CY1112105T1 - Ανοσογονα βακτηριακα κυστιδια με πρωτεϊνες εξωτερικης μεμβρανης - Google Patents
Ανοσογονα βακτηριακα κυστιδια με πρωτεϊνες εξωτερικης μεμβρανηςInfo
- Publication number
- CY1112105T1 CY1112105T1 CY20111100796T CY111100796T CY1112105T1 CY 1112105 T1 CY1112105 T1 CY 1112105T1 CY 20111100796 T CY20111100796 T CY 20111100796T CY 111100796 T CY111100796 T CY 111100796T CY 1112105 T1 CY1112105 T1 CY 1112105T1
- Authority
- CY
- Cyprus
- Prior art keywords
- bacterium
- mlta
- membrane proteins
- provides
- bladders
- Prior art date
Links
- 230000001580 bacterial effect Effects 0.000 title abstract 2
- 230000002163 immunogen Effects 0.000 title abstract 2
- 108010052285 Membrane Proteins Proteins 0.000 title 1
- 241000894006 Bacteria Species 0.000 abstract 5
- 230000037430 deletion Effects 0.000 abstract 2
- 238000012217 deletion Methods 0.000 abstract 2
- 101150084069 mltA gene Proteins 0.000 abstract 2
- 108090000623 proteins and genes Proteins 0.000 abstract 2
- 102000004169 proteins and genes Human genes 0.000 abstract 2
- MSFSPUZXLOGKHJ-UHFFFAOYSA-N Muraminsaeure Natural products OC(=O)C(C)OC1C(N)C(O)OC(CO)C1O MSFSPUZXLOGKHJ-UHFFFAOYSA-N 0.000 abstract 1
- 108010062010 N-Acetylmuramoyl-L-alanine Amidase Proteins 0.000 abstract 1
- 101710116435 Outer membrane protein Proteins 0.000 abstract 1
- 108010013639 Peptidoglycan Proteins 0.000 abstract 1
- 230000005875 antibody response Effects 0.000 abstract 1
- 239000001963 growth medium Substances 0.000 abstract 1
- 239000006166 lysate Substances 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/24—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Enterobacteriaceae (F), e.g. Citrobacter, Serratia, Proteus, Providencia, Morganella, Yersinia
- C07K14/245—Escherichia (G)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/095—Neisseria
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/22—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Neisseriaceae (F)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/1048—Glycosyltransferases (2.4)
- C12N9/1051—Hexosyltransferases (2.4.1)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/025—Enterobacteriales, e.g. Enterobacter
- A61K39/0258—Escherichia
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Genetics & Genomics (AREA)
- Immunology (AREA)
- Microbiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Epidemiology (AREA)
- Mycology (AREA)
- Gastroenterology & Hepatology (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Peptides Or Proteins (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Enzymes And Modification Thereof (AREA)
Abstract
Η εξάλειψη του μηνιγγιτιδοκοκκικού ομολόγου mltA δίνει βακτηρίδια που αυθόρμητα απελευθερώνουν κυστίδια, τα οποία είναι πλούσια σε ανοσογόνες πρωτεΐνες εξωτερικής μεμβράνης και που μπορούν να προκαλέσουν διασταυρούμενες προστατευτικές αποκρίσεις αντισωμάτων με υψηλότερους βακτηριοκτόνους τίτλους από εκείνους των OMV που παρασκευάστηκαν μέσω των κανονικών διαδικασιών παραγωγής. Κατά συνέπεια, η εφεύρεση παρέχει ένα βακτήριο που έχει μια μετάλλαξη εξάλειψης του mltA γονιδίου του. Η εφεύρεση παρέχει επίσης ένα βακτήριο, το οποίο βακτήριο: (i) έχει ένα κύτταρο που περιέχει πεπτιδογλυκάνη και (ii) δεν εκφράζει πρωτεΐνη που έχει τη λυτική δράση τρανς-γλυκοσυλάσης MltA πρωτεΐνης. Η εφεύρεση παρέχει επίσης συνθέσεις που περιλαμβάνουν κυστίδια τα οποία, κατά τη διάρκεια της καλλιέργειας των βακτηρίων της εφεύρεσης, απελευθερώνονται μέσα στο μέσο της καλλιέργειας.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB0424092.5A GB0424092D0 (en) | 2004-10-29 | 2004-10-29 | Immunogenic bacterial vesicles with outer membrane proteins |
