ME01846B - Mikroorganizmi kao nosači nukleotidnih sekvenci koje kodiraju antigene i proteinske toksine, postupak njihove proizvodnje i korišćenja - Google Patents
Mikroorganizmi kao nosači nukleotidnih sekvenci koje kodiraju antigene i proteinske toksine, postupak njihove proizvodnje i korišćenjaInfo
- Publication number
- ME01846B ME01846B MEP-2010-387A MEP38710A ME01846B ME 01846 B ME01846 B ME 01846B ME P38710 A MEP38710 A ME P38710A ME 01846 B ME01846 B ME 01846B
- Authority
- ME
- Montenegro
- Prior art keywords
- antigens
- microorganisms
- carriers
- manufacturing
- nucleotide sequences
- Prior art date
Links
- 108091028043 Nucleic acid sequence Proteins 0.000 title 1
- 239000000427 antigen Substances 0.000 title 1
- 108091007433 antigens Proteins 0.000 title 1
- 102000036639 antigens Human genes 0.000 title 1
- 239000000969 carrier Substances 0.000 title 1
- 238000004519 manufacturing process Methods 0.000 title 1
- 238000000034 method Methods 0.000 title 1
- 244000005700 microbiome Species 0.000 title 1
- 231100000654 protein toxin Toxicity 0.000 title 1
- 108700012359 toxins Proteins 0.000 title 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/62—DNA sequences coding for fusion proteins
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/385—Haptens or antigens, bound to carriers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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-
- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
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- A—HUMAN NECESSITIES
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- A61P17/00—Drugs for dermatological disorders
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
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- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P5/14—Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/62—DNA sequences coding for fusion proteins
- C12N15/625—DNA sequences coding for fusion proteins containing a sequence coding for a signal sequence
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/515—Animal cells
- A61K2039/5156—Animal cells expressing foreign proteins
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/52—Bacterial cells; Fungal cells; Protozoal cells
- A61K2039/523—Bacterial cells; Fungal cells; Protozoal cells expressing foreign proteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
- A61K2039/6031—Proteins
- A61K2039/6037—Bacterial toxins, e.g. diphteria toxoid [DT], tetanus toxoid [TT]
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/035—Fusion polypeptide containing a localisation/targetting motif containing a signal for targeting to the external surface of a cell, e.g. to the outer membrane of Gram negative bacteria, GPI- anchored eukaryote proteins
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/036—Fusion polypeptide containing a localisation/targetting motif targeting to the medium outside of the cell, e.g. type III secretion
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/55—Fusion polypeptide containing a fusion with a toxin, e.g. diphteria toxin
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Genetics & Genomics (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biomedical Technology (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Microbiology (AREA)
- Pulmonology (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Oncology (AREA)
- Biochemistry (AREA)
- Plant Pathology (AREA)
- Epidemiology (AREA)
- Virology (AREA)
- Mycology (AREA)
- Communicable Diseases (AREA)
- Dermatology (AREA)
- Rheumatology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Neurosurgery (AREA)
- Orthopedic Medicine & Surgery (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US86548406P | 2006-11-13 | 2006-11-13 | |
