JP2012530761A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2012530761A5 JP2012530761A5 JP2012516745A JP2012516745A JP2012530761A5 JP 2012530761 A5 JP2012530761 A5 JP 2012530761A5 JP 2012516745 A JP2012516745 A JP 2012516745A JP 2012516745 A JP2012516745 A JP 2012516745A JP 2012530761 A5 JP2012530761 A5 JP 2012530761A5
- Authority
- JP
- Japan
- Prior art keywords
- protein
- immunogenic composition
- composition according
- domain
- seq
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 108010068327 4-hydroxyphenylpyruvate dioxygenase Proteins 0.000 claims 31
- 239000000203 mixture Substances 0.000 claims 24
- 108090000765 processed proteins & peptides Proteins 0.000 claims 24
- 230000002163 immunogen Effects 0.000 claims 23
- 229920001184 polypeptide Polymers 0.000 claims 23
- 102000004196 processed proteins & peptides Human genes 0.000 claims 23
- 241000342334 Human metapneumovirus Species 0.000 claims 13
- 239000000427 antigen Substances 0.000 claims 12
- 102000036639 antigens Human genes 0.000 claims 12
- 108091007433 antigens Proteins 0.000 claims 12
- 102000040430 polynucleotide Human genes 0.000 claims 8
- 108091033319 polynucleotide Proteins 0.000 claims 8
- 239000002157 polynucleotide Substances 0.000 claims 8
- 241000700605 Viruses Species 0.000 claims 5
- 230000028993 immune response Effects 0.000 claims 5
- 208000015181 infectious disease Diseases 0.000 claims 4
- 102000039446 nucleic acids Human genes 0.000 claims 4
- 108020004707 nucleic acids Proteins 0.000 claims 4
- 150000007523 nucleic acids Chemical class 0.000 claims 4
- 208000002606 Paramyxoviridae Infections Diseases 0.000 claims 3
- 238000003776 cleavage reaction Methods 0.000 claims 3
- 230000007017 scission Effects 0.000 claims 3
- 238000006467 substitution reaction Methods 0.000 claims 3
- 102000004961 Furin Human genes 0.000 claims 2
- 108090001126 Furin Proteins 0.000 claims 2
- 150000001413 amino acids Chemical class 0.000 claims 2
- 238000012217 deletion Methods 0.000 claims 2
- 230000037430 deletion Effects 0.000 claims 2
- 201000010099 disease Diseases 0.000 claims 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 2
- 230000013595 glycosylation Effects 0.000 claims 2
- 238000006206 glycosylation reaction Methods 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- 230000000241 respiratory effect Effects 0.000 claims 2
- 108090000790 Enzymes Proteins 0.000 claims 1
- 102000004190 Enzymes Human genes 0.000 claims 1
- 206010061603 Respiratory syncytial virus infection Diseases 0.000 claims 1
- 239000002671 adjuvant Substances 0.000 claims 1
- 125000003275 alpha amino acid group Chemical group 0.000 claims 1
- 210000004899 c-terminal region Anatomy 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 230000004927 fusion Effects 0.000 claims 1
- 125000005842 heteroatom Chemical group 0.000 claims 1
- 230000002209 hydrophobic effect Effects 0.000 claims 1
- 230000005847 immunogenicity Effects 0.000 claims 1
- 230000004048 modification Effects 0.000 claims 1
- 238000012986 modification Methods 0.000 claims 1
- 230000001575 pathological effect Effects 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 239000002243 precursor Substances 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
