|
US3773919A
(en)
|
1969-10-23 |
1973-11-20 |
Du Pont |
Polylactide-drug mixtures
|
|
CU22545A1
(es)
|
1994-11-18 |
1999-03-31 |
Centro Inmunologia Molecular |
Obtención de un anticuerpo quimérico y humanizado contra el receptor del factor de crecimiento epidérmico para uso diagnóstico y terapéutico
|
|
US4179337A
(en)
|
1973-07-20 |
1979-12-18 |
Davis Frank F |
Non-immunogenic polypeptides
|
|
IL47062A
(en)
|
1975-04-10 |
1979-07-25 |
Yeda Res & Dev |
Process for diminishing antigenicity of tissues to be usedas transplants by treatment with glutaraldehyde
|
|
US4002531A
(en)
|
1976-01-22 |
1977-01-11 |
Pierce Chemical Company |
Modifying enzymes with polyethylene glycol and product produced thereby
|
|
US4307016A
(en)
|
1978-03-24 |
1981-12-22 |
Takeda Chemical Industries, Ltd. |
Demethyl maytansinoids
|
|
US4275149A
(en)
|
1978-11-24 |
1981-06-23 |
Syva Company |
Macromolecular environment control in specific receptor assays
|
|
US4318980A
(en)
|
1978-04-10 |
1982-03-09 |
Miles Laboratories, Inc. |
Heterogenous specific binding assay employing a cycling reactant as label
|
|
US4256746A
(en)
|
1978-11-14 |
1981-03-17 |
Takeda Chemical Industries |
Dechloromaytansinoids, their pharmaceutical compositions and method of use
|
|
JPS55102583A
(en)
|
1979-01-31 |
1980-08-05 |
Takeda Chem Ind Ltd |
20-acyloxy-20-demethylmaytansinoid compound
|
|
US4665077A
(en)
|
1979-03-19 |
1987-05-12 |
The Upjohn Company |
Method for treating rejection of organ or skin grafts with 6-aryl pyrimidine compounds
|
|
JPS55162791A
(en)
|
1979-06-05 |
1980-12-18 |
Takeda Chem Ind Ltd |
Antibiotic c-15003pnd and its preparation
|
|
JPS5645483A
(en)
|
1979-09-19 |
1981-04-25 |
Takeda Chem Ind Ltd |
C-15003phm and its preparation
|
|
EP0028683A1
(en)
|
1979-09-21 |
1981-05-20 |
Takeda Chemical Industries, Ltd. |
Antibiotic C-15003 PHO and production thereof
|
|
JPS5645485A
(en)
|
1979-09-21 |
1981-04-25 |
Takeda Chem Ind Ltd |
Production of c-15003pnd
|
|
US4458066A
(en)
|
1980-02-29 |
1984-07-03 |
University Patents, Inc. |
Process for preparing polynucleotides
|
|
WO1982001188A1
(en)
|
1980-10-08 |
1982-04-15 |
Takeda Chemical Industries Ltd |
4,5-deoxymaytansinoide compounds and process for preparing same
|
|
US4450254A
(en)
|
1980-11-03 |
1984-05-22 |
Standard Oil Company |
Impact improvement of high nitrile resins
|
|
US4315929A
(en)
|
1981-01-27 |
1982-02-16 |
The United States Of America As Represented By The Secretary Of Agriculture |
Method of controlling the European corn borer with trewiasine
|
|
US4313946A
(en)
|
1981-01-27 |
1982-02-02 |
The United States Of America As Represented By The Secretary Of Agriculture |
Chemotherapeutically active maytansinoids from Trewia nudiflora
|
|
US4415732A
(en)
|
1981-03-27 |
1983-11-15 |
University Patents, Inc. |
Phosphoramidite compounds and processes
|
|
JPS57192389A
(en)
|
1981-05-20 |
1982-11-26 |
Takeda Chem Ind Ltd |
Novel maytansinoid
|
|
US4816567A
(en)
|
1983-04-08 |
1989-03-28 |
Genentech, Inc. |
Recombinant immunoglobin preparations
|
|
US4943533A
(en)
|
1984-03-01 |
1990-07-24 |
The Regents Of The University Of California |
Hybrid cell lines that produce monoclonal antibodies to epidermal growth factor receptor
|
|
US5187098A
(en)
|
1984-03-02 |
1993-02-16 |
Board Of Regents Of The University Of Oklahoma |
