AR050693A1 - Composiciones que contienen interleuquina-15 mutante y supresion de una respuesta inmune. - Google Patents
Composiciones que contienen interleuquina-15 mutante y supresion de una respuesta inmune.Info
- Publication number
- AR050693A1 AR050693A1 ARP050103369A ARP050103369A AR050693A1 AR 050693 A1 AR050693 A1 AR 050693A1 AR P050103369 A ARP050103369 A AR P050103369A AR P050103369 A ARP050103369 A AR P050103369A AR 050693 A1 AR050693 A1 AR 050693A1
- Authority
- AR
- Argentina
- Prior art keywords
- immune response
- suppression
- interleuquina
- mutant
- compositions containing
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/20—Interleukins [IL]
- A61K38/2086—IL-13 to IL-16
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/39541—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against normal tissues, cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/54—Interleukins [IL]
- C07K14/5443—IL-15
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Organic Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Epidemiology (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Microbiology (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Toxicology (AREA)
- Mycology (AREA)
- Biomedical Technology (AREA)
- Transplantation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
Métodos de tratamiento de pacientes que han recibido, o programados para recibir, un transplante de corazon, de pulmon o cardio-pulmonar mediante la administracion a dichos pacientes de un agente que antagoniza la IL-15 o al receptor de IL-15 (IL- 15R). Reivindicacion 13: Uso de un polipéptido o de una molécula de ácido nucleico, caracterizado porque es para suprimir supresion de una respuesta inmune dependiente de IL-15, donde el polipéptido comprende la SEQ ID No.:6 y la molécula de ácido nucleico comprende una secuencia que codifica al polipéptido de la SEQ ID No.:6.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US60104204P | 2004-08-11 | 2004-08-11 | |
US60047804P | 2004-08-11 | 2004-08-11 |
Publications (1)
Publication Number | Publication Date |
---|---|
AR050693A1 true AR050693A1 (es) | 2006-11-15 |
Family
ID=35839987
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP050103371A AR050293A1 (es) | 2004-08-11 | 2005-08-11 | Polipeptidos de interleuquina-15 mutante |
ARP050103369A AR050693A1 (es) | 2004-08-11 | 2005-08-11 | Composiciones que contienen interleuquina-15 mutante y supresion de una respuesta inmune. |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP050103371A AR050293A1 (es) | 2004-08-11 | 2005-08-11 | Polipeptidos de interleuquina-15 mutante |
Country Status (4)
Country | Link |
---|---|
US (2) | US20060057102A1 (es) |
AR (2) | AR050293A1 (es) |
TW (2) | TW200619227A (es) |
WO (2) | WO2006020849A2 (es) |
Families Citing this family (30)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1586585A1 (de) * | 2004-04-14 | 2005-10-19 | F. Hoffmann-La Roche Ag | Expressionssystem zur Herstellung von IL-15/Fc-Fusionsproteinen und ihre Verwendung |
US20060057102A1 (en) * | 2004-08-11 | 2006-03-16 | Zheng Xin X | Mutant interleukin-15-containing compositions and suppression of an immune response |
NZ581779A (en) | 2005-05-17 | 2011-09-30 | Univ Connecticut | Composition and methods for immunomodulation in an organism comprising interleukin-15 polypeptide and interleukin-15 receptor subunit A polypeptide complex |
BRPI0707106B1 (pt) | 2006-01-13 | 2022-06-07 | The Government Of The United States, As Represented By The Secretary Of The Department Of Health And Human Services, National Institutes Of Health | Polinucleotídeo interleucina-15, vetor de expressão, e, composição farmacêutica |
EP1921452A1 (en) * | 2006-11-08 | 2008-05-14 | Medizinische Hochschule Hannover | Method for the diagnosis of leukemia |
KR100888022B1 (ko) | 2006-12-21 | 2009-03-09 | 재단법인 목암생명공학연구소 | 면역글로불린 Fc와 인간 아포리포단백질(a)크링글절편의 융합단백질 LK8Fc |
US20110020269A1 (en) * | 2007-05-08 | 2011-01-27 | Beth Israel Deaconess Medical Center, Inc. | Methods and compositions for modifying t cell immune responses and inflammation |
JP2010531878A (ja) | 2007-06-27 | 2010-09-30 | マリン ポリマー テクノロジーズ,インコーポレーテッド | IL‐15とIL‐15Rαとの複合体及びその使用 |
US9155801B2 (en) | 2009-05-28 | 2015-10-13 | The United States Government As Represented By The Department Of Veterans Affairs | Amino acid sequences which enhance peptide conjugate solubility |
US8871191B2 (en) | 2009-08-14 | 2014-10-28 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Use of IL-15 preparations to treat lymphopenia |
