HU231184B1 - Treprostinil-nátrium-monohidrát és eljárás ennek előállítására - Google Patents

Treprostinil-nátrium-monohidrát és eljárás ennek előállítására Download PDF

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HU231184B1
HU231184B1 HU1900346A HUP1900346A HU231184B1 HU 231184 B1 HU231184 B1 HU 231184B1 HU 1900346 A HU1900346 A HU 1900346A HU P1900346 A HUP1900346 A HU P1900346A HU 231184 B1 HU231184 B1 HU 231184B1
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ppm
sodium
nmr
reaction mixture
added
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HU1900346A
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English (en)
Hungarian (hu)
Inventor
Imre Juhász
Irén Hortobágyi
Tamás Altsach
István Lászlófi
Borkó Ágnes Nagyné
Imre Rozsumberszki
Gábor Havasi
Zsuzsanna Kardos
Péter Buzder-Lantos
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CHINOIN Gyógyszer és Vegyészeti Termékek Gyára Zrt.
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Priority to HU1900346A priority Critical patent/HU231184B1/hu
Publication of HUP1900346A1 publication Critical patent/HUP1900346A1/hu
Publication of HU231184B1 publication Critical patent/HU231184B1/hu

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  • Chemical Kinetics & Catalysis (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Pyrane Compounds (AREA)
HU1900346A 2014-10-08 2014-10-08 Treprostinil-nátrium-monohidrát és eljárás ennek előállítására HU231184B1 (hu)

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HU1900346A HU231184B1 (hu) 2014-10-08 2014-10-08 Treprostinil-nátrium-monohidrát és eljárás ennek előállítására

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HU1900346A HU231184B1 (hu) 2014-10-08 2014-10-08 Treprostinil-nátrium-monohidrát és eljárás ennek előállítására
HU1400475A HU231186B1 (hu) 2014-10-08 2014-10-08 Új eljárás treprostinil és sói előállítására

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HUP1900346A1 HUP1900346A1 (enExample) 2016-04-28
HU231184B1 true HU231184B1 (hu) 2021-07-28

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HU1900346A HU231184B1 (hu) 2014-10-08 2014-10-08 Treprostinil-nátrium-monohidrát és eljárás ennek előállítására
HU1400475A HU231186B1 (hu) 2014-10-08 2014-10-08 Új eljárás treprostinil és sói előállítására

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HU1400475A HU231186B1 (hu) 2014-10-08 2014-10-08 Új eljárás treprostinil és sói előállítására

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US (3) US10322990B2 (enExample)
EP (1) EP3204349A1 (enExample)
JP (2) JP6820255B2 (enExample)
KR (2) KR102841902B1 (enExample)
CN (2) CN107001221B (enExample)
AU (1) AU2015329740B2 (enExample)
CA (1) CA2963844C (enExample)
HU (2) HU231184B1 (enExample)
IL (1) IL251613B (enExample)
MX (1) MX384201B (enExample)
RU (1) RU2709200C2 (enExample)
SG (1) SG11201702790YA (enExample)
TW (2) TWI761731B (enExample)
WO (1) WO2016055819A1 (enExample)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9505737B2 (en) 2013-01-11 2016-11-29 Corsair Pharma, Inc. Treprostinil derivative compounds and methods of using same
ES2927844T3 (es) 2013-01-11 2022-11-11 Corsair Pharma Inc Profármacos de treprostinil
US9394227B1 (en) 2015-06-17 2016-07-19 Corsair Pharma, Inc. Treprostinil derivatives and compositions and uses thereof
US9643911B2 (en) 2015-06-17 2017-05-09 Corsair Pharma, Inc. Treprostinil derivatives and compositions and uses thereof
ES2909890T3 (es) 2016-01-27 2022-05-10 Emcure Pharmaceuticals Ltd Proceso de preparación de derivados de prostaciclina
KR101830693B1 (ko) 2016-04-28 2018-02-21 연성정밀화학(주) 트레프로스티닐의 제조방법 및 이를 위한 중간체
CA3038276A1 (en) 2016-09-26 2018-03-29 United Therapeutics Corporation Treprostinil prodrugs
HU231296B1 (hu) * 2018-03-09 2022-09-28 Chinoin Zrt Eljárás treprostinil-dietanol-amin só B polimorf formájának előállítására
KR102084044B1 (ko) * 2018-12-24 2020-03-03 주식회사 세미부스터 인산용액 중의 실리콘 농도 분석방법
US12435023B2 (en) 2019-05-21 2025-10-07 Shanghai Forefront Pharmceutical Co., Ltd. Crystal form of Treprostinil sodium salt and preparation method therefor
WO2021041320A1 (en) 2019-08-23 2021-03-04 United Therapeutics Corporation Treprostinil prodrugs
US10781160B1 (en) * 2019-10-04 2020-09-22 Chirogate International Inc. Hexadecyl Treprostinil crystals and methods for preparation thereof
US11339110B2 (en) * 2019-12-19 2022-05-24 Chirogate International Inc. Efficient crystallization process for preparing ultrapure Treprostinil and crystal prepared therefrom
IL296567A (en) 2020-04-17 2022-11-01 United Therapeutics Corp Terfostinil for use in the treatment of interstitial lung disease
US11793780B2 (en) 2020-06-09 2023-10-24 United Therapeutics Corporation Prodrugs of treprosiinil
US11447440B2 (en) * 2020-10-29 2022-09-20 Chirogate International Inc. Treprostinil monohydrate crystals and methods for preparation thereof
KR20250133451A (ko) 2020-12-14 2025-09-05 유나이티드 쎄러퓨틱스 코포레이션 트레프로스티닐 프로드러그로 질환을 치료하는 방법
AU2022229367A1 (en) 2021-03-03 2023-09-14 United Therapeutics Corporation A dry powder composition of trestinil and its prodrug thereof and further comprising comprising (e)-3,6-bis[4-(n-carbonyl-2-propenyl)amidobutyl]-2,5-diketopiperazine (fdkp)
US20230263807A1 (en) 2022-02-08 2023-08-24 United Therapeutics Corporation Treprostinil iloprost combination therapy
AU2024208919A1 (en) 2023-01-19 2025-07-17 United Therapeutics Corporation Treprostinil analogs
US20250197338A1 (en) 2023-11-09 2025-06-19 United Therapeutics Corporation Syntheses of compounds useful for producing treprostinil

