MX360085B - Identificacion de mutaciones de channelopsin-2 (chop2) y los metodos de uso. - Google Patents

Identificacion de mutaciones de channelopsin-2 (chop2) y los metodos de uso.

Info

Publication number
MX360085B
MX360085B MX2014010664A MX2014010664A MX360085B MX 360085 B MX360085 B MX 360085B MX 2014010664 A MX2014010664 A MX 2014010664A MX 2014010664 A MX2014010664 A MX 2014010664A MX 360085 B MX360085 B MX 360085B
Authority
MX
Mexico
Prior art keywords
methods
chop2
channelrhodopsin
mutations
identification
Prior art date
Application number
MX2014010664A
Other languages
English (en)
Other versions
MX2014010664A (es
Inventor
Pan Zhuo-Hua
Original Assignee
Univ Wayne State
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Wayne State filed Critical Univ Wayne State
Publication of MX2014010664A publication Critical patent/MX2014010664A/es
Publication of MX360085B publication Critical patent/MX360085B/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/405—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from algae
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Ophthalmology & Optometry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

La presente invención se refiere a una molécula de polipéptido aislada, caracterizada porque comprende la SEQ ID NO: 26 en la cual el aminoácido en la posición 132 de la SEQ ID NO: 26 es cisteína (C) y el aminoácido en la posición 159 es cisteína (C) o serina (S).
MX2014010664A 2012-03-05 2013-03-05 Identificacion de mutaciones de channelopsin-2 (chop2) y los metodos de uso. MX360085B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201261606663P 2012-03-05 2012-03-05
PCT/US2013/029171 WO2013134295A1 (en) 2012-03-05 2013-03-05 Identification of channelrhodopsin-2 (chop2) mutations and methods of use

Publications (2)

Publication Number Publication Date
MX2014010664A MX2014010664A (es) 2015-03-06
MX360085B true MX360085B (es) 2018-10-10

Family

ID=47892055

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2014010664A MX360085B (es) 2012-03-05 2013-03-05 Identificacion de mutaciones de channelopsin-2 (chop2) y los metodos de uso.

Country Status (16)

Country Link
US (3) US10947281B2 (es)
EP (1) EP2822964B1 (es)
JP (3) JP6395611B2 (es)
KR (1) KR102137717B1 (es)
CN (2) CN104334575A (es)
AU (4) AU2013230112A1 (es)
CA (1) CA2866405A1 (es)
DK (1) DK2822964T3 (es)
EA (1) EA201491643A1 (es)
ES (1) ES2703324T3 (es)
HU (1) HUE040487T2 (es)
MX (1) MX360085B (es)
NZ (1) NZ629843A (es)
PL (1) PL2822964T3 (es)
PT (1) PT2822964T (es)
WO (1) WO2013134295A1 (es)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3437473A1 (en) 2006-05-04 2019-02-06 Wayne State University Restoration of visual responses by in vivo delivery of rhodopsin nucleic acids
WO2011140279A1 (en) 2010-05-04 2011-11-10 Wayne State University Aav-mediated subcellular targeting of heterologous rhodopsins in retinal ganglion cells
JP6395611B2 (ja) 2012-03-05 2018-09-26 ウェイン・ステート・ユニバーシティー チャネルロドプシン−２（Ｃｈｏｐ２）の変異の同定および使用法
JP6483083B2 (ja) 2013-03-14 2019-03-13 ウェイン ステイト ユニバーシティー 治療用化合物の眼への送達を増強する方法
CN105358527B (zh) 2013-07-08 2018-09-25 巴斯夫欧洲公司 肟酯光引发剂
US10307492B2 (en) 2014-03-11 2019-06-04 Wayne State University Modified MGLUR6 promoter and methods of use
US20170319669A1 (en) 2016-05-03 2017-11-09 Wayne State University Method of enhancing viral-mediated gene delivery
EP3464341A1 (en) * 2016-06-03 2019-04-10 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. Mutant light-inducible ion channel of channelrhodopsin
US11041004B2 (en) * 2016-08-29 2021-06-22 Wayne State University Identification of mutations in channelopsin variants having improved light sensitivity and methods of use thereof
WO2018106369A2 (en) * 2016-11-06 2018-06-14 Nanoscope Technologies Llc Optogenetic modulation by multi-characteristic opsins for vision restoration and other applications thereof
CA3059652A1 (en) * 2017-04-12 2018-10-18 Max-Planck-Gesellschaft Zur Forderung Der Wissenschaften E.V. New optogenetic tool
PT3720428T (pt) * 2017-12-04 2023-04-03 Salvat Lab Sa Composição tópica oftálmica compreendendo ácido dobesílico para tratamento de doenças do segmento posterior do olho
JP6567153B1 (ja) * 2018-09-28 2019-08-28 学校法人東北工業大学 対象化合物の特性の予測を行うための方法、コンピュータシステム、プログラム
WO2024226667A2 (en) * 2023-04-24 2024-10-31 Nanoscope Therapeutics Inc. Optogenetic modulation by multi-characteristic opsins for vision restoration and other applications thereof

