MX2009012676A - Neuraminidasa neumococica no toxica y sus usos. - Google Patents
Neuraminidasa neumococica no toxica y sus usos.Info
- Publication number
- MX2009012676A MX2009012676A MX2009012676A MX2009012676A MX2009012676A MX 2009012676 A MX2009012676 A MX 2009012676A MX 2009012676 A MX2009012676 A MX 2009012676A MX 2009012676 A MX2009012676 A MX 2009012676A MX 2009012676 A MX2009012676 A MX 2009012676A
- Authority
- MX
- Mexico
- Prior art keywords
- subject
- methods
- composition
- administering
- nasal
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/24—Hydrolases (3) acting on glycosyl compounds (3.2)
- C12N9/2402—Hydrolases (3) acting on glycosyl compounds (3.2) hydrolysing O- and S- glycosyl compounds (3.2.1)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/09—Lactobacillales, e.g. aerococcus, enterococcus, lactobacillus, lactococcus, streptococcus
- A61K39/092—Streptococcus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y302/00—Hydrolases acting on glycosyl compounds, i.e. glycosylases (3.2)
- C12Y302/01—Glycosidases, i.e. enzymes hydrolysing O- and S-glycosyl compounds (3.2.1)
- C12Y302/01018—Exo-alpha-sialidase (3.2.1.18), i.e. trans-sialidase
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Immunology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- Molecular Biology (AREA)
- Epidemiology (AREA)
- Mycology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Abstract
Se proporcionan en la presente composiciones diseñadas para reducir o prevenir infecciones bacterianas (por ejemplo infeccione por neumococos), transporte nasal, colonización nasal, e invasión del sistema nervioso central. Se proporciona en la presente una composición que comprende un polipéptido que comprende la secuencia de aminoácidos de SEQ ID NO: 19 o una variante de la misma que pude producir una respuesta inmune anti-neuraminidasa. Se proporcionan además métodos para hacer y usar las composiciones descritas en la presente. Específicamente se proporcionan métodos para generar anticuerpos en un sujeto que comprenden administrar al sujeto un agente o composición enseñada en la presente. También se proporcionan métodos para reducir o prevenir el transporte nasal o infección por neumococo en un sujeto que comprende administra al sujeto una composición enseñada en la presente.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
PCT/US2007/069571 WO2008143676A1 (en) | 2007-05-23 | 2007-05-23 | Detoxified pneumococcal neuraminidase and uses thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2009012676A true MX2009012676A (es) | 2010-02-12 |
Family
ID=38610581
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2009012676A MX2009012676A (es) | 2007-05-23 | 2007-05-23 | Neuraminidasa neumococica no toxica y sus usos. |
Country Status (8)
Country | Link |
---|---|
US (2) | US8329195B2 (es) |
EP (1) | EP2164957B1 (es) |
CN (1) | CN101688194B (es) |
AU (1) | AU2007353789B2 (es) |
BR (1) | BRPI0721702A2 (es) |
CA (1) | CA2688009C (es) |
MX (1) | MX2009012676A (es) |
WO (1) | WO2008143676A1 (es) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7250494B2 (en) * | 1998-06-15 | 2007-07-31 | Biosynexus Incorporated | Opsonic monoclonal and chimeric antibodies specific for lipoteichoic acid of Gram positive bacteria |
CN101688194B (zh) | 2007-05-23 | 2013-09-11 | Uab研究基金会 | 去毒的肺炎球菌神经氨酸酶及其用途 |
JP6539289B2 (ja) * | 2014-01-24 | 2019-07-03 | ユニヴァーシティー コート オブ ザ ユニヴァーシティー オブ セント アンドリューズ | 免疫調節化合物 |
CN106414960B (zh) * | 2014-06-06 | 2020-01-14 | 洋马株式会社 | 发动机装置 |
GB201602105D0 (en) * | 2016-02-05 | 2016-03-23 | Inst Of Food Res | Intramolecular Trains- Sialidase |
CN112135904A (zh) | 2018-01-03 | 2020-12-25 | 帕利昂制药有限公司 | 重组人唾液酸酶、唾液酸酶融合蛋白及其使用方法 |
Family Cites Families (31)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR1601438A (es) | 1968-10-17 | 1970-08-24 | ||
US4342566A (en) | 1980-02-22 | 1982-08-03 | Scripps Clinic & Research Foundation | Solid phase anti-C3 assay for detection of immune complexes |
US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
US4704692A (en) | 1986-09-02 | 1987-11-03 | Ladner Robert C | Computer based system and method for determining and displaying possible chemical structures for converting double- or multiple-chain polypeptides to single-chain polypeptides |
DK0710719T3 (da) | 1990-01-12 | 2007-07-09 | Amgen Fremont Inc | Frembringelse af xenogene antistoffer |
US5612205A (en) | 1990-08-29 | 1997-03-18 | Genpharm International, Incorporated | Homologous recombination in mammalian cells |