WO2015048149A1 (en) * | 2013-09-24 | 2015-04-02 | Massachusetts Institute Of Technology | Self-assembled nanoparticle vaccines |
MA39711A (fr) * | 2014-04-03 | 2015-10-08 | Nektar Therapeutics | Conjugués d'une fraction d'il-15 et d'un polymère |
CN107001438A (zh) * | 2014-10-14 | 2017-08-01 | 阿尔莫生物科技股份有限公司 | 白细胞介素‑15组合物及其用途 |
EP3350205A1 (en) * | 2015-09-16 | 2018-07-25 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Specific interleukin-15 (il-15) antagonist polypeptide and uses thereof for the treatment of inflammatory and auto-immune diseases |
BR112018012262A2 (pt) * | 2015-12-21 | 2018-12-04 | Armo Biosciences Inc | composições de interleucina-15 e seus usos |
CN109715196A (zh) | 2016-06-13 | 2019-05-03 | 转矩医疗股份有限公司 | 用于促进免疫细胞功能的组合物和方法 |
CA3046387A1 (en) * | 2016-12-21 | 2018-06-28 | David Jose Simon LAINE | Antibodies that specifically bind to human il-15 and uses thereof |
CU24546B1 (es) * | 2016-12-30 | 2021-09-07 | Ct Ingenieria Genetica Biotecnologia | Composición vacunal que comprende un mutante de la interleucina-15 humana |
AU2018328209A1 (en) | 2017-09-05 | 2020-04-23 | Torque Therapeutics, Inc. | Therapeutic protein compositions and methods of making and using the same |
SG11202007728QA (en) * | 2018-02-26 | 2020-09-29 | Synthorx Inc | Il-15 conjugates and uses thereof |
EP3773918A4 (en) | 2019-03-05 | 2022-01-05 | Nkarta, Inc. | CD19 DIRECTED CHIMERIC ANTIGEN RECEPTORS AND THEIR USES IN IMMUNOTHERAPY |
JP2022533222A (ja) | 2019-05-20 | 2022-07-21 | サイチューン ファーマ | 癌又は感染性疾患を処置するためのIL-2/IL-15Rβγアゴニスト投薬レジメン |
JP2023512452A (ja) * | 2020-01-13 | 2023-03-27 | ンカルタ・インコーポレイテッド | Bcma指向性細胞免疫療法組成物および方法 |
WO2022090202A1 (en) | 2020-10-26 | 2022-05-05 | Cytune Pharma | IL-2/IL-15RBβү AGONIST FOR TREATING NON-MELANOMA SKIN CANCER |
WO2022090203A1 (en) | 2020-10-26 | 2022-05-05 | Cytune Pharma | IL-2/IL-15Rβү AGONIST FOR TREATING SQUAMOUS CELL CARCINOMA |
EP4359429A1 (en) | 2021-06-23 | 2024-05-01 | Cytune Pharma | Interleukin 15 variants |
KR20240043797A (ko) | 2021-08-13 | 2024-04-03 | 싸이튠 파마 | 암 치료용 IL-2/IL-15Rβγ 작용제와 항체-약물 접합체 조합 |
CN113956346B (zh) * | 2021-10-26 | 2024-03-01 | 西安龙腾景云生物科技有限公司 | 一种重组白介素-15变体 |
WO2023086772A1 (en) | 2021-11-12 | 2023-05-19 | Xencor, Inc. | Bispecific antibodies that bind to b7h3 and nkg2d |
WO2024102636A1 (en) | 2022-11-07 | 2024-05-16 | Xencor, Inc. | Bispecific antibodies that bind to b7h3 and mica/b |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5078997A (en) * | 1988-07-13 | 1992-01-07 | Cetus Corporation | Pharmaceutical composition for interleukin-2 containing physiologically compatible stabilizers |
US5962406A (en) * | 1991-10-25 | 1999-10-05 | Immunex Corporation | Recombinant soluble CD40 ligand polypeptide and pharmaceutical composition containing the same |
US5795966A (en) * | 1995-02-22 | 1998-08-18 | Immunex Corp | Antagonists of interleukin-15 |
DE69733610T2 (de) * | 1996-04-26 | 2006-05-11 | Beth Israel Deaconess Medical Center, Inc., Boston | Interleukin-15 antagonisten |
US6451308B1 (en) * | 1996-04-26 | 2002-09-17 | Beth Israel Deaconess Medical Center | Antagonists of interleukin-15 |
US20050123542A1 (en) * | 2003-11-06 | 2005-06-09 | Genmab A/S | Methods for treating disorders involving monocytes |
US20060057102A1 (en) * | 2004-08-11 | 2006-03-16 | Zheng Xin X | Mutant interleukin-15-containing compositions and suppression of an immune response |
WO2007018564A2 (en) * | 2004-10-05 | 2007-02-15 | Ochsner Clinic Foundation | Enhancement of b cell proliferation by il-15 |
-
2005
- 2005-08-11 US US11/202,287 patent/US20060057102A1/en not_active Abandoned
- 2005-08-11 TW TW094127391A patent/TW200619227A/zh unknown
- 2005-08-11 TW TW094127389A patent/TW200613552A/zh unknown
- 2005-08-11 WO PCT/US2005/028713 patent/WO2006020849A2/en active Application Filing
- 2005-08-11 WO PCT/US2005/028677 patent/WO2006017853A2/en active Application Filing
- 2005-08-11 AR ARP050103371A patent/AR050293A1/es not_active Application Discontinuation
- 2005-08-11 AR ARP050103369A patent/AR050693A1/es unknown
- 2005-08-11 US US11/201,585 patent/US20060057680A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
WO2006017853A2 (en) | 2006-02-16 |
WO2006020849A2 (en) | 2006-02-23 |
TW200613552A (en) | 2006-05-01 |
WO2006020849A3 (en) | 2006-10-05 |
US20060057102A1 (en) | 2006-03-16 |
TW200619227A (en) | 2006-06-16 |
AR050293A1 (es) | 2006-10-11 |
WO2006017853A3 (en) | 2007-01-04 |
US20060057680A1 (en) | 2006-03-16 |
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Legal Events
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FB | Suspension of granting procedure |