DE69839699D1 - Vaginales lactobacillus-medikament - Google Patents

Vaginales lactobacillus-medikament

Info

Publication number
DE69839699D1
DE69839699D1 DE69839699T DE69839699T DE69839699D1 DE 69839699 D1 DE69839699 D1 DE 69839699D1 DE 69839699 T DE69839699 T DE 69839699T DE 69839699 T DE69839699 T DE 69839699T DE 69839699 D1 DE69839699 D1 DE 69839699D1
Authority
DE
Germany
Prior art keywords
medicament
vaginal
disclosed
medicant
vaginal lactobacillus
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69839699T
Other languages
English (en)
Inventor
Gerald L Chrisope
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Osel Inc
Original Assignee
Osel Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Osel Inc filed Critical Osel Inc
Application granted granted Critical
Publication of DE69839699D1 publication Critical patent/DE69839699D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/66Microorganisms or materials therefrom
    • A61K35/74Bacteria
    • A61K35/741Probiotics
    • A61K35/744Lactic acid bacteria, e.g. enterococci, pediococci, lactococci, streptococci or leuconostocs
    • A61K35/747Lactobacilli, e.g. L. acidophilus or L. brevis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/02Bacterial antigens
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/02Bacterial antigens
    • A61K39/09Lactobacillales, e.g. aerococcus, enterococcus, lactobacillus, lactococcus, streptococcus
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
    • A61P15/02Drugs for genital or sexual disorders; Contraceptives for disorders of the vagina
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/14Antivirals for RNA viruses
    • A61P31/18Antivirals for RNA viruses for HIV
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00Antiparasitic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00Antiparasitic agents
    • A61P33/02Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20Bacteria; Culture media therefor
    • C12N1/205Bacterial isolates
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N11/00Carrier-bound or immobilised enzymes; Carrier-bound or immobilised microbial cells; Preparation thereof
    • C12N11/02Enzymes or microbial cells immobilised on or in an organic carrier
    • C12N11/10Enzymes or microbial cells immobilised on or in an organic carrier the carrier being a carbohydrate
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/51Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/52Bacterial cells; Fungal cells; Protozoal cells
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/54Medicinal preparations containing antigens or antibodies characterised by the route of administration
    • A61K2039/541Mucosal route
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12RINDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00Microorganisms ; Processes using microorganisms
    • C12R2001/01Bacteria or Actinomycetales ; using bacteria or Actinomycetales
    • C12R2001/225Lactobacillus

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Organic Chemistry (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Microbiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Mycology (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Epidemiology (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Virology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Reproductive Health (AREA)
  • Endocrinology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Gynecology & Obstetrics (AREA)
  • AIDS & HIV (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicinal Preparation (AREA)
DE69839699T 1997-04-11 1998-04-10 Vaginales lactobacillus-medikament Expired - Lifetime DE69839699D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/834,649 US6093394A (en) 1997-04-11 1997-04-11 Vaginal lactobacillus medicant
PCT/US1998/007510 WO1998046261A1 (en) 1997-04-11 1998-04-10 Vaginal lactobacillus medicant

Publications (1)

Publication Number Publication Date
DE69839699D1 true DE69839699D1 (de) 2008-08-21

Family

ID=25267456

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69839699T Expired - Lifetime DE69839699D1 (de) 1997-04-11 1998-04-10 Vaginales lactobacillus-medikament

Country Status (12)

Country Link
US (3) US6093394A (de)
EP (1) EP1011721B1 (de)
JP (2) JP2001523231A (de)
KR (1) KR20010006273A (de)
CN (1) CN1194758C (de)
AT (1) ATE400281T1 (de)
AU (1) AU732630B2 (de)
BR (1) BR9808520A (de)
CA (1) CA2285947C (de)
DE (1) DE69839699D1 (de)
NZ (2) NZ513835A (de)
WO (1) WO1998046261A1 (de)