DNA encoding hybrid streptokinases with plasminogen fibrin binding domains
|
|
US5807715A
(en)
|
1984-08-27 |
1998-09-15 |
The Board Of Trustees Of The Leland Stanford Junior University |
Methods and transformed mammalian lymphocyte cells for producing functional antigen-binding protein including chimeric immunoglobulin
|
|
US5342606A
(en)
|
1984-10-18 |
1994-08-30 |
Board Of Regents, The University Of Texas System |
Polyazamacrocyclic compounds for complexation of metal ions
|
|
US5316757A
(en)
|
1984-10-18 |
1994-05-31 |
Board Of Regents, The University Of Texas System |
Synthesis of polyazamacrocycles with more than one type of side-chain chelating groups
|
|
US4732863A
(en)
|
1984-12-31 |
1988-03-22 |
University Of New Mexico |
PEG-modified antibody with reduced affinity for cell surface Fc receptors
|
|
US4737456A
(en)
|
1985-05-09 |
1988-04-12 |
Syntex (U.S.A.) Inc. |
Reducing interference in ligand-receptor binding assays
|
|
US5206344A
(en)
|
1985-06-26 |
1993-04-27 |
Cetus Oncology Corporation |
Interleukin-2 muteins and polymer conjugation thereof
|
|
US5078998A
(en)
|
1985-08-02 |
1992-01-07 |
Bevan Michael J |
Hybrid ligand directed to activation of cytotoxic effector T lymphocytes and target associated antigen
|
|
US5583024A
(en)
|
1985-12-02 |
1996-12-10 |
The Regents Of The University Of California |
Recombinant expression of Coleoptera luciferase
|
|
US5091178A
(en)
|
1986-02-21 |
1992-02-25 |
Oncogen |
Tumor therapy with biologically active anti-tumor antibodies
|
|
IL85035A0
(en)
|
1987-01-08 |
1988-06-30 |
Int Genetic Eng |
Polynucleotide molecule,a chimeric antibody with specificity for human b cell surface antigen,a process for the preparation and methods utilizing the same
|
|
US5770701A
(en)
|
1987-10-30 |
1998-06-23 |
American Cyanamid Company |
Process for preparing targeted forms of methyltrithio antitumor agents
|
|
US5606040A
(en)
|
1987-10-30 |
1997-02-25 |
American Cyanamid Company |
Antitumor and antibacterial substituted disulfide derivatives prepared from compounds possessing a methyl-trithio group
|
|
WO1989006692A1
(en)
|
1988-01-12 |
1989-07-27 |
Genentech, Inc. |
Method of treating tumor cells by inhibiting growth factor receptor function
|
|
IL85746A
(en)
|
1988-03-15 |
1994-05-30 |
Yeda Res & Dev |
Preparations comprising t-lymphocyte cells treated with 8-methoxypsoralen or cell membranes separated therefrom for preventing or treating autoimmune diseases
|
|
FI891226L
(fi)
|
1988-04-28 |
1989-10-29 |
Univ Leland Stanford Junior |
Reseptordeterminanter i anti-t-celler foer behandling av autoimmunsjukdom.
|
|
US5601819A
(en)
|
1988-08-11 |
1997-02-11 |
The General Hospital Corporation |
Bispecific antibodies for selective immune regulation and for selective immune cell binding
|
|
US5047524A
(en)
|
1988-12-21 |
1991-09-10 |
Applied Biosystems, Inc. |
Automated system for polynucleotide synthesis and purification
|
|
US5262530A
(en)
|
1988-12-21 |
1993-11-16 |
Applied Biosystems, Inc. |
Automated system for polynucleotide synthesis and purification
|
|
WO1990008187A1
(en)
|
1989-01-19 |
1990-07-26 |
Dana Farber Cancer Institute |
Soluble two domain cd2 protein
|
|
ES2062519T5
(es)
|
1989-03-21 |
2003-07-16 |
Immune Response Corp Inc |
Vacunacion y metodos contra enfermedades originadas a partir de respuestas patogenicas mediante poblaciones especificas de linfocitos t.
