AR125815A1 - Composiciones farmacéuticas que comprenden anticuerpos biespecíficos que se unen a b7h4 y cd3 - Google Patents
Composiciones farmacéuticas que comprenden anticuerpos biespecíficos que se unen a b7h4 y cd3Info
- Publication number
- AR125815A1 AR125815A1 ARP220101222A ARP220101222A AR125815A1 AR 125815 A1 AR125815 A1 AR 125815A1 AR P220101222 A ARP220101222 A AR P220101222A AR P220101222 A ARP220101222 A AR P220101222A AR 125815 A1 AR125815 A1 AR 125815A1
- Authority
- AR
- Argentina
- Prior art keywords
- pharmaceutical compositions
- bind
- polysorbate
- binding
- pharmaceutical
- Prior art date
Links
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 5
- 101000955999 Homo sapiens V-set domain-containing T-cell activation inhibitor 1 Proteins 0.000 title abstract 3
- 102100038929 V-set domain-containing T-cell activation inhibitor 1 Human genes 0.000 title abstract 3
- 239000000427 antigen Substances 0.000 abstract 2
- 102000036639 antigens Human genes 0.000 abstract 2
- 108091007433 antigens Proteins 0.000 abstract 2
- 239000002552 dosage form Substances 0.000 abstract 2
- 239000000203 mixture Substances 0.000 abstract 2
- 239000000244 polyoxyethylene sorbitan monooleate Substances 0.000 abstract 2
- 235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 abstract 2
- 229920000053 polysorbate 80 Polymers 0.000 abstract 2
- 229940068968 polysorbate 80 Drugs 0.000 abstract 2
- 239000004094 surface-active agent Substances 0.000 abstract 2
- 229920001213 Polysorbate 20 Polymers 0.000 abstract 1
- 239000000872 buffer Substances 0.000 abstract 1
- 239000006172 buffering agent Substances 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 238000011275 oncology therapy Methods 0.000 abstract 1
- 239000000256 polyoxyethylene sorbitan monolaurate Substances 0.000 abstract 1
- 235000010486 polyoxyethylene sorbitan monolaurate Nutrition 0.000 abstract 1
- 229920000136 polysorbate Polymers 0.000 abstract 1
- 229950008882 polysorbate Drugs 0.000 abstract 1
- 229940068977 polysorbate 20 Drugs 0.000 abstract 1
- 238000002560 therapeutic procedure Methods 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
- 239000008215 water for injection Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39591—Stabilisation, fragmentation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2827—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against B7 molecules, e.g. CD80, CD86
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
- C07K2317/524—CH2 domain
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
- C07K2317/526—CH3 domain
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
Abstract
La presente invención se refiere a composiciones farmacéuticas y formas de dosificación unitarias que comprenden anticuerpos que se unen a B7H4 y CD3. La invención además proporciona un uso de las composiciones farmacéuticas y formas de dosificación unitarias para procedimientos terapéuticos, en particular en la terapia contra el cáncer. Reivindicación 1: Una composición farmacéutica que comprende que comprende: a) un anticuerpo que comprende una región de unión a antígenos capaz de unirse a B7H4 humana y una región de unión a antígenos capaz de unirse a 5 CD3 humana, b) un agente amortiguador: en donde el pH de la composición es de entre 4,0 a 8,0. Reivindicación 10: Una composición farmacéutica de acuerdo con la forma de realización 9 o 10, en donde el tensioactivo es un polisorbato, opcionalmente en donde el tensioactivo es un polisorbato 20 u 80, preferiblemente polisorbato 80. Reivindicación 59: Un método para preparar la composición farmacéutica como se define en una cualquiera de las formas de realización 1 - 47, que comprende las etapas de mezcla en agua para su inyección: a) 0,5 a 120 mg/ml del anticuerpo, y b) un agente amortiguador y ajustar el pH a 4,0 - 8,0, preferiblemente a 5,0 - 6,0.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202163185762P | 2021-05-07 | 2021-05-07 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR125815A1 true AR125815A1 (es) | 2023-08-16 |