EP05801788A EP1804834B1 (en) | 2004-10-29 | 2005-10-28 | Immunogenic bacterial vesicles with outer membrane proteins |
Publications (1)
Publication Number | Publication Date |
---|---|
CY1112105T1 true CY1112105T1 (el) | 2015-11-04 |
Family
ID=33515801
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CY20111100796T CY1112105T1 (el) | 2004-10-29 | 2011-08-18 | Ανοσογονα βακτηριακα κυστιδια με πρωτεϊνες εξωτερικης μεμβρανης |
Country Status (15)
Country | Link |
---|---|
US (3) | US9206399B2 (el) |
EP (2) | EP1804834B1 (el) |
JP (4) | JP5362221B2 (el) |
CN (1) | CN101048175B (el) |
AT (1) | ATE510559T1 (el) |
AU (1) | AU2005298332B2 (el) |
BR (1) | BRPI0517514A8 (el) |
CA (1) | CA2584778C (el) |
CY (1) | CY1112105T1 (el) |
ES (1) | ES2507499T3 (el) |
GB (1) | GB0424092D0 (el) |
NZ (1) | NZ553989A (el) |
PL (1) | PL2279747T3 (el) |
PT (1) | PT2279747E (el) |
WO (1) | WO2006046143A2 (el) |
Families Citing this family (47)
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GB9928196D0 (en) | 1999-11-29 | 2000-01-26 | Chiron Spa | Combinations of B, C and other antigens |
MX339524B (es) | 2001-10-11 | 2016-05-30 | Wyeth Corp | Composiciones inmunogenicas novedosas para la prevencion y tratamiento de enfermedad meningococica. |
GB0316560D0 (en) | 2003-07-15 | 2003-08-20 | Chiron Srl | Vesicle filtration |
GB0424092D0 (en) | 2004-10-29 | 2004-12-01 | Chiron Srl | Immunogenic bacterial vesicles with outer membrane proteins |
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AU2007285484B2 (en) * | 2006-08-16 | 2013-05-02 | Novartis Ag | Immunogens from uropathogenic Escherichia coli |
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GB0816284D0 (en) * | 2008-09-05 | 2008-10-15 | Nat Biolog Standards Board | Vaccine |
AU2009329193A1 (en) | 2008-12-17 | 2011-07-14 | Novartis Ag | Meningococcal vaccines including hemoglobin receptor |
GB0917003D0 (en) | 2009-09-28 | 2009-11-11 | Novartis Vaccines Inst For Global Health Srl | Purification of bacterial vesicles |
WO2011039631A2 (en) | 2009-09-30 | 2011-04-07 | Novartis Ag | Expression of meningococcal fhbp polypeptides |
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EP3831406B1 (en) | 2010-08-23 | 2024-06-05 | Wyeth LLC | Stable formulations of neisseria meningitidis rlp2086 antigens |
GB201014967D0 (en) * | 2010-09-09 | 2010-10-20 | Univ Southampton | Composition |
BR112013005626B1 (pt) | 2010-09-10 | 2022-07-26 | Glaxosmithkline Biologicals Sa | Meningococo, processo para a preparação de uma cepa meningocócica, vesículas de membrana externa, composição farmacêutica imunogênica, e, uso de uma composição |
AU2011300409B2 (en) | 2010-09-10 | 2015-03-26 | Wyeth Llc | Non-lipidated variants of Neisseria meningitidis ORF2086 antigens |
WO2012153302A1 (en) | 2011-05-12 | 2012-11-15 | Novartis Ag | Antipyretics to enhance tolerability of vesicle-based vaccines |
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ES2654613T3 (es) | 2012-02-02 | 2018-02-14 | Glaxosmithkline Biologicals Sa | Promotores para una expresión aumentada de proteínas en meningococos |