|
|
US5166322A
(en)
|
1989-04-21 |
1992-11-24 |
Genetics Institute |
Cysteine added variants of interleukin-3 and chemical modifications thereof
|
|
DE3920358A1
(de)
|
1989-06-22 |
1991-01-17 |
Behringwerke Ag |
Bispezifische und oligospezifische, mono- und oligovalente antikoerperkonstrukte, ihre herstellung und verwendung
|
|
EP0552142B2
(en)
|
1989-07-19 |
2003-12-17 |
Corporation Connetics |
T cell receptor peptides as therapeutics for autoimmune and malignant disease
|
|
WO1991003489A1
(en)
|
1989-09-08 |
1991-03-21 |
The Johns Hopkins University |
Structural alterations of the egf receptor gene in human gliomas
|
|
US5208020A
(en)
|
1989-10-25 |
1993-05-04 |
Immunogen Inc. |
Cytotoxic agents comprising maytansinoids and their therapeutic use
|
|
US5183884A
(en)
|
1989-12-01 |
1993-02-02 |
United States Of America |
Dna segment encoding a gene for a receptor related to the epidermal growth factor receptor
|
|
US6683046B1
(en)
|
1989-12-22 |
2004-01-27 |
Hoffmann-La Roche Inc. |
Purification and characterization of cytotoxic lymphocyte maturation factor and monoclonal antibodies thereto
|
|
US5766897A
(en)
|
1990-06-21 |
1998-06-16 |
Incyte Pharmaceuticals, Inc. |
Cysteine-pegylated proteins
|
|
US5187089A
(en)
|
1990-06-21 |
1993-02-16 |
Incyte Pharmaceuticals, Inc. |
Protease nexin-i variants which inhibit elastase
|
|
US6511663B1
(en)
*
|
1991-06-11 |
2003-01-28 |
Celltech R&D Limited |
Tri- and tetra-valent monospecific antigen-binding proteins
|
|
DE122004000008I1
(de)
|
1991-06-14 |
2005-06-09 |
Genentech Inc |
Humanisierter Heregulin Antikörper.
|
|
EP1136556B1
(en)
|
1991-11-25 |
2005-06-08 |
Enzon, Inc. |
Method of producing multivalent antigen-binding proteins
|
|
US5428139A
(en)
|
1991-12-10 |
1995-06-27 |
The Dow Chemical Company |
Bicyclopolyazamacrocyclophosphonic acid complexes for use as radiopharmaceuticals
|
|
US5480990A
(en)
|
1991-12-10 |
1996-01-02 |
The Dow Chemical Company |
Bicyclopolyazamacrocyclocarboxylic acid complexes for use as contrast agents
|
|
US5739294A
(en)
|
1991-12-10 |
1998-04-14 |
The Dow Chemical Company |
Bicyclopol yazamacrocyclophosphonic acid complexes for use as contrast agents
|
|
AU3423293A
(en)
|
1991-12-19 |
1993-07-19 |
Baylor College Of Medicine |
Pva or peg conjugates of peptides for epitope-specific immunosuppression
|
|
US6129914A
(en)
|
1992-03-27 |
2000-10-10 |
Protein Design Labs, Inc. |
Bispecific antibody effective to treat B-cell lymphoma and cell line
|
|
WO1993021319A1
(en)
|
1992-04-08 |
1993-10-28 |
Cetus Oncology Corporation |
HUMANIZED C-erbB-2 SPECIFIC ANTIBODIES
|
|
ZA932522B
(en)
|
1992-04-10 |
1993-12-20 |
Res Dev Foundation |
Immunotoxins directed against c-erbB-2(HER/neu) related surface antigens
|
|
EP1005870B1
(en)
|
1992-11-13 |
2009-01-21 |
Biogen Idec Inc. |
Therapeutic application of chimeric antibodies to human B lymphocyte restricted differentiation antigen for treatment of B cell lymphoma
|
|
CA2103323A1
(en)
|
1992-11-24 |
1994-05-25 |
Gregory D. Plowman |
Her4 human receptor tyrosine kinase
|
|
US5635483A
(en)
|
1992-12-03 |
1997-06-03 |
Arizona Board Of Regents Acting On Behalf Of Arizona State University |
Tumor inhibiting tetrapeptide bearing modified phenethyl amides
|
|
US5780588A
(en)
|
1993-01-26 |
1998-07-14 |
Arizona Board Of Regents |
Elucidation and synthesis of selected pentapeptides
|
|
DE69326937T2
(de)
|
1993-03-24 |
2000-12-28 |
Berlex Biosciences, Richmond |
