Classifications

• • C—CHEMISTRY; METALLURGY
  • C07—ORGANIC CHEMISTRY
  • C07D—HETEROCYCLIC COMPOUNDS
  • C07D475/00—Heterocyclic compounds containing pteridine ring systems
  • C07D475/06—Heterocyclic compounds containing pteridine ring systems with a nitrogen atom directly attached in position 4
  • C07D475/08—Heterocyclic compounds containing pteridine ring systems with a nitrogen atom directly attached in position 4 with a nitrogen atom directly attached in position 2
• • C—CHEMISTRY; METALLURGY
  • C07—ORGANIC CHEMISTRY
  • C07D—HETEROCYCLIC COMPOUNDS
  • C07D475/00—Heterocyclic compounds containing pteridine ring systems
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
  • A61K31/00—Medicinal preparations containing organic active ingredients
  • A61K31/33—Heterocyclic compounds
  • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
  • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
  • A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
  • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
  • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
  • A61P35/00—Antineoplastic agents
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
  • A61P37/00—Drugs for immunological or allergic disorders
  • A61P37/02—Immunomodulators
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
  • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
• • C—CHEMISTRY; METALLURGY
  • C07—ORGANIC CHEMISTRY
  • C07D—HETEROCYCLIC COMPOUNDS
  • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
  • C07D295/02—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements
  • C07D295/027—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements containing only one hetero ring
  • C07D295/033—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements containing only one hetero ring with the ring nitrogen atoms directly attached to carbocyclic rings

Definitions

• the present invention relates to a process for manufacturing dihydropteridinones of general formula (11)
• R 1 , R 2 , R 3 , R 4 , and R 5 have the meanings given in the claims and specification, as well as related intermediates thereof, optionally in form of the tautomers, racemates, enantiomers, diastereomers and the mixtures thereof and optionally the salts thereof.
• Pteridinone and pteridinone derivatives are known in prior art as active substances with an antiproliferative activity, particularly for the treatment of diseases comprising an abnormal cell proliferation by inhibition of polo-like kinases as mitotic regulators, especially in case the polo-like kinase is PLK-1 , preferably for the treatment and/or prevention of cancer, infections, inflammatory and autoimmune diseases.
• WO 01/019825 A1 discloses specific pteridinones which are described to be potent inhibitors of cyclin-dependent kinases (cdks) and growth-factor-mediated kinases and are used for the treatment of cell proliferative diseases and disorders, particularly tumour and viral diseases.
• cdks cyclin-dependent kinases
• WO 03/020711 discloses the use of dihydropteridinone derivatives for the treatment of tumoral diseases.
• WO 2006/018185 A2 is related to the use of dihydropteridinones in the cancer therapy. Also a number of manufacturing processes of pteridones is described in prior art:
• WO 2004/076454 A1 and WO 2006/018220 disclose specific dihydropteridinones, methods for the production and use thereof.
• the object of the present invention is therefore to provide a method according to which
• dihydropteridinones may be provided in a high yield with improved high purities which may be readily conducted in large-scale.
• the present invention relates to a process of manufacturing dihydropteridinones and related intermediates thereof.
• R 1 and R 2 denote independently from each other a hydrogen or d-C 6 -alkyl
• R 3 denotes hydrogen or a group selected from CrC 6 -alkyl and C 3 -C 8 -cycloalkyl
• R 4 denotes hydrogen or a group selected from among -CN, hydroxy, CrC 6 -alkyl, CrC 5 -alkyloxy and CrC 6 -alkylthio
• R 5 denotes CrC 6 -alkyl, CrC 4 -alkyl-C3-C 8 -cycloalkyl or C 3 -C 8 -cycloalkyl, optionally in the form of the tautomers, the racemates, the enantiomers, the diastereomers and the mixtures thereof, and optionally the salts thereof.
