MX2007007288A - Desacilacion de lps en bacterias gram negativas. - Google Patents

Desacilacion de lps en bacterias gram negativas.

Info

Publication number
MX2007007288A
MX2007007288A MX2007007288A MX2007007288A MX2007007288A MX 2007007288 A MX2007007288 A MX 2007007288A MX 2007007288 A MX2007007288 A MX 2007007288A MX 2007007288 A MX2007007288 A MX 2007007288A MX 2007007288 A MX2007007288 A MX 2007007288A
Authority
MX
Mexico
Prior art keywords
gram negative
lps
negative bacteria
deacylation
bordetella
Prior art date
Application number
MX2007007288A
Other languages
English (en)
Inventor
Peter Andre Van Der Ley
Johannes Petrus Maria Tommassen
Jeroen Johannes Gerardus
Original Assignee
Nvi Nl Vaccininst
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nvi Nl Vaccininst filed Critical Nvi Nl Vaccininst
Publication of MX2007007288A publication Critical patent/MX2007007288A/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/099—Bordetella
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/235—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Bordetella (G)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
    • C12N9/18—Carboxylic ester hydrolases (3.1.1)

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Wood Science & Technology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Microbiology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biotechnology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Biomedical Technology (AREA)
  • Biophysics (AREA)
  • General Engineering & Computer Science (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

La presente invencion proporciona polipeptidos gram negativos novedosos que exhiben actividad 3-O-desacilasa del lipido A y son capaces de modificar y/o destoxificar LPS gram negativos. La presente invencion tambien proporciona bacterias gram negativas, lipopolisacaridos (LPS) de bacterias gram negativas y composiciones que comprenden los LPS, los cuales se proporcionan o se tratan con una actividad 3-O-desasilasa de acuerdo con la invencion, y los cuales se pueden utilizar para fines farmaceuticos y/o veterinarios, en particular para la preparacion de vacunas de celula total a acelulares, en contra de gram negativos patogenicos tales como por ejemplo, Bordetella pertusis, Bordetella parapertusis y Bordetella bronchiseptica.
MX2007007288A 2004-12-17 2005-12-16 Desacilacion de lps en bacterias gram negativas. MX2007007288A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP04078445 2004-12-17
PCT/NL2005/050081 WO2006065139A2 (en) 2004-12-17 2005-12-16 Deacylation of lps in gram negative bacteria

Publications (1)

Publication Number Publication Date
MX2007007288A true MX2007007288A (es) 2008-02-25

Family

ID=34928754

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2007007288A MX2007007288A (es) 2004-12-17 2005-12-16 Desacilacion de lps en bacterias gram negativas.

Country Status (15)

Country Link
US (1) US8048433B2 (es)
EP (1) EP1828378B1 (es)
JP (1) JP5378685B2 (es)
CN (1) CN101203605B (es)
AU (1) AU2005317304B2 (es)
BR (1) BRPI0519923A8 (es)
CA (1) CA2590906C (es)
DK (1) DK1828378T3 (es)
ES (1) ES2493440T3 (es)
MX (1) MX2007007288A (es)
NO (1) NO340331B1 (es)
NZ (1) NZ555889A (es)
PL (1) PL1828378T3 (es)
PT (1) PT1828378E (es)
WO (1) WO2006065139A2 (es)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT2134743E (pt) * 2007-03-26 2012-12-21 Nederlanden Staat Vacinas melhoradas contra bordotella pertussis baseadas nos mutantes do lps glicosiltransferase
JP2015525794A (ja) 2012-08-06 2015-09-07 グラクソスミスクライン バイオロジカルズ ソシエテ アノニム 乳児においてｒｓｖ及び百日咳菌に対する免疫応答を惹起するための方法
US20140037680A1 (en) 2012-08-06 2014-02-06 Glaxosmithkline Biologicals, S.A. Novel method
US11052142B2 (en) 2013-06-04 2021-07-06 Petr G. Aparin Modified endotoxic bacteria lipopolysaccharide (variants), combination of modified lipopolysaccharides (variants) and, containing same, a vaccine (variants) and a pharmaceutical composition (variants)
US20160120967A1 (en) 2013-06-04 2016-05-05 Petr Gennadievich Aparin Modified endotoxic bacteria lipopolysaccharide (variants), combination of modified lipopolysaccharides (variants) and, containing same, a vaccine (variants) and a pharmaceutical composition (variants)
EP3492097A1 (en) 2013-08-05 2019-06-05 GlaxoSmithKline Biologicals S.A. Combination immunogenic compositions
WO2015179270A2 (en) 2014-05-19 2015-11-26 Board Of Regents, The University Of Texas System Combinatorial platform for the display of surface adjuvants and antigens
CN104388368B (zh) * 2014-10-30 2017-02-15 四川农业大学 一株低内毒素大肠杆菌原核表达工程菌突变株及构建方法
CA3011282A1 (en) * 2016-01-28 2017-08-03 De Staat Der Nederlanden, Vert. Door De Minister Van Vws, Ministerie Van Volksgezondheid, Welzijn En Sport Modified tetra-acylated neisserial lps
CN105567620B (zh) * 2016-01-29 2019-03-19 江南大学 一株产减毒类脂A的Cronobacter sakazakii突变株及其应用
CN105695540A (zh) * 2016-03-18 2016-06-22 辽宁成大生物股份有限公司 一种革兰氏阴性菌胞壁抗原的制备方法
CA3055757A1 (en) 2017-03-13 2018-09-20 De Staat Der Nederlanden, Vert. Door De Minister Van Vws, Ministerie Van Volksgezondheid, Welzijn En Sport Bordetella vaccines comprising lps with reduced reactogenicity
CA3063419A1 (en) * 2017-05-15 2018-11-22 University Of Maryland, Baltimore Live salmonella typhi vectors engineered to express heterologous outer membrane protein antigens and methods of use thereof
KR20200136361A (ko) * 2017-12-04 2020-12-07 드 슈타트 데르 네덜란덴, 베르테겐부어디그트 두어 드 미니스터 반 베이웨이에스, 미니스테리 반 폭스겐트존하이트, 벨지인 엔 스포츠 외막 소포의 생성을 위한 개선된 방법
EP4208472A1 (en) 2020-09-04 2023-07-12 Intravacc B.V. Ompa mutations enhance omv production in bordetella pertussis
EP4169513A1 (en) 2021-10-19 2023-04-26 GlaxoSmithKline Biologicals S.A. Adjuvant composition comprising sting agonists

