CU24546B1 - Composición vacunal que comprende un mutante de la interleucina-15 humana - Google Patents
Composición vacunal que comprende un mutante de la interleucina-15 humanaInfo
- Publication number
- CU24546B1 CU24546B1 CU2016000194A CU20160194A CU24546B1 CU 24546 B1 CU24546 B1 CU 24546B1 CU 2016000194 A CU2016000194 A CU 2016000194A CU 20160194 A CU20160194 A CU 20160194A CU 24546 B1 CU24546 B1 CU 24546B1
- Authority
- CU
- Cuba
- Prior art keywords
- human interleukin
- mutant
- composition including
- vaccinal composition
- composition
- Prior art date
Links
- 101001055157 Homo sapiens Interleukin-15 Proteins 0.000 title abstract 2
- 102000056003 human IL15 Human genes 0.000 title abstract 2
- 208000023275 Autoimmune disease Diseases 0.000 abstract 1
- 208000002250 Hematologic Neoplasms Diseases 0.000 abstract 1
- 102000003812 Interleukin-15 Human genes 0.000 abstract 1
- 108090000172 Interleukin-15 Proteins 0.000 abstract 1
- AZDRQVAHHNSJOQ-UHFFFAOYSA-N alumane Chemical class [AlH3] AZDRQVAHHNSJOQ-UHFFFAOYSA-N 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 238000009169 immunotherapy Methods 0.000 abstract 1
- 230000002018 overexpression Effects 0.000 abstract 1
- 229920001184 polypeptide Polymers 0.000 abstract 1
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 1
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 1
- 229960005486 vaccine Drugs 0.000 abstract 1
- 239000012646 vaccine adjuvant Substances 0.000 abstract 1
- 229940124931 vaccine adjuvant Drugs 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
- C07K16/244—Interleukins [IL]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
- A61K39/0011—Cancer antigens
- A61K39/001136—Cytokines
- A61K39/00114—Interleukins [IL]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55505—Inorganic adjuvants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55522—Cytokines; Lymphokines; Interferons
- A61K2039/55527—Interleukins
- A61K2039/55538—IL-12
Abstract
<p>Se describe una composición vacunal caracterizada porque comprende un polipéptido mutado de interleucina-15 humana identificado como SEQ ID NO: 1 en una concentración de 200-500 µg y un adyuvante vacunal, seleccionado de sales de aluminio a 1,8 mg/mL o de tipo oleoso en una relación 50:50 (v/v). La composición se emplea para la inmunoterapia activa de enfermedades relacionadas con la sobre-expresión de la IL-15 entre las que se encuentran algunas enfermedades autoinmunes y neoplasias hematológicas.</p>
Priority Applications (10)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CU2016000194A CU24546B1 (es) | 2016-12-30 | 2016-12-30 | Composición vacunal que comprende un mutante de la interleucina-15 humana |
PCT/CU2017/050008 WO2018121802A1 (es) | 2016-12-30 | 2017-12-20 | Composición vacunal que comprende un mutante de la interleucina-15 humana |
CN201780086587.4A CN110300762B (zh) | 2016-12-30 | 2017-12-20 | 包含人白介素-15的突变体的疫苗组合物 |
MX2019007906A MX2019007906A (es) | 2016-12-30 | 2017-12-20 | Composicion vacunal que comprende un mutante de la interleucina-15 humana. |
RU2019122635A RU2745199C2 (ru) | 2016-12-30 | 2017-12-20 | Вакцинная композиция, содержащая мутантный человеческий интерлейкин-15 |
US16/474,913 US20200181254A1 (en) | 2016-12-30 | 2017-12-20 | Vaccine composition comprising a mutant of human interleukin-15 |
EP17840472.9A EP3564264B1 (en) | 2016-12-30 | 2017-12-20 | Vaccine composition comprising a mutant of human interleukin-15 |
ES17840472T ES2892148T3 (es) | 2016-12-30 | 2017-12-20 | Composición vacunal que comprende un mutante de la interleucina-15 humana |
BR112019013542A BR112019013542A2 (pt) | 2016-12-30 | 2017-12-20 | composição de vacina, uso de um polipeptídeo, e, método para o tratamento de doenças associadas à superexpressão da il-15 |
