JP2017529840A5 - - Google Patents
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- Publication number
- JP2017529840A5 JP2017529840A5 JP2017514343A JP2017514343A JP2017529840A5 JP 2017529840 A5 JP2017529840 A5 JP 2017529840A5 JP 2017514343 A JP2017514343 A JP 2017514343A JP 2017514343 A JP2017514343 A JP 2017514343A JP 2017529840 A5 JP2017529840 A5 JP 2017529840A5
- Authority
- JP
- Japan
- Prior art keywords
- cbr
- polynucleotide
- seq
- variant polypeptide
- polypeptide
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 102000040430 polynucleotide Human genes 0.000 claims 20
- 108091033319 polynucleotide Proteins 0.000 claims 20
- 239000002157 polynucleotide Substances 0.000 claims 20
- 108090000765 processed proteins & peptides Proteins 0.000 claims 17
- 229920001184 polypeptide Polymers 0.000 claims 16
- 102000004196 processed proteins & peptides Human genes 0.000 claims 16
- 238000006467 substitution reaction Methods 0.000 claims 7
- 125000003275 alpha amino acid group Chemical group 0.000 claims 6
- 102000037865 fusion proteins Human genes 0.000 claims 5
- 108020001507 fusion proteins Proteins 0.000 claims 5
- 108060001084 Luciferase Proteins 0.000 claims 3
- 239000005089 Luciferase Substances 0.000 claims 3
- 238000005415 bioluminescence Methods 0.000 claims 3
- 230000029918 bioluminescence Effects 0.000 claims 3
- 239000012634 fragment Substances 0.000 claims 2
- 238000000034 method Methods 0.000 claims 2
- 108090000623 proteins and genes Proteins 0.000 claims 2
- 102000004169 proteins and genes Human genes 0.000 claims 2
- 239000000758 substrate Substances 0.000 claims 2
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 1
- 241000059559 Agriotes sordidus Species 0.000 claims 1
- 108020004705 Codon Proteins 0.000 claims 1
- IGXWBGJHJZYPQS-SSDOTTSWSA-N D-Luciferin Chemical class OC(=O)[C@H]1CSC(C=2SC3=CC=C(O)C=C3N=2)=N1 IGXWBGJHJZYPQS-SSDOTTSWSA-N 0.000 claims 1
- 102220629217 Dolichyl-diphosphooligosaccharide-protein glycosyltransferase subunit STT3B_H16Q_mutation Human genes 0.000 claims 1
- 102220477051 Dynein axonemal assembly factor 10_S51N_mutation Human genes 0.000 claims 1
- 241001465754 Metazoa Species 0.000 claims 1
- 150000001413 amino acids Chemical class 0.000 claims 1
- 239000003153 chemical reaction reagent Substances 0.000 claims 1
- 238000004020 luminiscence type Methods 0.000 claims 1
- 238000002165 resonance energy transfer Methods 0.000 claims 1
- 102200005671 rs1013940 Human genes 0.000 claims 1
- 102220233973 rs1060500235 Human genes 0.000 claims 1
- 102200019363 rs121908930 Human genes 0.000 claims 1
- 102200137700 rs121964987 Human genes 0.000 claims 1
- 102200005555 rs137852383 Human genes 0.000 claims 1
- 102220000042 rs137853595 Human genes 0.000 claims 1
- 102220288775 rs1554193610 Human genes 0.000 claims 1
- 102200027769 rs199475598 Human genes 0.000 claims 1
- 102200142793 rs35418374 Human genes 0.000 claims 1
- 102200142997 rs371802902 Human genes 0.000 claims 1
- 102200093904 rs3810948 Human genes 0.000 claims 1
- 102200076376 rs61060395 Human genes 0.000 claims 1
- 102220082831 rs780379280 Human genes 0.000 claims 1
- 102220059871 rs786203573 Human genes 0.000 claims 1
- 102220009778 rs80358502 Human genes 0.000 claims 1
- 230000009261 transgenic effect Effects 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462049150P | 2014-09-11 | 2014-09-11 | |
| US62/049,150 | 2014-09-11 | ||
| PCT/US2015/049661 WO2016040788A1 (en) | 2014-09-11 | 2015-09-11 | Luciferase sequences utilizing infrared-emitting substrates to produce enhanced luminescence |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020000374A Division JP7058677B2 (ja) | 2014-09-11 | 2020-01-06 | 増強された発光を産生するために赤外発光基質を活用するルシフェラーゼ配列 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017529840A JP2017529840A (ja) | 2017-10-12 |
| JP2017529840A5 true JP2017529840A5 (https=) | 2018-10-18 |
| JP6811173B2 JP6811173B2 (ja) | 2021-01-13 |
Family