Kombination von Antihormonale und bindende Moleküle zur Krebsbehandlung
|
|
US5385893A
(en)
|
1993-05-06 |
1995-01-31 |
The Dow Chemical Company |
Tricyclopolyazamacrocyclophosphonic acids, complexes and derivatives thereof, for use as contrast agents
|
|
US5462725A
(en)
|
1993-05-06 |
1995-10-31 |
The Dow Chemical Company |
2-pyridylmethylenepolyazamacrocyclophosphonic acids, complexes and derivatives thereof, for use as contrast agents
|
|
US6214345B1
(en)
|
1993-05-14 |
2001-04-10 |
Bristol-Myers Squibb Co. |
Lysosomal enzyme-cleavable antitumor drug conjugates
|
|
KR100332254B1
(ko)
|
1993-10-01 |
2002-09-27 |
데이꼬꾸 조끼 세이야꾸 가부시키가이샤 |
신규인펩티드유도체
|
|
US5880131A
(en)
|
1993-10-20 |
1999-03-09 |
Enzon, Inc. |
High molecular weight polymer-based prodrugs
|
|
ATE207366T1
(de)
|
1993-12-24 |
2001-11-15 |
Merck Patent Gmbh |
Immunokonjugate
|
|
CZ292061B6
(cs)
|
1994-03-17 |
2003-07-16 |
Merck Patent Gmbh |
Jednořetězcové fragmenty protilátek a protilátky proti receptoru epidermálního růstového faktoru, způsob jejich přípravy a farmaceutický prostředek, který je obsahuje
|
|
US5773001A
(en)
|
1994-06-03 |
1998-06-30 |
American Cyanamid Company |
Conjugates of methyltrithio antitumor agents and intermediates for their synthesis
|
|
ATE198712T1
(de)
*
|
1994-07-11 |
2001-02-15 |
Univ Texas |
Verfahren und zusammensetzungen für die spezifische koagulation von tumorgefässen
|
|
CA2195537C
(en)
|
1994-07-21 |
2006-09-12 |
Reinder Torenbeek |
Cyclic ketone peroxide formulations
|
|
US5804396A
(en)
|
1994-10-12 |
1998-09-08 |
Sugen, Inc. |
Assay for agents active in proliferative disorders
|
|
US5824784A
(en)
|
1994-10-12 |
1998-10-20 |
Amgen Inc. |
N-terminally chemically modified protein compositions and methods
|
|
CA2207869A1
(en)
|
1994-12-02 |
1996-06-06 |
Chiron Corporation |
Method of promoting an immune response with a bispecific antibody
|
|
US5663149A
(en)
|
1994-12-13 |
1997-09-02 |
Arizona Board Of Regents Acting On Behalf Of Arizona State University |
Human cancer inhibitory pentapeptide heterocyclic and halophenyl amides
|
|
US5731168A
(en)
|
1995-03-01 |
1998-03-24 |
Genentech, Inc. |
Method for making heteromultimeric polypeptides
|
|
EP1110953B1
(en)
|
1995-03-30 |
2009-10-28 |
Pfizer Products Inc. |
Quinazoline derivatives
|
|
US5641870A
(en)
|
1995-04-20 |
1997-06-24 |
Genentech, Inc. |
Low pH hydrophobic interaction chromatography for antibody purification
|
|
JPH08336393A
(ja)
|
1995-04-13 |
1996-12-24 |
Mitsubishi Chem Corp |
光学活性なγ−置換−β−ヒドロキシ酪酸エステルの製造法
|
|
GB9508565D0
(en)
|
1995-04-27 |
1995-06-14 |
Zeneca Ltd |
Quiazoline derivative
|
|
GB9508538D0
(en)
|
1995-04-27 |
1995-06-14 |
Zeneca Ltd |
Quinazoline derivatives
|
|
US5837234A
(en)
|
1995-06-07 |
1998-11-17 |
Cytotherapeutics, Inc. |
Bioartificial organ containing cells encapsulated in a permselective polyether suflfone membrane
|
|
US5714586A
(en)
|
1995-06-07 |
1998-02-03 |
American Cyanamid Company |
Methods for the preparation of monomeric calicheamicin derivative/carrier conjugates
|
|
WO1996040210A1
(en)
|
1995-06-07 |
1996-12-19 |
Imclone Systems Incorporated |
Antibody and antibody fragments for inhibiting the growth of tumors
|
|
US5712374A
(en)
|
1995-06-07 |
1998-01-27 |
American Cyanamid Company |
Method for the preparation of substantiallly monomeric calicheamicin derivative/carrier conjugates
|
|
MX9800684A
(es)
|
1995-07-27 |
1998-04-30 |
Genentech Inc |
Formulacion de proteinas liofilizadas isotonicas estables.