- 230000001681 protective effect Effects 0.000 claims 1
- 102000004169 proteins and genes Human genes 0.000 claims 1
- 108090000623 proteins and genes Proteins 0.000 claims 1
- 208000024891 symptom Diseases 0.000 claims 1
- 239000013638 trimer Substances 0.000 claims 1
- 238000005829 trimerization reaction Methods 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US21995809P | 2009-06-24 | 2009-06-24 | |
| US61/219,958 | 2009-06-24 | ||
| PCT/EP2010/059006 WO2010149743A2 (en) | 2009-06-24 | 2010-06-24 | Vaccine |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2012530761A JP2012530761A (ja) | 2012-12-06 |
| JP2012530761A5 true JP2012530761A5 (enExample) | 2013-08-15 |
| JP5796011B2 JP5796011B2 (ja) | 2015-10-21 |
Family
ID=42797417
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012516745A Active JP5796011B2 (ja) | 2009-06-24 | 2010-06-24 | ワクチン |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US8889146B2 (enExample) |
| EP (1) | EP2445527A2 (enExample) |
| JP (1) | JP5796011B2 (enExample) |
| KR (1) | KR20120093811A (enExample) |
| CN (1) | CN102548578A (enExample) |
| AU (1) | AU2010264686A1 (enExample) |
| CA (1) | CA2766205A1 (enExample) |
| EA (1) | EA201270062A1 (enExample) |
| IL (1) | IL217008A0 (enExample) |
| MX (1) | MX2012000036A (enExample) |
| SG (1) | SG176807A1 (enExample) |
| WO (1) | WO2010149743A2 (enExample) |
| ZA (1) | ZA201109164B (enExample) |
Families Citing this family (58)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP4206231A1 (en) * | 2007-12-24 | 2023-07-05 | ID Biomedical Corporation of Quebec | Recombinant rsv antigens |
| ES2583257T3 (es) | 2009-06-24 | 2016-09-20 | Glaxosmithkline Biologicals S.A. | Antígenos recombinantes del VSR |
| ES2563730T3 (es) | 2009-07-15 | 2016-03-16 | Glaxosmithkline Biologicals S.A. | Composiciones de proteína RSV F y procedimientos de fabricación de las mismas |
| WO2012103361A1 (en) | 2011-01-26 | 2012-08-02 | Novartis Ag | Rsv immunization regimen |
| EP2668282A2 (en) * | 2011-01-28 | 2013-12-04 | MedImmune, LLC | Expression of soluble viral fusion glycoproteins in mammalian cells |
| SI2707385T1 (en) * | 2011-05-13 | 2018-01-31 | Glaxosmithkline Biologicals Sa | Pregnant RSV F antigens |
| EP2752199A4 (en) | 2011-08-29 | 2015-04-29 | Univ Tokushima | RSV MUCOSA VACCINE |
| ES2673957T5 (es) | 2011-10-03 | 2021-12-15 | Croda Int Plc | Nanopartículas, procedimiento para la preparación y utilización de las mismas como portadoras de moléculas anfipáticas o hidrofóbicas en el campo de la medicina, incluyendo el tratamiento del cáncer, y compuestos de tipo alimentario |
| NZ630920A (en) * | 2012-03-20 | 2017-01-27 | Humabs Biomed Sa | Antibodies that neutralize rsv, mpv and pvm and uses thereof |
| EA039682B1 (ru) * | 2012-06-04 | 2022-02-28 | Хумабс Биомед Са | Антитела, нейтрализующие rsv, mpv и pvm, и их применения |
| CN102743750B (zh) * | 2012-07-09 | 2013-11-20 | 江苏省农业科学院 | 一种复方免疫增强剂、禽用疫苗及其制备方法 |
| EA201891945A3 (ru) | 2012-08-01 | 2019-05-31 | Бавариан Нордик А/С | Вакцина рекомбинантного модифицированного вируса осповакцины анкара (mva) респираторно-синцитиального вируса (rsv) |
