JP2024041747A5 - - Google Patents
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- Publication number
- JP2024041747A5 JP2024041747A5 JP2023202447A JP2023202447A JP2024041747A5 JP 2024041747 A5 JP2024041747 A5 JP 2024041747A5 JP 2023202447 A JP2023202447 A JP 2023202447A JP 2023202447 A JP2023202447 A JP 2023202447A JP 2024041747 A5 JP2024041747 A5 JP 2024041747A5
- Authority
- JP
- Japan
- Prior art keywords
- interleukin
- analog
- aldesleukin
- mutated
- sequence
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 108010002350 Interleukin-2 Proteins 0.000 claims 3
- 102000000588 Interleukin-2 Human genes 0.000 claims 3
- 108010063738 Interleukins Proteins 0.000 claims 1
- 102000015696 Interleukins Human genes 0.000 claims 1
- 108700025316 aldesleukin Proteins 0.000 claims 1
- 229960005310 aldesleukin Drugs 0.000 claims 1
- 150000001413 amino acids Chemical class 0.000 claims 1
- 102000005962 receptors Human genes 0.000 claims 1
- 108020003175 receptors Proteins 0.000 claims 1
Claims (1)
- アルデスロイキン（aldesleukin）に比べてインターロイキン２β受容体結合力が増大したインターロイキン２アナログ（analog）であって、前記インターロイキン２アナログは、天然インターロイキン２において、１番目、１２番目、１８番目、１９番目、２０番目、２２番目、３２番目、３５番目、３８番目、４２番目、４３番目、４５番目、４８番目、４９番目、６１番目、６８番目、６９番目、７４番目、７６番目、８０番目、８１番目、８２番目、８４番目、８５番目、８６番目、８７番目、８８番目、８９番目、９１番目、９２番目、９４番目、９５番目、９６番目、１２５番目、１２６番目及び１３３番目の位置に相当するアミノ酸の少なくとも１つが変異した配列を含む、インターロイキン２アナログ。
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR20200039476 | 2020-03-31 | ||
| KR10-2020-0039476 | 2020-03-31 | ||
| PCT/KR2021/004028 WO2021201615A1 (ko) | 2020-03-31 | 2021-03-31 | 신규한 면역 활성 인터루킨 2 아날로그 |
| JP2022559531A JP2023515247A (ja) | 2020-03-31 | 2021-03-31 | 新規な免疫活性インターロイキン２アナログ |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022559531A Division JP2023515247A (ja) | 2020-03-31 | 2021-03-31 | 新規な免疫活性インターロイキン２アナログ |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2024041747A JP2024041747A (ja) | 2024-03-27 |
| JP2024041747A5 true JP2024041747A5 (ja) | 2024-04-08 |
Family
ID=77930406
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022559531A Pending JP2023515247A (ja) | 2020-03-31 | 2021-03-31 | 新規な免疫活性インターロイキン２アナログ |
| JP2023202447A Pending JP2024041747A (ja) | 2020-03-31 | 2023-11-30 | 新規な免疫活性インターロイキン２アナログ |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022559531A Pending JP2023515247A (ja) | 2020-03-31 | 2021-03-31 | 新規な免疫活性インターロイキン２アナログ |
Country Status (16)
| Country | Link |
|---|---|
| US (2) | US11746137B2 (ja) |
| EP (1) | EP4130027A4 (ja) |
| JP (2) | JP2023515247A (ja) |
| KR (2) | KR102545250B1 (ja) |
| CN (2) | CN115427437B (ja) |
| AR (1) | AR121713A1 (ja) |
| AU (2) | AU2021202825B2 (ja) |
| BR (1) | BR112022018730A2 (ja) |
| CA (1) | CA3169564A1 (ja) |
| CL (1) | CL2022002562A1 (ja) |
| IL (1) | IL295826A (ja) |
| MX (1) | MX2022011893A (ja) |
| PE (1) | PE20221759A1 (ja) |
| TW (1) | TW202204387A (ja) |
| WO (1) | WO2021201615A1 (ja) |