US17/531,914 US20220259300A1 (en) | 2016-12-30 | 2021-11-22 | Vaccine composition comprising a mutant of human interleukin-15 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CU2016000194A CU24546B1 (es) | 2016-12-30 | 2016-12-30 | Composición vacunal que comprende un mutante de la interleucina-15 humana |
Publications (2)
Publication Number | Publication Date |
---|---|
CU20160194A7 CU20160194A7 (es) | 2018-08-06 |
CU24546B1 true CU24546B1 (es) | 2021-09-07 |
Family
ID=61188581
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CU2016000194A CU24546B1 (es) | 2016-12-30 | 2016-12-30 | Composición vacunal que comprende un mutante de la interleucina-15 humana |
Country Status (9)
Country | Link |
---|---|
US (2) | US20200181254A1 (es) |
EP (1) | EP3564264B1 (es) |
CN (1) | CN110300762B (es) |
BR (1) | BR112019013542A2 (es) |
CU (1) | CU24546B1 (es) |
ES (1) | ES2892148T3 (es) |
MX (1) | MX2019007906A (es) |
RU (1) | RU2745199C2 (es) |
WO (1) | WO2018121802A1 (es) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU2021273789A1 (en) * | 2020-05-18 | 2023-02-02 | Shandong Simcere Biopharmaceutical Co., Ltd. | Human IL-15 mutant and use thereof |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5795966A (en) | 1995-02-22 | 1998-08-18 | Immunex Corp | Antagonists of interleukin-15 |
EP0927254B1 (en) | 1996-04-26 | 2005-06-22 | Beth Israel Deaconess Medical Center, Inc. | Antagonists of interleukin-15 |
CU23093A1 (es) | 2002-10-09 | 2005-10-19 | Ct Ingenieria Genetica Biotech | Composición vacunal que comprende interleucina-15 (il-15) |
NZ570709A (en) * | 2003-06-13 | 2010-04-30 | Univ Pennsylvania | Nucleic acid sequences encoding and compositions comprising IgE signal peptide and/or IL-15 and methods for using the same |
EP1718670B1 (en) * | 2004-02-27 | 2011-07-13 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Il-15 binding site for il 15-ralpha and specific il-15 mutants having agonist/antagonist activity |
US20060057102A1 (en) * | 2004-08-11 | 2006-03-16 | Zheng Xin X | Mutant interleukin-15-containing compositions and suppression of an immune response |
WO2006063974A2 (en) * | 2004-12-13 | 2006-06-22 | Cytos Biotechnology Ag | Il-15 antigen arrays and uses thereof |
CU23716A1 (es) * | 2008-09-30 | 2011-10-05 | Ct Ingenieria Genetica Biotech | Péptido antagonista de la actividad de la interleucina-15 |
US20220106374A1 (en) * | 2018-06-22 | 2022-04-07 | Cugene Inc | Novel interleukin-15 (il-15) fusion proteins and uses thereof |
-
2016
- 2016-12-30 CU CU2016000194A patent/CU24546B1/es unknown
-
2017
- 2017-12-20 BR BR112019013542A patent/BR112019013542A2/pt unknown
- 2017-12-20 WO PCT/CU2017/050008 patent/WO2018121802A1/es unknown
- 2017-12-20 US US16/474,913 patent/US20200181254A1/en not_active Abandoned
- 2017-12-20 MX MX2019007906A patent/MX2019007906A/es unknown
- 2017-12-20 RU RU2019122635A patent/RU2745199C2/ru active
- 2017-12-20 ES ES17840472T patent/ES2892148T3/es active Active
- 2017-12-20 CN CN201780086587.4A patent/CN110300762B/zh active Active
- 2017-12-20 EP EP17840472.9A patent/EP3564264B1/en active Active
-
2021
- 2021-11-22 US US17/531,914 patent/US20220259300A1/en active Pending
Also Published As
Publication number | Publication date |
---|---|
US20200181254A1 (en) | 2020-06-11 |
RU2019122635A3 (es) | 2021-02-01 |
MX2019007906A (es) | 2019-09-04 |
US20220259300A1 (en) | 2022-08-18 |
EP3564264A1 (en) | 2019-11-06 |
BR112019013542A2 (pt) | 2020-02-04 |
CN110300762A (zh) | 2019-10-01 |
RU2745199C2 (ru) | 2021-03-22 |
CN110300762B (zh) | 2023-05-02 |
EP3564264B1 (en) | 2021-09-08 |
RU2019122635A (ru) | 2021-02-01 |
ES2892148T3 (es) | 2022-02-02 |
WO2018121802A1 (es) | 2018-07-05 |
CU20160194A7 (es) | 2018-08-06 |
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