Family
ID=81974983
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP220101222A AR125815A1 (es) | 2021-05-07 | 2022-05-09 | Composiciones farmacéuticas que comprenden anticuerpos biespecíficos que se unen a b7h4 y cd3 |
Country Status (11)
| Country | Link |
|---|---|
| EP (1) | EP4334359A1 (es) |
| JP (1) | JP2024519212A (es) |
| KR (1) | KR20240004949A (es) |
| CN (1) | CN117396509A (es) |
| AR (1) | AR125815A1 (es) |
| AU (1) | AU2022268652A1 (es) |
| BR (1) | BR112023021089A2 (es) |
| CA (1) | CA3214582A1 (es) |
| IL (1) | IL308300A (es) |
| MX (1) | MX2023012351A (es) |
| WO (1) | WO2022234146A1 (es) |
Family Cites Families (54)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| LU91067I2 (fr) | 1991-06-14 | 2004-04-02 | Genentech Inc | Trastuzumab et ses variantes et dérivés immuno chimiques y compris les immotoxines |
| GB9203459D0 (en) | 1992-02-19 | 1992-04-08 | Scotgen Ltd | Antibodies with germ-line variable regions |
| US5731168A (en) | 1995-03-01 | 1998-03-24 | Genentech, Inc. | Method for making heteromultimeric polypeptides |
| DK0979281T3 (da) | 1997-05-02 | 2005-11-21 | Genentech Inc | Fremgangsmåde til fremstilling af multispecifikke antistoffer med heteromultimere og fælles bestanddele |
| US20100081792A1 (en) | 2001-06-28 | 2010-04-01 | Smithkline Beecham Corporation | Ligand |
| KR20040088572A (ko) | 2002-03-01 | 2004-10-16 | 이뮤노메딕스, 인코오포레이티드 | 제거율 증강을 위한 양특이성 항체 점 돌연변이들 |
| SI1523496T1 (sl) | 2002-07-18 | 2011-11-30 | Merus B V | Rekombinantno proizvajanje zmesi protiteles |
| WO2005004809A2 (en) | 2003-07-01 | 2005-01-20 | Immunomedics, Inc. | Multivalent carriers of bi-specific antibodies |
| US7235641B2 (en) | 2003-12-22 | 2007-06-26 | Micromet Ag | Bispecific antibodies |
| US7741568B2 (en) | 2005-01-13 | 2010-06-22 | The Wiremold Company | Downward facing receptacle assembly for cable raceway |
| EP1870459B1 (en) | 2005-03-31 | 2016-06-29 | Chugai Seiyaku Kabushiki Kaisha | Methods for producing polypeptides by regulating polypeptide association |
| US7612181B2 (en) | 2005-08-19 | 2009-11-03 | Abbott Laboratories | Dual variable domain immunoglobulin and uses thereof |
| CA2631184A1 (en) | 2005-11-28 | 2007-05-31 | Genmab A/S | Recombinant monovalent antibodies and methods for production thereof |
| EA015992B1 (ru) | 2006-03-17 | 2012-01-30 | Байоджен Айдек Эмэй Инк. | Стабилизированное антитело и многовалентная антигенсвязывающая молекула на его основе, способы получения и использования вышеназванного стабилизированного антитела |
| JP5474531B2 (ja) | 2006-03-24 | 2014-04-16 | メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツング | 操作されたヘテロ二量体タンパク質ドメイン |
| AT503902B1 (de) | 2006-07-05 | 2008-06-15 | F Star Biotech Forsch & Entw | Verfahren zur manipulation von immunglobulinen |
| CA2681974C (en) | 2007-03-29 | 2019-12-31 | Genmab A/S | Bispecific antibodies and methods for production thereof |
| AU2008265984B2 (en) | 2007-06-21 | 2014-07-17 | Macrogenics, Inc. | Covalent diabodies and uses thereof |
| ES2667729T3 (es) | 2007-09-26 | 2018-05-14 | Ucb Biopharma Sprl | Fusiones de anticuerpos con doble especificidad |
| EP2050764A1 (en) | 2007-10-15 | 2009-04-22 | sanofi-aventis | Novel polyvalent bispecific antibody format and uses thereof |
| EA201000910A1 (ru) | 2007-11-30 | 2011-04-29 | Бристоль-Мейерз Сквибб Компани | Конъюгат "моноклональное антитело против в7н4/лекарственное средство" и способы его применения |
| US8227577B2 (en) | 2007-12-21 | 2012-07-24 | Hoffman-La Roche Inc. | Bivalent, bispecific antibodies |
