JP2012525349A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2012525349A5 JP2012525349A5 JP2012507720A JP2012507720A JP2012525349A5 JP 2012525349 A5 JP2012525349 A5 JP 2012525349A5 JP 2012507720 A JP2012507720 A JP 2012507720A JP 2012507720 A JP2012507720 A JP 2012507720A JP 2012525349 A5 JP2012525349 A5 JP 2012525349A5
- Authority
- JP
- Japan
- Prior art keywords
- oxazol
- methyl
- pharmaceutically acceptable
- acceptable salt
- pyridinyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US17403309P | 2009-04-30 | 2009-04-30 | |
| US61/174,033 | 2009-04-30 | ||
| PCT/EP2010/055666 WO2010125082A1 (en) | 2009-04-30 | 2010-04-28 | Oxazole substituted indazoles as pi3-kinase inhibitors |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2012525349A JP2012525349A (ja) | 2012-10-22 |
| JP2012525349A5 true JP2012525349A5 (enExample) | 2013-06-20 |
| JP5570589B2 JP5570589B2 (ja) | 2014-08-13 |
Family
ID=42225106
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012507720A Expired - Fee Related JP5570589B2 (ja) | 2009-04-30 | 2010-04-28 | Pi3キナーゼ阻害剤としてのオキサゾール置換インダゾール |
Country Status (39)
Families Citing this family (86)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2009147190A1 (en) | 2008-06-05 | 2009-12-10 | Glaxo Group Limited | Novel compounds |
| WO2009147188A1 (en) * | 2008-06-05 | 2009-12-10 | Glaxo Group Limited | Benzpyrazol derivatives as inhibitors of pi3 kinases |
| JP5502076B2 (ja) | 2008-06-05 | 2014-05-28 | グラクソ グループ リミテッド | 新規化合物 |
| US8524751B2 (en) | 2009-03-09 | 2013-09-03 | GlaxoSmithKline Intellecutual Property Development | 4-oxadiazol-2-YL-indazoles as inhibitors of P13 kinases |
| RS53830B1 (sr) | 2009-04-30 | 2015-06-30 | Glaxo Group Limited | Indazoli supstituisani oksazolom kao inhibitori pi3-kinaze |
| CN102372675B (zh) * | 2010-08-14 | 2013-12-18 | 王娜 | 6-氯-4-碘吲唑及其制备方法与应用 |
| EP2613781B1 (en) | 2010-09-08 | 2016-08-24 | GlaxoSmithKline Intellectual Property Development Limited | Indazole derivatives for use in the treatment of influenza virus infection |
| US9102668B2 (en) * | 2010-09-08 | 2015-08-11 | Glaxo Group Limited | Polymorphs and salts |
| HRP20151017T1 (hr) | 2010-09-08 | 2015-10-23 | Glaxosmithkline Intellectual Property Development Limited | Polimorfi i soli n-[5-[4-(5-{[(2r,6s)-2,6-dimetil-4-morfolinil]metil}-1,3-oksazol-2-il)-1h-indazol-6-il]-2-(metiloksi)-3-piridinil]metansulfonamida |
| GB201018124D0 (en) | 2010-10-27 | 2010-12-08 | Glaxo Group Ltd | Polymorphs and salts |
| JP6063870B2 (ja) * | 2010-11-08 | 2017-01-18 | ライセラ・コーポレイション | RORγ活性の阻害用のN−スルホニル化テトラヒドロキノリンおよび関連二環化合物および病気の治療 |
| ES2661510T3 (es) | 2011-12-15 | 2018-04-02 | Novartis Ag | Uso de inhibidores de la actividad o función de PI3K |
| EP2847198B1 (en) | 2012-05-08 | 2016-12-14 | Lycera Corporation | Tetrahydro[1,8]naphthyridine sulfonamide and related compounds for use as agonists of ror-gamma and the treatment of disease |
