NO20073088L - Deacylering av LPS i gramnegative bakterier - Google Patents
Deacylering av LPS i gramnegative bakterierInfo
- Publication number
- NO20073088L NO20073088L NO20073088A NO20073088A NO20073088L NO 20073088 L NO20073088 L NO 20073088L NO 20073088 A NO20073088 A NO 20073088A NO 20073088 A NO20073088 A NO 20073088A NO 20073088 L NO20073088 L NO 20073088L
- Authority
- NO
- Norway
- Prior art keywords
- gram
- lps
- negative
- negative bacteria
- deacylation
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/099—Bordetella
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/235—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Bordetella (G)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
- C12N9/18—Carboxylic ester hydrolases (3.1.1)
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Microbiology (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Biochemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Molecular Biology (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Mycology (AREA)
- Epidemiology (AREA)
- Biomedical Technology (AREA)
- Biophysics (AREA)
- General Chemical & Material Sciences (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Enzymes And Modification Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Den foreliggende oppfinnelse tilveiebringer Gram-negative polypeptider som oppviser lipid A 3-0-deacylaseaktivitet og som er i stand til å modifisere og/eller detoksifisere gram-negativ LPS. Foreliggende oppfinnelse tilveiebringer også Gram-negative bakterier, Gram-negative bakterielle lipopolysakkarider (LPS) og sammensetninger som omfatter LPS, som er tilveiebrakt med eller behandlet med 3-0-deacylaseaktivitet i samsvar med oppfinnelsen og som kan anvendes for farmasøytiske og veterinæriske formål, spesielt for fremstilling av helcelle eller acellulære vaksiner mot patogent Gram-negative så som Bordetella pertussis, Bordetella parapertussis og Bordetella bronchiseptica.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP04078445 | 2004-12-17 | ||
| PCT/NL2005/050081 WO2006065139A2 (en) | 2004-12-17 | 2005-12-16 | Deacylation of lps in gram negative bacteria |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| NO20073088L true NO20073088L (no) | 2007-09-17 |
| NO340331B1 NO340331B1 (no) | 2017-04-03 |
Family
ID=34928754
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO20073088A NO340331B1 (no) | 2004-12-17 | 2007-06-18 | Deacylering av LPS i gramnegative bakterier |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US8048433B2 (no) |
| EP (1) | EP1828378B1 (no) |
| JP (1) | JP5378685B2 (no) |
| CN (1) | CN101203605B (no) |
| AU (1) | AU2005317304B2 (no) |
| BR (1) | BRPI0519923A8 (no) |
| CA (1) | CA2590906C (no) |
| DK (1) | DK1828378T3 (no) |
| ES (1) | ES2493440T3 (no) |
| MX (1) | MX2007007288A (no) |
| NO (1) | NO340331B1 (no) |
| NZ (1) | NZ555889A (no) |
| PL (1) | PL1828378T3 (no) |
| PT (1) | PT1828378E (no) |
| WO (1) | WO2006065139A2 (no) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9296995B2 (en) * | 2007-03-26 | 2016-03-29 | De Staat Der Nederlanden, Vert. Door De Minister Van Vws | Vaccines against Bordetella pertussis based on LPS glycosyltransferase mutants |
| JP2015525794A (ja) | 2012-08-06 | 2015-09-07 | グラクソスミスクライン バイオロジカルズ ソシエテ アノニム | 乳児においてｒｓｖ及び百日咳菌に対する免疫応答を惹起するための方法 |
| US20140037680A1 (en) | 2012-08-06 | 2014-02-06 | Glaxosmithkline Biologicals, S.A. | Novel method |
| KR102125600B1 (ko) | 2013-06-04 | 2020-06-23 | 페트르 젠나디에비치 아파린 | 개질된 내독성 세균 지질다당류(변형체), 개질된 지질다당류들(변형체들)의 조합물, 및 이를 함유한 백신(변형체) 및 약제 조성물(변형체) |
| US11052142B2 (en) | 2013-06-04 | 2021-07-06 | Petr G. Aparin | Modified endotoxic bacteria lipopolysaccharide (variants), combination of modified lipopolysaccharides (variants) and, containing same, a vaccine (variants) and a pharmaceutical composition (variants) |