• the process according to the present invention may provide a single step process (step 1 , or step 2 or step 3) or may provide combinations of steps in a multi-stage process, the process steps and compounds which may be manufactured according to the processes according to the present invention are as follows:
• the present invention relates to a process (step 1) for manufacturing a compound of formula (5)
• R 5 denotes d-C 6 -alkyl, CrC 4 -alkyl-C 3 -Ci 0 -cycloalkyl or C 3 -Ci 0 -cycloalkyl, characterised in that a compound of formula (3)
• R 5 is as hereinbefore defined
• the solvent is preferably an aprotic organic solvent or an alcohol or a mixture of an aprotic solvent and an alcohol. Particularly use is made of a toluene/ethanol mixture.
• the present invention relates also to a process (step 2) for manufacturing a compound of formula (6)
• R 5 is as hereinbefore defined, characterised in that
• R 5 and PG are as hereinbefore and hereinafter defined, is removed by acidic hydrolysis using p-toluenesulfonic acid (TsOH) as non- nucleophilic acidic reagent for cleavage of the protecting group.
• TsOH p-toluenesulfonic acid
• the present invention also relates to a process (step 3) for manufacturing a compound of formula (8)
• R 5 is as hereinbefore defined
• R 4 denotes hydrogen or a group selected from among -CN, hydroxy, CrC 6 -alkyl, CrC 5 -alkyloxy and CrC 6 -alkylthio, characterised in that a compound of general formula (7)
• R 4 is as hereinbefore defined, optionally converted into an acyl halide compound, is reacted with the amine compound of formula (6)
• R 5 is as hereinbefore defined
• an alkali or alkaline earth hydroxide preferably NaOH or KOH
• a protic solvent preferably water
• the present invention also relates to a process (step 1 to step 5) for manufacturing a comp
• R 1 to R 5 are as hereinbefore defined, comprising the following steps: step 1 : a compound of formula (3)
• R 5 is as hereinbefore defined
• step 2 in a compound of formula (5) as hereinbefore defined, the protecting group PG is removed by acidic hydrolysis using p-toluenesulfonic acid (TsOH) as non-nucleophilic acidic reagent for cleavage of the protecting group to obtain a compound of fo
• TsOH p-toluenesulfonic acid
• step 3 a compound of general formula (7)
• R 4 is as hereinbefore defined, optionally converted into an acyl halide compound, is reacted with the amine com
• R 5 is as hereinbefore defined
• step 4 a compound of general formula (8) as hereinbefore defined is hydrogenated to obtain a compound of formula (9)
• step 5 a compound of formula (9) as hereinbefore defined, is reacted with a compound of formula 10)
• R 1 to R 5 are as hereinbefore defined.
• the present invention also relates to a process for manufacturing a compound of formula (9)
• R 4 and R 5 are as hereinbefore defined, using process step 1 and/or process step 2 and/or process step 3 as hereinbefore defined.
• the present invention also relates to a process for manufacturing a compound of formula (1 1)
• R 1 to R 5 are as hereinbefore defined, using process step 1 and/or process step 2 and/or process step 3 as hereinbefore defined.
• the present invention also relates to a process for manufacturing a compound of formula
• R 1 to R 5 are as hereinbefore defined using a compound of formula (8)
• R 4 and R 5 are as hereinbefore defined, wherein the compound of formula (8) is obtained using process step 1 and/or process step 2 and/or process step 3 as hereinbefore defined; or using a compoun
• R 4 and R 5 are as hereinbefore defined
• the present invention also relates to a process (step 4) for manufacturing a compound of formula (9)
• R 4 and R 5 are as hereinbefore defined, characterised in that a compound of gen
• R 4 and R 5 are as hereinbefore defined
• the present invention also relates to a process (step 5) for manufacturing a compound of formula (1 1)
• R 1 to R 5 are as hereinbefore defined, wherein a compound of formula (9)
• R 4 and R 5 are as hereinbefore defined
• alkyl groups including alkyl groups which are a part of other groups, denotes branched and unbranched alkyl groups with 1 to 12 carbon atoms, preferably 1 to 6 carbon atoms, most preferably 1 to 4 carbon atoms, such as, for example methyl, ethyl, propyl, butyl, pentyl, hexyl, heptyl, octyl, nonyl, decyl and dodecyl.
