JP2012525819A5 - - Google Patents
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- Publication number
- JP2012525819A5 JP2012525819A5 JP2012508822A JP2012508822A JP2012525819A5 JP 2012525819 A5 JP2012525819 A5 JP 2012525819A5 JP 2012508822 A JP2012508822 A JP 2012508822A JP 2012508822 A JP2012508822 A JP 2012508822A JP 2012525819 A5 JP2012525819 A5 JP 2012525819A5
- Authority
- JP
- Japan
- Prior art keywords
- polynucleotide
- seq
- amino acid
- positions
- wild
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 102000040430 polynucleotide Human genes 0.000 claims 17
- 239000002157 polynucleotide Substances 0.000 claims 17
- 108091033319 polynucleotide Proteins 0.000 claims 17
- 108060001084 Luciferase Proteins 0.000 claims 13
- 239000005089 Luciferase Substances 0.000 claims 13
- 125000003275 alpha amino acid group Chemical group 0.000 claims 10
- 229920001184 polypeptide Polymers 0.000 claims 9
- 102000004196 processed proteins & peptides Human genes 0.000 claims 9
- 108090000765 processed proteins & peptides Proteins 0.000 claims 9
- 238000006467 substitution reaction Methods 0.000 claims 9
- 238000004020 luminiscence type Methods 0.000 claims 2
- 108090000623 proteins and genes Proteins 0.000 claims 2
- 102000004169 proteins and genes Human genes 0.000 claims 2
- 102220531101 Left-right determination factor 1_L92S_mutation Human genes 0.000 claims 1
- 102220492844 Olfactory receptor 8K5_F68S_mutation Human genes 0.000 claims 1
- 102220634786 Potassium voltage-gated channel subfamily A member 3_F77W_mutation Human genes 0.000 claims 1
- 241001284373 Spinus Species 0.000 claims 1
- 102220604980 Transcription factor Sp2_A33K_mutation Human genes 0.000 claims 1
- 150000001413 amino acids Chemical class 0.000 claims 1
- 102220357107 c.224T>G Human genes 0.000 claims 1
- 230000037430 deletion Effects 0.000 claims 1
- 238000012217 deletion Methods 0.000 claims 1
- 239000002773 nucleotide Substances 0.000 claims 1
- 125000003729 nucleotide group Chemical group 0.000 claims 1
- 102200080930 rs137852221 Human genes 0.000 claims 1
- 102220055135 rs149428656 Human genes 0.000 claims 1
- 102220050200 rs150634297 Human genes 0.000 claims 1
- 102200082940 rs33936254 Human genes 0.000 claims 1
- 102200036809 rs387907341 Human genes 0.000 claims 1
- 102220000379 rs397514441 Human genes 0.000 claims 1
- 102220087238 rs541028076 Human genes 0.000 claims 1
- 102220025301 rs587778874 Human genes 0.000 claims 1
- 102220045199 rs587781908 Human genes 0.000 claims 1
- 102220058220 rs730881937 Human genes 0.000 claims 1
- 102220101693 rs771554497 Human genes 0.000 claims 1
- 102200137195 rs7897309 Human genes 0.000 claims 1
- 102220021365 rs80357174 Human genes 0.000 claims 1
- 102220106669 rs879255364 Human genes 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US17483809P | 2009-05-01 | 2009-05-01 | |
| US61/174,838 | 2009-05-01 | ||
| PCT/US2010/033449 WO2010127368A1 (en) | 2009-05-01 | 2010-05-03 | Synthetic oplophorus luciferases with enhanced light output |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015208321A Division JP6227615B2 (ja) | 2009-05-01 | 2015-10-22 | 増大した光出力を有する合成オプロフォルスルシフェラーゼ |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2012525819A JP2012525819A (ja) | 2012-10-25 |
| JP2012525819A5 true JP2012525819A5 (https=) | 2013-06-20 |
| JP6038649B2 JP6038649B2 (ja) | 2016-12-07 |