|
|
EP0799244A1
(en)
*
|
1995-10-16 |
1997-10-08 |
Unilever N.V. |
A bifunctional or bivalent antibody fragment analogue
|
|
US5834456A
(en)
|
1996-02-23 |
1998-11-10 |
The Dow Chemical Company |
Polyazamacrocyclofluoromonoalkylphosphonic acids, and their complexes, for use as contrast agents
|
|
EP1728802A3
(en)
|
1996-03-27 |
2006-12-13 |
Genentech, Inc. |
ErbB3 antibodies
|
|
RO121900B1
(ro)
|
1996-04-12 |
2008-07-30 |
Warner-Lambert Company |
Compuşi inhibitori, ireversibili, ai tirozin kinazelor, compoziţie farmaceutică care îi conţine şi utilizarea acestora
|
|
US5922845A
(en)
|
1996-07-11 |
1999-07-13 |
Medarex, Inc. |
Therapeutic multispecific compounds comprised of anti-Fcα receptor antibodies
|
|
US7122636B1
(en)
|
1997-02-21 |
2006-10-17 |
Genentech, Inc. |
Antibody fragment-polymer conjugates and uses of same
|
|
UA73073C2
(uk)
|
1997-04-03 |
2005-06-15 |
Уайт Холдінгз Корпорейшн |
Заміщені 3-ціанохіноліни, спосіб їх одержання та фармацевтична композиція
|
|
US5994071A
(en)
|
1997-04-04 |
1999-11-30 |
Albany Medical College |
Assessment of prostate cancer
|
|
US6235883B1
(en)
|
1997-05-05 |
2001-05-22 |
Abgenix, Inc. |
Human monoclonal antibodies to epidermal growth factor receptor
|
|
US6753165B1
(en)
|
1999-01-14 |
2004-06-22 |
Bolder Biotechnology, Inc. |
Methods for making proteins containing free cysteine residues
|
|
ATE375363T1
(de)
|
1997-07-14 |
2007-10-15 |
Bolder Biotechnology Inc |
Derivate des wachstumshormons und verwandte proteine
|
|
US7270809B2
(en)
|
1997-07-14 |
2007-09-18 |
Bolder Biotechnology, Inc. |
Cysteine variants of alpha interferon-2
|
|
ZA986729B
(en)
|
1997-07-29 |
1999-02-02 |
Warner Lambert Co |
Irreversible inhibitors of tyrosine kinases
|
|
ZA986732B
(en)
|
1997-07-29 |
1999-02-02 |
Warner Lambert Co |
Irreversible inhibitiors of tyrosine kinases
|
|
TW436485B
(en)
|
1997-08-01 |
2001-05-28 |
American Cyanamid Co |
Substituted quinazoline derivatives
|
|
US6602677B1
(en)
|
1997-09-19 |
2003-08-05 |
Promega Corporation |
Thermostable luciferases and methods of production
|
|
WO1999019488A1
(en)
|
1997-10-15 |
1999-04-22 |
Children's Medical Center Corporation |
Novel human egf receptors and use thereof
|
|
US7005504B2
(en)
|
1998-01-22 |
2006-02-28 |
Genentech, Inc. |
Antibody fragment-peg conjugates
|
|
ES2222689T3
(es)
|
1998-03-12 |
2005-02-01 |
Nektar Therapeutics Al, Corporation |
Derivados del polietilenglicol con grupos reactivos proximales.
