NO20092278L - Mikroorganismer som baerere av nukleotid sekvenser kodende for antigener og protein toksiner, fremgangsmate for fremstilling og anvendelser derav - Google Patents

Mikroorganismer som baerere av nukleotid sekvenser kodende for antigener og protein toksiner, fremgangsmate for fremstilling og anvendelser derav

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Publication number
NO20092278L
NO20092278L NO20092278A NO20092278A NO20092278L NO 20092278 L NO20092278 L NO 20092278L NO 20092278 A NO20092278 A NO 20092278A NO 20092278 A NO20092278 A NO 20092278A NO 20092278 L NO20092278 L NO 20092278L
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Norway
Prior art keywords
microorganism
component
specific
nucleotide sequence
expression
Prior art date
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NO20092278A
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English (en)
Inventor
Joachim Fensterle
Ivaylo Gentschev
Ulf R Rapp
Werner Goebel
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Aeterna Zentaris Gmbh
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Application filed by Aeterna Zentaris Gmbh filed Critical Aeterna Zentaris Gmbh
Publication of NO20092278L publication Critical patent/NO20092278L/no

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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/62—DNA sequences coding for fusion proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/385—Haptens or antigens, bound to carriers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
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    • A61P11/06—Antiasthmatics
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/04—Antipruritics
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P17/06—Antipsoriatics
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
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    • A61P37/08—Antiallergic agents
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    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/14—Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4
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    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/62—DNA sequences coding for fusion proteins
    • C12N15/625—DNA sequences coding for fusion proteins containing a sequence coding for a signal sequence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/515—Animal cells
    • A61K2039/5156—Animal cells expressing foreign proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/52—Bacterial cells; Fungal cells; Protozoal cells
    • A61K2039/523—Bacterial cells; Fungal cells; Protozoal cells expressing foreign proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
    • A61K2039/6031—Proteins
    • A61K2039/6037—Bacterial toxins, e.g. diphteria toxoid [DT], tetanus toxoid [TT]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
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    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/035—Fusion polypeptide containing a localisation/targetting motif containing a signal for targeting to the external surface of a cell, e.g. to the outer membrane of Gram negative bacteria, GPI- anchored eukaryote proteins
    • C—CHEMISTRY; METALLURGY
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    • C07K—PEPTIDES
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    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/036—Fusion polypeptide containing a localisation/targetting motif targeting to the medium outside of the cell, e.g. type III secretion
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/55—Fusion polypeptide containing a fusion with a toxin, e.g. diphteria toxin
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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Abstract

Oppfinnelsen angår en mikroorganisme som en bærer av nukleotidsekvenser som koder for antigener og protein toksiner som innbefatter følgende komponenter: (I) minst en nukleotidsekvens som koder for minst ett fullstendig eller delvis antigen til minst ett villtype eller mutert protein; og (II) minst en nukleotidsekvens som koder for minst ett protein toksin og/eller minst en protein toksin underenhet; og (III) a) minst en nukleotidsekvens som koder for minst et transport system som muliggjør ekspresjonen av ekspresjonsproduktene til komponent (I) og komponent (II) på den ytre overflaten til mikroorganismen og/eller muliggjør sekresjonen av ekspresjonsproduktene til komponent (I) og komponent (II); og/eller som koder for minst en signalsekvens som muliggjør sekresjonen av ekspresjonsproduktene til komponent (I) og komponent (II); og/eller (III) b) eventuelt, minst en nukleotidsekvens som koder for minst ett protein for lysering av mikroorganismen i cytosolen til pattedyrceller og for intracellulært frigivende plasmider eller ekspresjonsvektorer, som er innbefattet i den lyserte mikroorganismen; og (IV) minst en nukleotidsekvens for minst en aktiveringssekvens for ekspresjonen av en eller flere av komponentene (I) til (III), hvori nevnte aktiveringssekvens kan bli aktivert i mikroorganismen og/eller er vevscelle spesifikk, tumorcelle spesifikk, makrofag spesifikk, dendritt spesifikk, lymfocytt spesifikk, funksjonsspesifikk eller ikke-celle spesifikk"; hvori en hvilken som helst av komponentene (I) til (IV) kan være tilstede enten en eller flere ganger og identiske eller forskjellige. Også beskrevet er en fremgangsmåte for fremstilling derav, korresponderende plasmider eller ekspresjonsvektorer og anvendelser av mikroorganismen som et medikament.
NO20092278A 2006-11-13 2009-06-12 Mikroorganismer som baerere av nukleotid sekvenser kodende for antigener og protein toksiner, fremgangsmate for fremstilling og anvendelser derav NO20092278L (no)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US86548406P 2006-11-13 2006-11-13
EP06123974A EP1921149A1 (en) 2006-11-13 2006-11-13 Microorganisms as carriers of nucleotide sequences coding for antigens and protein toxins, process of manufacturing and uses thereof
US93914007P 2007-05-21 2007-05-21
PCT/EP2007/062237 WO2008058944A1 (en) 2006-11-13 2007-11-13 Microorganisms as carriers of nucleotide sequences coding for antigens and protein toxins, process of manufacturing and uses thereof

Publications (1)

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NO20092278L true NO20092278L (no) 2009-08-13

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NO20092278A NO20092278L (no) 2006-11-13 2009-06-12 Mikroorganismer som baerere av nukleotid sekvenser kodende for antigener og protein toksiner, fremgangsmate for fremstilling og anvendelser derav

Country Status (30)

Country Link
US (1) US8669091B2 (no)
EP (2) EP1921149A1 (no)
JP (1) JP5479102B2 (no)
KR (1) KR101505413B1 (no)
CN (1) CN101595219B (no)
AR (1) AR063795A1 (no)
AT (1) ATE469971T1 (no)
AU (1) AU2007321266B2 (no)
BR (1) BRPI0719003A2 (no)
CA (1) CA2669219A1 (no)
CY (1) CY1111035T1 (no)
DE (1) DE602007006985D1 (no)
DK (1) DK2092067T3 (no)
ES (1) ES2347019T3 (no)
HK (1) HK1138314A1 (no)
HR (1) HRP20100466T1 (no)
IL (1) IL198736A0 (no)
ME (1) ME01846B (no)
MX (1) MX2009005038A (no)
NO (1) NO20092278L (no)
NZ (1) NZ576947A (no)
PL (1) PL2092067T3 (no)
PT (1) PT2092067E (no)
RS (1) RS51416B (no)
RU (1) RU2447145C2 (no)
SI (1) SI2092067T1 (no)
TW (1) TWI394834B (no)
UA (1) UA94974C2 (no)
WO (1) WO2008058944A1 (no)
ZA (1) ZA200903022B (no)

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