CN101203605B - 革兰氏阴性菌的lps的脱酰基化 - Google Patents

革兰氏阴性菌的lps的脱酰基化 Download PDF

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Publication number
CN101203605B
CN101203605B CN200580048420.6A CN200580048420A CN101203605B CN 101203605 B CN101203605 B CN 101203605B CN 200580048420 A CN200580048420 A CN 200580048420A CN 101203605 B CN101203605 B CN 101203605B
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CN
China
Prior art keywords
lps
pagl
lipid
bordetella
gram
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Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
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CN200580048420.6A
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English (en)
Chinese (zh)
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CN101203605A (zh
Inventor
J·P·M·托马森
P·A·范德莱
J·J·G·戈尔特森
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Nederlanden Staat
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STAAT DER NEDERLANDEN VERT DOO
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/099—Bordetella
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/235—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Bordetella (G)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
    • C12N9/18—Carboxylic ester hydrolases (3.1.1)

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biochemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biotechnology (AREA)
  • Epidemiology (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Mycology (AREA)
  • General Engineering & Computer Science (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CN200580048420.6A 2004-12-17 2005-12-16 革兰氏阴性菌的lps的脱酰基化 Expired - Fee Related CN101203605B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP04078445 2004-12-17
EP04078445.6 2004-12-17
PCT/NL2005/050081 WO2006065139A2 (en) 2004-12-17 2005-12-16 Deacylation of lps in gram negative bacteria

Publications (2)

Publication Number Publication Date
CN101203605A CN101203605A (zh) 2008-06-18
CN101203605B true CN101203605B (zh) 2016-01-27

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CN200580048420.6A Expired - Fee Related CN101203605B (zh) 2004-12-17 2005-12-16 革兰氏阴性菌的lps的脱酰基化

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Country Link
US (1) US8048433B2 (enExample)
EP (1) EP1828378B1 (enExample)
JP (1) JP5378685B2 (enExample)
CN (1) CN101203605B (enExample)
AU (1) AU2005317304B2 (enExample)
BR (1) BRPI0519923A8 (enExample)
CA (1) CA2590906C (enExample)
DK (1) DK1828378T3 (enExample)
ES (1) ES2493440T3 (enExample)
MX (1) MX2007007288A (enExample)
NO (1) NO340331B1 (enExample)
NZ (1) NZ555889A (enExample)
PL (1) PL1828378T3 (enExample)
PT (1) PT1828378E (enExample)
WO (1) WO2006065139A2 (enExample)

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Publication number Priority date Publication date Assignee Title
ES2393682T3 (es) 2007-03-26 2012-12-27 De Staat Der Nederlanden, Vert. Door De Minister Van Vws Vacunas mejoradas contra Bordotella pertussis basadas en mutantes de glicosiltransferasa LPS
WO2014024026A1 (en) 2012-08-06 2014-02-13 Glaxosmithkline Biologicals S.A. Method for eliciting in infants an immune response against rsv and b. pertussis
US20140037680A1 (en) 2012-08-06 2014-02-06 Glaxosmithkline Biologicals, S.A. Novel method
ES2828373T3 (es) 2013-06-04 2021-05-26 Aparin Petr Gennadievich Lipopolisacárido modificado (variantes) de bacterias endotóxicas, combinación de lipopolisacáridos modificados (variantes) y una vacuna (variantes), que los contiene, y una composición farmacéutica (variantes)
US11052142B2 (en) 2013-06-04 2021-07-06 Petr G. Aparin Modified endotoxic bacteria lipopolysaccharide (variants), combination of modified lipopolysaccharides (variants) and, containing same, a vaccine (variants) and a pharmaceutical composition (variants)
EP3030260A1 (en) 2013-08-05 2016-06-15 GlaxoSmithKline Biologicals S.A. Combination immunogenic compositions
US10420833B2 (en) 2014-05-19 2019-09-24 Board Of Regents, The University Of Texas System Combinatorial platform for the display of surface adjuvants and antigens
CN104388368B (zh) * 2014-10-30 2017-02-15 四川农业大学 一株低内毒素大肠杆菌原核表达工程菌突变株及构建方法
CN109071586B (zh) * 2016-01-28 2022-10-28 由卫生福利和体育大臣代表的荷兰王国 经修饰的四酰化奈瑟球菌lps
CN105567620B (zh) * 2016-01-29 2019-03-19 江南大学 一株产减毒类脂A的Cronobacter sakazakii突变株及其应用
CN105695540A (zh) * 2016-03-18 2016-06-22 辽宁成大生物股份有限公司 一种革兰氏阴性菌胞壁抗原的制备方法
EP3596110B1 (en) 2017-03-13 2024-09-04 Intravacc B.V. Bordetella vaccines comprising lps with reduced reactogenicity
US11744884B2 (en) * 2017-05-15 2023-09-05 University Of Maryland, Baltimore Live Salmonella typhi vectors engineered to express heterologous outer membrane protein antigens and methods of use thereof
AU2018379236B2 (en) * 2017-12-04 2025-02-27 Intravacc B.V. An improved process for producing outer membrane vesicles
CN115552020A (zh) * 2020-05-14 2022-12-30 默克专利股份公司 用于纯化腺相关病毒颗粒或腺病毒的方法和组合物
CN116438193A (zh) 2020-09-04 2023-07-14 Intravacc有限责任公司 OmpA突变增强百日咳博德特氏菌中OMV产生
EP4169513A1 (en) 2021-10-19 2023-04-26 GlaxoSmithKline Biologicals S.A. Adjuvant composition comprising sting agonists