| CN105555304A (zh) | 2013-08-05 | 2016-05-04 | 葛兰素史密丝克莱恩生物有限公司 | 联合免疫原性组合物 |
| WO2015179270A2 (en) | 2014-05-19 | 2015-11-26 | Board Of Regents, The University Of Texas System | Combinatorial platform for the display of surface adjuvants and antigens |
| CN104388368B (zh) * | 2014-10-30 | 2017-02-15 | 四川农业大学 | 一株低内毒素大肠杆菌原核表达工程菌突变株及构建方法 |
| US11389520B2 (en) * | 2016-01-28 | 2022-07-19 | Intravacc B.V. | Modified tetra-acylated neisserial LPS |
| CN105567620B (zh) * | 2016-01-29 | 2019-03-19 | 江南大学 | 一株产减毒类脂A的Cronobacter sakazakii突变株及其应用 |
| CN105695540A (zh) * | 2016-03-18 | 2016-06-22 | 辽宁成大生物股份有限公司 | 一种革兰氏阴性菌胞壁抗原的制备方法 |
| CA3055757A1 (en) * | 2017-03-13 | 2018-09-20 | De Staat Der Nederlanden, Vert. Door De Minister Van Vws, Ministerie Van Volksgezondheid, Welzijn En Sport | Bordetella vaccines comprising lps with reduced reactogenicity |
| US11744884B2 (en) * | 2017-05-15 | 2023-09-05 | University Of Maryland, Baltimore | Live Salmonella typhi vectors engineered to express heterologous outer membrane protein antigens and methods of use thereof |
| CN111433348B (zh) * | 2017-12-04 | 2024-07-02 | Intravacc有限责任公司 | 一种改良的生产外膜囊泡的方法 |
| CN116438193A (zh) | 2020-09-04 | 2023-07-14 | Intravacc有限责任公司 | OmpA突变增强百日咳博德特氏菌中OMV产生 |
| EP4169513A1 (en) | 2021-10-19 | 2023-04-26 | GlaxoSmithKline Biologicals S.A. | Adjuvant composition comprising sting agonists |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CH650681A5 (en) | 1981-08-14 | 1985-08-15 | Dso Pharmachim | Whooping cough vaccine |
| KR0168039B1 (ko) * | 1987-09-04 | 1999-01-15 | 로버트 디. 웨스트 | 재조합 dna에서 유도한 보르데텔라 외독소 소단위체의 유사체 및 그를 포함하는 백신 |
| EP0484621A3 (en) * | 1990-07-11 | 1992-08-26 | American Cyanamid Company | Efficacious vaccines against bordetella pertussis comprising a combination of individually purified pertussis antigens |
| EP0656948B1 (en) * | 1992-08-18 | 2004-03-31 | Dimminaco Ag | Bordetella bronchiseptica vaccine |
| EP1234579A1 (en) * | 1995-05-04 | 2002-08-28 | Aventis Pasteur Limited | Acellular Pertussis Vaccines and Methods of Preparation Thereof |
| US6887483B2 (en) | 1995-12-01 | 2005-05-03 | University Of Iowa Research Foundation | Non-toxic mutants of pathogenic gram-negative bacteria |
| EP0971739B1 (en) * | 1997-04-01 | 2004-10-06 | Corixa Corporation | Aqueous immunologic adjuvant compositions of monophosphoryl lipid a |
| CA2264970A1 (en) | 1998-03-10 | 1999-09-10 | American Cyanamid Company | Antigenic conjugates of conserved lipolysaccharides of gram negative bacteria |
| AU762369B2 (en) * | 1998-11-03 | 2003-06-26 | De Staat Der Nederlanden Vertegenwoordigd Door De Minister Van Welzijn, Volksgezonheid En Cultuur | LPS with reduced toxicity from genetically modified gram negative bacteria |
| US6531131B1 (en) * | 1999-08-10 | 2003-03-11 | The United States Of America As Represented By The Department Of Health And Human Services | Conjugate vaccine for Neisseria meningitidis |
| WO2002085295A2 (en) * | 2001-04-20 | 2002-10-31 | The University Of Iowa Research Foundation | Methods and compositions for the modulation of biofilm formation |
-
2005
- 2005-12-16 DK DK05815467.5T patent/DK1828378T3/da active
- 2005-12-16 US US11/722,034 patent/US8048433B2/en not_active Expired - Fee Related
- 2005-12-16 AU AU2005317304A patent/AU2005317304B2/en not_active Ceased
- 2005-12-16 JP JP2007546589A patent/JP5378685B2/ja not_active Expired - Fee Related
- 2005-12-16 MX MX2007007288A patent/MX2007007288A/es active IP Right Grant
- 2005-12-16 PT PT58154675T patent/PT1828378E/pt unknown
- 2005-12-16 BR BRPI0519923A patent/BRPI0519923A8/pt not_active Application Discontinuation
- 2005-12-16 CA CA2590906A patent/CA2590906C/en not_active Expired - Fee Related
- 2005-12-16 CN CN200580048420.6A patent/CN101203605B/zh not_active Expired - Fee Related
- 2005-12-16 EP EP05815467.5A patent/EP1828378B1/en not_active Not-in-force