ID=54186325
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017514343A Active JP6811173B2 (ja) | 2014-09-11 | 2015-09-11 | 増強された発光を産生するために赤外発光基質を活用するルシフェラーゼ配列 |
| JP2020000374A Active JP7058677B2 (ja) | 2014-09-11 | 2020-01-06 | 増強された発光を産生するために赤外発光基質を活用するルシフェラーゼ配列 |
| JP2022010240A Active JP7443405B2 (ja) | 2014-09-11 | 2022-01-26 | 増強された発光を産生するために赤外発光基質を活用するルシフェラーゼ配列 |
| JP2024024330A Active JP7780560B2 (ja) | 2014-09-11 | 2024-02-21 | 増強された発光を産生するために赤外発光基質を活用するルシフェラーゼ配列 |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020000374A Active JP7058677B2 (ja) | 2014-09-11 | 2020-01-06 | 増強された発光を産生するために赤外発光基質を活用するルシフェラーゼ配列 |
| JP2022010240A Active JP7443405B2 (ja) | 2014-09-11 | 2022-01-26 | 増強された発光を産生するために赤外発光基質を活用するルシフェラーゼ配列 |
| JP2024024330A Active JP7780560B2 (ja) | 2014-09-11 | 2024-02-21 | 増強された発光を産生するために赤外発光基質を活用するルシフェラーゼ配列 |
Country Status (4)
| Country | Link |
|---|---|
| US (4) | US9732373B2 (https=) |
| EP (1) | EP3191600A1 (https=) |
| JP (4) | JP6811173B2 (https=) |
| WO (1) | WO2016040788A1 (https=) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9732373B2 (en) | 2014-09-11 | 2017-08-15 | Promega Corporation | Luciferase sequences utilizing infrared-emitting substrates to produce enhanced luminescence |
| EP3578978B1 (en) * | 2017-02-03 | 2022-07-13 | Osaka University | Device and determination system using same |
| EP3661932B1 (en) * | 2017-08-04 | 2021-10-06 | Promega Corporation | Compositions and methods for stabilizing benzothiazole luciferin analogs |
| CN111315875B (zh) | 2017-10-25 | 2024-02-20 | 豪夫迈·罗氏有限公司 | 改进修饰的/突变的细菌萤光素酶 |
| WO2019236731A1 (en) | 2018-06-05 | 2019-12-12 | Promega Corporation | Luciferase enzymes for use with thermostable luciferins in bioluminescent assays |
| JP2025522599A (ja) * | 2022-06-30 | 2025-07-15 | 青島華大智造普恵科技有限公司 | ルシフェラーゼ変異体及びその使用 |
| CN118516381B (zh) * | 2024-07-22 | 2024-11-01 | 北京剂泰医药科技有限公司 | 编码荧光素酶的mRNA及其应用 |
Family Cites Families (42)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5583024A (en) | 1985-12-02 | 1996-12-10 | The Regents Of The University Of California | Recombinant expression of Coleoptera luciferase |
| JPH088864B2 (ja) | 1988-04-12 | 1996-01-31 | キッコーマン株式会社 | ルシフェラーゼ |
| US5049358A (en) | 1988-09-30 | 1991-09-17 | Miles Inc. | Composition and test device for assaying for proteins |
| US5196524A (en) | 1989-01-06 | 1993-03-23 | Eli Lilly And Company | Fusion reporter gene for bacterial luciferase |
| US5219737A (en) | 1990-03-27 | 1993-06-15 | Kikkoman Corporation | Mutant luciferase of a firefly, mutant luciferase genes, recombinant dnas containing the genes and a method of producing mutant luciferase |
| US5480789A (en) | 1991-04-01 | 1996-01-02 | Florigene Europe B.V. | Genetically transformed rose plants and methods for their production |
| US5229285A (en) | 1991-06-27 | 1993-07-20 | Kikkoman Corporation | Thermostable luciferase of firefly, thermostable luciferase gene of firefly, novel recombinant dna, and process for the preparation of thermostable luciferase of firefly |
| JP3048466B2 (ja) | 1991-06-27 | 2000-06-05 | キッコーマン株式会社 | 耐熱性ホタルルシフェラーゼ、耐熱性ホタルルシフェラーゼ遺伝子、新規な組み換え体ｄｎａ、及び耐熱性ホタルルシフェラーゼの製造法 |
| GB9301118D0 (en) | 1993-01-21 | 1993-03-10 | Secr Defence | Enzyme linked assays |
| CA2157476C (en) * | 1994-01-03 | 2009-08-25 | Keith V. Wood | Mutant luciferases |
| US6387675B1 (en) | 1994-01-03 | 2002-05-14 | Promega Corporation | Mutant luciferases |
| US5605793A (en) | 1994-02-17 | 1997-02-25 | Affymax Technologies N.V. | Methods for in vitro recombination |
| GB2301592B (en) | 1994-03-23 | 1998-06-17 | Secr Defence | Luciferases |
| GB9501170D0 (en) | 1994-03-23 | 1995-03-08 | Secr Defence | Luciferases |
| ATE215608T1 (de) | 1994-07-13 | 2002-04-15 | Secr Defence Brit | Mikrobiologisches testverfahren und reagenzien |
| US5670356A (en) | 1994-12-12 | 1997-09-23 | Promega Corporation | Modified luciferase |
| WO1996022376A1 (en) | 1995-01-20 | 1996-07-25 | The Secretary Of State For Defence | Mutant luciferases |