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US4554101A (en) 1981-01-09 1985-11-19 New York Blood Center, Inc. Identification and preparation of epitopes on antigens and allergens on the basis of hydrophilicity
US4498919A (en) 1983-10-31 1985-02-12 Corning Glass Works Method for making colored photochromic prescription ophthalmic lenses
US6610287B1 (en) 1990-04-16 2003-08-26 The General Hospital Corporation Transfer and expression of gene sequences into nervous system cells using herpes simplex virus mutants with deletions in genes for viral replication
US5827702A (en) 1994-10-31 1998-10-27 Genentech, Inc. Ocular gene therapy
BR9809284A (pt) 1997-04-21 2004-08-03 Univ Florida Construto e processo para expressão de polinucleotìdeo em altos nìveis
EP1114171A1 (en) 1998-09-17 2001-07-11 University of Florida Methods for treatment of degenerative retinal diseases
JP2004514407A (ja) 2000-04-28 2004-05-20 ザ・トラステイーズ・オブ・ザ・ユニバーシテイ・オブ・ペンシルベニア 異種キャプシド中にシュードタイピングされたａａｖ５キャプシドおよびａａｖ５ベクターを含む組換えａａｖベクター
CA2442670A1 (en) 2001-04-13 2002-10-24 The Trustees Of The University Of Pennsylvania Method of treating or retarding the development of blindness
WO2003016486A2 (en) 2001-08-16 2003-02-27 Sloan Kettering Institute For Cancer Research Bio-synthetic photostimulators and methods of use
DE10216005A1 (de) 2002-04-11 2003-10-30 Max Planck Gesellschaft Verwendung von biologischen Photorezeptoren als direkt lichtgesteuerte Ionenkanäle
WO2004009022A2 (en) 2002-07-18 2004-01-29 The General Hospital Corp. Method for augmenting vision in persons suffering from photoreceptor cell degeneration
US7186699B2 (en) 2003-06-03 2007-03-06 Cell Genesys, Inc. Method for treating cancer by vector-mediated delivery of one or more anti-angiogenic or pro-apoptotic genes
WO2005044096A2 (en) 2003-11-05 2005-05-19 Neurovision, Inc. Method for improving visual perception
EP1919497B1 (en) 2005-07-22 2020-02-12 The Board of Trustees of the Leland Stanford Junior University Light-activated cation channel and uses thereof
EP3437473A1 (en) * 2006-05-04 2019-02-06 Wayne State University Restoration of visual responses by in vivo delivery of rhodopsin nucleic acids
WO2011140279A1 (en) * 2010-05-04 2011-11-10 Wayne State University Aav-mediated subcellular targeting of heterologous rhodopsins in retinal ganglion cells
HRP20150846T1 (hr) * 2010-09-08 2015-09-11 MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. Mutirani kalanski rodopsin 2
JP6395611B2 (ja) * 2012-03-05 2018-09-26 ウェイン・ステート・ユニバーシティー チャネルロドプシン−２（Ｃｈｏｐ２）の変異の同定および使用法
KR101639859B1 (ko) 2014-03-06 2016-07-14 포항공과대학교 산학협력단 광 자극에 의한 미토콘드리아 활성의 시공간적 가역 조절 방법

Also Published As

Publication number Publication date
KR102137717B1 (ko) 2020-07-27
AU2021245195A1 (en) 2021-11-04
US20150044181A1 (en) 2015-02-12
JP6395611B2 (ja) 2018-09-26
AU2019216638A1 (en) 2019-09-05
JP2019193656A (ja) 2019-11-07
ES2703324T3 (es) 2019-03-08
KR20140132401A (ko) 2014-11-17
CA2866405A1 (en) 2013-09-12
AU2013230112A1 (en) 2014-09-25
HK1205744A1 (en) 2015-12-24
PL2822964T3 (pl) 2019-05-31
NZ727041A (en) 2022-01-28
JP2015510759A (ja) 2015-04-13
WO2013134295A1 (en) 2013-09-12
US10947281B2 (en) 2021-03-16
EP2822964A1 (en) 2015-01-14
CN111378020A (zh) 2020-07-07
HUE040487T2 (hu) 2019-03-28
AU2017239601A1 (en) 2017-10-26
AU2017239601B2 (en) 2019-05-16
JP2018134098A (ja) 2018-08-30
CN104334575A (zh) 2015-02-04
DK2822964T3 (en) 2018-12-10
PT2822964T (pt) 2018-11-29
US20250066431A1 (en) 2025-02-27
AU2019216638B2 (en) 2021-07-08
EA201491643A1 (ru) 2015-02-27
NZ629843A (en) 2017-03-31
EP2822964B1 (en) 2018-08-22
AU2021245195B2 (en) 2023-09-28
US20220033449A1 (en) 2022-02-03
MX2014010664A (es) 2015-03-06

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