JP2013539771A5 - - Google Patents

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JP2013539771A5
JP2013539771A5 JP2013533178A JP2013533178A JP2013539771A5 JP 2013539771 A5 JP2013539771 A5 JP 2013539771A5 JP 2013533178 A JP2013533178 A JP 2013533178A JP 2013533178 A JP2013533178 A JP 2013533178A JP 2013539771 A5 JP2013539771 A5 JP 2013539771A5
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Japan
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formula
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alkyl
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cycloalkyl
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JP2013533178A
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English (en)
Japanese (ja)
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JP2013539771A (ja
JP5937087B2 (ja
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Priority claimed from PCT/EP2011/067696 external-priority patent/WO2012049153A1/en
Publication of JP2013539771A publication Critical patent/JP2013539771A/ja
Publication of JP2013539771A5 publication Critical patent/JP2013539771A5/ja
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JP2013533178A 2010-10-12 2011-10-11 ジヒドロプテリジノン及びその中間体を製造する方法 Active JP5937087B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP10187194 2010-10-12
EP10187194.5 2010-10-12
PCT/EP2011/067696 WO2012049153A1 (en) 2010-10-12 2011-10-11 Process for manufacturing dihydropteridinones and intermediates thereof

Publications (3)

Publication Number Publication Date
JP2013539771A JP2013539771A (ja) 2013-10-28
JP2013539771A5 true JP2013539771A5 (enExample) 2014-12-04
JP5937087B2 JP5937087B2 (ja) 2016-06-22

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ID=43902841

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JP2013533178A Active JP5937087B2 (ja) 2010-10-12 2011-10-11 ジヒドロプテリジノン及びその中間体を製造する方法

Country Status (18)

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US (1) US8546566B2 (enExample)
EP (1) EP2627656B1 (enExample)
JP (1) JP5937087B2 (enExample)
KR (1) KR20140005877A (enExample)
CN (1) CN103168040A (enExample)
AU (1) AU2011315552B2 (enExample)
BR (1) BR112013008883A2 (enExample)
CA (1) CA2813838A1 (enExample)
CL (1) CL2013000730A1 (enExample)
DK (1) DK2627656T3 (enExample)
EA (1) EA024256B1 (enExample)
ES (1) ES2509741T3 (enExample)
IL (1) IL224602A (enExample)
MX (1) MX2013003994A (enExample)
NZ (1) NZ606700A (enExample)
PH (1) PH12013500694A1 (enExample)
PL (1) PL2627656T3 (enExample)
WO (1) WO2012049153A1 (enExample)

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US8546566B2 (en) 2010-10-12 2013-10-01 Boehringer Ingelheim International Gmbh Process for manufacturing dihydropteridinones and intermediates thereof
US9358233B2 (en) 2010-11-29 2016-06-07 Boehringer Ingelheim International Gmbh Method for treating acute myeloid leukemia
US9370535B2 (en) 2011-05-17 2016-06-21 Boehringer Ingelheim International Gmbh Method for treatment of advanced solid tumors
WO2015011236A1 (en) 2013-07-26 2015-01-29 Boehringer Ingelheim International Gmbh Treatment of myelodysplastic syndrome
CN104003989B (zh) * 2014-05-26 2015-11-11 苏州明锐医药科技有限公司 伏拉塞替及其中间体的制备方法
US9867831B2 (en) 2014-10-01 2018-01-16 Boehringer Ingelheim International Gmbh Combination treatment of acute myeloid leukemia and myelodysplastic syndrome
CN105646398B (zh) * 2014-12-05 2018-09-07 上海医药工业研究院 N-((1r,4r)-4-(4-(环丙基甲基)哌嗪-1-基)环己基)乙酰胺的制备方法
CN108610343A (zh) * 2018-06-12 2018-10-02 杨文思 一种用于治疗癌症的表皮生长因子受体抑制剂及其合成方法
US20220040324A1 (en) 2018-12-21 2022-02-10 Daiichi Sankyo Company, Limited Combination of antibody-drug conjugate and kinase inhibitor

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