| ZA (1) | ZA202209565B (ja) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI815194B (zh) | 2020-10-22 | 2023-09-11 | 美商基利科學股份有限公司 | 介白素2-Fc融合蛋白及使用方法 |
| KR20230095612A (ko) * | 2021-12-22 | 2023-06-29 | 한미약품 주식회사 | 신규 면역 억제 인터루킨 2 (Interleukin 2) 아날로그 |
| KR102445492B1 (ko) * | 2021-12-24 | 2022-09-21 | 엔케이젠 주식회사 | 신규한 펩타이드를 포함하는 자연살해세포 대량증식용 조성물 및 이를 이용한 자연살해세포 대량증식방법 |
| TW202413442A (zh) * | 2022-06-16 | 2024-04-01 | 美商希佛隆有限責任公司 | 抗pd-1抗體減弱之il-2免疫結合物及其用途 |
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| WO1989004665A2 (en) * | 1987-11-25 | 1989-06-01 | Cetus Corporation | Treatment of infections caused by a primary immunodeficiency with interleukin-2 |
| AU627477B2 (en) * | 1988-07-05 | 1992-08-27 | Amgen, Inc. | Interleukin ii analogs |
| CA2019714A1 (en) * | 1989-06-27 | 1990-12-27 | Richard A. Chizzonite | Process for the determination of interleukins |
| DZ2788A1 (fr) * | 1998-05-15 | 2003-12-01 | Bayer Ag | Agonistes et antagonistes selectifs à IL-2. |
| HUP0203133A3 (en) * | 1999-10-04 | 2005-07-28 | Chiron Corp Emeryville | Stabilized liquid polypeptide-containing pharmaceutical compositions |
| ES2343518T3 (es) * | 2002-09-09 | 2010-08-03 | Hanall Biopharma Co., Ltd. | Polipeptidos interferon alfa modificados resistentes a proteasas. |
| WO2005007121A2 (en) | 2003-07-18 | 2005-01-27 | Massachusetts Institute Of Technology | Mutant interleukin-2(il-2) polypeptides |
| WO2005091956A2 (en) * | 2004-03-05 | 2005-10-06 | Chiron Corporation | In vitro test system for predicting patient tolerability of therapeutic agents |
| CN1930300A (zh) * | 2004-03-05 | 2007-03-14 | 希龙公司 | 预测患者治疗药物耐受性的体外试验系统 |
| AU2007201663A1 (en) * | 2007-04-16 | 2008-10-30 | Nautilus Biotech | Oral dosage formulations of protease resistant polypeptides |
| CN102462837B (zh) * | 2010-11-19 | 2016-08-03 | 生物林格斯Ip有限公司 | 抗炎组合物 |
| JP6093712B2 (ja) * | 2010-12-22 | 2017-03-08 | ザ ボード オブ トラスティーズ オブ ザ レランド スタンフォード ジュニア ユニバーシティー | インターロイキン２のスーパーアゴニストおよびアンタゴニスト |
| KR20140106452A (ko) * | 2013-02-26 | 2014-09-03 | 한미약품 주식회사 | 신규한 인슐린 아날로그 및 이의 용도 |
| US10781242B2 (en) * | 2013-09-24 | 2020-09-22 | Medicenna Therapeutics Inc. | Interleukin-2 fusion proteins and uses thereof |
| JP2017505141A (ja) * | 2014-01-20 | 2017-02-16 | ハンミ ファーマシューティカル カンパニー リミテッド | 長時間作用型インスリンおよびその使用 |
| CN106659757B (zh) * | 2014-04-24 | 2022-01-28 | 利兰斯坦福初级大学董事会 | 白介素2的超级激动剂、部分激动剂和拮抗剂 |
| BR112017007817A2 (pt) | 2014-10-21 | 2017-12-19 | Sciclone Pharmaceuticals Inc | tratamento do câncer com estimuladores imunológicos |
| CN104403004B (zh) * | 2014-11-24 | 2017-10-13 | 苏州丁孚靶点生物技术有限公司 | 抗体‑干扰素异二聚体的制备和用途 |
| KR20160134989A (ko) * | 2015-05-14 | 2016-11-24 | 순천향대학교 산학협력단 | 인간 인터류킨-2 단백질을 포함하는 약학조성물 |
| CN107266553A (zh) * | 2016-04-08 | 2017-10-20 | 南京康志制药有限公司 | 高效人白细胞介素ⅱ突变体融合蛋白及其应用 |
| KR102687530B1 (ko) * | 2016-05-04 | 2024-07-25 | 암젠 인크 | T-조절 세포의 증식을 위한 인터류킨-2 뮤테인 |
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| CN111094356B (zh) * | 2017-09-25 | 2022-11-01 | 苏州丁孚靶点生物技术有限公司 | 一种蛋白质异二聚体及其用途 |
