JP2017531661A5 - - Google Patents
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- JP2017531661A5 JP2017531661A5 JP2017518846A JP2017518846A JP2017531661A5 JP 2017531661 A5 JP2017531661 A5 JP 2017531661A5 JP 2017518846 A JP2017518846 A JP 2017518846A JP 2017518846 A JP2017518846 A JP 2017518846A JP 2017531661 A5 JP2017531661 A5 JP 2017531661A5
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- JP
- Japan
- Prior art keywords
- compound
- formula
- group
- general formula
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- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 0 *O[C@](C1)C(C*O)[C@@](C2)[C@]1Cc1c2cccc1O* Chemical compound *O[C@](C1)C(C*O)[C@@](C2)[C@]1Cc1c2cccc1O* 0.000 description 3
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2019165225A JP6898401B2 (ja) | 2014-10-08 | 2019-09-11 | トレプロスチニルの製造方法 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| HU1400475A HU231186B1 (hu) | 2014-10-08 | 2014-10-08 | Új eljárás treprostinil és sói előállítására |
| HUP1400475 | 2014-10-08 | ||
| PCT/HU2015/000065 WO2016055819A1 (en) | 2014-10-08 | 2015-09-28 | Process for the preparation of treprostinil |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019165225A Division JP6898401B2 (ja) | 2014-10-08 | 2019-09-11 | トレプロスチニルの製造方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017531661A JP2017531661A (ja) | 2017-10-26 |
| JP2017531661A5 true JP2017531661A5 (enExample) | 2020-06-11 |
| JP6820255B2 JP6820255B2 (ja) | 2021-01-27 |
Family
ID=89991608
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017518846A Active JP6820255B2 (ja) | 2014-10-08 | 2015-09-28 | トレプロスチニルの製造方法 |
| JP2019165225A Active JP6898401B2 (ja) | 2014-10-08 | 2019-09-11 | トレプロスチニルの製造方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019165225A Active JP6898401B2 (ja) | 2014-10-08 | 2019-09-11 | トレプロスチニルの製造方法 |
Country Status (14)
| Country | Link |
|---|---|
| US (3) | US10322990B2 (enExample) |
| EP (1) | EP3204349A1 (enExample) |
| JP (2) | JP6820255B2 (enExample) |
| KR (2) | KR102651020B1 (enExample) |
| CN (2) | CN107001221B (enExample) |
| AU (1) | AU2015329740B2 (enExample) |
| CA (1) | CA2963844C (enExample) |
| HU (2) | HU231184B1 (enExample) |
| IL (1) | IL251613B (enExample) |
| MX (1) | MX384201B (enExample) |
| RU (1) | RU2709200C2 (enExample) |
| SG (1) | SG11201702790YA (enExample) |
| TW (2) | TWI761731B (enExample) |
| WO (1) | WO2016055819A1 (enExample) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9505737B2 (en) | 2013-01-11 | 2016-11-29 | Corsair Pharma, Inc. | Treprostinil derivative compounds and methods of using same |
| EP3712142B1 (en) | 2013-01-11 | 2022-07-06 | Corsair Pharma, Inc. | Prodrugs of treprostinil |
| US9643911B2 (en) | 2015-06-17 | 2017-05-09 | Corsair Pharma, Inc. | Treprostinil derivatives and compositions and uses thereof |
| US9394227B1 (en) | 2015-06-17 | 2016-07-19 | Corsair Pharma, Inc. | Treprostinil derivatives and compositions and uses thereof |
| EP3408252B1 (en) | 2016-01-27 | 2022-03-02 | Emcure Pharmaceuticals Limited | Process for preparation of prostacyclin derivatives |