| HUE028536T2 (en) | 2008-01-07 | 2016-12-28 | Amgen Inc | Method for producing antibody to FC heterodimer molecules using electrostatic control effects |
| WO2010015792A1 (en) | 2008-08-06 | 2010-02-11 | Argenta Discovery Limited | Nitrogen containing heterocyclic compounds useful as bifunctional modulators of m3 receptors and beta-2 receptors |
| CN102282168A (zh) | 2008-11-18 | 2011-12-14 | 梅里麦克制药股份有限公司 | 人血清白蛋白接头以及其结合物 |
| BRPI0918122A8 (pt) | 2008-12-19 | 2017-01-24 | Macrogenics Inc | molécula de diabody, diabody, e mólecula dart |
| KR20110134494A (ko) | 2009-03-27 | 2011-12-14 | 자이모제네틱스, 인코포레이티드 | 항체-수용체 조합물을 포함하는 다중특이적-결합 단백질을 사용하기 위한 조성물 및 방법 |
| US9067986B2 (en) | 2009-04-27 | 2015-06-30 | Oncomed Pharmaceuticals, Inc. | Method for making heteromultimeric molecules |
| KR101224468B1 (ko) | 2009-05-20 | 2013-01-23 | 주식회사 파멥신 | 신규한 형태의 이중표적항체 및 그 용도 |
| US9493578B2 (en) | 2009-09-02 | 2016-11-15 | Xencor, Inc. | Compositions and methods for simultaneous bivalent and monovalent co-engagement of antigens |
| CN107337734A (zh) | 2009-12-04 | 2017-11-10 | 弗·哈夫曼-拉罗切有限公司 | 多特异性抗体、抗体类似物、组合物和方法 |
| MX345232B (es) | 2010-03-04 | 2017-01-20 | Macrogenics Inc | Anticuerpos reactivos con b7-h3, fragmentos inmunologicamente activos de los mismos y sus usos. |
| AR080794A1 (es) | 2010-03-26 | 2012-05-09 | Hoffmann La Roche | Anticuerpos bivalentes biespecificos anti- vegf/ anti-ang-2 |
| JP6040148B2 (ja) | 2010-04-20 | 2016-12-07 | ゲンマブ エー／エス | ヘテロ二量体抗体Ｆｃ含有タンパク質およびその産生方法 |
| JP6022444B2 (ja) | 2010-05-14 | 2016-11-09 | ライナット ニューロサイエンス コーポレイション | ヘテロ二量体タンパク質ならびにそれを生産および精製するための方法 |
| CN107253992B (zh) | 2010-05-27 | 2022-03-11 | 根马布股份公司 | 针对her2的单克隆抗体 |
| MX338953B (es) | 2010-08-16 | 2016-05-06 | Novimmune Sa | Metodos para la generacion de anticuerpos multiespecificos y multivalentes. |
| WO2012025525A1 (en) | 2010-08-24 | 2012-03-01 | Roche Glycart Ag | Activatable bispecific antibodies |
| CA2807278A1 (en) | 2010-08-24 | 2012-03-01 | F. Hoffmann - La Roche Ag | Bispecific antibodies comprising a disulfide stabilized - fv fragment |
| DK2635607T3 (da) | 2010-11-05 | 2019-11-18 | Zymeworks Inc | Stabilt heterodimert antistofdesign med mutationer i fc-domænet |
| CN102250246A (zh) | 2011-06-10 | 2011-11-23 | 常州亚当生物技术有限公司 | 抗VEGF/PDGFRβ双特异性抗体及其应用 |
| AU2012328322A1 (en) | 2011-10-27 | 2014-06-12 | Genmab A/S | Production of heterodimeric proteins |
| EA035344B1 (ru) | 2012-04-20 | 2020-05-29 | Мерюс Н.В. | Способ получения двух антител из одной клетки-хозяина |
| US11180572B2 (en) | 2012-07-06 | 2021-11-23 | Genmab B.V. | Dimeric protein with triple mutations |
| EP2924052B1 (en) | 2012-11-21 | 2019-07-17 | Pharmabcine Inc. | Dual-target antibody targeting vegfr-2 and dll4, and pharmaceutical composition comprising same |
| EP3299391B1 (en) | 2013-03-14 | 2019-12-04 | Genentech, Inc. | Anti-b7-h4 antibodies and immunoconjugates |
| UA119646C2 (uk) | 2013-07-05 | 2019-07-25 | Ґенмаб А/С | Гуманізоване антитіло, що зв`язується з сd3 людини |
| MX2018000347A (es) | 2015-07-15 | 2018-03-14 | Genmab As | Anticuerpos de grupo de diferenciacion 3 (cd3) humanizados o quimericos. |
| CN109563503B (zh) * | 2016-07-26 | 2023-09-29 | 静冈县 | 抗b7-h4抗体 |
| BR112020003533A2 (pt) | 2017-08-25 | 2020-11-17 | Five Prime Therapeutics, Inc. | anticorpos b7-h4 e métodos de uso dos mesmos |
| KR20200123170A (ko) * | 2018-02-21 | 2020-10-28 | 파이브 프라임 테라퓨틱스, 인크. | B7-h4 항체 제형 |
| MX2021005085A (es) * | 2018-11-06 | 2021-11-04 | Genmab As | Formulacion de anticuerpo. |
| US20220411505A1 (en) * | 2019-08-15 | 2022-12-29 | Genmab A/S | Pharmaceutical compositions comprising bispecific antibodies directed against cd3 and cd20 and their uses |
| IL296362A (en) * | 2020-03-18 | 2022-11-01 | Genmab As | Antibodies that bind to b7h4 |
-
2022
- 2022-05-09 IL IL308300A patent/IL308300A/en unknown