| US20140037680A1 (en) | 2012-08-06 | 2014-02-06 | Glaxosmithkline Biologicals, S.A. | Novel method |
| AU2013301312A1 (en) | 2012-08-06 | 2015-03-19 | Glaxosmithkline Biologicals S.A. | Method for eliciting in infants an immune response against RSV and B. pertussis |
| EA201590683A1 (ru) * | 2012-11-20 | 2015-11-30 | Глаксосмитклайн Байолоджикалс С.А. | Тримеры rsv f, предшествующие слиянию |
| US9738689B2 (en) | 2013-03-13 | 2017-08-22 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Prefusion RSV F proteins and their use |
| WO2014160463A1 (en) * | 2013-03-13 | 2014-10-02 | The United States Of America, As Represented By The Secretary, Department Of Health & Human Services | Prefusion rsv f proteins and their use |
| US9060975B2 (en) | 2013-03-14 | 2015-06-23 | Mucosis Bv | Heat-stable respiratory syncytial virus F protein oligomers and their use in immunological compositions |
| MX2015013832A (es) * | 2013-04-08 | 2016-06-10 | Medimmune Llc | Composicion de vacuna y metodo de uso. |
| CN105188745B (zh) | 2013-04-25 | 2019-10-18 | 扬森疫苗与预防公司 | 稳定化的可溶性融合前rsv f多肽 |
| CN105408348B (zh) | 2013-06-17 | 2021-07-06 | 扬森疫苗与预防公司 | 稳定化的可溶性融合前rsv f多肽 |
| US20160193322A1 (en) | 2013-08-05 | 2016-07-07 | Glaxosmithkline Biologicals S.A. | Combination immunogenic compositions |
| EP3035959A1 (en) | 2013-08-21 | 2016-06-29 | CureVac AG | Combination vaccine |
| US9388430B2 (en) * | 2013-09-06 | 2016-07-12 | President And Fellows Of Harvard College | Cas9-recombinase fusion proteins and uses thereof |
| EP3236998A1 (en) | 2014-12-24 | 2017-11-01 | The U.S.A. as represented by the Secretary, Department of Health and Human Services | Recombinant metapneumovirus f proteins and their use |
| WO2016144675A1 (en) * | 2015-03-06 | 2016-09-15 | Medimmune, Llc | Vaccine dose and use thereof |
| KR20180026734A (ko) | 2015-07-07 | 2018-03-13 | 얀센 백신스 앤드 프리벤션 비.브이. | 안정화된 가용성 융합-전 rsv f 폴리펩티드 |
| CA2991002C (en) | 2015-07-07 | 2023-11-28 | Janssen Vaccines & Prevention B.V. | Vaccine against rsv |
| EP3718565B1 (en) | 2015-10-22 | 2022-04-27 | ModernaTX, Inc. | Respiratory virus vaccines |
| KR102136678B1 (ko) | 2015-12-23 | 2020-07-22 | 화이자 인코포레이티드 | Rsv f 단백질 돌연변이체 |
| US10729757B2 (en) | 2016-04-05 | 2020-08-04 | Janssen Vaccines & Prevention B.V. | Vaccine against RSV |
| CN116063551A (zh) | 2016-04-05 | 2023-05-05 | 扬森疫苗与预防公司 | 稳定化的可溶性融合前rsv f蛋白 |
| CN105693829B (zh) * | 2016-04-14 | 2022-03-15 | 青岛易邦生物工程有限公司 | 一种b型禽偏肺病毒f蛋白 |
| US12128113B2 (en) | 2016-05-18 | 2024-10-29 | Modernatx, Inc. | Polynucleotides encoding JAGGED1 for the treatment of Alagille syndrome |
| WO2017207477A1 (en) | 2016-05-30 | 2017-12-07 | Janssen Vaccines & Prevention B.V. | Stabilized pre-fusion rsv f proteins |
| BR112018074483A2 (pt) | 2016-05-30 | 2019-03-19 | Janssen Vaccines & Prevention B.V. | proteínas f do rsv pré-fusão estabilizadas |
| CN106119287B (zh) * | 2016-08-29 | 2019-10-11 | 广东华南疫苗股份有限公司 | 一种表达呼吸道合胞病毒f蛋白的重组载体及方法 |
| EP3532096B1 (en) | 2016-10-25 | 2023-02-22 | The U.S.A. as represented by the Secretary, Department of Health and Human Services | Prefusion piv f immunogens and their use |
| TWI683826B (zh) * | 2016-11-22 | 2020-02-01 | 國立臺灣大學 | 重組ｒｓｖ抗原 |