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1033072A (zh) * 1987-09-04 1989-05-24 安姆根有限公司 重组dna产生的博德特氏菌毒素亚基类似物

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CH650681A5 (en) * 1981-08-14 1985-08-15 Dso Pharmachim Whooping cough vaccine
EP0484621A3 (en) * 1990-07-11 1992-08-26 American Cyanamid Company Efficacious vaccines against bordetella pertussis comprising a combination of individually purified pertussis antigens
HU219819B (hu) * 1992-08-18 2001-08-28 Dimminaco Ag/Sa/Ltd. Izolált polinukleotidok, ezeket tartalmazó Bordetella bronchiseptica törzs, és Bordetella bronchiseptica elleni vakcina
NZ306391A (en) * 1995-05-04 1999-03-29 Connaught Lab Acellular pertussis vaccines comprising purified toxin, filamentous haemagglutinin, pertactin and fimbrial agglutinogins
US6887483B2 (en) 1995-12-01 2005-05-03 University Of Iowa Research Foundation Non-toxic mutants of pathogenic gram-negative bacteria
PL190237B1 (pl) * 1997-04-01 2005-11-30 Corixa Corp Kompozycja adiuwantowa, szczepionka, sposób wytwarzania kompozycji adiuwantowej oraz zastosowanie
CA2264970A1 (en) 1998-03-10 1999-09-10 American Cyanamid Company Antigenic conjugates of conserved lipolysaccharides of gram negative bacteria
JP3595264B2 (ja) * 1998-11-03 2004-12-02 デ・スタート・デル・ネーデルランデン・ベルテゲンボールディクト・ドール・デ・ミニステル・バン・ベルジーン・ボルクスゲツォントヘイト・エン・クルトゥール 遺伝的に修飾されたグラム陰性細菌由来の低毒性ｌｐｓ
US6531131B1 (en) * 1999-08-10 2003-03-11 The United States Of America As Represented By The Department Of Health And Human Services Conjugate vaccine for Neisseria meningitidis
WO2002085295A2 (en) * 2001-04-20 2002-10-31 The University Of Iowa Research Foundation Methods and compositions for the modulation of biofilm formation

Patent Citations (1)

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Publication number Priority date Publication date Assignee Title
CN1033072A (zh) * 1987-09-04 1989-05-24 安姆根有限公司 重组dna产生的博德特氏菌毒素亚基类似物

Non-Patent Citations (2)

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Caroff M at al.Structural variability and originality of the Bordetella endotoxins.《JOURNAL OF ENDOTOXIN RESEARCH》.2001,第7卷(第1期),63-68. *
Parkhill Julian et al.Comparative analysis of the genome sequence of Bordetella pertussis,Bordetella parapertussis and bordetella bronchiseptica.《NATURE GENETICS》.2003,第35卷(第1期),32-40. *

Also Published As

Publication number Publication date
PT1828378E (pt) 2014-10-10
WO2006065139A2 (en) 2006-06-22
CN101203605A (zh) 2008-06-18
US8048433B2 (en) 2011-11-01
MX2007007288A (es) 2008-02-25
NO340331B1 (no) 2017-04-03
AU2005317304A1 (en) 2006-06-22
NO20073088L (no) 2007-09-17
CA2590906A1 (en) 2006-06-22
BRPI0519923A8 (pt) 2018-01-23
CA2590906C (en) 2017-01-03
WO2006065139A3 (en) 2006-10-19
NZ555889A (en) 2009-07-31
EP1828378A2 (en) 2007-09-05
PL1828378T3 (pl) 2014-10-31
US20080274145A1 (en) 2008-11-06
EP1828378B1 (en) 2014-06-11
ES2493440T3 (es) 2014-09-11
JP2008523805A (ja) 2008-07-10
BRPI0519923A2 (pt) 2009-08-11
JP5378685B2 (ja) 2013-12-25
DK1828378T3 (da) 2014-09-01
AU2005317304B2 (en) 2011-06-23

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Owner name: YOUWEISHENGFULIHE SPORTS

Free format text: FORMER OWNER: NV NETHERLANDS VACCINE INSTITUTE

Effective date: 20090515

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Effective date of registration: 20090515

Address after: Holland Hague

Applicant after: DE STAAT DER NEDERLANDEN, VERT. DOOR DE MINISTER VAN VWS

Address before: Bill de Holland

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CF01 Termination of patent right due to non-payment of annual fee

Granted publication date: 20160127

Termination date: 20211216

CF01 Termination of patent right due to non-payment of annual fee