| EP06123974A EP1921149A1 (en) | 2006-11-13 | 2006-11-13 | Microorganisms as carriers of nucleotide sequences coding for antigens and protein toxins, process of manufacturing and uses thereof |
| US93914007P | 2007-05-21 | 2007-05-21 | |
| EP07822513A EP2092067B1 (en) | 2006-11-13 | 2007-11-13 | Microorganisms as carriers of nucleotide sequences coding for antigens and protein toxins, process of manufacturing and uses thereof |
| PCT/EP2007/062237 WO2008058944A1 (en) | 2006-11-13 | 2007-11-13 | Microorganisms as carriers of nucleotide sequences coding for antigens and protein toxins, process of manufacturing and uses thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ME01846B true ME01846B (me) | 2011-02-28 |
Family
ID=37846081
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MEP-2010-387A ME01846B (me) | 2006-11-13 | 2007-11-13 | Mikroorganizmi kao nosači nukleotidnih sekvenci koje kodiraju antigene i proteinske toksine, postupak njihove proizvodnje i korišćenja |
Country Status (30)
| Country | Link |
|---|---|
| US (1) | US8669091B2 (me) |
| EP (2) | EP1921149A1 (me) |
| JP (1) | JP5479102B2 (me) |
| KR (1) | KR101505413B1 (me) |
| CN (1) | CN101595219B (me) |
| AR (1) | AR063795A1 (me) |
| AT (1) | ATE469971T1 (me) |
| AU (1) | AU2007321266B2 (me) |
| BR (1) | BRPI0719003A2 (me) |
| CA (1) | CA2669219A1 (me) |
| CY (1) | CY1111035T1 (me) |
| DE (1) | DE602007006985D1 (me) |
| DK (1) | DK2092067T3 (me) |
| ES (1) | ES2347019T3 (me) |
| HK (1) | HK1138314A1 (me) |
| HR (1) | HRP20100466T1 (me) |
| IL (1) | IL198736A0 (me) |
| ME (1) | ME01846B (me) |
| MX (1) | MX2009005038A (me) |
| NO (1) | NO20092278L (me) |
| NZ (1) | NZ576947A (me) |
| PL (1) | PL2092067T3 (me) |
| PT (1) | PT2092067E (me) |
| RS (1) | RS51416B (me) |
| RU (1) | RU2447145C2 (me) |
| SI (1) | SI2092067T1 (me) |
| TW (1) | TWI394834B (me) |
| UA (1) | UA94974C2 (me) |
| WO (1) | WO2008058944A1 (me) |
| ZA (1) | ZA200903022B (me) |
Families Citing this family (59)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2331271B1 (es) * | 2007-06-29 | 2010-10-14 | Universidad Del Pais Vasco | Metodo para la internalizacion de bacterias no invasivas en celulas eucariotas. |
| WO2009094006A2 (en) * | 2007-10-25 | 2009-07-30 | Wake Forest University Health Sciences | Bordetella outer-membrane protein antigens and methods of making and using the same |
| MX2010008555A (es) * | 2008-02-05 | 2010-08-30 | Aeterna Zentaris Gmbh | Bacteria recombinante con sistema de secrecion de hemolisina de e-coli y expresion incrementada y/o secrecion de hiya. proceso de elaboracion y usos de la misma. |
| CA2733425A1 (en) * | 2008-08-06 | 2010-02-11 | Emergent Product Development Uk Limited | Vaccines against clostridium difficile and methods of use |
| KR101104077B1 (ko) * | 2008-10-14 | 2012-01-11 | 건국대학교 산학협력단 | Ｅｇｒ－１의 발현을 증가시키는 활성을 갖는 신규한 엔터로박테리아속에 속하는 신규균주 및 그 균주를 포함하는 조성물의 항암제로서의 용도 |
| CN101480489B (zh) * | 2008-12-03 | 2012-07-04 | 中国人民解放军第三军医大学 | 疟原虫环子孢子蛋白抗肿瘤增殖和迁移的新用途 |
| US8524220B1 (en) | 2010-02-09 | 2013-09-03 | David Gordon Bermudes | Protease inhibitor: protease sensitivity expression system composition and methods improving the therapeutic activity and specificity of proteins delivered by bacteria |
| US8771669B1 (en) | 2010-02-09 | 2014-07-08 | David Gordon Bermudes | Immunization and/or treatment of parasites and infectious agents by live bacteria |
| US9597379B1 (en) | 2010-02-09 | 2017-03-21 | David Gordon Bermudes | Protease inhibitor combination with therapeutic proteins including antibodies |
| GB2478734A (en) * | 2010-03-15 | 2011-09-21 | Sense Proteomic Ltd | Auto-antibody biomarkers of prostate cancer |