- 2005-12-16 PL PL05815467T patent/PL1828378T3/pl unknown
- 2005-12-16 NZ NZ555889A patent/NZ555889A/en not_active IP Right Cessation
- 2005-12-16 WO PCT/NL2005/050081 patent/WO2006065139A2/en active Application Filing
- 2005-12-16 ES ES05815467.5T patent/ES2493440T3/es active Active
-
2007
- 2007-06-18 NO NO20073088A patent/NO340331B1/no not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| US20080274145A1 (en) | 2008-11-06 |
| EP1828378A2 (en) | 2007-09-05 |
| AU2005317304B2 (en) | 2011-06-23 |
| DK1828378T3 (da) | 2014-09-01 |
| MX2007007288A (es) | 2008-02-25 |
| BRPI0519923A8 (pt) | 2018-01-23 |
| CN101203605B (zh) | 2016-01-27 |
| JP2008523805A (ja) | 2008-07-10 |
| EP1828378B1 (en) | 2014-06-11 |
| WO2006065139A3 (en) | 2006-10-19 |
| CA2590906C (en) | 2017-01-03 |
| WO2006065139A2 (en) | 2006-06-22 |
| CN101203605A (zh) | 2008-06-18 |
| JP5378685B2 (ja) | 2013-12-25 |
| US8048433B2 (en) | 2011-11-01 |
| PL1828378T3 (pl) | 2014-10-31 |
| NO340331B1 (no) | 2017-04-03 |
| ES2493440T3 (es) | 2014-09-11 |
| CA2590906A1 (en) | 2006-06-22 |
| BRPI0519923A2 (pt) | 2009-08-11 |
| AU2005317304A1 (en) | 2006-06-22 |
| PT1828378E (pt) | 2014-10-10 |
| NZ555889A (en) | 2009-07-31 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| NO20073088L (no) | Deacylering av LPS i gramnegative bakterier | |
| CY1119753T1 (el) | Λυσινικη αλφα αζτρεοναμη | |
| BRPI0411505A (pt) | uso de um composto, método para modular a resposta imune de um indivìduo, composição farmacêutica, vacina, complexo, e, kit para a captura de uma molécula biologicamente ativa | |
| ECSP055725A (es) | Formulaciones nutricionales que contienen sustancias simbióticas | |
| NO20072906L (no) | Metode for forhindring eller behandling av respiratoriske infeksjoner og akutt otitis media hos barn | |
| BR9900972A (pt) | Uso de uma associação de lactobacilos para a preparação de uma composição para tratamento de vaginoses e vaginites, e composições farmacêuticas assim preparadas. | |
| NO20064584L (no) | Tetrahydropyridoindolderivater | |
| SG164344A1 (en) | Immunogens from uropathogenic escherichia coli | |
| DK1648505T3 (da) | Quil A-fraktion med lav toksicitet og anvendelse deraf | |
| WO2007084633A3 (en) | Viable non-toxic gram negative bacteria | |
| NO20075069L (no) | Vaksiner mot Clamydia infeksjon | |
| DK2561880T3 (da) | Mælkesyrebakterier som priobiotiske stammer og sammensætninger dermed | |
| NO20062605L (no) | Farmasoytisk formulering inneholdende smakssubstanser med forbedrede farmasoytiske egenskaper | |
| JP2008523805A5 (no) | ||
| DK2054431T3 (da) | Konformere af bakterielle adhæsiner | |
| BRPI0518080A (pt) | bactéria transformada ou uma progênie da mesma, método para transformar uma bactéria, mycobacterium transformada ou uma progênie da mesma e vacina compreendendo uma mycobacterium transformada ou uma progênie da mesma | |
| NO20062878L (no) | Isoflavonoidpromedikamenter, terapeutiske sammensetninger derav og terapeutiske fremgangsmater som innbefatter de samme | |
| DE602005016548D1 (de) | Silikonvesikel | |
| HK1083296A1 (en) | Enteral composition for the prevention and/or treatment of sepsis | |
| IL156942A0 (en) | Compounds, pharmaceutical compositions and methods for treatment of bacteremia and/or septicemia | |
| ATE550647T1 (de) | Auflösungszusammensetzung zur untersuchung von arzneistofflöslichkeit | |
| ATE544471T1 (de) | Zusammensetzung mit iscom-teilchen und lebenden mikroorganismen | |
| MY146444A (en) | Benzooxazol-2-one derivatives as inhibitors of lipases and phospholipases | |
| EA200400197A1 (ru) | Способы получения поливалентных бактериофагов для лечения бактериальных инфекций | |
| BRPI0407176B8 (pt) | composições compreendendo uma ou mais cepas de bifidobacterium e seus usos |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MM1K | Lapsed by not paying the annual fees |