤

Also Published As

Publication number Publication date
US20140256005A1 (en) 2014-09-11
WO2009103547A1 (en) 2009-08-27
US20100324258A1 (en) 2010-12-23
EP2247724A1 (en) 2010-11-10
KR20110004368A (ko) 2011-01-13
CN101945997A (zh) 2011-01-12
CN101945997B (zh) 2014-12-03
CN104357431A (zh) 2015-02-18
US8771998B2 (en) 2014-07-08
JP2015119707A (ja) 2015-07-02

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