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH650681A5 (en) 1981-08-14 1985-08-15 Dso Pharmachim Whooping cough vaccine
WO1989001976A1 (en) * 1987-09-04 1989-03-09 Amgen Inc. Recombinant dna-derived bordetella toxin subunit analogs
EP0484621A3 (en) * 1990-07-11 1992-08-26 American Cyanamid Company Efficacious vaccines against bordetella pertussis comprising a combination of individually purified pertussis antigens
EP0656948B1 (en) * 1992-08-18 2004-03-31 Dimminaco Ag Bordetella bronchiseptica vaccine
ES2182971T3 (es) * 1995-05-04 2003-03-16 Aventis Pasteur Vacunas de pertussis acelulares y metodos de preparacion de las mismas.
US6887483B2 (en) * 1995-12-01 2005-05-03 University Of Iowa Research Foundation Non-toxic mutants of pathogenic gram-negative bacteria
PT971739E (pt) * 1997-04-01 2004-12-31 Corixa Corp Composicoes aquosas de adjuvante imunologico de monofosforil lipido a
CA2264970A1 (en) 1998-03-10 1999-09-10 American Cyanamid Company Antigenic conjugates of conserved lipolysaccharides of gram negative bacteria
DE69838460T3 (de) * 1998-11-03 2014-04-30 De Staat Der Nederlanden Vertegenwoordigd Door De Minister Van Welzijn, Volksgezondheid En Cultuur LPS mit reduzierter Toxizität von genetisch modifizierten Gram-Negativen Bakterien
US6531131B1 (en) * 1999-08-10 2003-03-11 The United States Of America As Represented By The Department Of Health And Human Services Conjugate vaccine for Neisseria meningitidis
WO2002085295A2 (en) * 2001-04-20 2002-10-31 The University Of Iowa Research Foundation Methods and compositions for the modulation of biofilm formation

Also Published As

Publication number Publication date
NZ555889A (en) 2009-07-31
CA2590906A1 (en) 2006-06-22
CN101203605A (zh) 2008-06-18
PL1828378T3 (pl) 2014-10-31
NO20073088L (no) 2007-09-17
PT1828378E (pt) 2014-10-10
AU2005317304B2 (en) 2011-06-23
CA2590906C (en) 2017-01-03
CN101203605B (zh) 2016-01-27
US8048433B2 (en) 2011-11-01
WO2006065139A2 (en) 2006-06-22
NO340331B1 (no) 2017-04-03
JP5378685B2 (ja) 2013-12-25
EP1828378B1 (en) 2014-06-11
DK1828378T3 (da) 2014-09-01
EP1828378A2 (en) 2007-09-05
ES2493440T3 (es) 2014-09-11
US20080274145A1 (en) 2008-11-06
JP2008523805A (ja) 2008-07-10
WO2006065139A3 (en) 2006-10-19
BRPI0519923A2 (pt) 2009-08-11
AU2005317304A1 (en) 2006-06-22
BRPI0519923A8 (pt) 2018-01-23

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