JP2024041747A5 - - Google Patents
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- Publication number
- JP2024041747A5 JP2024041747A5 JP2023202447A JP2023202447A JP2024041747A5 JP 2024041747 A5 JP2024041747 A5 JP 2024041747A5 JP 2023202447 A JP2023202447 A JP 2023202447A JP 2023202447 A JP2023202447 A JP 2023202447A JP 2024041747 A5 JP2024041747 A5 JP 2024041747A5
- Authority
- JP
- Japan
- Prior art keywords
- interleukin
- expression vector
- recombinant expression
- amino acid
- nucleic acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR20200039476 | 2020-03-31 | ||
| KR10-2020-0039476 | 2020-03-31 | ||
| PCT/KR2021/004028 WO2021201615A1 (ko) | 2020-03-31 | 2021-03-31 | 신규한 면역 활성 인터루킨 2 아날로그 |
| JP2022559531A JP7846627B2 (ja) | 2020-03-31 | 2021-03-31 | 新規な免疫活性インターロイキン２アナログ |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022559531A Division JP7846627B2 (ja) | 2020-03-31 | 2021-03-31 | 新規な免疫活性インターロイキン２アナログ |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2024041747A JP2024041747A (ja) | 2024-03-27 |
| JP2024041747A5 true JP2024041747A5 (https=) | 2026-04-20 |
Family
ID=77930406
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022559531A Active JP7846627B2 (ja) | 2020-03-31 | 2021-03-31 | 新規な免疫活性インターロイキン２アナログ |
| JP2023202447A Pending JP2024041747A (ja) | 2020-03-31 | 2023-11-30 | 新規な免疫活性インターロイキン２アナログ |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022559531A Active JP7846627B2 (ja) | 2020-03-31 | 2021-03-31 | 新規な免疫活性インターロイキン２アナログ |
Country Status (17)
| Country | Link |
|---|---|
| US (2) | US11746137B2 (https=) |
| EP (1) | EP4130027A4 (https=) |
| JP (2) | JP7846627B2 (https=) |
| KR (2) | KR102545250B1 (https=) |
| CN (2) | CN118271419A (https=) |
| AR (1) | AR121713A1 (https=) |
| AU (2) | AU2021202825B2 (https=) |
| BR (1) | BR112022018730A2 (https=) |
| CA (2) | CA3266069A1 (https=) |
| CL (1) | CL2022002562A1 (https=) |
| IL (1) | IL295826B2 (https=) |
| MX (1) | MX2022011893A (https=) |
| NZ (1) | NZ793819A (https=) |
| PE (1) | PE20221759A1 (https=) |
| TW (1) | TWI876021B (https=) |
| WO (1) | WO2021201615A1 (https=) |
| ZA (1) | ZA202209565B (https=) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN118271419A (zh) * | 2020-03-31 | 2024-07-02 | 韩美药品株式会社 | 新型免疫刺激il-2类似物 |
| TW202406932A (zh) | 2020-10-22 | 2024-02-16 | 美商基利科學股份有限公司 | 介白素2-Fc融合蛋白及使用方法 |
| AU2022306974A1 (en) | 2021-07-09 | 2024-01-04 | Bright Peak Therapeutics Ag | Modified il-2 polypeptides for treatment of inflammatory and autoimmune diseases |
| KR20230095612A (ko) * | 2021-12-22 | 2023-06-29 | 한미약품 주식회사 | 신규 면역 억제 인터루킨 2 (Interleukin 2) 아날로그 |
| KR102445492B1 (ko) * | 2021-12-24 | 2022-09-21 | 엔케이젠 주식회사 | 신규한 펩타이드를 포함하는 자연살해세포 대량증식용 조성물 및 이를 이용한 자연살해세포 대량증식방법 |
| US20240076343A1 (en) * | 2022-06-16 | 2024-03-07 | Cephalon Llc | Anti-pd-1 antibody-attenuated il-2 immunoconjugates and uses thereof |
| JP2025527694A (ja) * | 2022-08-23 | 2025-08-22 | マストバイオ株式会社 | Ｉｌ２変異体及びそれを含むタンパク質複合体 |