• propyl, butyl, pentyl, hexyl, heptyl, octyl, nonyl, decyl and dodecyl include all the possible isomeric forms.
• propyl includes the two isomeric groups n-propyl and isopropyl
• butyl includes n-butyl, iso-butyl, sec-butyl and tert.-butyl
• pentyl includes iso-pentyl, neopentyl, etc.
• one or more hydrogen atoms may optionally be replaced by other groups.
• these alkyl groups may be substituted by halogen, preferably fluorine, chlorine and bromine. All the hydrogen atoms of the alkyl group may optionally be replaced.
• cycloalkyl groups are cycloalkyl groups with 3 to 8 carbon atoms, for example cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, cycloheptyl or cyclooctyl, preferably cyclopropyl, cyclopentyl or cyclohexyl, while each of the above-mentioned cycloalkyl groups may optionally also carry one or more substituents, for example OH, N0 2 , CN, OMe, -OCHF 2 , -OCF 3 , -NH 2 or halogen, preferably fluorine or chlorine, C Cio-alkyl, preferably CrC 5 -alkyl, preferably CrC 3 -alkyl, more preferably methyl or ethyl, -O-d-Cs-alkyl, preferably -O-methyl or -O-ethyl, -COOH, -
• halogen denotes fluorine, chlorine, bromine or iodine
• fluorine preferably fluorine, chlorine or bromine, most preferably chlorine.
• the "leaving group A” denotes a leaving group such as for example -O-methyl, -SCN, fluorine, chlorine, bromine, iodine, methanesulphonyl, ethanesulphonyl, trifluoromethanesulphonyl or p-toluenesulphonyl, preferably chlorine.
• the protective group "PG” denotes a protective group such as for example methyl carbamate, ethyl carbamate, 2,2,2-trichloroethyl carbamate, 2-trimethylsilylethyl carbamate, 2-chloroethyl carbamate, t-butyl carbamate, vinyl carbamate, allyl carbamate, benzyl carbamate, p-methoxybenzyl carbamate, N-formyl amide,
• R 3 to R 5 are as hereinbefore defined, and R 1 and R 2 denote independently from each other a hydrogen or CrC 3 -alkyl. More preferred R 1 and R 2 denote independently from each other a hydrogen, methyl, or ethyl. Most preferably, R 1 denotes hydrogen and R 2 denotes ethyl.
• R 1 , R 2 , R 4 and R 5 are as hereinbefore defined, and R 3 preferably denotes hydrogen or a group selected from CrC 3 -alkyl and C 3 -C 6 - cycloalkyl. More preferred R 3 denotes methyl, ethyl, propyl or isopropyl. Most preferably, the substituent of R 3 denotes isopropyl.
• R 1 , R 2 , R 3 and R 5 are as hereinbefore defined, and R 4 preferably denotes hydrogen or a group selected from among -CN, hydroxy, C C 3 -alkyl, C C 3 -alkyloxy and C C 3 -alkylthio. More preferred R 4 denotes, methoxy, ethoxy, methylthio and ethylthio. Most preferably, the substituent of R 4 denotes methoxy.
• R 1 to R 4 are as hereinbefore defined, and R 5 preferably denotes C C 4 -alkyl, CrC 2 -alkyl-C3-C 6 -cycloalkyl or C 3 -C 6 -cycloalkyl. More preferred R 5 denotes methyl, ethyl, propyl or -CH 2 -cyclopropyl.
• R 5 denotes -CH 2 -cyclopropyl.
