JP2008523805A5 - - Google Patents
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- Publication number
- JP2008523805A5 JP2008523805A5 JP2007546589A JP2007546589A JP2008523805A5 JP 2008523805 A5 JP2008523805 A5 JP 2008523805A5 JP 2007546589 A JP2007546589 A JP 2007546589A JP 2007546589 A JP2007546589 A JP 2007546589A JP 2008523805 A5 JP2008523805 A5 JP 2008523805A5
- Authority
- JP
- Japan
- Prior art keywords
- lps
- bordetella
- deacylated
- polypeptide
- composition
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000002158 endotoxin Substances 0.000 claims 16
- 229920006008 lipopolysaccharide Polymers 0.000 claims 16
- 229920001184 polypeptide Polymers 0.000 claims 7
- 102000004196 processed proteins & peptides Human genes 0.000 claims 7
- 108090000765 processed proteins & peptides Proteins 0.000 claims 7
- 241000894006 Bacteria Species 0.000 claims 4
- 241000588807 Bordetella Species 0.000 claims 4
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 4
- 241000588832 Bordetella pertussis Species 0.000 claims 3
- 108020004414 DNA Proteins 0.000 claims 3
- 201000005702 Pertussis Diseases 0.000 claims 3
- 238000004519 manufacturing process Methods 0.000 claims 3
- 238000000034 method Methods 0.000 claims 3
- 208000018150 Bordetella infection Diseases 0.000 claims 2
- 125000003275 alpha amino acid group Chemical group 0.000 claims 2
- 239000003795 chemical substances by application Substances 0.000 claims 2
- 239000012528 membrane Substances 0.000 claims 2
- 230000001225 therapeutic effect Effects 0.000 claims 2
- 150000001413 amino acids Chemical class 0.000 claims 1
- 230000015572 biosynthetic process Effects 0.000 claims 1
- 229940030156 cell vaccine Drugs 0.000 claims 1
- 238000012258 culturing Methods 0.000 claims 1
- 230000020176 deacylation Effects 0.000 claims 1
- 238000005947 deacylation reaction Methods 0.000 claims 1
- 230000000694 effects Effects 0.000 claims 1
- 230000002255 enzymatic effect Effects 0.000 claims 1
- 230000028993 immune response Effects 0.000 claims 1
- 238000000338 in vitro Methods 0.000 claims 1
- 239000000411 inducer Substances 0.000 claims 1
- GZQKNULLWNGMCW-PWQABINMSA-N lipid A (E. coli) Chemical class O1[C@H](CO)[C@@H](OP(O)(O)=O)[C@H](OC(=O)C[C@@H](CCCCCCCCCCC)OC(=O)CCCCCCCCCCCCC)[C@@H](NC(=O)C[C@@H](CCCCCCCCCCC)OC(=O)CCCCCCCCCCC)[C@@H]1OC[C@@H]1[C@@H](O)[C@H](OC(=O)C[C@H](O)CCCCCCCCCCC)[C@@H](NC(=O)C[C@H](O)CCCCCCCCCCC)[C@@H](OP(O)(O)=O)O1 GZQKNULLWNGMCW-PWQABINMSA-N 0.000 claims 1
- 150000002632 lipids Chemical class 0.000 claims 1
- 230000003449 preventive effect Effects 0.000 claims 1
- 230000000069 prophylactic effect Effects 0.000 claims 1
- 238000011084 recovery Methods 0.000 claims 1
- 230000001105 regulatory effect Effects 0.000 claims 1
- 241000894007 species Species 0.000 claims 1
- 238000003786 synthesis reaction Methods 0.000 claims 1
- 230000002103 transcriptional effect Effects 0.000 claims 1
- 229960005486 vaccine Drugs 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP04078445 | 2004-12-17 | ||
| EP04078445.6 | 2004-12-17 | ||
| PCT/NL2005/050081 WO2006065139A2 (en) | 2004-12-17 | 2005-12-16 | Deacylation of lps in gram negative bacteria |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2008523805A JP2008523805A (ja) | 2008-07-10 |