| MA50335A (fr) * | 2016-12-08 | 2020-08-19 | Modernatx Inc | Vaccins à acide nucléique contre des virus respiratoires |
| US20200030432A1 (en) | 2017-03-17 | 2020-01-30 | Modernatx, Inc. | Zoonotic disease rna vaccines |
| JP7406377B2 (ja) | 2017-05-15 | 2023-12-27 | ヤンセン ファッシンズ アンド プリベンション ベーフェー | 安定なウイルス含有組成物 |
| EP3624851A1 (en) | 2017-05-15 | 2020-03-25 | Janssen Vaccines & Prevention B.V. | Stable virus-containing composition |
| AU2018267971A1 (en) | 2017-05-17 | 2019-11-07 | Janssen Vaccines & Prevention B.V. | Methods and compositions for inducing protective immunity against RSV infection |
| JP2020533367A (ja) | 2017-09-15 | 2020-11-19 | ヤンセン ファッシンズ アンド プリベンション ベーフェーＪａｎｓｓｅｎ Ｖａｃｃｉｎｅｓ ＆ Ｐｒｅｖｅｎｔｉｏｎ Ｂ．Ｖ． | Ｒｓｖに対する免疫の安全な誘導方法 |
| WO2019063844A1 (en) * | 2017-09-29 | 2019-04-04 | Universiteit Antwerpen | VACCINATION AGAINST SYNCYTIAL RESPIRATORY VIRUS |
| WO2019092002A1 (en) * | 2017-11-07 | 2019-05-16 | Valneva Se | Pharmaceutical compositions for treatment or prevention of viral infections |
| EP3746090A4 (en) | 2018-01-29 | 2021-11-17 | ModernaTX, Inc. | RSV RNA Vaccines |
| CA3117275A1 (en) | 2018-11-13 | 2020-05-22 | Janssen Vaccines & Prevention B.V. | Stabilized pre-fusion rsv f proteins |
| EP3923983A4 (en) * | 2019-02-11 | 2023-02-22 | Emory University | RSV AND HMPV CHIMERIC F-PROTEINS, IMMUNOGENIC COMPOSITIONS, AND METHODS OF USE |
| US11351242B1 (en) | 2019-02-12 | 2022-06-07 | Modernatx, Inc. | HMPV/hPIV3 mRNA vaccine composition |
| PH12021552736A1 (en) | 2019-05-20 | 2022-07-11 | Valneva Se | A subunit vaccine for treatment or prevention of a respiratory tract infection |
| IL295148A (en) * | 2020-01-30 | 2022-09-01 | Modernatx Inc | Respiratory virus immunizing compositions |
| TW202233232A (zh) | 2020-11-06 | 2022-09-01 | 法商賽諾菲公司 | 遞送mRNA疫苗的脂質奈米顆粒 |
| JP2024512215A (ja) * | 2021-02-12 | 2024-03-19 | メルク・シャープ・アンド・ドーム・エルエルシー | メタニューモウイルス、抗原性メタニューモウイルスタンパク質に結合する抗体、及びその使用 |
| JP2024509756A (ja) | 2021-02-19 | 2024-03-05 | ヤンセン ファッシンズ アンド プリベンション ベーフェー | 安定化された融合前ｒｓｖ ｆｂ抗原 |
| IL312997A (en) * | 2021-11-30 | 2024-07-01 | Sanofi Pasteur Inc | Human metapneumovirus vaccines |
| MX2024006506A (es) * | 2021-11-30 | 2024-08-14 | Sanofi Pasteur Inc | Vacunas basadas en vectores virales de metapneumovirus humano. |
Family Cites Families (60)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4235877A (en) | 1979-06-27 | 1980-11-25 | Merck & Co., Inc. | Liposome particle containing viral or bacterial antigenic subunit |
| US4372945A (en) | 1979-11-13 | 1983-02-08 | Likhite Vilas V | Antigen compounds |
| IL61904A (en) | 1981-01-13 | 1985-07-31 | Yeda Res & Dev | Synthetic vaccine against influenza virus infections comprising a synthetic peptide and process for producing same |
| US4436727A (en) | 1982-05-26 | 1984-03-13 | Ribi Immunochem Research, Inc. | Refined detoxified endotoxin product |
| US4866034A (en) | 1982-05-26 | 1989-09-12 | Ribi Immunochem Research Inc. | Refined detoxified endotoxin |
| SE8205892D0 (sv) | 1982-10-18 | 1982-10-18 | Bror Morein | Immunogent membranproteinkomplex, sett for framstellning och anvendning derav som immunstimulerande medel och sasom vaccin |