| KR101229596B1 (ko) * | 2010-05-13 | 2013-02-04 | 한국외국어대학교 연구산학협력단 | 사람 락토페리신 펩티드의 대장균 발현 플라스미드 및 그 용도 |
| LT2753352T (lt) | 2010-09-03 | 2017-05-25 | Valneva Austria Gmbh | Išskirtas toksino a ir toksino b baltymų polipeptidas iš c. difficile ir jo panaudojimas |
| CN106978437A (zh) * | 2011-03-02 | 2017-07-25 | 富途锐基尼以色列有限公司 | 具有功能失调的t3ss蛋白的抗菌性转基因植物 |
| EP2683400A4 (en) | 2011-03-11 | 2014-09-17 | Advaxis | ADJUVANZIA ON LISTERIA BASE |
| US10258676B2 (en) * | 2011-09-06 | 2019-04-16 | Agency For Science, Technology And Research | Polypeptide vaccine |
| US11680273B2 (en) | 2011-09-23 | 2023-06-20 | Loma Linda University | Treatment of autoimmune diseases |
| DK2758074T3 (da) | 2011-09-23 | 2020-07-27 | Univ Loma Linda | Bakteriestammer der udtrykker methylasegener og anvendelser deraf |
| EP2583975A1 (en) * | 2011-10-21 | 2013-04-24 | Heinrich-Heine-Universität Düsseldorf | Agents and methods for the expression and secretion of peptides and proteins |
| PT2782598T (pt) * | 2011-11-23 | 2020-09-02 | In3Bio Ltd Codan Services Ltd | Proteínas recombinantes e suas utilizações terapêuticas |
| US10058599B2 (en) | 2012-03-12 | 2018-08-28 | Advaxis, Inc. | Suppressor cell function inhibition following Listeria vaccine treatment |
| US9499856B2 (en) | 2012-04-02 | 2016-11-22 | The Board Institute, Inc. | DDR2 mutations in squamous cell lung cancer |
| WO2013177291A1 (en) * | 2012-05-23 | 2013-11-28 | The United States Of America, As Represented By The Secretary, Department Of Health & Human Services | Salmonella typhi ty21a expressing yersinia pestis f1-v fusion protein and uses thereof |
| EP2878672A4 (en) * | 2012-07-26 | 2016-02-17 | Nat Cancer Ct | FUSIONSGEN OF CEP55-GEN AND RET-GEN |
| US9593339B1 (en) | 2013-02-14 | 2017-03-14 | David Gordon Bermudes | Bacteria carrying bacteriophage and protease inhibitors for the treatment of disorders and methods of treatment |
| EP2970409A2 (en) * | 2013-03-15 | 2016-01-20 | Bioven 3 Limited | Self-assembling synthetic proteins |
| EP2792686A1 (en) | 2013-04-17 | 2014-10-22 | Heinrich-Heine-Universität Düsseldorf | Methods for the expression of peptides and proteins |
| US9920297B2 (en) | 2013-04-25 | 2018-03-20 | Vaximm Ag | Salmonella-based vectors for cancer immunotherapy targeting wilms' tumor gene WT1 |
| CN105017256A (zh) | 2014-04-29 | 2015-11-04 | 浙江导明医药科技有限公司 | 多氟化合物作为布鲁顿酪氨酸激酶抑制剂 |
| WO2015177197A1 (en) * | 2014-05-21 | 2015-11-26 | Universitaet Basel | Bacteria-based protein delivery |
| EP3166637B1 (en) | 2014-07-10 | 2020-01-29 | The J. David Gladstone Institutes | Compositions and methods for treating dengue virus infection |
| US20160030531A1 (en) * | 2014-08-01 | 2016-02-04 | Northwestern University | Bacterial toxins and uses thereof as ras specific proteases |
| MA41217A (fr) * | 2014-12-19 | 2017-10-24 | Advaxis Inc | Polythérapies ayant des souches de listeria recombinées |
| US9717745B2 (en) | 2015-03-19 | 2017-08-01 | Zhejiang DTRM Biopharma Co. Ltd. | Pharmaceutical compositions and their use for treatment of cancer and autoimmune diseases |
| CN106146508A (zh) * | 2015-03-19 | 2016-11-23 | 浙江导明医药科技有限公司 | 优化的联合用药及其治疗癌症和自身免疫疾病的用途 |
| CA3018308A1 (en) | 2015-04-28 | 2016-11-03 | Albert Einstein College Of Medicine, Inc. | Treatment of cancer using recall antigens delivered by attenuated bacteria |
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| JPH02170053A (ja) * | 1988-12-23 | 1990-06-29 | Meiji Seika Kaisha Ltd | 微生物の検出方法及び装置 |
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| DE10208653A1 (de) | 2002-02-28 | 2003-09-18 | Medinnova Ges Med Innovationen | Mikroorganismus als Träger von Nukleotidsequenzen kodierend für Zellantigene zur Behandlung von Tumoren |
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