EP2823312B1 (en) | 2012-03-08 | 2019-08-07 | GlaxoSmithKline Biologicals SA | In vitro potency assay for protein-based meningococcal vaccines |
MX351993B (es) | 2012-03-09 | 2017-11-03 | Pfizer | Composiciones de neisseria meningitidis y metodos de las mismas. |
SA115360586B1 (ar) | 2012-03-09 | 2017-04-12 | فايزر انك | تركيبات لعلاج الالتهاب السحائي البكتيري وطرق لتحضيرها |
NZ630133A (en) | 2012-06-14 | 2016-10-28 | Novartis Ag | Vaccines for serogroup x meningococcus |
AU2013311702A1 (en) | 2012-09-06 | 2015-02-19 | Novartis Ag | Combination vaccines with serogroup B meningococcus and D/T/P |
CA2882382A1 (en) * | 2012-09-18 | 2014-03-27 | Novartis Ag | Outer membrane vesicles |
BR112015018877A2 (pt) * | 2013-02-07 | 2017-08-22 | Externautics Spa | Método para preparar uma composição farmacêutica, e, composição farmacêutica imunogênica |
CA2903716C (en) | 2013-03-08 | 2019-04-09 | Pfizer Inc. | Immunogenic fusion polypeptides |
MX369534B (es) | 2013-09-08 | 2019-11-11 | Pfizer | Composiciones de neisseria meningitidis y sus metodos. |
HUE052293T2 (hu) | 2014-02-28 | 2021-04-28 | Glaxosmithkline Biologicals Sa | Módosított fHbp meningococcus-polipeptidek |
RU2723045C2 (ru) | 2015-02-19 | 2020-06-08 | Пфайзер Инк. | Композиции neisseria meningitidis и способы их получения |
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2004
- 2004-10-29 GB GBGB0424092.5A patent/GB0424092D0/en not_active Ceased
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2005
- 2005-10-28 CN CN2005800368277A patent/CN101048175B/zh not_active Expired - Fee Related
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- 2005-10-28 WO PCT/IB2005/003494 patent/WO2006046143A2/en active Application Filing
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- 2005-10-28 BR BRPI0517514A patent/BRPI0517514A8/pt not_active Application Discontinuation
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- 2005-10-28 ES ES10183544.5T patent/ES2507499T3/es active Active
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Also Published As
Publication number | Publication date |
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CN101048175B (zh) | 2013-03-13 |
WO2006046143A3 (en) | 2007-03-15 |
US20180009852A1 (en) | 2018-01-11 |
JP2014039566A (ja) | 2014-03-06 |
WO2006046143A2 (en) | 2006-05-04 |
US9206399B2 (en) | 2015-12-08 |
CA2584778A1 (en) | 2006-05-04 |
JP2016135139A (ja) | 2016-07-28 |
ES2507499T3 (es) | 2014-10-15 |
US9771399B2 (en) | 2017-09-26 |
AU2005298332B2 (en) | 2012-05-03 |
PL2279747T3 (pl) | 2015-01-30 |
BRPI0517514A (pt) | 2008-10-14 |
ATE510559T1 (de) | 2011-06-15 |
US20100015212A1 (en) | 2010-01-21 |
CA2584778C (en) | 2014-04-08 |
PT2279747E (pt) | 2014-10-02 |
US10336794B2 (en) | 2019-07-02 |
JP6077983B2 (ja) | 2017-02-08 |
BRPI0517514A8 (pt) | 2017-10-03 |
EP1804834B1 (en) | 2011-05-25 |
JP2008517617A (ja) | 2008-05-29 |
EP2279747B1 (en) | 2014-06-25 |
NZ553989A (en) | 2010-03-26 |
GB0424092D0 (en) | 2004-12-01 |
US20160108094A1 (en) | 2016-04-21 |
AU2005298332A1 (en) | 2006-05-04 |
JP2011188870A (ja) | 2011-09-29 |
JP5362221B2 (ja) | 2013-12-11 |
EP1804834A2 (en) | 2007-07-11 |
EP2279747A1 (en) | 2011-02-02 |
CN101048175A (zh) | 2007-10-03 |
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