| JP2008523805A5 true JP2008523805A5 (enExample) | 2009-03-26 |
| JP5378685B2 JP5378685B2 (ja) | 2013-12-25 |
Family
ID=34928754
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007546589A Expired - Fee Related JP5378685B2 (ja) | 2004-12-17 | 2005-12-16 | グラム陰性菌におけるｌｐｓの脱アシル化 |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US8048433B2 (enExample) |
| EP (1) | EP1828378B1 (enExample) |
| JP (1) | JP5378685B2 (enExample) |
| CN (1) | CN101203605B (enExample) |
| AU (1) | AU2005317304B2 (enExample) |
| BR (1) | BRPI0519923A8 (enExample) |
| CA (1) | CA2590906C (enExample) |
| DK (1) | DK1828378T3 (enExample) |
| ES (1) | ES2493440T3 (enExample) |
| MX (1) | MX2007007288A (enExample) |
| NO (1) | NO340331B1 (enExample) |
| NZ (1) | NZ555889A (enExample) |
| PL (1) | PL1828378T3 (enExample) |
| PT (1) | PT1828378E (enExample) |
| WO (1) | WO2006065139A2 (enExample) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2681924C (en) * | 2007-03-26 | 2019-12-31 | De Staat Der Nederlanden, Vert. Door De Minster Van Vws | Improved vaccines against bordetella pertussis based on lps glycosyltransferase mutants |
| US20140037680A1 (en) | 2012-08-06 | 2014-02-06 | Glaxosmithkline Biologicals, S.A. | Novel method |
| JP2015525794A (ja) | 2012-08-06 | 2015-09-07 | グラクソスミスクライン バイオロジカルズ ソシエテ アノニム | 乳児においてｒｓｖ及び百日咳菌に対する免疫応答を惹起するための方法 |
| US11052142B2 (en) | 2013-06-04 | 2021-07-06 | Petr G. Aparin | Modified endotoxic bacteria lipopolysaccharide (variants), combination of modified lipopolysaccharides (variants) and, containing same, a vaccine (variants) and a pharmaceutical composition (variants) |
| US20160120967A1 (en) | 2013-06-04 | 2016-05-05 | Petr Gennadievich Aparin | Modified endotoxic bacteria lipopolysaccharide (variants), combination of modified lipopolysaccharides (variants) and, containing same, a vaccine (variants) and a pharmaceutical composition (variants) |
| CA2919773A1 (en) | 2013-08-05 | 2015-02-12 | Glaxosmithkline Biologicals S.A. | Combination immunogenic compositions |
| WO2015179270A2 (en) | 2014-05-19 | 2015-11-26 | Board Of Regents, The University Of Texas System | Combinatorial platform for the display of surface adjuvants and antigens |
| CN104388368B (zh) * | 2014-10-30 | 2017-02-15 | 四川农业大学 | 一株低内毒素大肠杆菌原核表达工程菌突变株及构建方法 |
| KR102888356B1 (ko) * | 2016-01-28 | 2025-11-19 | 인트라백 비.브이. | 변형된 테트라-아실화된 나이세리아 lps |
| CN105567620B (zh) * | 2016-01-29 | 2019-03-19 | 江南大学 | 一株产减毒类脂A的Cronobacter sakazakii突变株及其应用 |
| CN105695540A (zh) * | 2016-03-18 | 2016-06-22 | 辽宁成大生物股份有限公司 | 一种革兰氏阴性菌胞壁抗原的制备方法 |
| CA3055757A1 (en) * | 2017-03-13 | 2018-09-20 | De Staat Der Nederlanden, Vert. Door De Minister Van Vws, Ministerie Van Volksgezondheid, Welzijn En Sport | Bordetella vaccines comprising lps with reduced reactogenicity |
| US11744884B2 (en) * | 2017-05-15 | 2023-09-05 | University Of Maryland, Baltimore | Live Salmonella typhi vectors engineered to express heterologous outer membrane protein antigens and methods of use thereof |
| AU2018379236B2 (en) * | 2017-12-04 | 2025-02-27 | Intravacc B.V. | An improved process for producing outer membrane vesicles |
| WO2021228930A2 (en) * | 2020-05-14 | 2021-11-18 | Merck Patent Gmbh | Methods and compositions for purifying adeno associated virus particles or adenoviruses |