| US10946068B2 (en) * | 2017-12-06 | 2021-03-16 | Pandion Operations, Inc. | IL-2 muteins and uses thereof |
| EP3743438A4 (en) * | 2018-01-24 | 2022-02-23 | Beijing Percans Oncology Co. Ltd. | CYTOKI FUSION PROTEINS |
| CN108503714A (zh) * | 2018-04-10 | 2018-09-07 | 浙江科途医学科技有限公司 | 一种人白介素2和抗人上皮细胞黏附分子单链抗体融合蛋白及其应用 |
| EP4242238A3 (en) * | 2018-05-14 | 2023-12-06 | Werewolf Therapeutics, Inc. | Activatable interleukin-2 polypeptides and methods of use thereof |
| US20210269497A1 (en) | 2018-06-22 | 2021-09-02 | Cugene Inc | Interleukin-2 variants and methods of uses thereof |
| EP3827014A1 (en) | 2018-07-24 | 2021-06-02 | BioNTech RNA Pharmaceuticals GmbH | Il2 agonists |
| MX2020007072A (es) * | 2018-09-17 | 2020-11-11 | Gi Innovation Inc | Proteina de fusion que comprende proteina il-2 y proteina cd80 y uso de la misma. |
| EP3854806A4 (en) | 2018-09-21 | 2022-09-21 | Innovent Biologics (Suzhou) Co., Ltd. | NEW INTERLEUKIN 2 AND ASSOCIATED USE |
| CN113316590A (zh) * | 2018-11-16 | 2021-08-27 | 百时美施贵宝公司 | 抗nkg2a抗体及其用途 |
| US20220025007A1 (en) * | 2018-12-21 | 2022-01-27 | Hanmi Pharm. Co., Ltd. | Novel immunosuppressive interleukin 2 |
| CN111944036B (zh) * | 2019-05-14 | 2024-09-06 | 上海盖浦生物科技有限公司 | 一种增殖免疫细胞的突变体蛋白 |
| CN114437198A (zh) | 2019-12-17 | 2022-05-06 | 北京志道生物科技有限公司 | 白介素-2衍生物 |
| JP2023525200A (ja) * | 2020-03-05 | 2023-06-15 | ザ ボード オブ トラスティーズ オブ ザ レランド スタンフォード ジュニア ユニバーシティー | 設計されたｉｌ－２変異型 |
-
2021
- 2021-03-31 KR KR1020210042319A patent/KR102545250B1/ko active IP Right Grant
- 2021-03-31 BR BR112022018730A patent/BR112022018730A2/pt unknown
- 2021-03-31 WO PCT/KR2021/004028 patent/WO2021201615A1/ko active Application Filing
- 2021-03-31 AR ARP210100815A patent/AR121713A1/es unknown
- 2021-03-31 AU AU2021202825A patent/AU2021202825B2/en active Active
- 2021-03-31 JP JP2022559531A patent/JP2023515247A/ja active Pending
- 2021-03-31 CA CA3169564A patent/CA3169564A1/en active Pending
- 2021-03-31 US US17/915,808 patent/US11746137B2/en active Active
- 2021-03-31 TW TW110111922A patent/TW202204387A/zh unknown
- 2021-03-31 MX MX2022011893A patent/MX2022011893A/es unknown
- 2021-03-31 EP EP21781220.5A patent/EP4130027A4/en active Pending
- 2021-03-31 IL IL295826A patent/IL295826A/en unknown
- 2021-03-31 CN CN202180025732.4A patent/CN115427437B/zh active Active
- 2021-03-31 PE PE2022001948A patent/PE20221759A1/es unknown
- 2021-03-31 CN CN202410385677.5A patent/CN118271419A/zh active Pending
-
2022
- 2022-06-02 AU AU2022203841A patent/AU2022203841A1/en not_active Abandoned
- 2022-08-26 ZA ZA2022/09565A patent/ZA202209565B/en unknown
- 2022-09-21 CL CL2022002562A patent/CL2022002562A1/es unknown
-
2023
- 2023-06-09 KR KR1020230074093A patent/KR20230088656A/ko active Application Filing
- 2023-07-10 US US18/349,656 patent/US20230348550A1/en active Pending
- 2023-11-30 JP JP2023202447A patent/JP2024041747A/ja active Pending
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