| US4707543A (en) | 1985-09-17 | 1987-11-17 | The United States Of America As Represented By The Secretary Of The Army | Process for the preparation of detoxified polysaccharide-outer membrane protein complexes, and their use as antibacterial vaccines |
| US5149650A (en) | 1986-01-14 | 1992-09-22 | University Of North Carolina At Chapel Hill | Vaccines for human respiratory virus |
| US4877611A (en) | 1986-04-15 | 1989-10-31 | Ribi Immunochem Research Inc. | Vaccine containing tumor antigens and adjuvants |
| CA1331443C (en) | 1987-05-29 | 1994-08-16 | Charlotte A. Kensil | Saponin adjuvant |
| US5057540A (en) | 1987-05-29 | 1991-10-15 | Cambridge Biotech Corporation | Saponin adjuvant |
| US5726292A (en) | 1987-06-23 | 1998-03-10 | Lowell; George H. | Immuno-potentiating systems for preparation of immunogenic materials |
| US5278302A (en) | 1988-05-26 | 1994-01-11 | University Patents, Inc. | Polynucleotide phosphorodithioates |
| US4912094B1 (en) | 1988-06-29 | 1994-02-15 | Ribi Immunochem Research Inc. | Modified lipopolysaccharides and process of preparation |
| US6245549B1 (en) * | 1990-06-28 | 2001-06-12 | Connaught Laboratories Limited | Production of virus and purification of viral envelope proteins for vaccine use |
| GB9120221D0 (en) | 1991-09-23 | 1991-11-06 | Smithkline Beecham Biolog | Novel compounds |
| GB9200117D0 (en) * | 1992-01-06 | 1992-02-26 | Connaught Lab | Production of recombinant chimeric proteins for vaccine use |
| EP0671948B1 (en) | 1992-06-25 | 1997-08-13 | SMITHKLINE BEECHAM BIOLOGICALS s.a. | Vaccine composition containing adjuvants |
| ES2109685T5 (es) | 1993-03-23 | 2005-09-01 | Smithkline Beecham Biologicals S.A. | Composiciones para vacunas que contienen monofosforil-lipido a 3-o-desacilado. |
| US5961970A (en) | 1993-10-29 | 1999-10-05 | Pharmos Corporation | Submicron emulsions as vaccine adjuvants |
| AU700485B2 (en) | 1993-11-17 | 1999-01-07 | Om Pharma | Glucosamine disaccharides, method for their preparation, pharmaceutical composition comprising same, and their use |
| WO1995026204A1 (en) | 1994-03-25 | 1995-10-05 | Isis Pharmaceuticals, Inc. | Immune stimulation by phosphorothioate oligonucleotide analogs |
| FR2718452B1 (fr) | 1994-04-06 | 1996-06-28 | Pf Medicament | Elément d'immunogène, agent immunogène, composition pharmaceutique et procédé de préparation. |
| CA2560114A1 (en) | 1994-07-15 | 1996-02-01 | The University Of Iowa Research Foundation | Immunomodulatory oligonucleotides |
| AUPM873294A0 (en) | 1994-10-12 | 1994-11-03 | Csl Limited | Saponin preparations and use thereof in iscoms |
| UA56132C2 (uk) | 1995-04-25 | 2003-05-15 | Смітклайн Бічем Байолоджікалс С.А. | Композиція вакцини (варіанти), спосіб стабілізації qs21 відносно гідролізу (варіанти), спосіб приготування композиції вакцини |
| US5666153A (en) | 1995-10-03 | 1997-09-09 | Virtual Shopping, Inc. | Retractable teleconferencing apparatus |
| US5856462A (en) | 1996-09-10 | 1999-01-05 | Hybridon Incorporated | Oligonucleotides having modified CpG dinucleosides |
| US6113918A (en) | 1997-05-08 | 2000-09-05 | Ribi Immunochem Research, Inc. | Aminoalkyl glucosamine phosphate compounds and their use as adjuvants and immunoeffectors |