Family
ID=42358981
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012508822A Active JP6038649B2 (ja) | 2009-05-01 | 2010-05-03 | 増大した光出力を有する合成オプロフォルスルシフェラーゼ |
| JP2015208321A Active JP6227615B2 (ja) | 2009-05-01 | 2015-10-22 | 増大した光出力を有する合成オプロフォルスルシフェラーゼ |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015208321A Active JP6227615B2 (ja) | 2009-05-01 | 2015-10-22 | 増大した光出力を有する合成オプロフォルスルシフェラーゼ |
Country Status (16)
| Country | Link |
|---|---|
| US (7) | US8557970B2 (https=) |
| EP (5) | EP2990478B1 (https=) |
| JP (2) | JP6038649B2 (https=) |
| KR (1) | KR101665352B1 (https=) |
| CN (2) | CN102459579B (https=) |
| AU (1) | AU2010242771B2 (https=) |
| BR (1) | BRPI1010019B1 (https=) |
| CA (1) | CA2758572A1 (https=) |
| DK (4) | DK2456864T3 (https=) |
| ES (5) | ES2795287T3 (https=) |
| IL (3) | IL215697B (https=) |
| LT (1) | LT3409764T (https=) |
| PL (5) | PL3409764T3 (https=) |
| PT (4) | PT2456864E (https=) |
| SG (3) | SG175180A1 (https=) |
| WO (1) | WO2010127368A1 (https=) |
Families Citing this family (75)
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|---|---|---|---|---|
| ES2795287T3 (es) | 2009-05-01 | 2020-11-23 | Promega Corp | Luciferasas de Oplophorus sintéticas con mayor emisión de luz |
| SG10202103336SA (en) | 2010-11-02 | 2021-04-29 | Promega Corp | Novel coelenterazine substrates and methods of use |
| CN103180324A (zh) | 2010-11-02 | 2013-06-26 | 普罗美加公司 | 腔肠素衍生物及其使用方法 |
| JP5896679B2 (ja) * | 2011-03-15 | 2016-03-30 | オリンパス株式会社 | オオオバボタル由来ルシフェラーゼ |
| WO2013078244A1 (en) | 2011-11-21 | 2013-05-30 | Promega Corporation | Carboxy x rhodamine analogs |
| BR112014020512B1 (pt) | 2012-02-21 | 2022-07-12 | Laboratory Corporation Of America Holdings | Métodos e sistemas para a detecção de microorganismos |
| US10519483B2 (en) | 2012-02-21 | 2019-12-31 | Laboratory Corporation Of America Holdings | Methods and systems for rapid detection of microorganisms using infectious agents |
| US20140099654A1 (en) | 2012-09-26 | 2014-04-10 | Promega Corporation | Real-time monitoring |
| AU2013359160B2 (en) | 2012-12-12 | 2018-11-15 | Promega Corporation | Compositions and methods for capture of cellular targets of bioactive agents |
| KR102292431B1 (ko) * | 2012-12-12 | 2021-08-20 | 프로메가 코포레이션 | 세포내 생물발광 공명 에너지 전이를 이용하여 생물활성제에 의한 세포 표적 결합의 인식 |
| US10067149B2 (en) * | 2012-12-12 | 2018-09-04 | Promega Corporation | Recognition of cellular target binding by a bioactive agent using intracellular bioluminescence resonance energy transfer |
| JP6511720B2 (ja) * | 2013-02-28 | 2019-05-15 | Jnc株式会社 | コドン最適化変異エビルシフェラーゼ遺伝子およびその使用方法 |
| JP6604938B2 (ja) | 2013-03-15 | 2019-11-13 | プロメガ コーポレイション | タンパク質を官能基または固体表面に共有結合的に係留するための基質 |
| ES2926463T3 (es) | 2013-03-15 | 2022-10-26 | Promega Corp | Activación de la bioluminiscencia mediante complementación estructural |
| US10168323B2 (en) * | 2013-03-15 | 2019-01-01 | Promega Corporation | Compositions and methods for capture of cellular targets of bioactive agents |
| AU2014241191A1 (en) | 2013-03-27 | 2015-10-22 | Sample Technologies, Inc. | Recombinant phage and bacterial detection methods |
| JP6040846B2 (ja) | 2013-04-08 | 2016-12-07 | Jnc株式会社 | セレンテラジン類縁体 |
| CN105531382A (zh) | 2013-06-19 | 2016-04-27 | 六品科技公司 | 基于噬菌体的细菌检测法 |
| JP6484987B2 (ja) | 2013-10-21 | 2019-03-20 | Jnc株式会社 | エビルシフェラーゼの触媒蛋白質の変異遺伝子とその使用法 |