| KR20250126198A (ko) | 2024-02-15 | 2025-08-25 | 한림대학교 산학협력단 | 인슐린 저항성의 예방 또는 치료를 위한 약학적 조성물 |
Family Cites Families (38)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU3285989A (en) * | 1987-11-25 | 1989-06-14 | Cetus Corporation | Treatment of infections caused by a primary immunodeficiency with interleukin-2 |
| AU627477B2 (en) * | 1988-07-05 | 1992-08-27 | Amgen, Inc. | Interleukin ii analogs |
| CA2019714A1 (en) | 1989-06-27 | 1990-12-27 | Richard A. Chizzonite | Process for the determination of interleukins |
| DZ2788A1 (fr) | 1998-05-15 | 2003-12-01 | Bayer Ag | Agonistes et antagonistes selectifs à IL-2. |
| CZ20021186A3 (cs) * | 1999-10-04 | 2002-11-13 | Chiron Corporation | Farmaceutické prostředky obsahující stabilizovaný kapalný polypeptid |
| DE60332358D1 (de) | 2002-09-09 | 2010-06-10 | Hanall Pharmaceutical Co Ltd | Protease-resistente modifizierte interferon alpha polypeptide |
| US7569215B2 (en) * | 2003-07-18 | 2009-08-04 | Massachusetts Institute Of Technology | Mutant interleukin-2 (IL-2) polypeptides |
| US20060234205A1 (en) | 2004-03-05 | 2006-10-19 | Chiron Corporation | In vitro test system for predicting patient tolerability of therapeutic agents |
| CN1930300A (zh) | 2004-03-05 | 2007-03-14 | 希龙公司 | 预测患者治疗药物耐受性的体外试验系统 |
| AU2007201663A1 (en) | 2007-04-16 | 2008-10-30 | Nautilus Biotech | Oral dosage formulations of protease resistant polypeptides |
| CN102462837B (zh) | 2010-11-19 | 2016-08-03 | 生物林格斯Ip有限公司 | 抗炎组合物 |
| CA2860170C (en) * | 2010-12-22 | 2022-06-14 | The Board Of Trustees Of The Leland Stanford Junior University | Superagonists and antagonists of interleukin-2 |
| DK2963056T3 (da) | 2013-02-26 | 2020-02-17 | Hanmi Pharm Ind Co Ltd | Insulinanalog og anvendelse deraf |
| CN105722860A (zh) | 2013-09-24 | 2016-06-29 | 梅迪塞纳医疗股份有限公司 | 白介素-2融合蛋白及其应用 |
| CR20160376A (es) | 2014-01-20 | 2016-10-07 | Hanmi Pharm Ind Co Ltd | Insulina de acción prolongada y uso de la misma |
| WO2015164815A1 (en) * | 2014-04-24 | 2015-10-29 | The Board Of Trustees Of The Leland Stanford Junior University | Superagonists, partial agonists and antagonists of interleukin-2 |
| JP6821560B2 (ja) | 2014-10-21 | 2021-01-27 | サイクロン ファーマシューティカルズ インターナショナル エルティーディー．Ｓｃｉｃｌｏｎｅ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｉｎｔｅｒｎａｔｉｏｎａｌ Ｌｔｄ． | 免疫刺激剤による癌治療 |
| CN104403004B (zh) * | 2014-11-24 | 2017-10-13 | 苏州丁孚靶点生物技术有限公司 | 抗体‑干扰素异二聚体的制备和用途 |
| KR20160134989A (ko) * | 2015-05-14 | 2016-11-24 | 순천향대학교 산학협력단 | 인간 인터류킨-2 단백질을 포함하는 약학조성물 |
| CN107266553A (zh) * | 2016-04-08 | 2017-10-20 | 南京康志制药有限公司 | 高效人白细胞介素ⅱ突变体融合蛋白及其应用 |
| JP7422480B2 (ja) * | 2016-05-04 | 2024-01-26 | アムジエン・インコーポレーテツド | 制御性ｔ細胞の増殖のためのインターロイキン－２変異タンパク質 |
| CA3055200A1 (en) * | 2017-03-03 | 2018-09-07 | Obsidian Therapeutics, Inc. | Compositions and methods for immunotherapy |
| CN111201035A (zh) * | 2017-06-19 | 2020-05-26 | 梅迪塞纳医疗股份有限公司 | Il-2超激动剂、激动剂及其融合体的用途和方法 |
| CN111094356B (zh) * | 2017-09-25 | 2022-11-01 | 苏州丁孚靶点生物技术有限公司 | 一种蛋白质异二聚体及其用途 |
