CY1112105T1 - Ανοσογονα βακτηριακα κυστιδια με πρωτεϊνες εξωτερικης μεμβρανης - Google Patents

Ανοσογονα βακτηριακα κυστιδια με πρωτεϊνες εξωτερικης μεμβρανης

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Publication number
CY1112105T1
CY1112105T1 CY20111100796T CY111100796T CY1112105T1 CY 1112105 T1 CY1112105 T1 CY 1112105T1 CY 20111100796 T CY20111100796 T CY 20111100796T CY 111100796 T CY111100796 T CY 111100796T CY 1112105 T1 CY1112105 T1 CY 1112105T1
Authority
CY
Cyprus
Prior art keywords
bacterium
mlta
membrane proteins
provides
bladders
Prior art date
Application number
CY20111100796T
Other languages
English (en)
Inventor
Jeannette Adu-Bobie
Mariagrazia Pizza
Nathalie Norais
Germano Ferrari
Guido Grandi
Original Assignee
Novartis Vaccines And Diagnostics S.R.L.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Vaccines And Diagnostics S.R.L. filed Critical Novartis Vaccines And Diagnostics S.R.L.
Publication of CY1112105T1 publication Critical patent/CY1112105T1/el

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/24—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Enterobacteriaceae (F), e.g. Citrobacter, Serratia, Proteus, Providencia, Morganella, Yersinia
    • C07K14/245—Escherichia (G)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/095—Neisseria
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/22—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Neisseriaceae (F)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1048—Glycosyltransferases (2.4)
    • C12N9/1051—Hexosyltransferases (2.4.1)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/025—Enterobacteriales, e.g. Enterobacter
    • A61K39/0258—Escherichia
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

Η εξάλειψη του μηνιγγιτιδοκοκκικού ομολόγου mltA δίνει βακτηρίδια που αυθόρμητα απελευθερώνουν κυστίδια, τα οποία είναι πλούσια σε ανοσογόνες πρωτεΐνες εξωτερικής μεμβράνης και που μπορούν να προκαλέσουν διασταυρούμενες προστατευτικές αποκρίσεις αντισωμάτων με υψηλότερους βακτηριοκτόνους τίτλους από εκείνους των OMV που παρασκευάστηκαν μέσω των κανονικών διαδικασιών παραγωγής. Κατά συνέπεια, η εφεύρεση παρέχει ένα βακτήριο που έχει μια μετάλλαξη εξάλειψης του mltA γονιδίου του. Η εφεύρεση παρέχει επίσης ένα βακτήριο, το οποίο βακτήριο: (i) έχει ένα κύτταρο που περιέχει πεπτιδογλυκάνη και (ii) δεν εκφράζει πρωτεΐνη που έχει τη λυτική δράση τρανς-γλυκοσυλάσης MltA πρωτεΐνης. Η εφεύρεση παρέχει επίσης συνθέσεις που περιλαμβάνουν κυστίδια τα οποία, κατά τη διάρκεια της καλλιέργειας των βακτηρίων της εφεύρεσης, απελευθερώνονται μέσα στο μέσο της καλλιέργειας.
CY20111100796T 2004-10-29 2011-08-18 Ανοσογονα βακτηριακα κυστιδια με πρωτεϊνες εξωτερικης μεμβρανης CY1112105T1 (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0424092.5A GB0424092D0 (en) 2004-10-29 2004-10-29 Immunogenic bacterial vesicles with outer membrane proteins
EP05801788A EP1804834B1 (en) 2004-10-29 2005-10-28 Immunogenic bacterial vesicles with outer membrane proteins

Publications (1)

Publication Number Publication Date
CY1112105T1 true CY1112105T1 (el) 2015-11-04

Family

ID=33515801

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20111100796T CY1112105T1 (el) 2004-10-29 2011-08-18 Ανοσογονα βακτηριακα κυστιδια με πρωτεϊνες εξωτερικης μεμβρανης

Country Status (15)

Country Link
US (3) US9206399B2 (el)
EP (2) EP1804834B1 (el)
JP (4) JP5362221B2 (el)
CN (1) CN101048175B (el)
AT (1) ATE510559T1 (el)
AU (1) AU2005298332B2 (el)
BR (1) BRPI0517514A8 (el)
CA (1) CA2584778C (el)
CY (1) CY1112105T1 (el)
ES (1) ES2507499T3 (el)
GB (1) GB0424092D0 (el)
NZ (1) NZ553989A (el)
PL (1) PL2279747T3 (el)
PT (1) PT2279747E (el)
WO (1) WO2006046143A2 (el)

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EP1804834A2 (en) 2007-07-11
ATE510559T1 (de) 2011-06-15
US10336794B2 (en) 2019-07-02
US20180009852A1 (en) 2018-01-11
PT2279747E (pt) 2014-10-02
US9771399B2 (en) 2017-09-26
JP2016135139A (ja) 2016-07-28
JP2008517617A (ja) 2008-05-29
US9206399B2 (en) 2015-12-08
EP2279747B1 (en) 2014-06-25
ES2507499T3 (es) 2014-10-15
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CN101048175A (zh) 2007-10-03
US20160108094A1 (en) 2016-04-21
CN101048175B (zh) 2013-03-13
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CA2584778A1 (en) 2006-05-04
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CA2584778C (en) 2014-04-08
JP2014039566A (ja) 2014-03-06
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AU2005298332A1 (en) 2006-05-04
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