| US5716851A (en) | 1996-01-16 | 1998-02-10 | Bayer Corporation | Glass/cellulose as protein reagent |
| JPH09294600A (ja) | 1996-04-26 | 1997-11-18 | Kikkoman Corp | 複数のプロモーター活性の測定法 |
| JP2001504325A (ja) | 1996-09-27 | 2001-04-03 | マキシジェン，インコーポレイテッド | 回帰的配列シャフリングおよび選択による遺伝子治療の最適化のための方法 |
| GB9707486D0 (en) | 1997-04-11 | 1997-05-28 | Secr Defence | Enzyme assays |
| US6074859A (en) | 1997-07-08 | 2000-06-13 | Kikkoman Corporation | Mutant-type bioluminescent protein, and process for producing the mutant-type bioluminescent protein |
| EP2860252A1 (en) | 1997-09-19 | 2015-04-15 | Promega Corporation | Thermostable luciferases and methods of production |
| US6602677B1 (en) | 1997-09-19 | 2003-08-05 | Promega Corporation | Thermostable luciferases and methods of production |
| GB9823468D0 (en) | 1998-10-28 | 1998-12-23 | Secr Defence | Novel enzyme |
| NZ518413A (en) | 1999-10-26 | 2004-11-26 | Secr Defence | Novel enzyme |
| GB9925161D0 (en) | 1999-10-26 | 1999-12-22 | Secr Defence | Novel enzyme |
| US7879540B1 (en) * | 2000-08-24 | 2011-02-01 | Promega Corporation | Synthetic nucleic acid molecule compositions and methods of preparation |
| US7083911B2 (en) | 2001-02-16 | 2006-08-01 | Promega Corporation | Method for detection of ATP |
| US7268229B2 (en) * | 2001-11-02 | 2007-09-11 | Promega Corporation | Compounds to co-localize luminophores with luminescent proteins |
| WO2005035719A2 (en) | 2003-10-03 | 2005-04-21 | Board Of Control Of Michigan Technological University | Modified luciferase |
| EP2308978B8 (en) * | 2003-10-10 | 2015-04-08 | Promega Corporation | Luciferase biosensor |
| US7728118B2 (en) | 2004-09-17 | 2010-06-01 | Promega Corporation | Synthetic nucleic acid molecule compositions and methods of preparation |
| EP2272972A1 (en) * | 2005-05-31 | 2011-01-12 | Promega Corporation | Luminogenic and fluorogenic compounds and methods to detect molecules or conditions |
| EP2004813B1 (en) * | 2006-04-03 | 2015-06-03 | Promega Corporation | Permuted and nonpermuted luciferase biosensors binding cyclic nucleotides |
| WO2009140662A1 (en) * | 2008-05-15 | 2009-11-19 | Illumina, Inc. | Engineered luciferases |
| US8288559B2 (en) * | 2008-08-18 | 2012-10-16 | Promega Corporation | Luminogenic compounds and methods to detect cytochrome P450 3A enzymes |
| ES2795287T3 (es) | 2009-05-01 | 2020-11-23 | Promega Corp | Luciferasas de Oplophorus sintéticas con mayor emisión de luz |
| JP5644994B2 (ja) * | 2009-08-31 | 2014-12-24 | 独立行政法人産業技術総合研究所 | バイオイメージングに特化した変異型赤色発光ルシフェラーゼ |
| SG10202103336SA (en) | 2010-11-02 | 2021-04-29 | Promega Corp | Novel coelenterazine substrates and methods of use |
| JP6495232B2 (ja) * | 2013-03-12 | 2019-04-03 | プロメガ コーポレイションＰｒｏｍｅｇａ Ｃｏｒｐｏｒａｔｉｏｎ | 赤方偏移ルシフェリン及びその使用方法 |
| US9732373B2 (en) | 2014-09-11 | 2017-08-15 | Promega Corporation | Luciferase sequences utilizing infrared-emitting substrates to produce enhanced luminescence |
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2015
- 2015-09-11 US US14/851,608 patent/US9732373B2/en active Active
- 2015-09-11 JP JP2017514343A patent/JP6811173B2/ja active Active
- 2015-09-11 WO PCT/US2015/049661 patent/WO2016040788A1/en not_active Ceased
- 2015-09-11 EP EP15767679.2A patent/EP3191600A1/en active Pending
-
2017
- 2017-07-10 US US15/644,876 patent/US10550420B2/en active Active
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2019
- 2019-12-23 US US16/725,586 patent/US11293047B2/en active Active
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2020
- 2020-01-06 JP JP2020000374A patent/JP7058677B2/ja active Active
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2022
- 2022-01-26 JP JP2022010240A patent/JP7443405B2/ja active Active
- 2022-03-01 US US17/683,939 patent/US12460245B2/en active Active
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2024
- 2024-02-21 JP JP2024024330A patent/JP7780560B2/ja active Active