- 2022-05-09 BR BR112023021089A patent/BR112023021089A2/pt unknown
- 2022-05-09 KR KR1020237041813A patent/KR20240004949A/ko unknown
- 2022-05-09 AU AU2022268652A patent/AU2022268652A1/en active Pending
- 2022-05-09 CN CN202280033116.8A patent/CN117396509A/zh active Pending
- 2022-05-09 CA CA3214582A patent/CA3214582A1/en active Pending
- 2022-05-09 JP JP2023568247A patent/JP2024519212A/ja active Pending
- 2022-05-09 WO PCT/EP2022/062518 patent/WO2022234146A1/en active Application Filing
- 2022-05-09 AR ARP220101222A patent/AR125815A1/es unknown
- 2022-05-09 MX MX2023012351A patent/MX2023012351A/es unknown
- 2022-05-09 EP EP22728462.7A patent/EP4334359A1/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| JP2024519212A (ja) | 2024-05-09 |
| WO2022234146A1 (en) | 2022-11-10 |
| EP4334359A1 (en) | 2024-03-13 |
| CN117396509A (zh) | 2024-01-12 |
| AU2022268652A9 (en) | 2024-02-22 |
| AU2022268652A1 (en) | 2023-10-05 |
| KR20240004949A (ko) | 2024-01-11 |
| IL308300A (en) | 2024-01-01 |
| BR112023021089A2 (pt) | 2023-12-12 |
| CA3214582A1 (en) | 2022-11-10 |
| MX2023012351A (es) | 2023-10-31 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DOP2019000280A (es) | Formulaciones estables de anticuerpos contra el receptor de muerte programada 1 (pd-1) y métodos para su uso | |
| CL2022003747A1 (es) | Anticuerpos ccr8 para aplicaciones terapéuticas | |
| CL2020002945A1 (es) | Métodos para tratar cánceres y potenciar la eficacia de agentes terapéuticos para el redireccionamiento de células t | |
| ECSP22080714A (es) | Anticuerpos que se unen a b7h4 | |
| CL2008002923A1 (es) | Anticuerpo monoclonal humano aislado porque se adhiere a mesotelina humana; composicion que comprende dicho anticuerpo; conjugado entre anticuerpo y agente terapeutico; molecula de acido nucleico que codifica el anticuerpo; uso para preparar un medicamento para tratar cancer. | |
| CO2018005932A2 (es) | Moléculas biespecíficas que tienen inmunorreactividad con pd-1 y ctla-4, y métodos de uso de las mismas | |
| AR059922A1 (es) | Anticuerpos monoclonales humanizados para el factor de crecimiento de hepatocitos | |
| EA201792273A1 (ru) | Композиции, содержащие комбинацию анти-pd-1 антитела и другого антитела | |
| CO5700791A2 (es) | Metodos para tratar enfermedades relacionadas con interleukin-6 | |
| EA201490957A1 (ru) | Лечение гематологических злокачественных заболеваний с помощью анти-cxcr4 антитела | |
| PE20121397A1 (es) | Anticuerpos especificos para cadherina-17 | |
| CR10996A (es) | Metodo de tratamiento del cancer mediante administracion de combinaciones de il-18 humana | |
| BR112022016643A2 (pt) | Epítopos e anticorpos contra kras | |
| CO2023000536A2 (es) | Formas farmacéuticas de maleato de acalabrutinib | |
| AR082353A1 (es) | Ligando ox40 y de linfopoyetina del estroma timico (tslp) en el cancer | |
| PE20212158A1 (es) | Composicion farmaceutica acuosa de anticuerpo anti-il17a y su uso | |
| CO2023002375A2 (es) | Anticuerpos contra ilt2 y uso de los mismos | |
| AR125815A1 (es) | Composiciones farmacéuticas que comprenden anticuerpos biespecíficos que se unen a b7h4 y cd3 | |
| BR112022009482A2 (pt) | Anticorpo monoclonal anti-b7-h3 e métodos de uso do mesmo | |
| CL2023000916A1 (es) | Anticuerpos con capacidad de unirse a ror2 y anticuerpos biespecíficos que se unen a ror2 y cd3. | |
| AR118778A1 (es) | Formulación de anticuerpo | |
| AR116897A1 (es) | Métodos para tratar el cáncer con una combinación de un anticuerpo anti-vegf y un conjugado anticuerpo-fármaco anti-factor tisular | |
| AR115571A1 (es) | Conjugados anticuerpo droga para ablación de células madre hematopoyéticas | |
| CO2022011944A2 (es) | Moléculas de unión a antígeno contra alppl2 y/o alpp y usos de las mismas | |
| CO2022001643A2 (es) | Anticuerpos anti-grp78 y método de uso de los mismos |