Families Citing this family (99)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6093394A (en) * 1997-04-11 2000-07-25 Gynelogix, Inc. Vaginal lactobacillus medicant
GB9916790D0 (en) * 1999-07-16 1999-09-22 Health Lab Service Board Storage of microorganisms,cells and tissue
SE521022C2 (sv) * 2001-09-20 2003-09-23 Ellen Ab Mjölksyraproducerande bakterier för användning som probiotiska organismer i vaginan hos människa
GB0124580D0 (en) * 2001-10-12 2001-12-05 Univ Reading New composition
US7709026B2 (en) * 2001-10-29 2010-05-04 Columbia Laboratories, Inc. Low concentration of peroxide for treating or preventing vaginal infections
AU2003276822A1 (en) * 2002-03-08 2004-02-02 Osel, Inc. Lactobacilli expressing biologically active polypeptides and uses thereof
KR100993562B1 (ko) 2002-03-21 2010-11-11 비포단 에이/에스 락토바실러스 균주
DK1485463T3 (da) * 2002-03-21 2008-11-10 Bifodan As Lactobacillus stamme
US7829079B2 (en) * 2002-03-28 2010-11-09 Christian Hansen A/S Lactobacillus iners for the enhancement of urogenital health
JP2004067599A (ja) * 2002-08-07 2004-03-04 Kunihiko Tominaga 腟内洗浄剤
AT413334B (de) * 2002-12-23 2006-02-15 Belihart Josephine Feste darreichungsformen mit lebenden milchsäurebakterien
US20040126369A1 (en) * 2002-12-30 2004-07-01 Richard Payne Delivery of peroxide-generating enzymes to the vaginal tract
US20050095660A1 (en) * 2003-10-31 2005-05-05 Unibio, S.R.I. Enzyme activities and pH tests for the determination of the risk of obstetric and gynecologic complications in samples of body fluids of women
ES2237732T3 (es) 2003-11-03 2005-08-01 Peter-Hansen Volkmann Composicion para el cuidado vaginal.
GB2408750B (en) * 2003-12-02 2008-12-10 Arthur A Codd Preservation of biological material
US7125963B2 (en) * 2004-03-03 2006-10-24 En N Tech Inc Treatments for contaminant reduction in lactoferrin preparations and lactoferrin containing compositions
AU2005269773B2 (en) * 2004-07-23 2008-01-31 Femaceuticals, Llc Mini pad for reducing inflammation of the vulva and method of making the same
SE528382C2 (sv) * 2004-10-05 2006-10-31 Probi Ab Probiotiska lactobacillusstammar för förbättrad vaginal hälsa
WO2006045347A1 (en) * 2004-10-22 2006-05-04 Medinova Ag Lactobacillus helveticus strain useful in the treatment or prevention of infections caused by urogenital pathogens
EP1802318A1 (de) * 2004-10-22 2007-07-04 Medinova AG Milchsäurebakterien-stämme gegen gastrointestinale erreger und diese enthaltende zusammensetzungen
US20060106117A1 (en) * 2004-11-12 2006-05-18 Kimberly-Clark Worldwide, Inc. Compound and method for prevention and/or treatment of vaginal infections
US7619008B2 (en) * 2004-11-12 2009-11-17 Kimberly-Clark Worldwide, Inc. Xylitol for treatment of vaginal infections