| US10946068B2 (en) | 2017-12-06 | 2021-03-16 | Pandion Operations, Inc. | IL-2 muteins and uses thereof |
| WO2019147837A2 (en) * | 2018-01-24 | 2019-08-01 | Beijing Percans Oncology Co. Ltd. | Cytokine fusion proteins |
| CN108503714A (zh) | 2018-04-10 | 2018-09-07 | 浙江科途医学科技有限公司 | 一种人白介素2和抗人上皮细胞黏附分子单链抗体融合蛋白及其应用 |
| AU2019271148B9 (en) * | 2018-05-14 | 2025-05-29 | Werewolf Therapeutics, Inc. | Activatable interleukin-2 polypeptides and methods of use thereof |
| KR20250156190A (ko) * | 2018-06-22 | 2025-10-31 | 큐진 인크. | 인터루킨-2 변이체 및 이의 사용 방법 |
| MX2021000801A (es) * | 2018-07-24 | 2021-04-12 | BioNTech SE | Agonistas de il2. |
| US11492384B2 (en) * | 2018-09-17 | 2022-11-08 | Gi Innovation, Inc. | Fusion protein comprising IL-2 protein and CD80 protein, and use thereof |
| CA3098930A1 (en) * | 2018-09-21 | 2020-03-26 | Innovent Biologics (Suzhou) Co., Ltd. | Novel interleukin-2 and use thereof |
| CN113316590B (zh) * | 2018-11-16 | 2025-02-28 | 百时美施贵宝公司 | 抗nkg2a抗体及其用途 |
| EP3901167A4 (en) * | 2018-12-21 | 2022-11-16 | Hanmi Pharm. Co., Ltd. | NOVEL IMMUNOSUPRESSIVE INTERLEUKIN 2 |
| CN111944036B (zh) | 2019-05-14 | 2024-09-06 | 上海盖浦生物科技有限公司 | 一种增殖免疫细胞的突变体蛋白 |
| CN114437198A (zh) | 2019-12-17 | 2022-05-06 | 北京志道生物科技有限公司 | 白介素-2衍生物 |
| CA3169095A1 (en) | 2020-03-05 | 2021-09-10 | Kenan Christopher GARCIA | Designed il-2 variants |
| CN118271419A (zh) * | 2020-03-31 | 2024-07-02 | 韩美药品株式会社 | 新型免疫刺激il-2类似物 |
-
2021
- 2021-03-31 CN CN202410385677.5A patent/CN118271419A/zh active Pending
- 2021-03-31 JP JP2022559531A patent/JP7846627B2/ja active Active
- 2021-03-31 BR BR112022018730A patent/BR112022018730A2/pt unknown
- 2021-03-31 MX MX2022011893A patent/MX2022011893A/es unknown
- 2021-03-31 TW TW110111922A patent/TWI876021B/zh active
- 2021-03-31 WO PCT/KR2021/004028 patent/WO2021201615A1/ko not_active Ceased
- 2021-03-31 IL IL295826A patent/IL295826B2/en unknown
- 2021-03-31 PE PE2022001948A patent/PE20221759A1/es unknown
- 2021-03-31 CA CA3266069A patent/CA3266069A1/en active Pending
- 2021-03-31 CN CN202180025732.4A patent/CN115427437B/zh active Active
- 2021-03-31 NZ NZ793819A patent/NZ793819A/en unknown
- 2021-03-31 EP EP21781220.5A patent/EP4130027A4/en active Pending
- 2021-03-31 US US17/915,808 patent/US11746137B2/en active Active
- 2021-03-31 CA CA3169564A patent/CA3169564C/en active Active
- 2021-03-31 AU AU2021202825A patent/AU2021202825B2/en active Active
- 2021-03-31 KR KR1020210042319A patent/KR102545250B1/ko active Active
- 2021-03-31 AR ARP210100815A patent/AR121713A1/es unknown
-
2022
- 2022-06-02 AU AU2022203841A patent/AU2022203841A1/en not_active Abandoned
- 2022-08-26 ZA ZA2022/09565A patent/ZA202209565B/en unknown
- 2022-09-21 CL CL2022002562A patent/CL2022002562A1/es unknown
-
2023
- 2023-06-09 KR KR1020230074093A patent/KR102946368B1/ko active Active
- 2023-07-10 US US18/349,656 patent/US12415842B2/en active Active
- 2023-11-30 JP JP2023202447A patent/JP2024041747A/ja active Pending
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