| KR101830693B1 (ko) * | 2016-04-28 | 2018-02-21 | 연성정밀화학(주) | 트레프로스티닐의 제조방법 및 이를 위한 중간체 |
| WO2018058124A1 (en) | 2016-09-26 | 2018-03-29 | United Therapeutics Corporation | Treprostinil prodrugs |
| HU231296B1 (hu) * | 2018-03-09 | 2022-09-28 | Chinoin Zrt | Eljárás treprostinil-dietanol-amin só B polimorf formájának előállítására |
| KR102084044B1 (ko) * | 2018-12-24 | 2020-03-03 | 주식회사 세미부스터 | 인산용액 중의 실리콘 농도 분석방법 |
| JP7365073B2 (ja) * | 2019-05-21 | 2023-10-19 | ジァンスー フォアフロント ファーマシューティカル カンパニー，リミテッド | トレプロスチニルナトリウムの新規な結晶形および製造方法 |
| CN114616225A (zh) | 2019-08-23 | 2022-06-10 | 联合治疗公司 | 曲前列环素前药 |
| US10781160B1 (en) * | 2019-10-04 | 2020-09-22 | Chirogate International Inc. | Hexadecyl Treprostinil crystals and methods for preparation thereof |
| US11339110B2 (en) * | 2019-12-19 | 2022-05-24 | Chirogate International Inc. | Efficient crystallization process for preparing ultrapure Treprostinil and crystal prepared therefrom |
| IL296567A (en) | 2020-04-17 | 2022-11-01 | United Therapeutics Corp | Terfostinil for use in the treatment of interstitial lung disease |
| AU2021289336B2 (en) | 2020-06-09 | 2025-08-28 | Mannkind Corporation | Fumaryl diketopiperidine prodrugs of treprostinil |
| US11447440B2 (en) * | 2020-10-29 | 2022-09-20 | Chirogate International Inc. | Treprostinil monohydrate crystals and methods for preparation thereof |
| KR102849520B1 (ko) | 2020-12-14 | 2025-08-25 | 유나이티드 쎄러퓨틱스 코포레이션 | 트레프로스티닐 프로드러그로 질환을 치료하는 방법 |
| WO2022187352A1 (en) | 2021-03-03 | 2022-09-09 | United Therapeutics Corporation | A dry powder composition of trestinil and its prodrug thereof and further comprising comprising (e)-3,6-bis[4-(n-carbonyl-2-propenyl)amidobutyl]-2,5-diketopiperazine (fdkp) |
| WO2023154705A1 (en) | 2022-02-08 | 2023-08-17 | United Therapeutics Corporation | Treprostinil iloprost combination therapy |
| CN121241041A (zh) | 2023-01-19 | 2025-12-30 | 联合治疗公司 | 曲前列尼尔类似物及相关制备和使用方法 |
| CN122514512A (zh) | 2023-11-09 | 2026-08-04 | 联合治疗公司 | 可用于生产曲前列尼尔的化合物的合成 |
| US20260166056A1 (en) | 2024-12-13 | 2026-06-18 | United Therapeutics Corporation | Treprostinil formulations and their uses |
Family Cites Families (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA1313670C (en) | 1980-02-28 | 1993-02-16 | Robert Charles Kelly | Carbacyclin analogs |
| US4338457A (en) | 1980-02-28 | 1982-07-06 | The Upjohn Company | Composition and process |
| DK1025083T3 (da) | 1997-10-24 | 2004-03-01 | United Therapeutics Corp | Fremgangsmåde til stereoselektiv syntese af prostacyclin-derivater |
| US6441245B1 (en) | 1997-10-24 | 2002-08-27 | United Therapeutics Corporation | Process for stereoselective synthesis of prostacyclin derivatives |
| ES2214753T3 (es) | 1997-11-14 | 2004-09-16 | United Therapeutics Corporation | Uso de 9-desoxi-2',9-alfa-metano-3-oxa-4,5,6-trinor-3,7-(1',3'-interfenilen)-13,14-dihidro-prostaglandina f1 para tratar la enfermedad vascular periferica. |
| CN102697790A (zh) * | 2003-05-22 | 2012-10-03 | 联合治疗公司 | 化合物和释放前列环素类似物的方法 |
| JP5038031B2 (ja) | 2006-07-11 | 2012-10-03 | キヤノン株式会社 | 放射線撮影装置、その駆動方法及び放射線撮影システム |
| WO2009078965A1 (en) | 2007-12-17 | 2009-06-25 | United Therapeutics Corporation | An improved process to prepare treprostinil, the active ingredient in remodulin |