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4338457A (en) 1980-02-28 1982-07-06 The Upjohn Company Composition and process
CA1313670C (en) 1980-02-28 1993-02-16 Robert Charles Kelly Carbacyclin analogs
US6441245B1 (en) 1997-10-24 2002-08-27 United Therapeutics Corporation Process for stereoselective synthesis of prostacyclin derivatives
PT1025083E (pt) * 1997-10-24 2003-10-31 United Therapeutics Corp Processo para a sintese estereo-selectiva de derivados da prostaciclina
KR100638684B1 (ko) 1997-11-14 2006-10-27 유나이티드 세러퓨틱스 코오포레이션 말초 혈관 질환의 치료를 위한 9-데옥시-2',9-알파-메타노-3-옥사-4,5,6-트리노르-3,7-(1',3'-인터페닐렌)-13,14-디하이드로-프로스타글란딘 에프1의 용도
ES2670872T3 (es) 2003-05-22 2018-06-01 United Therapeutics Corporation Polimorfo de una sal de dietanolamina de treprostinil
JP5038031B2 (ja) 2006-07-11 2012-10-03 キヤノン株式会社 放射線撮影装置、その駆動方法及び放射線撮影システム
WO2009078965A1 (en) * 2007-12-17 2009-06-25 United Therapeutics Corporation An improved process to prepare treprostinil, the active ingredient in remodulin
KR20110010753A (ko) * 2008-05-08 2011-02-07 유나이티드 세러퓨틱스 코오포레이션 트레프로스티닐 일수화물
US20110294815A1 (en) 2008-06-27 2011-12-01 Harbeson Scott L Prostacyclin analogs
CN102040618B (zh) 2009-04-30 2013-09-04 上海天伟生物制药有限公司 一种PGF2a类似物的制备方法及其相关中间体
US8481782B2 (en) * 2010-06-03 2013-07-09 United Therapeutics Corporation Treprostinil production
CA2710726C (en) 2010-07-22 2016-02-23 Alphora Research Inc. Synthesis of treprostinil and intermediates useful therein
CN102906520B (zh) 2010-11-19 2014-11-12 岛产业株式会社 干燥减容处理装置
CA2726599C (en) * 2010-12-30 2017-07-25 Alphora Research Inc. Process for treprostinil salt preparation
EP2495235B1 (en) * 2011-03-04 2015-08-05 Newchem S.p.A. Process for the synthesis of prostaglandins and intermediates thereof
US8524939B2 (en) * 2011-08-24 2013-09-03 Chirogate International Inc. Intermediates for the synthesis of benzindene prostaglandins and preparations thereof
CN103193627B (zh) * 2012-01-10 2016-04-20 上海天伟生物制药有限公司 一种前列腺素类似物的晶型及其制备方法和用途
LT2674413T (lt) * 2012-06-15 2017-09-25 Scipharm Sąrl Treprostinilo ir jo darinių gavimo būdas
MX369094B (es) * 2012-12-07 2019-10-29 Cayman Chemical Co Inc Metodos para sintetizar un analogo de prostaciclina.
ES2927844T3 (es) * 2013-01-11 2022-11-11 Corsair Pharma Inc Profármacos de treprostinil
KR20150128903A (ko) * 2013-03-15 2015-11-18 유나이티드 세러퓨틱스 코오포레이션 트레프로스티닐의 염
JP6561109B2 (ja) * 2014-07-16 2019-08-14 コルセア ファーマ インコーポレイテッド トレプロスチニル誘導体化合物およびその使用方法

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