US20060217446A1 (en) * 2005-03-28 2006-09-28 Kimberly-Clark Worldwide, Inc. Method for preventing and/or treating trichomonas vaginitis
US20060223765A1 (en) * 2005-03-30 2006-10-05 Kimberly-Clark Worldwide, Inc. Method for inhibiting and/or treating vaginal infection
US7786176B2 (en) * 2005-07-29 2010-08-31 Kimberly-Clark Worldwide, Inc. Vaginal treatment composition containing xylitol
JP2009503098A (ja) * 2005-08-04 2009-01-29 フェマシューティカルズ リミテッド ライアビリティ カンパニー おむつかぶれおよび同等物などの皮膚炎を治療するための方法
US20070082035A1 (en) 2005-10-06 2007-04-12 New York Blood Center, Inc. Anti-infective hygiene products based on cellulose acetate phthalate
AU2005339318A1 (en) 2005-12-22 2007-06-28 Sca Hygiene Products Ab Absorbent article
US8399012B2 (en) * 2006-04-17 2013-03-19 Kimberly-Clark Worldwide, Inc. Degradable therapeutic delivery device
AU2006350773A1 (en) 2006-11-17 2008-05-22 Sca Hygiene Products Ab Sanitary article comprising a microbe-inhibiting composition
BRPI0622146B1 (pt) * 2006-11-17 2016-08-23 Sca Hygiene Prod Ab tecido higiênico compreendendo uma composição inibidora de micróbio
WO2008060198A1 (en) 2006-11-17 2008-05-22 Sca Hygiene Products Ab Lactobacillus fermentum ess-1, dsm17851 and its use for the treatment and/or prevention of candidiasis and urinary tracrinfections
ITMI20062286A1 (it) * 2006-11-28 2008-05-29 Anidral Srl Una composizione per la somministrazione di principi biologicamente attivi in ambito ginecologico e rettale nonche' i suoi usi
US20110066137A1 (en) * 2007-12-18 2011-03-17 Osel, Inc. Applicator for applying powder formulations and uses thereof
US8642029B2 (en) 2008-03-31 2014-02-04 Osel, Inc. Transiently buffered Lactobacillus preparations and use thereof
ITMI20080949A1 (it) * 2008-05-22 2009-11-23 Sinclair Pharma Srl Nuovo ceppo del genere lactobacillus e formulazioni farmaceutiche topiche che lo contengono
EP2206506A1 (de) 2008-12-18 2010-07-14 Bracco Imaging S.p.A Probiotische Formulierungen
US7888062B1 (en) 2010-02-01 2011-02-15 Microbios, Inc. Process and composition for the manufacture of a microbial-based product
US8445226B2 (en) 2010-02-01 2013-05-21 Microbios, Inc. Process and composition for the manufacture of a microbial-based product
IL208820A0 (en) 2010-10-19 2011-01-31 Rachel Teitelbaum Biologic female contraceptives
TWI401086B (zh) * 2010-07-20 2013-07-11 Univ China Medical 胚芽乳酸桿菌及其用途
US9034593B2 (en) 2010-11-22 2015-05-19 Kimberly-Clark Worldwide, Inc. Vaginal indicator to detect biomarkers of good health
CZ302683B6 (cs) * 2010-12-15 2011-08-31 Valosun A.S. Probiotické kmeny Lactobacillus fermentum 16A/1 a Lactobacillus crispatus 13A a jejich využití k vaginální aplikaci
BR112014011198A2 (pt) * 2011-11-10 2017-04-25 Gen Mills Inc dispositivos e métodos para aumento da viabiliade de bactérias em forma de bastonete