| JP6442825B2 (ja) | 2013-12-26 | 2018-12-26 | Jnc株式会社 | エビルシフェラーゼの触媒蛋白質の変異遺伝子とその使用法 |
| EP3099691B1 (en) | 2014-01-29 | 2019-11-20 | Promega Corporation | Pro-substrates for live cell applications |
| US9790537B2 (en) | 2014-01-29 | 2017-10-17 | Promega Corporation | Quinone-masked probes as labeling reagents for cell uptake measurements |
| JP6256118B2 (ja) * | 2014-03-11 | 2018-01-10 | Jnc株式会社 | エビルシフェラーゼの触媒蛋白質のキメラ遺伝子及びその使用法 |
| JP6265020B2 (ja) * | 2014-04-16 | 2018-01-24 | Jnc株式会社 | エビルシフェラーゼの触媒蛋白質の変異遺伝子とその使用法 |
| US9732373B2 (en) | 2014-09-11 | 2017-08-15 | Promega Corporation | Luciferase sequences utilizing infrared-emitting substrates to produce enhanced luminescence |
| JP6814132B2 (ja) * | 2014-09-12 | 2021-01-13 | プロメガ コーポレイションＰｒｏｍｅｇａ Ｃｏｒｐｏｒａｔｉｏｎ | 内部タンパク質タグ |
| US11365402B2 (en) | 2014-09-12 | 2022-06-21 | Promega Corporation | Internal protein tags |
| WO2016127100A1 (en) * | 2015-02-05 | 2016-08-11 | Promega Corporation | Luciferase-based thermal shift assays |
| EP3304078B1 (en) | 2015-06-05 | 2022-08-31 | Promega Corporation | Cell-permeable, cell-compatible, and cleavable linkers for covalent tethering of functional elements |
| WO2016210294A1 (en) | 2015-06-25 | 2016-12-29 | Promega Corporation | Thienopyrrole compounds and uses thereof as inhibitors of oplophorus-derived luciferases |
| WO2018049241A1 (en) | 2016-09-09 | 2018-03-15 | Promega Corporation | Dual protected pro-coelenterazine substrates |
| EP4596707A3 (en) | 2016-09-19 | 2025-10-08 | University of Southern California | Non-radioactive cytotoxicity assays |
| WO2018075783A2 (en) | 2016-10-20 | 2018-04-26 | President And Fellows Of Harvard College | In vitro and cell based assays for measuring the activity of botulinum neurotoxins |
| JP7200102B2 (ja) | 2016-11-01 | 2023-01-06 | プロメガ コーポレイション | エネルギー受容体に係留されたセレンテラジン類縁体 |
| EP3548492B1 (en) | 2016-12-01 | 2023-07-05 | Promega Corporation | Cell impermeable coelenterazine analogues |
| WO2018125992A1 (en) | 2016-12-28 | 2018-07-05 | Promega Corporation | Functionalized nanoluc inhibitors |
| EP3395803A1 (en) | 2017-04-28 | 2018-10-31 | Institut Pasteur | Imidazopyrazine derivatives, process for preparation thereof, and their uses as luciferins |
| CN111315875B (zh) * | 2017-10-25 | 2024-02-20 | 豪夫迈·罗氏有限公司 | 改进修饰的/突变的细菌萤光素酶 |
| US20200393446A1 (en) | 2017-12-08 | 2020-12-17 | Centre National De La Recherche Scientifique (Cnrs) | Bioluminescent screening test for detecting cell cytolysis |
| EP3775240A1 (en) | 2018-03-30 | 2021-02-17 | INVISTA Textiles (U.K.) Limited | Method for controlling dissolved oxygen concentration in a continuous aerobic fermentation |
| WO2019191767A1 (en) | 2018-03-30 | 2019-10-03 | Invista Textiles (U.K.) Limited | High hydrogen utilization and gas recycle |
| EP3775182A1 (en) * | 2018-03-30 | 2021-02-17 | INVISTA Textiles (U.K.) Limited | Materials and methods for biosynthetic manufacture of pimelic acid and utilization of synthetic polypeptides |
| JP7419260B2 (ja) | 2018-05-01 | 2024-01-22 | プロメガ コーポレイション | ＮａｎｏＬｕｃ自殺基質としてのセレンテラジン化合物 |
| US11999943B2 (en) | 2018-05-02 | 2024-06-04 | Inv Nylon Chemicals Americas, Llc | Materials and methods for maximizing biosynthesis through alteration of pyruvate-acetyl-CoA-TCA balance in species of the genera ralstonia and cupriavidus and organisms related thereto |