| EP4208472A1 (en) | 2020-09-04 | 2023-07-12 | Intravacc B.V. | Ompa mutations enhance omv production in bordetella pertussis |
| EP4169513A1 (en) | 2021-10-19 | 2023-04-26 | GlaxoSmithKline Biologicals S.A. | Adjuvant composition comprising sting agonists |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CH650681A5 (en) | 1981-08-14 | 1985-08-15 | Dso Pharmachim | Whooping cough vaccine |
| WO1989001976A1 (en) * | 1987-09-04 | 1989-03-09 | Amgen Inc. | Recombinant dna-derived bordetella toxin subunit analogs |
| EP0484621A3 (en) * | 1990-07-11 | 1992-08-26 | American Cyanamid Company | Efficacious vaccines against bordetella pertussis comprising a combination of individually purified pertussis antigens |
| HU219819B (hu) * | 1992-08-18 | 2001-08-28 | Dimminaco Ag/Sa/Ltd. | Izolált polinukleotidok, ezeket tartalmazó Bordetella bronchiseptica törzs, és Bordetella bronchiseptica elleni vakcina |
| ES2180758T3 (es) * | 1995-05-04 | 2003-02-16 | Aventis Pasteur | Vacunas de pertussis acelulares y metodos de preparacion de las mismas. |
| US6887483B2 (en) | 1995-12-01 | 2005-05-03 | University Of Iowa Research Foundation | Non-toxic mutants of pathogenic gram-negative bacteria |
| CA2284586C (en) * | 1997-04-01 | 2011-02-08 | Ribi Immunochem Research, Inc. | Aqueous immunologic adjuvant compositions of monophosphoryl lipid a |
| CA2264970A1 (en) | 1998-03-10 | 1999-09-10 | American Cyanamid Company | Antigenic conjugates of conserved lipolysaccharides of gram negative bacteria |
| DK1127137T4 (da) * | 1998-11-03 | 2014-02-10 | Nederlanden Staat | LPS med reduceret toksicitet fra genetisk modificerede gram-negative bakterier |
| US6531131B1 (en) * | 1999-08-10 | 2003-03-11 | The United States Of America As Represented By The Department Of Health And Human Services | Conjugate vaccine for Neisseria meningitidis |
| US20030113742A1 (en) * | 2001-04-20 | 2003-06-19 | University Of Iowa Research Foundation | Methods and compositions for the modulation of biofilm formation |
-
2005
- 2005-12-16 CN CN200580048420.6A patent/CN101203605B/zh not_active Expired - Fee Related
- 2005-12-16 NZ NZ555889A patent/NZ555889A/en not_active IP Right Cessation
- 2005-12-16 MX MX2007007288A patent/MX2007007288A/es active IP Right Grant
- 2005-12-16 BR BRPI0519923A patent/BRPI0519923A8/pt not_active Application Discontinuation
- 2005-12-16 US US11/722,034 patent/US8048433B2/en not_active Expired - Fee Related
- 2005-12-16 PL PL05815467T patent/PL1828378T3/pl unknown
- 2005-12-16 PT PT58154675T patent/PT1828378E/pt unknown
- 2005-12-16 ES ES05815467.5T patent/ES2493440T3/es not_active Expired - Lifetime
- 2005-12-16 CA CA2590906A patent/CA2590906C/en not_active Expired - Fee Related
- 2005-12-16 EP EP05815467.5A patent/EP1828378B1/en not_active Expired - Lifetime
- 2005-12-16 JP JP2007546589A patent/JP5378685B2/ja not_active Expired - Fee Related
- 2005-12-16 WO PCT/NL2005/050081 patent/WO2006065139A2/en not_active Ceased
- 2005-12-16 AU AU2005317304A patent/AU2005317304B2/en not_active Ceased
- 2005-12-16 DK DK05815467.5T patent/DK1828378T3/da active
-
2007
- 2007-06-18 NO NO20073088A patent/NO340331B1/no not_active IP Right Cessation
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