LT2782584T (lt) 2011-11-23 2021-09-10 Therapeuticsmd, Inc. Natūralios kombinuotos pakaitinės hormonų terapijos kompozicijos ir gydymas
US9301920B2 (en) 2012-06-18 2016-04-05 Therapeuticsmd, Inc. Natural combination hormone replacement formulations and therapies
US9987222B2 (en) 2012-01-31 2018-06-05 Biosoma B.V. Method for administration of a probiotic
BR112014030984B1 (pt) 2012-06-13 2022-05-24 Evofem, Inc Composições e métodos para aumentar a eficácia de microbicidas contraceptivos
US10806740B2 (en) 2012-06-18 2020-10-20 Therapeuticsmd, Inc. Natural combination hormone replacement formulations and therapies
US20130338122A1 (en) 2012-06-18 2013-12-19 Therapeuticsmd, Inc. Transdermal hormone replacement therapies
US10806697B2 (en) 2012-12-21 2020-10-20 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
US20150196640A1 (en) 2012-06-18 2015-07-16 Therapeuticsmd, Inc. Progesterone formulations having a desirable pk profile
CN102716325A (zh) * 2012-06-28 2012-10-10 刘倩 一种治疗慢性盆腔炎的中药制剂
FR2992861B1 (fr) 2012-07-09 2014-10-17 Probionov Utilisation de thiosulfate pour potentialiser l'effet anti-pathogene des lactobacilles
FR2992973B1 (fr) 2012-07-09 2015-12-18 S P M D Nouvelle souche de lactobacillus crispatus
CN103074270A (zh) * 2012-11-15 2013-05-01 上海交大昂立股份有限公司 一种卷曲乳杆菌及其应用
US10568891B2 (en) 2012-12-21 2020-02-25 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
US10537581B2 (en) 2012-12-21 2020-01-21 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
US10471072B2 (en) 2012-12-21 2019-11-12 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
US11266661B2 (en) 2012-12-21 2022-03-08 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
US11246875B2 (en) 2012-12-21 2022-02-15 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
US9180091B2 (en) 2012-12-21 2015-11-10 Therapeuticsmd, Inc. Soluble estradiol capsule for vaginal insertion
CN103911308A (zh) * 2013-01-05 2014-07-09 欣力菲生物医药技术(天津)有限公司 卷曲乳杆菌菌株及其用途
CN104178437B (zh) * 2013-11-08 2016-08-24 苏州欧赛微科生物医药科技有限公司 一种卷曲乳杆菌及其在妇科疾病中的应用
KR101808972B1 (ko) 2013-11-08 2017-12-13 쑤저우 오셀 바이오-팜 컴퍼니 리미티드 락토바실러스 크리스파투스 및 이의 사용
CN114452298A (zh) 2013-12-19 2022-05-10 伊沃菲姆股份有限公司 使用基于藻酸的抗微生物化合物抑制炎症和疾病的组合物和方法
AU2015264003A1 (en) 2014-05-22 2016-11-17 Therapeuticsmd, Inc. Natural combination hormone replacement formulations and therapies
CN104293718B (zh) * 2014-10-11 2017-01-18 中国科学院微生物研究所 一株詹氏乳杆菌及其应用
KR101980252B1 (ko) 2015-05-26 2019-05-21 (주)투라인스 질증 치료용 조성물
US10328087B2 (en) 2015-07-23 2019-06-25 Therapeuticsmd, Inc. Formulations for solubilizing hormones
KR102587444B1 (ko) * 2015-09-29 2023-10-11 킴벌리-클라크 월드와이드, 인크. 미생물총의 건강한 균형을 유지하기 위한 상승 조성물
FR3048361B1 (fr) * 2016-03-01 2020-12-18 Biose Compositions pour le traitement des candidoses