US6027734A (en) | 1991-02-15 | 2000-02-22 | Uab Research Foundation | Mucosal administration of pneumococcal antigens |
US6592876B1 (en) | 1993-04-20 | 2003-07-15 | Uab Research Foundation | Pneumococcal genes, portions thereof, expression products therefrom, and uses of such genes, portions and products |
US5792457A (en) | 1991-05-03 | 1998-08-11 | The Rockefeller University | Antibody recognizing endothelial cell ligand for leukocyte CR3 |
US5565332A (en) | 1991-09-23 | 1996-10-15 | Medical Research Council | Production of chimeric antibodies - a combinatorial approach |
US5652138A (en) | 1992-09-30 | 1997-07-29 | The Scripps Research Institute | Human neutralizing monoclonal antibodies to human immunodeficiency virus |
DK0701571T3 (da) | 1993-06-03 | 1997-09-15 | Therapeutic Antibodies Inc | Antistoffragmenter til terapi |
US6180377B1 (en) | 1993-06-16 | 2001-01-30 | Celltech Therapeutics Limited | Humanized antibodies |
GB9326174D0 (en) | 1993-12-22 | 1994-02-23 | Biocine Sclavo | Mucosal adjuvant |
US20030072774A1 (en) | 1994-06-10 | 2003-04-17 | Diane M. Gajewczyk | Proteinaceous adjuvants |
US6019982A (en) | 1994-08-26 | 2000-02-01 | The Administrators Of The Tulane Educational Fund | Mutant enterotoxin effective as a non-toxic oral adjuvant |
US6130364A (en) | 1995-03-29 | 2000-10-10 | Abgenix, Inc. | Production of antibodies using Cre-mediated site-specific recombination |
US6410690B1 (en) | 1995-06-07 | 2002-06-25 | Medarex, Inc. | Therapeutic compounds comprised of anti-Fc receptor antibodies |
EP1770164B1 (en) | 1996-10-31 | 2010-09-01 | Human Genome Sciences, Inc. | Streptococcus pneumoniae antigens and vaccines |
FR2765243B1 (fr) | 1997-06-30 | 1999-07-30 | Usinor | Acier inoxydable austenoferritique a tres bas nickel et presentant un fort allongement en traction |
US6800744B1 (en) * | 1997-07-02 | 2004-10-05 | Genome Therapeutics Corporation | Nucleic acid and amino acid sequences relating to Streptococcus pneumoniae for diagnostics and therapeutics |
IS4518A (is) | 1997-07-09 | 1999-01-10 | Lyfjathroun Hf, The Icelandic Bio Pharmaceutical Group | Nýtt lyfjaform fyrir bóluefni |
JP2002531055A (ja) | 1998-07-27 | 2002-09-24 | マイクロビアル テクニクス リミティッド | 肺炎連鎖球菌のタンパク質及び核酸分子 |
AT407958B (de) | 1999-02-11 | 2001-07-25 | Immuno Ag | Inaktivierte influenza-virus-vakzine zur nasalen oder oralen applikation |
GB0107658D0 (en) | 2001-03-27 | 2001-05-16 | Chiron Spa | Streptococcus pneumoniae |
WO2002083855A2 (en) | 2001-04-16 | 2002-10-24 | Wyeth Holdings Corporation | Novel streptococcus pneumoniae open reading frames encoding polypeptide antigens and uses thereof |
US7202056B2 (en) | 2002-03-28 | 2007-04-10 | Bristol-Myers Squibb Company | Polynucleotides encoding a human cell surface protein with immunoglobulin folds, BGS-19 |
WO2004092209A2 (en) * | 2003-04-15 | 2004-10-28 | Intercell Ag | S. pneumoniae antigens |
JP2007512006A (ja) * | 2003-11-10 | 2007-05-17 | ザ ユーエービー リサーチ ファウンデーション | 細菌輸送およびcns侵襲を低減させるための組成物およびこの組成物を使用する方法 |
CN1660421A (zh) * | 2004-12-10 | 2005-08-31 | 中国科学院武汉病毒研究所 | 预防流感病毒的截短的神经氨酸酶疫苗及其制备方法 |
CN101688194B (zh) | 2007-05-23 | 2013-09-11 | Uab研究基金会 | 去毒的肺炎球菌神经氨酸酶及其用途 |
-
2007
- 2007-05-23 CN CN2007800537575A patent/CN101688194B/zh not_active Expired - Fee Related
- 2007-05-23 WO PCT/US2007/069571 patent/WO2008143676A1/en active Application Filing
- 2007-05-23 EP EP07797691.8A patent/EP2164957B1/en not_active Not-in-force
- 2007-05-23 AU AU2007353789A patent/AU2007353789B2/en not_active Ceased
- 2007-05-23 CA CA2688009A patent/CA2688009C/en not_active Expired - Fee Related
- 2007-05-23 US US12/601,233 patent/US8329195B2/en not_active Expired - Fee Related
- 2007-05-23 BR BRPI0721702-1A patent/BRPI0721702A2/pt not_active Application Discontinuation
- 2007-05-23 MX MX2009012676A patent/MX2009012676A/es active IP Right Grant
-
2012
- 2012-11-07 US US13/670,839 patent/US9080159B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
CA2688009A1 (en) | 2008-11-27 |
WO2008143676A4 (en) | 2009-01-22 |
EP2164957A1 (en) | 2010-03-24 |
US8329195B2 (en) | 2012-12-11 |
WO2008143676A1 (en) | 2008-11-27 |
CN101688194A (zh) | 2010-03-31 |
US20110104168A1 (en) | 2011-05-05 |
EP2164957B1 (en) | 2017-07-12 |
BRPI0721702A2 (pt) | 2013-01-15 |
CN101688194B (zh) | 2013-09-11 |
US9080159B2 (en) | 2015-07-14 |
AU2007353789B2 (en) | 2014-05-22 |
CA2688009C (en) | 2019-04-02 |
US20140004138A1 (en) | 2014-01-02 |
AU2007353789A1 (en) | 2008-11-27 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG | Grant or registration |