|
|
US6528624B1
(en)
|
1998-04-02 |
2003-03-04 |
Genentech, Inc. |
Polypeptide variants
|
|
JP4169478B2
(ja)
|
1998-04-21 |
2008-10-22 |
マイクロメット アーゲー |
Ｃｄ１９×ｃｄ３特異的ポリペプチドおよびその使用
|
|
US6489447B1
(en)
|
1998-05-06 |
2002-12-03 |
Genentech, Inc. |
Protein purification
|
|
GB9812545D0
(en)
|
1998-06-10 |
1998-08-05 |
Celltech Therapeutics Ltd |
Biological products
|
|
EP1089766B1
(en)
|
1998-06-22 |
2010-03-17 |
Immunomedics, Inc. |
Use of bi-specific antibodies for pre-targeting diagnosis and therapy
|
|
IL127127A0
(en)
|
1998-11-18 |
1999-09-22 |
Peptor Ltd |
Small functional units of antibody heavy chain variable regions
|
|
US6723538B2
(en)
|
1999-03-11 |
2004-04-20 |
Micromet Ag |
Bispecific antibody and chemokine receptor constructs
|
|
US7049410B2
(en)
|
1999-05-14 |
2006-05-23 |
Majumdar Adhip P N |
Antibodies to a novel EGF-receptor related protein (ERRP)
|
|
US6399743B1
(en)
|
1999-05-14 |
2002-06-04 |
Dept. Of Veterans Affairs |
Isolation and characterization of a rat epidermal growth factor related protein
|
|
MXPA01013458A
(es)
|
1999-06-25 |
2002-07-30 |
Genentech Inc |
Anticuerpos humanizados anti-erbb2 y tratamiento con anticuerpos anti-erbb2.
|
|
EP2266607A3
(en)
|
1999-10-01 |
2011-04-20 |
Immunogen, Inc. |
Immunoconjugates for treating cancer
|
|
US6372907B1
(en)
|
1999-11-03 |
2002-04-16 |
Apptera Corporation |
Water-soluble rhodamine dye peptide conjugates
|
|
DE60041715D1
(de)
|
1999-12-22 |
2009-04-16 |
Nektar Therapeutics Al Corp |
Verfahren zur herstellung von 1-benzotriazolcarbonatestern von wasserlöslichen polymeren
|
|
US20040001827A1
(en)
|
2002-06-28 |
2004-01-01 |
Dennis Mark S. |
Serum albumin binding peptides for tumor targeting
|
|
WO2001045746A2
(en)
|
1999-12-24 |
2001-06-28 |
Genentech, Inc. |
Methods and compositions for prolonging elimination half-times of bioactive compounds
|
|
US20020119148A1
(en)
|
2000-09-01 |
2002-08-29 |
Gerritsen Mary E. |
ErbB4 antagonists
|
|
AR030612A1
(es)
|
2000-09-12 |
2003-08-27 |
Smithkline Beecham Corp |
Procedimiento e intermedios
|
|
US6673580B2
(en)
|
2000-10-27 |
2004-01-06 |
Genentech, Inc. |
Identification and modification of immunodominant epitopes in polypeptides
|
|
TW593427B
(en)
|
2000-12-18 |
2004-06-21 |
Nektar Therapeutics Al Corp |
Synthesis of high molecular weight non-peptidic polymer derivatives
|
|
US8372954B2
(en)
|
2000-12-22 |
2013-02-12 |
National Research Council Of Canada |
Phage display libraries of human VH fragments
|
|
US6884869B2
(en)
|
2001-04-30 |
2005-04-26 |
Seattle Genetics, Inc. |
Pentapeptide compounds and uses related thereto
|
|
CN1195779C
(zh)
|
2001-05-24 |
2005-04-06 |
中国科学院遗传与发育生物学研究所 |
抗人卵巢癌抗人cd3双特异性抗体
|
|
US6441163B1
(en)
|
2001-05-31 |
2002-08-27 |
Immunogen, Inc. |
Methods for preparation of cytotoxic conjugates of maytansinoids and cell binding agents
|
|
JP4619651B2
(ja)
*
|
2001-06-01 |
2011-01-26 |
コーネル・リサーチ・ファンデーション・インコーポレイテッド |
前立腺特異的膜抗原に対する修飾抗体およびその使用
|
|
WO2003026577A2
(en)
|
2001-09-24 |
2003-04-03 |
Seattle Genetics, Inc. |
P-amidobenzylethers in drug delivery agents
|
|
US7091186B2
(en)
|
2001-09-24 |
2006-08-15 |
Seattle Genetics, Inc. |
p-Amidobenzylethers in drug delivery agents
|
|
US6908963B2
(en)
|
2001-10-09 |
2005-06-21 |
Nektar Therapeutics Al, Corporation |