KR101957211B1 (ko) * 2016-03-21 2019-03-13 한국생명공학연구원 조산 및 질염 원인균에 대한 항균 활성, 성병 원인 바이러스에 대한 항바이러스 활성 및 질내 부착능이 우수한 락토바실러스 속 균주 및 이의 용도
WO2017173071A1 (en) 2016-04-01 2017-10-05 Therapeuticsmd, Inc. Steroid hormone pharmaceutical composition
US10286077B2 (en) 2016-04-01 2019-05-14 Therapeuticsmd, Inc. Steroid hormone compositions in medium chain oils
KR101784847B1 (ko) * 2016-05-10 2017-10-13 주식회사 하우동천 질염 예방 및 치료용 유산균 함유 조성물 및 이의 용도
US20200069630A1 (en) * 2016-07-11 2020-03-05 Hennipen Life Sciences, Llc Compositions for sexually transmitted diseases
CN106176821A (zh) * 2016-08-31 2016-12-07 汪金小 一种微生态阴道菌剂及其制备方法和应用
CN109715181B (zh) * 2016-09-16 2022-11-08 杜邦营养生物科学有限公司 细菌
US11419835B2 (en) 2016-10-04 2022-08-23 Evofem, Inc. Method of treatment and prevention of bacterial vaginosis
CN110799198A (zh) * 2016-11-30 2020-02-14 普罗生物瑞士股份公司 用于稳定阴道液的酸度和氧化还原状态的基于合适的生化组合物的泌尿生殖器医疗设备制剂
KR102048690B1 (ko) * 2016-12-16 2019-11-26 (주)휴온스 안정성이 증진된 유산균 및 이의 제조방법
KR20190120235A (ko) 2017-02-28 2019-10-23 킴벌리-클라크 월드와이드, 인크. 미생물총의 건강한 균형을 유지하기 위한 상승적 조성물
EP3600365A4 (de) 2017-03-29 2021-01-06 President and Fellows of Harvard College Verfahren zur regelung der genexpression in einer zelle
DE102017113263A1 (de) 2017-06-16 2018-12-20 Lactopia GmbH Pharmazeutische Zusammensetzung enthaltend Bakterienstämme aus der Familie der Lactobacillaceae und Molke
CN107299065B (zh) * 2017-06-20 2020-02-14 广东强基药业有限公司 一种植物乳杆菌及其用于制备阴道抑菌药物的应用
US11278581B2 (en) 2017-07-07 2022-03-22 Osel, Inc. Use of vaginal Lactobacilli for improving the success rate of in vitro fertilization
EP3648778A4 (de) * 2017-07-07 2021-05-05 Osel, Inc. Hochwirksame stabile formulierungen von vaginalem lactobacillus
JP7330517B2 (ja) 2017-10-20 2023-08-22 プレジデント アンド フェローズ オブ ハーバード カレッジ 異種タンパク質産生のための人工分泌ペプチド
CN107815432B (zh) * 2017-12-07 2021-09-28 广州柏芳生物科技有限公司 一种人用灭活乳酸菌制剂及其用途
WO2020047203A2 (en) * 2018-08-30 2020-03-05 Osel, Inc. Bacteriocins to improve vaginal colonization of hydrogen peroxide producing lactobacillus for female reproductive health
GB201816425D0 (en) * 2018-10-09 2018-11-28 Tervisetehnoloogiate Arenduskeskus As Probiotics
KR102053744B1 (ko) * 2018-11-27 2019-12-09 한국생명공학연구원 질염 원인균에 대한 항균 활성 및 질내 부착능이 우수한 락토바실러스 속 균주 및 이의 용도
US11633405B2 (en) 2020-02-07 2023-04-25 Therapeuticsmd, Inc. Steroid hormone pharmaceutical formulations
AU2022222460A1 (en) 2021-02-19 2023-09-07 Imperial College Innovations Limited Lactobacillus crispatus composition for use in pregnant subjects
KR20230059753A (ko) * 2021-10-26 2023-05-03 일동제약(주) 락토바실러스 크리스파투스 균주 및 이를 포함하는 질염의 예방 또는 치료용 조성물
KR102683248B1 (ko) 2021-11-10 2024-07-10 장효영 질염 예방 및 치료를 위한 주입형 질 유산균 조성물
CN115337256A (zh) * 2022-06-24 2022-11-15 郑州伊品医药科技有限公司 一种含有益生菌的阴道栓塞及胶囊的制备方法
CN118308277B (zh) * 2024-06-12 2024-09-13 广州莱可福生物科技有限公司 一种卷曲乳杆菌及其应用