| US6764840B2 (en) | 1997-05-08 | 2004-07-20 | Corixa Corporation | Aminoalkyl glucosaminide phosphate compounds and their use as adjuvants and immunoeffectors |
| US6303347B1 (en) | 1997-05-08 | 2001-10-16 | Corixa Corporation | Aminoalkyl glucosaminide phosphate compounds and their use as adjuvants and immunoeffectors |
| US7208161B1 (en) | 1997-05-23 | 2007-04-24 | The United States Of America, Represented By The Secretary, Department Of Health And Human Services | Production of attenuated parainfluenza virus vaccines from cloned nucleotide sequences |
| EP1015595B1 (en) | 1997-09-19 | 2005-01-26 | Wyeth Holdings Corporation | Peptides derived from the attachment (g) protein of respiratory syncytial virus |
| GB9727262D0 (en) | 1997-12-24 | 1998-02-25 | Smithkline Beecham Biolog | Vaccine |
| EP1089913A1 (fr) | 1998-06-08 | 2001-04-11 | SCA Emballage France | Emballage a remise a plat rapide |
| CZ302062B6 (cs) | 1998-06-30 | 2010-09-22 | Om Pharma | Derivát acyldipeptidu, zpusob jeho prípravy, meziprodukty pro jeho prípravu a farmaceutický prostredek, který ho obsahuje |
| DK1126876T3 (da) | 1998-10-16 | 2007-07-02 | Glaxosmithkline Biolog Sa | Adjuvanssystemer og vacciner |
| US20040006242A1 (en) | 1999-02-01 | 2004-01-08 | Hawkins Lynn D. | Immunomodulatory compounds and method of use thereof |
| US6551600B2 (en) | 1999-02-01 | 2003-04-22 | Eisai Co., Ltd. | Immunological adjuvant compounds compositions and methods of use thereof |
| WO2001046127A1 (fr) | 1999-12-22 | 2001-06-28 | Om Pharma | Pseudodipeptides acyles porteurs d'un bras auxiliaire fonctionnalise |
| WO2002042326A1 (en) | 2000-11-22 | 2002-05-30 | Biota Scientific Management Pty Ltd | A method of expression and agents identified thereby |
| EP1395669B1 (en) | 2001-01-26 | 2009-07-22 | Selexis S.A. | Matrix attachment regions and methods for use thereof |
| MXPA03008154A (es) | 2001-03-09 | 2004-11-12 | Id Biomedical Corp Quebec | Novedoso adyuvante de vacuna de proteosoma-liposacarido. |
| US7157465B2 (en) | 2001-04-17 | 2007-01-02 | Dainippon Simitomo Pharma Co., Ltd. | Adenine derivatives |
| AU2002343728A1 (en) | 2001-11-16 | 2003-06-10 | 3M Innovative Properties Company | Methods and compositions related to irm compounds and toll-like receptor pathways |
| DE10221836A1 (de) * | 2002-05-16 | 2003-12-04 | Lohmann Animal Health Gmbh | Attenuierung von Metapneumovirus |
| WO2004010935A2 (en) * | 2002-07-25 | 2004-02-05 | Medimmune, Inc. | Methods of treating and preventing rsv, hmpv, and piv using anti-rsv, anti-hmpv, and anti-piv antibodies |
| WO2004071459A2 (en) | 2003-02-13 | 2004-08-26 | 3M Innovative Properties Company | Methods and compositions related to irm compounds and toll-like receptor 8 |
| US7563449B2 (en) | 2003-04-21 | 2009-07-21 | Pfizer Inc, | Methods for reducing cattle reproductive diseases |
| MXPA05011268A (es) * | 2003-04-25 | 2006-06-20 | Medimmune Vaccines Inc | Sistemas de expresion de virus de parainfluenza recombinante y vacunas que comprenden antigenos heterologos derivados del metaneumovirus. |
| US7368537B2 (en) | 2003-07-15 | 2008-05-06 | Id Biomedical Corporation Of Quebec | Subunit vaccine against respiratory syncytial virus infection |