• the compounds of general formula (5), (6), (8), (9) or (1 1) produced according to the processes of the present invention may be optionally in form of its tautomers, racemates, enantiomers, diastereomers and the mixtures thereof and optionally in form of the salts.
• the compounds of general formula (1 1) also embrace the physiologically acceptable or pharmacologically acceptable salts, solvates, hydrates or polymorphs thereof.
• the compounds of formula (5), (6), (8) and (9) represent important intermediate products for preparing the compounds of formula (1 1).
• the compounds produced according to the invention may be prepared by synthesis methods described hereinafter, while the substituents of general formulae (3) to (11) have the meanings given hereinbefore. In case a number of steps, for example 2 steps, are combined, the product of every step may be purified according to known
• Step 1 a compound of formula (3) is reacted with a compound of formula (4) to obtain a compound of formula (5) (see Diagram 1).
• Compound (3) and compound (4) are either commercially available or may be prepared by procedures known from the chemical literature.
• Step 1 the compound (3), an aminocyclohexanone wherein the nitrogen atom is protected by a protecting group PG, is reacted with the heterocyclic compound of general formula (4) in a suitable solvent or mixture of solvents.
• the reaction is preferably conducted under reflux.
• the resulting enamine is then hydrogenated with a metal catalyst, preferably, Pt catalyst, preferably selected from Pt/C and platinum-IV- oxide (Pt0 2 ), most preferably platinum-IV-oxide (Pt0 2 ), in an appropriate solvent, like THF, toluene, ethanol, methanol, ethylacetate and mixtures thereof under a suitable hydrogen pressure, e.g. between 30 and 60 psi.
• the reaction is usually performed at a temperature above room temperature, for example, in the range of 35°C to 65°C. Then the catalyst is removed.
• the reaction product in form of a mixture of the cis- and transform (free base) is obtained and may be worked up as usual (e.g. addition of water and subsequently diluted acid such as aqueous hydrochloric acid).
• the cis- and trans- compounds are separated by cristallisation out of water.
• the crude product may be recrystallised from a suitable solvent in order to obtain the pure trans- product.
• a heterogeneous catalytical method with hydrogen is performed.
• a suitable catalyst is a metal catalyst, pereferably a Pt catalyst.
• Preferable catalysts are Pt/C and platinum-IV-oxide (Pt0 2 ).
• platinum-IV-oxide (Pt0 2 ) is platinum-IV-oxide (Pt0 2 ).
• the solvent is preferably an aprotic organic solvent, for example,
• a preferred solvent is also an alcohol such as ethanol, methanol, isopropanol, n-propanol, n- butanol and/or tert.-butanol, most preferably ethanol or methanol. More preferably the solvent is a mixture of an aprotic solvent and an alcohol. Preferably the solvent is a mixture of toluene and an alcohol. Particularly use is made of a toluene/ethanol mixture.
• the ratio of the mixture of toluene/alcohol, preferably toluene/ethanol is preferably adjusted in the range from about 4 - 5 : 1 .
• Present step 1 allows for a significantly improved ratio of trans-compound : cis-compound which is about 3 : 1 . Therefore, a stereoselective reductive amination is achieved.
• platinum-IV-oxide as catalyst in a mixture of toluene/ethanol, preferably in the range from about 4 - 5 : 1.
• Other catalysts like Pd/C or Raney-Ni hydrogenate the enamine as well, with trans/cis ratios as shown in the following table:
• Step 2 in compound (5) obtained in Step 1 the protecting group is removed to obtain compound (6) (see Diagram 2).
• the cleavage of a protecting group PG is a procedure well known in the prior art.
• the amino-protecting group PG can be any suitable amino-protecting group that is known in the art. Typical examples of protecting groups have already been described above such as tert-butyloxycarbonyl (Boc), acetyl and formyl.