Family Cites Families (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK127268A (de) * 1970-01-12 1900-01-01
JPS52102419A (en) * 1976-02-23 1977-08-27 Seikenkai Lactic acid producing bacillus preparation
FI59925C (fi) * 1980-01-11 1981-11-10 Esko Viljo Nurmi Foerfarande foer framstaellning av ett bakteriepreparat anvaendbart foer foerhindrande av salmonellainfektion hos fjaederfae
JPS5953425A (ja) * 1982-09-22 1984-03-28 Meiji Milk Prod Co Ltd 「ちつ」
DK242083D0 (da) * 1983-05-27 1983-05-27 Hansens Chr Bio Syst Vaginalkapsler
US4592748A (en) * 1984-05-18 1986-06-03 Vortex Research Corp. Yoghurt based douche kit and assembly therefor
US4839281A (en) * 1985-04-17 1989-06-13 New England Medical Center Hospitals, Inc. Lactobacillus strains and methods of selection
US4956177A (en) * 1985-11-04 1990-09-11 Microlife Technics, Inc. Method for inhibiting fungi
US5804179A (en) * 1985-12-31 1998-09-08 Research Corporation Technologies, Inc. Lactobacillus compositions and methods for treating urinary tract infections
SU1364341A1 (ru) * 1986-09-18 1988-01-07 Центральный научно-исследовательский институт вакцин и сывороток им.И.И.Мечникова Способ получени бифидумбактерина
US4946791A (en) * 1986-10-02 1990-08-07 Bio Techniques Laboratories, Inc. Novel strain of Lactobacillus acidophilus
US4980164A (en) * 1986-10-02 1990-12-25 Bio Techniques Laboratories, Inc. Strains of lactobacillus for enhancing feed conversion efficiency
US4765978A (en) * 1986-12-16 1988-08-23 Schering Corporation Novel vaginal suppository
NO179479C (no) * 1988-03-11 1996-10-16 Teikoku Seiyaku Kk Fremgangsmåte for fremstilling av et intravaginalt farmasöytisk preparat
IT1227154B (it) * 1988-08-05 1991-03-19 A Tosi Farmaceutici S R L Nova Composizioni farmaceutiche per uso ginecologico a base di lattobacilli
US5296221A (en) * 1990-01-31 1994-03-22 Sani-Ei Sucrochemical Co., Ltd. Lactobacillus johnsonii ferm bp-2680 lactic acid bacteria preparations using the same and a process of manufacturing the preparations
JPH0421633A (ja) * 1990-05-17 1992-01-24 Saikon Medics:Kk 生体下口腔内有用微生物叢の維持管理法および維持管理組成物
JP3014148B2 (ja) * 1991-01-17 2000-02-28 株式会社ヤクルト本社 悪性腫瘍再発抑制剤
US5573765A (en) * 1991-02-19 1996-11-12 Mark S. Reinhard Composition and method for treatment of vaginal yeast infections
DE4109036C1 (de) * 1991-03-15 1992-08-13 Eckhard Dr. 1000 Berlin De Lauer
US5256425A (en) * 1991-08-19 1993-10-26 Bio Techniques Laboratories, Inc. Antibiotic resistant strain of lactobacillus acidophilus
GB2261372A (en) * 1991-11-15 1993-05-19 Gregor Reid Lactobacillus and skim milk compositions for prevention of urogenital infection
UA39965C2 (uk) * 1993-12-03 2001-07-16 Лайфор Леборетріз Лтд Вірусоцидний, бактерицидний та руйнуючий сперматозоїди вагінальний засіб і вагінальний супозиторій ( варіанти )
ZA942302B (en) * 1993-12-03 1995-09-29 Lafor Lab Ltd Viracidal bactericidal and spermicidal vaginal suppository
FR2746109B1 (fr) * 1996-03-12 1998-04-17 Rhone Poulenc Rorer Sa Milieu pour la conservation de materiel biologique
DE69731477D1 (de) * 1996-09-13 2004-12-09 Univ Clemson Mittel zur akne behandlung
US6093394A (en) * 1997-04-11 2000-07-25 Gynelogix, Inc. Vaginal lactobacillus medicant
EP0956858B1 (de) 1998-04-30 2001-10-31 Renata Maria Anna Cavaliere Vesely Pharmazeutische Zusammensetzungen enthaltend Lactobacillus brevis und Lactobacillus salivarius zur Behandlung von Vaginainfektionen