Thioester polymer derivatives and method of modifying the N-terminus of a polypeptide therewith
|
|
JP2005289809A
(ja)
|
2001-10-24 |
2005-10-20 |
Vlaams Interuniversitair Inst Voor Biotechnologie Vzw (Vib Vzw) |
突然変異重鎖抗体
|
|
US20050123536A1
(en)
|
2001-11-20 |
2005-06-09 |
Che-Leung Law |
Treatment of immunological disorders using anti-dc30 antibodies
|
|
AU2002358469A1
(en)
|
2001-12-21 |
2003-07-15 |
7Tm Pharma A/S |
Modified receptors for the discovery of therapeutic ligands
|
|
US6716821B2
(en)
|
2001-12-21 |
2004-04-06 |
Immunogen Inc. |
Cytotoxic agents bearing a reactive polyethylene glycol moiety, cytotoxic conjugates comprising polyethylene glycol linking groups, and methods of making and using the same
|
|
BR0307548A
(pt)
|
2002-02-11 |
2006-01-17 |
Genentech Inc |
Método de produção de uma variante de anticorpo, variante de anticorpo, composição, ácido nucléico isolado, vetor, célula hospedeira, processo para a produção de uma variante de anticorpo e método de determinação do coeficiente de associação de antìgeno de um anticorpo
|
|
EP1947470A3
(en)
|
2002-06-20 |
2011-09-28 |
Snaptrack Inc. |
Reducing cross-interference in a combined GPS receiver and communication system
|
|
SI1523496T1
(sl)
|
2002-07-18 |
2011-11-30 |
Merus B V |
Rekombinantno proizvajanje zmesi protiteles
|
|
EP1575514A2
(en)
|
2002-07-31 |
2005-09-21 |
Seattle Genetics, Inc. |
Anti-cd20 antibody-drug conjugates for the treatment of cancer and immune disorders
|
|
CA2495795C
(en)
|
2002-08-16 |
2011-12-13 |
Immunogen, Inc. |
Cross-linkers with high reactivity and solubility and their use in the preparation of conjugates for targeted delivery of small molecule drugs
|
|
CA2501818C
(en)
*
|
2002-10-10 |
2012-03-27 |
Merck Patent Gesellschaft Mit Beschraenkter Haftung |
Pharmaceutical compositions directed to erb-b1 receptors
|
|
US7608429B2
(en)
|
2002-10-31 |
2009-10-27 |
Genentech, Inc. |
Methods and compositions for increasing antibody production
|
|
WO2004043493A1
(en)
|
2002-11-14 |
2004-05-27 |
Syntarga B.V. |
Prodrugs built as multiple self-elimination-release spacers
|
|
US7575893B2
(en)
|
2003-01-23 |
2009-08-18 |
Genentech, Inc. |
Methods for producing humanized antibodies and improving yield of antibodies or antigen binding fragments in cell culture
|
|
AU2004212641B2
(en)
|
2003-02-19 |
2009-08-06 |
Merck Millipore Ltd. |
Composite materials comprising supported porous gels
|
|
KR101130181B1
(ko)
*
|
2003-02-27 |
2012-03-28 |
예다 리서치 앤드 디벨럽먼트 캄파니 리미티드 |
인플루엔자 바이러스 감염의 치료 및 검출에 유용한 핵산분자, 폴리펩티드, 항체 및 이를 포함하는 조성물
|
|
JP4764818B2
(ja)
*
|
2003-04-11 |
2011-09-07 |
メディミューン，エルエルシー |
組換えｉｌ−９抗体およびその使用
|
|
KR100512483B1
(ko)
|
2003-05-07 |
2005-09-05 |
선바이오(주) |
신규한 폴리에틸렌글리콜-말레이미드 유도체의 합성방법
|
|
US8088387B2
(en)
|
2003-10-10 |
2012-01-03 |
Immunogen Inc. |
Method of targeting specific cell populations using cell-binding agent maytansinoid conjugates linked via a non-cleavable linker, said conjugates, and methods of making said conjugates
|
|
DK1639011T3
(da)
|
2003-06-30 |
2009-02-16 |
Domantis Ltd |
Pegylerede enkelt-domæne antistoffer (dAb)
|
|
EP1660519B1
(en)
*
|
2003-07-29 |
2014-05-14 |
Immunomedics, Inc. |
Conjugates comprising 2-[18F]fluoro-2-deoxy-D-glucose and a peptide molecule
|
|
US20050106667A1
(en)
|