| WO2019213118A1 (en) | 2018-05-02 | 2019-11-07 | Invista North America S.A.R.L. | Methods for controlling pha biosynthesis in cupriavidus or ralstonia |
| US11442063B2 (en) | 2018-05-30 | 2022-09-13 | Promega Corporation | Broad spectrum kinase binding agents |
| EP3802514B1 (en) | 2018-06-01 | 2022-08-03 | Promega Corporation | Inhibitors of oplophorus luciferase-derived bioluminescent complexes |
| US10962538B2 (en) | 2018-06-14 | 2021-03-30 | The Trustees Of Columbia University In The City Of New York | Assays using arrestin recruitment and unmodified receptors |
| CA3114424A1 (en) | 2018-10-03 | 2020-04-09 | Promega Corporation | Compositions and methods for stabilizing coelenterazine and analogs and derivatives thereof |
| JP7703446B2 (ja) | 2018-11-28 | 2025-07-07 | プロメガ コーポレイション | 反応性ペプチド標識付け |
| EP3891503A2 (en) | 2018-12-04 | 2021-10-13 | Promega Corporation | Broad spectrum gpcr binding agents |
| US11913944B2 (en) | 2019-03-20 | 2024-02-27 | Promega Corporation | Photoaffinity probes |
| US11360096B2 (en) | 2019-05-16 | 2022-06-14 | Duke University | Complex BRET technique for measuring biological interactions |
| CA3140294A1 (en) | 2019-06-21 | 2020-12-24 | Jose S. GIL | Methods for producing mutant bacteriophages for the detection of listeria |
| EP3986956A1 (en) | 2019-06-24 | 2022-04-27 | Promega Corporation | Modified polyamine polymers for delivery of biomolecules into cells |
| JP7781741B2 (ja) | 2019-08-26 | 2025-12-08 | ラボラトリー コーポレイション オブ アメリカ ホールディングス | 組換え繁殖欠損指標バクテリオファージを使用して微生物を検出するためのデバイスおよび方法 |
| CN115052991B (zh) | 2019-09-11 | 2025-08-12 | 美国控股实验室公司 | 使用重组感染因子以表达指示亚基来快速检测微生物的方法和系统 |
| CA3158729A1 (en) | 2019-11-27 | 2021-06-03 | Virginia Kincaid | Multipartite luciferase peptides and polypeptides |
| JP7745550B2 (ja) | 2019-12-10 | 2025-09-29 | プロメガ コーポレイション | 多官能性プローブを使用する生物発光検出用組成物及び生物発光検出方法 |
| KR20220133969A (ko) | 2020-01-28 | 2022-10-05 | 프리라인 테라퓨틱스 리미티드 | 바이러스 벡터에 대한 중화 항체 역가를 결정하기 위한 개선된 분석법 |
| US20210363565A1 (en) | 2020-05-22 | 2021-11-25 | Promega Corporation | Enhancement of kinase target engagement |
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| WO2022138892A1 (ja) | 2020-12-25 | 2022-06-30 | 中外製薬株式会社 | 複数の標的分子と共に複合体を形成し得る候補分子のスクリーニング方法 |
| CN115161296B (zh) * | 2021-04-01 | 2024-08-13 | 深圳华大生命科学研究院 | 一种刺虾荧光素酶Nluc的突变体及其应用 |
| CN113025586B (zh) * | 2021-04-06 | 2022-10-04 | 湖北省中医院 | 一种经改造的萤光素酶突变体蛋白、生物发光探针、探针组、制备方法和检测方法 |
| US12606863B2 (en) | 2021-05-13 | 2026-04-21 | Promega Corporation | Bioluminescent detection of DNA synthesis |
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| GB202213479D0 (en) | 2022-09-14 | 2022-10-26 | Ipsen Biopharm Ltd | Cell-free clostridial neurotoxin assays |
| US20260077065A1 (en) * | 2022-09-15 | 2026-03-19 | The Board Of Trustees Of The Leland Stanford Junior University | Compositions and Methods for Assessing Kinase Activity |
| GB202404021D0 (en) | 2024-03-20 | 2024-05-01 | Ipsen Biopharm Ltd | Cell-based neurotoxin assay |
| CN118516381B (zh) * | 2024-07-22 | 2024-11-01 | 北京剂泰医药科技有限公司 | 编码荧光素酶的mRNA及其应用 |
| CN119709661B (zh) * | 2024-12-30 | 2025-10-10 | 佰翱得(无锡)新药开发有限公司 | 一种荧光素酶OLuc突变体及其应用 |
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| SG10202103336SA (en) * | 2010-11-02 | 2021-04-29 | Promega Corp | Novel coelenterazine substrates and methods of use |
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2010
