AR063795A1 - Microorganismos como vehiculos de secuencias de nucleotidos codificantes de antigenos y toxinas proteicas, proceso de elaboracion y usos de los mismos - Google Patents

Microorganismos como vehiculos de secuencias de nucleotidos codificantes de antigenos y toxinas proteicas, proceso de elaboracion y usos de los mismos

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Publication number
AR063795A1
AR063795A1 ARP070105040A ARP070105040A AR063795A1 AR 063795 A1 AR063795 A1 AR 063795A1 AR P070105040 A ARP070105040 A AR P070105040A AR P070105040 A ARP070105040 A AR P070105040A AR 063795 A1 AR063795 A1 AR 063795A1
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Argentina
Prior art keywords
component
nucleotide sequence
specific
microorganism
protein
Prior art date
Application number
ARP070105040A
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English (en)
Inventor
Ivaylo Gentschev
Joachim Fensterle
Ulf R Rapp
Werner Goebel
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Aeterna Zentaris Gmbh
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Application filed by Aeterna Zentaris Gmbh filed Critical Aeterna Zentaris Gmbh
Publication of AR063795A1 publication Critical patent/AR063795A1/es

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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/62—DNA sequences coding for fusion proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/385—Haptens or antigens, bound to carriers
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
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    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
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    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
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    • A61P11/08—Bronchodilators
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P17/04—Antipruritics
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    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/62—DNA sequences coding for fusion proteins
    • C12N15/625—DNA sequences coding for fusion proteins containing a sequence coding for a signal sequence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/515—Animal cells
    • A61K2039/5156—Animal cells expressing foreign proteins
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/52—Bacterial cells; Fungal cells; Protozoal cells
    • A61K2039/523—Bacterial cells; Fungal cells; Protozoal cells expressing foreign proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
    • A61K2039/6031—Proteins
    • A61K2039/6037—Bacterial toxins, e.g. diphteria toxoid [DT], tetanus toxoid [TT]
    • C—CHEMISTRY; METALLURGY
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    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
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    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/035—Fusion polypeptide containing a localisation/targetting motif containing a signal for targeting to the external surface of a cell, e.g. to the outer membrane of Gram negative bacteria, GPI- anchored eukaryote proteins
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    • C07K2319/036—Fusion polypeptide containing a localisation/targetting motif targeting to the medium outside of the cell, e.g. type III secretion
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    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/55—Fusion polypeptide containing a fusion with a toxin, e.g. diphteria toxin
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
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    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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Abstract

Microorganismos como vehículos de secuencias de nucleótidos codificantes de antígenos y toxinas proteicas que comprenden los siguientes componentes: (I) al menos una secuencia de nucleótidos que codifica al menos un antígeno completo o parcial de al menos una proteína de tipo salvaje o mutada; y (II) al menos una secuencia de nucleótidos que codifica al menos una toxina proteica y/o al menos una subunidad de una toxina proteica; y (III) a) al menos una secuencia de nucleótidos que codifica al menos un sistema de transporte que permite expresar los productos de expresión del componente (I) y del componente (II) sobre la superficie externa del microorganismo y/o permite la secreción de los productos de expresión del componente (I) y del componente (II); y/o que codifica al menos una secuencia senal que permite la secreción de los productos de expresión del componente (I) y del componente (II); y/o (III) b) opcionalmente, al menos una secuencia de nucleótidos que codifica al menos una proteína para lisar el microorganismo en el citosol de células de mamífero y para liberar intracelularmente plásmidos o vectores de expresión que están contenidos en el microorganismo lisado; y (IV) al menos una secuencia de nucleótidos de al menos una secuencia de activación para la expresión de uno o más de los componentes (I) a (III) , en donde dicha secuencia de activación puede ser activada en el microorganismo y/o es específica de células de tejidos, específica de células tumorales, específica de macrófagos, específica de dendritas, específica de linfocitos, específica de la función o específica de un componente no celular"; en donde cualquiera de los componentes (I) a (IV) pueden estar presentes ya sea una vez o varias veces y pueden ser idénticos o diferentes. También se revela un proceso de elaboración de los mismos, los correspondientes plásmidos o vectores de expresión y los usos del microorganismo como medicamento.
ARP070105040A 2006-11-13 2007-11-13 Microorganismos como vehiculos de secuencias de nucleotidos codificantes de antigenos y toxinas proteicas, proceso de elaboracion y usos de los mismos AR063795A1 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US86548406P 2006-11-13 2006-11-13
EP06123974A EP1921149A1 (en) 2006-11-13 2006-11-13 Microorganisms as carriers of nucleotide sequences coding for antigens and protein toxins, process of manufacturing and uses thereof
US93914007P 2007-05-21 2007-05-21

Publications (1)

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AR063795A1 true AR063795A1 (es) 2009-02-18

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Country Status (30)

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US (1) US8669091B2 (es)
EP (2) EP1921149A1 (es)
JP (1) JP5479102B2 (es)
KR (1) KR101505413B1 (es)
CN (1) CN101595219B (es)
AR (1) AR063795A1 (es)
AT (1) ATE469971T1 (es)
AU (1) AU2007321266B2 (es)
BR (1) BRPI0719003A2 (es)
CA (1) CA2669219A1 (es)
CY (1) CY1111035T1 (es)
DE (1) DE602007006985D1 (es)
DK (1) DK2092067T3 (es)
ES (1) ES2347019T3 (es)
HK (1) HK1138314A1 (es)
HR (1) HRP20100466T1 (es)
IL (1) IL198736A0 (es)
ME (1) ME01846B (es)
MX (1) MX2009005038A (es)
NO (1) NO20092278L (es)
NZ (1) NZ576947A (es)
PL (1) PL2092067T3 (es)
PT (1) PT2092067E (es)
RS (1) RS51416B (es)
RU (1) RU2447145C2 (es)
SI (1) SI2092067T1 (es)
TW (1) TWI394834B (es)
UA (1) UA94974C2 (es)
WO (1) WO2008058944A1 (es)
ZA (1) ZA200903022B (es)

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