2003-08-01 |
2005-05-19 |
Genentech, Inc |
Binding polypeptides with restricted diversity sequences
|
|
CA2534898A1
(en)
|
2003-08-08 |
2005-02-17 |
Immunomedics, Inc. |
Bispecific antibodies for inducing apoptosis of tumor and diseased cells
|
|
AU2004272607B2
(en)
|
2003-09-11 |
2008-11-06 |
Cornerstone Therapeutics Inc. |
Monoclonal antibodies against HMGB1
|
|
SG149815A1
(en)
|
2003-11-06 |
2009-02-27 |
Seattle Genetics Inc |
Monomethylvaline compounds capable of conjugation to ligands
|
|
US7235641B2
(en)
|
2003-12-22 |
2007-06-26 |
Micromet Ag |
Bispecific antibodies
|
|
JP5460958B2
(ja)
|
2004-03-17 |
2014-04-02 |
アンチキャンサー インコーポレーテッド |
タンパク質ポリエチレングリコール（ｐｅｇ）複合体形成を増大させる方法
|
|
GT200500155A
(es)
*
|
2004-06-16 |
2006-05-15 |
|
Terapia del càncer resistente al platino
|
|
KR20190126461A
(ko)
*
|
2004-07-22 |
2019-11-11 |
제넨테크, 인크. |
Ｈｅｒ２ 항체 조성물
|
|
US7662926B2
(en)
*
|
2004-09-02 |
2010-02-16 |
Genentech, Inc. |
Anti-Fc-gamma receptor antibodies, bispecific variants and uses therefor
|
|
BRPI0515589A
(pt)
*
|
2004-09-02 |
2008-07-29 |
Genentech Inc |
polipeptìdeos ou anticorpos de ligação de antìgeno isolado, anticorpo isolado, método para regular de forma negativa a atividade de fc(gama)riib, métodos de tratamento, anticorpos biespecìficos isolados, métodos de inibição de uma resposta imune, de supressão na liberação de histamina, de ativação de fc(gama)riib, de inibição da expressão do receptor fc(épsilon)ri, composição e kit
|
|
TR201808537T4
(tr)
|
2004-09-23 |
2018-07-23 |
Genentech Inc |
Sistein değiştirilmiş antikorlar ve konjugatlar.
|
|
US8802820B2
(en)
|
2004-11-12 |
2014-08-12 |
Xencor, Inc. |
Fc variants with altered binding to FcRn
|
|
MX2008008564A
(es)
*
|
2006-01-04 |
2009-01-29 |
Merck Patent Gmbh |
Terapeutica combinada con anticuerpos anti-egfr y anti-her2.
|
|
CA2637988A1
(en)
|
2006-02-10 |
2007-11-29 |
Genentech, Inc. |
Anti-fgf19 antibodies and methods using same
|
|
US20090098574A1
(en)
|
2006-04-25 |
2009-04-16 |
Centre National De La Recherche Scientifique (Cnrs) |
Functionalization of gold nanoparticles with oriented proteins, application to the high-density labelling of cell membranes
|
|
KR20090019890A
(ko)
*
|
2006-06-05 |
2009-02-25 |
제넨테크, 인크. |
Ｅｇｆ 또는 ｔｇｆ-알파 수준이 상승된 암 환자의 생존 연장
|
|
JP2009539841A
(ja)
|
2006-06-06 |
2009-11-19 |
トラークス，インコーポレイテッド |
自己免疫疾患の治療における抗ｃｄ３抗体の投与
|
|
CA2670315A1
(en)
|
2006-11-21 |
2008-11-20 |
The Regents Of The University Of California |
Anti-egfr family antibodies, bispecific anti-egfr family antibodies and methods of use thereof
|
|
AR067543A1
(es)
|
2007-07-16 |
2009-10-14 |
Genentech Inc |
Anticuerpos anti-cd79b e inmunoconjugados humanizados y metodos de uso
|
|
WO2009023270A2
(en)
*
|
2007-08-15 |
2009-02-19 |
Amunix, Inc. |
Compositions and methods for modifying properties of biologically active polypeptides
|
|
NZ584514A
(en)
|
2007-10-19 |
2012-07-27 |
Genentech Inc |
Cysteine engineered anti-tenb2 antibodies and antibody drug conjugates
|
|
WO2009070243A2
(en)
*
|
2007-11-21 |
2009-06-04 |
Amgen Inc. |
Wise binding agents and epitopes
|
|
US9101645B2
(en)
*
|
2008-10-22 |
2015-08-11 |
Genentech, Inc. |
Modulation of axon degeneration
|
|
NZ594665A
(en)
|
2009-03-20 |
2013-08-30 |
Genentech Inc |
Bispecific anti-her antibodies
|