Also Published As

Publication number Publication date
CN1194758C (zh) 2005-03-30
AU732630B2 (en) 2001-04-26
EP1011721B1 (de) 2008-07-09
WO1998046261A1 (en) 1998-10-22
US6468526B2 (en) 2002-10-22
BR9808520A (pt) 2002-01-15
JP2010031031A (ja) 2010-02-12
US6372209B1 (en) 2002-04-16
EP1011721A4 (de) 2003-09-24
CN1259874A (zh) 2000-07-12
KR20010006273A (ko) 2001-01-26
JP2001523231A (ja) 2001-11-20
NZ513835A (en) 2001-09-28
NZ500788A (en) 2003-04-29
AU7359098A (en) 1998-11-11
EP1011721A1 (de) 2000-06-28
ATE400281T1 (de) 2008-07-15
CA2285947A1 (en) 1998-10-22
US20020090365A1 (en) 2002-07-11
CA2285947C (en) 2012-02-28
US6093394A (en) 2000-07-25

Similar Documents

Publication Publication Date Title
DE69839699D1 (de) Vaginales lactobacillus-medikament
GB9822440D0 (en) Medicaments
GEP19991538B (en) Derivatives of Erytromycin and Pharmaceutical Composition on their Basis
NZ506058A (en) Antibacterial 9-substituted tetracyclines, and pharmaceuticals and uses thereof
DK0506817T3 (da) Farmaceutisk præparat til kontrol med patogene intestinale bakterier
SE9702083D0 (sv) Farmaceutisk beredning för bekämpning av patogena tarmbakterier
AUPN881396A0 (en) Enhancement of microbial colonization of the gastrointestinal tract
AR017404A1 (es) UNA COMPOSICIoN DE LACTOBACILOS Y USO DE LA MISMA PARA PREPARAR UN MEDICAMENTO PARA EL TRATAMIENTO DE INFECCIONES VAGINALES.
NZ335521A (en) Bacillus thuringiensis strain AQ52 for controlling antimicrobial activity against fungi and bacteria
PT754050E (pt) Metodos e materiais contra bacterias gram-positivas
DE59410052D1 (de) Verwendung von nona- und dekapeptiden zur herstellung eines arzneimittels zur bekämpfung von aids
ATE279940T1 (de) Behandlung und prävention von helicobacter- infektionen
BR0009663A (pt) Composições de vacinas antibacterianas
WO1997018790A3 (en) Therapeutic and diagnostic agents for the treatment of microbial infections
WO2001040280A3 (en) Composition and method for treating a microbial infection
AU1665900A (en) Foulbrood treatments
WO2003009859A1 (fr) Immunotherapie pour humains
EP1060745A3 (de) Zusammensetzung und Methode zur Behandlung von bakteriellen Infektionen
IT1316985B1 (it) Terreno di coltura per la coltura di lactobacillus clearans e metodoper la conservazione di detto ceppo batterico.
BR0112514A (pt) Usos para inibidores de nad sintetase
TW365538B (en) Pharmaceutical composition for preventing a bacterial disease of fishes and crustaceans
EA200200704A1 (ru) Ослабленные микроорганизмы для лечения инфекции
EP0949330A3 (de) Lactobacilli Stämme die eine hemmende Wirkung gegen pathogenische Mikroorganismen besitzen und Verfahren zur induzierung und Behaltung dieser Aktivität in Lactobacillikulturen
WO1999066049A3 (en) A novel gene and method of treating a gram negative bacterial infection
MD20010055A (ro) Preparat microbian sanogenic pentru profilaxia şi tratamentul disbacteriozei intestinale

Legal Events

Date Code Title Description
8364 No opposition during term of opposition