• the step of cleaving the nitrogen protecting group is generally accomplished by well known techniques in prior art. Usually an acidic hydrolysis with an organic or inorganic acid is used such as HCI, H 2 S0 4 , TFA, AcOH, MeS0 3 H or TsOH in a variety of protic or polar nonprotic solvents such as alcohols, ethers or dichloromethane (DCM).
• step 2 the formation of this impurity is circumvented.
• the acidic hydrolysis is performed using p- toluenesulfonic acid (tosic acid, TsOH) as non-nucleophilic acidic reagent for cleavage of the protecting group.
• TsOH p- toluenesulfonic acid
• This kind of non-nucleophilic acidic reagent does not react with any substituent under decomposition of the compound in an undesired side-reaction.
• protecting groups used in step 2 according to the present invention are acetyl, formyl,
• step 2 trifluoracetyl, ethoxycarbonyl, tert.-butoxycarbonyl, benzyloxycarbonyl, benzyl, methoxybenzyl or 2,4-dimethoxybenzyl group.
• the product in step 2 is therefore a crystalline tritosylate salt which is usually obtained in good yield.
• Step 3 the compound of formula (6) obtained in Step 2 is reacted with a compound of general formula (7) to obtain a compound of general formula (8) (see Diagram 3). iagram 3
• Step 3 the benzoic acid compound (7), optionally at first converted into an acyl halide compound, is reacted with the amine compound of formula (6) using a base and a solvent.
• the reaction is usually performed at a temperature which is above room temperature, preferably in the range of 35°C to 75°C.
• the reaction product (compound (8)) precipitates and is then worked up as usual.
• the obtained compound (6) may be purified by chromatography or by crystallisation or used as the crude product in the subsequent Step 4 of the synthesis.
• the base commonly used is N-ethyldiisopropyl- amine (Hunigsbase) and the solvent commonly used is THF.
• base commonly used is N-ethyldiisopropyl- amine (Hunigsbase) and the solvent commonly used is THF.
• THF solvent commonly used
• Step 4 the compound of formula (8) obtained in Step 3 is hydrogenated to form the compound of formula (9) (see Diagram 4).
• This step may be carried out using methods known from the chemical literature.
• the compound of formula (8) is hydrogenated using a catalyst in a solvent under a suitable hydrogen pressure (20-100 psi), preferably in the range of 30 to 60 psi.
• the hydrogenation reaction is usually performed at a temperature which exceeds room temperature, for example in the range of 40 to 70°C.
• the catalyst may be any catalyst known from prior art, particularly preferred is Raney-Nickel. After completion of the reaction the catalyst is removed.
• the obtained compound of formula (9) may be purified or used as such in the next step without further purification.
• Step 5 the reaction of the compound of formula (9) obtained in Step 4 to yield the compound of formula (1 1) (Diagram 5) may be carried out using methods known from the chemical literature, for e.g. in WO 2009/019205; WO 2007/090844, WO 2006/021378, WO 2006/018220 and 2004/076454.
• step 5 compound of formula (10) and compound of formula (9) are stirred with acid, for example hydrochloric acid or tosic acid, in a solvent, for example ethanol, propanol, butanol, pentanol, 4-methyl-2-pentanol at reflux temperature for several hours.
• acid for example hydrochloric acid or tosic acid
• a solvent for example ethanol, propanol, butanol, pentanol, 4-methyl-2-pentanol at reflux temperature for several hours.
• the precipitated product (1 1) is separated and worked up as ususal, optionally washed with water, and dried.
• the obtained compound (11) may be purified by chromatography or by crystallisation.
• reaction conditions and reaction times for each individual step may vary depending on the particular reactants employed. Unless otherwise specified, solvents, temperatures and other reaction conditions may be readily selected by one of ordinary skill in the art. Specific procedures are provided in the Synthesis Example section. Typically, reaction progress may be monitored by high pressure liquid chromatography (HPLC) if desired. Intermediates and products may be purified by crystallization.
• HPLC high pressure liquid chromatography

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