BRPI0517514A8 - Vesículas bacterianas imunogênicas com proteínas da membrana externa - Google Patents

Vesículas bacterianas imunogênicas com proteínas da membrana externa

Info

Publication number
BRPI0517514A8
BRPI0517514A8 BRPI0517514A BRPI0517514A BRPI0517514A8 BR PI0517514 A8 BRPI0517514 A8 BR PI0517514A8 BR PI0517514 A BRPI0517514 A BR PI0517514A BR PI0517514 A BRPI0517514 A BR PI0517514A BR PI0517514 A8 BRPI0517514 A8 BR PI0517514A8
Authority
BR
Brazil
Prior art keywords
outer membrane
membrane proteins
provides
vesicles
bacterium
Prior art date
Application number
BRPI0517514A
Other languages
English (en)
Inventor
Pizza Mariagrazia
Adu-Bobie Jeannette
Norais Nathalie
Ferrari Germano
Grandi Guido
Original Assignee
Chiron Srl
Novartis Vaccines And Diagnostics S R L
Gsk Vaccines S R L
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chiron Srl, Novartis Vaccines And Diagnostics S R L, Gsk Vaccines S R L filed Critical Chiron Srl
Publication of BRPI0517514A publication Critical patent/BRPI0517514A/pt
Publication of BRPI0517514A8 publication Critical patent/BRPI0517514A8/pt

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/24—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Enterobacteriaceae (F), e.g. Citrobacter, Serratia, Proteus, Providencia, Morganella, Yersinia
    • C07K14/245—Escherichia (G)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/025—Enterobacteriales, e.g. Enterobacter
    • A61K39/0258—Escherichia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/095—Neisseria
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/22—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Neisseriaceae (F)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1048—Glycosyltransferases (2.4)
    • C12N9/1051—Hexosyltransferases (2.4.1)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Epidemiology (AREA)
  • Mycology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)

Abstract

VESÍCULAS BACTERIANAS IMUNOGÊNICAS COM PROTEÍNAS DA MEMBRANA EXTERNA. Knock out do homólogo mItA meningocócico proporciona bactérias que liberam espontaneamente vesículas que são ricas em proteínas da membrana externa imunogênicas e que podem estimular respostas de anticorpo protetoras cruzadas com titulações bactericidas do que OMVs preparadas através de processos normais de produção. Assim, a invenção proporciona uma bactéria tendo uma mutação por knock out de seu gene mltA. A invenção também proporciona uma bactéria em que a bactéria: (i) tem uma parede celular que inclui peptidoglicana; e (ii) não expressa uma proteína tendo a atividade de transglicosilase lítica da proteína MltA. A invenção também proporciona composições compreendendo vesículas que, durante cultura das bactérias da invenção, são liberadas no meio de cultura.
BRPI0517514A 2004-10-29 2005-10-28 Vesículas bacterianas imunogênicas com proteínas da membrana externa BRPI0517514A8 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0424092.5A GB0424092D0 (en) 2004-10-29 2004-10-29 Immunogenic bacterial vesicles with outer membrane proteins
PCT/IB2005/003494 WO2006046143A2 (en) 2004-10-29 2005-10-28 Immunogenic bacterial vesicles with outer membrane proteins

Publications (2)

Publication Number Publication Date
BRPI0517514A BRPI0517514A (pt) 2008-10-14
BRPI0517514A8 true BRPI0517514A8 (pt) 2017-10-03

Family

ID=33515801

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0517514A BRPI0517514A8 (pt) 2004-10-29 2005-10-28 Vesículas bacterianas imunogênicas com proteínas da membrana externa

Country Status (15)

Country Link
US (3) US9206399B2 (pt)
EP (2) EP1804834B1 (pt)
JP (4) JP5362221B2 (pt)
CN (1) CN101048175B (pt)
AT (1) ATE510559T1 (pt)
AU (1) AU2005298332B2 (pt)
BR (1) BRPI0517514A8 (pt)
CA (1) CA2584778C (pt)
CY (1) CY1112105T1 (pt)
ES (1) ES2507499T3 (pt)
GB (1) GB0424092D0 (pt)
NZ (1) NZ553989A (pt)
PL (1) PL2279747T3 (pt)
PT (1) PT2279747E (pt)
WO (1) WO2006046143A2 (pt)

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RU2020122024A (ru) 2017-12-04 2022-01-10 Де Стат Дер Недерланден, Верт. Дор Де Министер Ван Ввс, Министери Ван Волксгезондхейд, Велзейн Ен Спорт Улучшенный способ получения везикул внешней мембраны
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US9206399B2 (en) 2015-12-08
CA2584778A1 (en) 2006-05-04
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US9771399B2 (en) 2017-09-26
AU2005298332B2 (en) 2012-05-03
PL2279747T3 (pl) 2015-01-30
BRPI0517514A (pt) 2008-10-14
ATE510559T1 (de) 2011-06-15
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