- 2010-05-03 ES ES18184699T patent/ES2795287T3/es active Active
- 2010-05-03 PL PL18184699T patent/PL3409764T3/pl unknown
- 2010-05-03 DK DK10717013.6T patent/DK2456864T3/en active
- 2010-05-03 CA CA2758572A patent/CA2758572A1/en active Pending
- 2010-05-03 DK DK18184699.9T patent/DK3409764T3/da active
- 2010-05-03 PT PT107170136T patent/PT2456864E/pt unknown
- 2010-05-03 EP EP15186652.2A patent/EP2990478B1/en active Active
- 2010-05-03 LT LTEP18184699.9T patent/LT3409764T/lt unknown
- 2010-05-03 US US12/773,002 patent/US8557970B2/en active Active
- 2010-05-03 PL PL17154777T patent/PL3181687T3/pl unknown
- 2010-05-03 PL PL10717013T patent/PL2456864T3/pl unknown
- 2010-05-03 ES ES20169057T patent/ES3042791T3/es active Active
- 2010-05-03 EP EP20169057.5A patent/EP3744834B1/en active Active
- 2010-05-03 SG SG2011074242A patent/SG175180A1/en unknown
- 2010-05-03 KR KR1020117028749A patent/KR101665352B1/ko active Active
- 2010-05-03 DK DK15186652.2T patent/DK2990478T3/en active
- 2010-05-03 BR BRPI1010019A patent/BRPI1010019B1/pt active IP Right Grant
- 2010-05-03 EP EP10717013.6A patent/EP2456864B1/en active Active
- 2010-05-03 ES ES15186652.2T patent/ES2629390T3/es active Active
- 2010-05-03 CN CN201080019477.4A patent/CN102459579B/zh active Active
- 2010-05-03 WO PCT/US2010/033449 patent/WO2010127368A1/en not_active Ceased
- 2010-05-03 SG SG10201601281WA patent/SG10201601281WA/en unknown
- 2010-05-03 AU AU2010242771A patent/AU2010242771B2/en active Active
- 2010-05-03 PT PT151866522T patent/PT2990478T/pt unknown
- 2010-05-03 PL PL15186652T patent/PL2990478T3/pl unknown
- 2010-05-03 DK DK17154777.1T patent/DK3181687T3/en active
- 2010-05-03 EP EP17154777.1A patent/EP3181687B1/en active Active
- 2010-05-03 ES ES10717013.6T patent/ES2559505T3/es active Active
- 2010-05-03 CN CN201810043641.3A patent/CN108192950B/zh active Active
- 2010-05-03 PT PT181846999T patent/PT3409764T/pt unknown
- 2010-05-03 PT PT17154777T patent/PT3181687T/pt unknown
- 2010-05-03 JP JP2012508822A patent/JP6038649B2/ja active Active
- 2010-05-03 PL PL20169057.5T patent/PL3744834T3/pl unknown
- 2010-05-03 ES ES17154777T patent/ES2691539T3/es active Active
- 2010-05-03 EP EP18184699.9A patent/EP3409764B1/en active Active
- 2010-05-03 SG SG10201901453PA patent/SG10201901453PA/en unknown
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2011
- 2011-10-11 IL IL215697A patent/IL215697B/en active IP Right Grant
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2013
- 2013-10-14 US US14/053,252 patent/US9777311B2/en active Active
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2015
- 2015-10-22 JP JP2015208321A patent/JP6227615B2/ja active Active
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2017
- 2017-09-25 US US15/714,210 patent/US10233485B2/en active Active
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2019
- 2019-03-06 US US16/294,464 patent/US10633690B2/en active Active
- 2019-03-10 IL IL265263A patent/IL265263B/en active IP Right Grant
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2020
- 2020-03-17 US US16/821,682 patent/US10844422B2/en active Active
- 2020-04-22 IL IL274145A patent/IL274145B/en unknown
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2022
- 2022-06-20 US US17/844,371 patent/US11667950B2/en active Active
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