| SG147468A1 (en) | 2003-10-24 | 2008-11-28 | Selexis Sa | High efficiency gene transfer and expression in mammalian cells by a multiple transfection procedure of matrix attachment region sequences |
| FR2873378A1 (fr) | 2004-07-23 | 2006-01-27 | Pierre Fabre Medicament Sa | Complexes immunogenes, leur procede de preparation et leur utilisation dans des compositions pharmaceutiques |
| GB0422439D0 (en) * | 2004-10-08 | 2004-11-10 | European Molecular Biology Lab Embl | Inhibitors of infection |
| TWI457133B (zh) | 2005-12-13 | 2014-10-21 | Glaxosmithkline Biolog Sa | 新穎組合物 |
| CA2684578A1 (en) * | 2007-03-21 | 2008-09-25 | Id Biomedical Corporation Of Quebec | Chimeric antigens |
| US20100261155A1 (en) * | 2007-06-06 | 2010-10-14 | Nationwide Children's Hospital, Inc. | Methods and compositions relating to viral fusion proteins |
| JP5508266B2 (ja) | 2007-08-13 | 2014-05-28 | グラクソスミスクライン バイオロジカルズ ソシエテ アノニム | ワクチン |
| EP4206231A1 (en) * | 2007-12-24 | 2023-07-05 | ID Biomedical Corporation of Quebec | Recombinant rsv antigens |
| ES2583257T3 (es) * | 2009-06-24 | 2016-09-20 | Glaxosmithkline Biologicals S.A. | Antígenos recombinantes del VSR |
-
2010
- 2010-06-24 WO PCT/EP2010/059006 patent/WO2010149743A2/en not_active Ceased
- 2010-06-24 AU AU2010264686A patent/AU2010264686A1/en not_active Abandoned
- 2010-06-24 CA CA2766205A patent/CA2766205A1/en active Pending
- 2010-06-24 EP EP10728203A patent/EP2445527A2/en not_active Withdrawn
- 2010-06-24 JP JP2012516745A patent/JP5796011B2/ja active Active
- 2010-06-24 EA EA201270062A patent/EA201270062A1/ru unknown
- 2010-06-24 SG SG2011091881A patent/SG176807A1/en unknown
- 2010-06-24 CN CN2010800374300A patent/CN102548578A/zh active Pending
- 2010-06-24 US US13/378,402 patent/US8889146B2/en active Active
- 2010-06-24 MX MX2012000036A patent/MX2012000036A/es not_active Application Discontinuation
- 2010-06-24 KR KR1020127001752A patent/KR20120093811A/ko not_active Withdrawn
-
2011
- 2011-12-13 ZA ZA2011/09164A patent/ZA201109164B/en unknown
- 2011-12-15 IL IL217008A patent/IL217008A0/en unknown
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2012530761A5 (enExample) | ||
| JP2012530504A5 (enExample) | ||
| CN107847580B (zh) | 针对rsv的疫苗 | |
| RU2723039C2 (ru) | Мутанты белка f rsv | |
| HRP20161353T1 (hr) | Rekombinantni rsv antigeni | |
| JP2010522540A5 (enExample) | ||
| FI2970398T3 (fi) | Rsv f -prefuusioproteiineja ja niiden käyttö | |
| US9060975B2 (en) | Heat-stable respiratory syncytial virus F protein oligomers and their use in immunological compositions | |
| JP2011528222A5 (enExample) | ||
| HRP20160798T1 (hr) | Rekombinantni antigeni iz rsv | |
| JP2022533318A (ja) | 気道感染の治療または予防のためのサブユニットワクチン | |
| JP2011502479A5 (enExample) | ||
| JP2016509011A5 (enExample) | ||
| JP2010500399A5 (enExample) | ||
| JP2013517783A5 (enExample) | ||
| JP2013507907A5 (enExample) | ||
| EA202090738A1 (ru) | Способ безопасного индуцирования иммунитета против rsv | |
| JP2015521467A5 (enExample) | ||
| JP2011250797A5 (enExample) | ||
| JP2012501959A5 (enExample) | ||
| JP2015509707A5 (enExample) | ||
| JP2014507146A5 (enExample) | ||
| JP2015164424A5 (enExample) | ||
| JP2016504993A5 (enExample) | ||
| JP2019531293A5 (enExample) |