| JP6219016B2 (ja) * | 2008-05-08 | 2017-10-25 | ユナイテッド セラピューティクス コーポレーション | トレプロスチニル一水和物 |
| WO2009158010A1 (en) * | 2008-06-27 | 2009-12-30 | Concert Pharmaceuticals, Inc. | Prostacyclin analogs |
| CN102040618B (zh) | 2009-04-30 | 2013-09-04 | 上海天伟生物制药有限公司 | 一种PGF2a类似物的制备方法及其相关中间体 |
| CN103261142B (zh) * | 2010-06-03 | 2014-12-10 | 联合治疗公司 | 曲前列环素的制备 |
| CA2710726C (en) | 2010-07-22 | 2016-02-23 | Alphora Research Inc. | Synthesis of treprostinil and intermediates useful therein |
| KR101306180B1 (ko) | 2010-11-19 | 2013-09-10 | 시마 상요 코퍼레이션 리미티드 | 건조 감용 처리 장치 |
| CA2726599C (en) * | 2010-12-30 | 2017-07-25 | Alphora Research Inc. | Process for treprostinil salt preparation |
| EP2495235B1 (en) * | 2011-03-04 | 2015-08-05 | Newchem S.p.A. | Process for the synthesis of prostaglandins and intermediates thereof |
| US8524939B2 (en) * | 2011-08-24 | 2013-09-03 | Chirogate International Inc. | Intermediates for the synthesis of benzindene prostaglandins and preparations thereof |
| CN103193627B (zh) * | 2012-01-10 | 2016-04-20 | 上海天伟生物制药有限公司 | 一种前列腺素类似物的晶型及其制备方法和用途 |
| SI2674413T1 (sl) * | 2012-06-15 | 2017-10-30 | Scipharm Sarl | Postopek za pripravo treprostinila in derivatov le-tega |
| CN104837806A (zh) | 2012-12-07 | 2015-08-12 | 开曼化学股份有限公司 | 前列环素类似物的合成方法 |
| EP3712142B1 (en) * | 2013-01-11 | 2022-07-06 | Corsair Pharma, Inc. | Prodrugs of treprostinil |
| EP2970081A4 (en) * | 2013-03-15 | 2016-10-12 | United Therapeutics Corp | SALTS OF TREPROSTINIL |
| EP3169660A1 (en) * | 2014-07-16 | 2017-05-24 | Corsair Pharma, Inc. | Treprostinil derivative compounds and methods of using same |
-
2014
- 2014-10-08 HU HU1900346A patent/HU231184B1/hu unknown
- 2014-10-08 HU HU1400475A patent/HU231186B1/hu unknown
-
2015
- 2015-09-28 CN CN201580066416.6A patent/CN107001221B/zh active Active
- 2015-09-28 WO PCT/HU2015/000065 patent/WO2016055819A1/en not_active Ceased
- 2015-09-28 CN CN202110561010.2A patent/CN113292419A/zh active Pending
- 2015-09-28 RU RU2017115930A patent/RU2709200C2/ru active
- 2015-09-28 KR KR1020177012210A patent/KR102651020B1/ko active Active
- 2015-09-28 KR KR1020247009377A patent/KR102841902B1/ko active Active
- 2015-09-28 EP EP15787660.8A patent/EP3204349A1/en active Pending
- 2015-09-28 AU AU2015329740A patent/AU2015329740B2/en active Active
- 2015-09-28 JP JP2017518846A patent/JP6820255B2/ja active Active
- 2015-09-28 CA CA2963844A patent/CA2963844C/en active Active
- 2015-09-28 MX MX2017004672A patent/MX384201B/es unknown
- 2015-09-28 SG SG11201702790YA patent/SG11201702790YA/en unknown
- 2015-09-28 US US15/518,096 patent/US10322990B2/en active Active
- 2015-10-06 TW TW108142477A patent/TWI761731B/zh active
- 2015-10-06 TW TW104132764A patent/TWI761299B/zh active
-
2017
- 2017-04-06 IL IL251613A patent/IL251613B/en active IP Right Grant
-
2019
- 2019-04-29 US US16/397,139 patent/US11098001B2/en active Active
- 2019-09-11 JP JP2019165225A patent/JP6898401B2/ja active Active
-
2021
- 2021-07-15 US US17/377,125 patent/US11724979B2/en active Active
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