| RU2014149136A (ru) | 2012-05-08 | 2016-07-10 | Мерк Шарп И Доум Корп. | ТЕТРАГИДРОНАФТИРИДИНОВЫЕ И РОДСТВЕННЫЕ БИЦИКЛИЧЕСКИЕ СОЕДИНЕНИЯ ДЛЯ ИНГИБИРОВАНИЯ RORγ АКТИВНОСТИ И ЛЕЧЕНИЯ ЗАБОЛЕВАНИЯ |
| EP2872143B1 (en) * | 2012-07-16 | 2017-12-13 | Neuropore Therapies, Inc. | Di-and tri-heteroaryl derivatives as inhibitors of protein aggregation |
| WO2014068070A1 (en) | 2012-10-31 | 2014-05-08 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods for preventing antiphospholipid syndrome (aps) |
| WO2014098232A1 (ja) * | 2012-12-21 | 2014-06-26 | Yamashita Chikamasa | Pi3キナーゼ阻害剤を含む医薬組成物、ビタミンd受容体に作用する化合物を含む医薬組成物、凍結乾燥組成物、凍結乾燥組成物の製造方法、及び経肺投与用医薬組成物 |
| EP3057588A1 (en) * | 2013-10-17 | 2016-08-24 | GlaxoSmithKline Intellectual Property Development Limited | Pi3k inhibitor for treatment of respiratory disease |
| KR20160062179A (ko) * | 2013-10-17 | 2016-06-01 | 글락소스미스클라인 인털렉츄얼 프로퍼티 디벨로프먼트 리미티드 | 호흡기 질병의 치료를 위한 pi3k 억제제 |
| WO2015095788A1 (en) | 2013-12-20 | 2015-06-25 | Merck Sharp & Dohme Corp. | 2-ACYLAMIDOMETHYL AND SULFONYLAMIDOMETHYL BENZOXAZINE CARBAMATES FOR INHIBITION OF RORgamma ACTIVITY AND THE TREATMENT OF DISEASE |
| WO2015095792A1 (en) | 2013-12-20 | 2015-06-25 | Merck Sharp & Dohme Corp. | Carbamate benzoxaxine propionic acids and acid derivatives for modulation of rorgamma activity and the treatment of disease |
| WO2015095795A1 (en) | 2013-12-20 | 2015-06-25 | Merck Sharp & Dohme Corp. | TETRAHYDRONAPHTHYRIDINE, BENZOXAZINE, AZA-BENZOXAZINE, AND RELATED BICYCLIC COMPOUNDS FOR INHIBITION OF RORgamma ACTIVITY AND THE TREATMENT OF DISEASE |
| CA2937111A1 (en) * | 2014-01-24 | 2015-07-30 | Abbvie Inc. | 6-phenyl- or 6-(pyridin-3-yl)indazole derivatives and methods of use |
| AU2015222917A1 (en) | 2014-02-27 | 2016-09-15 | Lycera Corporation | Adoptive cellular therapy using an agonist of retinoic acid receptor-related orphan receptor gamma and related therapeutic methods |
| US11806266B2 (en) | 2014-03-19 | 2023-11-07 | Purewick Corporation | Apparatus and methods for receiving discharged urine |
| US10390989B2 (en) | 2014-03-19 | 2019-08-27 | Purewick Corporation | Apparatus and methods for receiving discharged urine |
| US10226376B2 (en) | 2014-03-19 | 2019-03-12 | Purewick Corporation | Apparatus and methods for receiving discharged urine |
| US10952889B2 (en) | 2016-06-02 | 2021-03-23 | Purewick Corporation | Using wicking material to collect liquid for transport |
| EP3140291A4 (en) | 2014-05-05 | 2018-01-10 | Lycera Corporation | Tetrahydroquinoline sulfonamide and related compounds for use as agonists of rory and the treatment of disease |
| WO2015171558A2 (en) | 2014-05-05 | 2015-11-12 | Lycera Corporation | BENZENESULFONAMIDO AND RELATED COMPOUNDS FOR USE AS AGONISTS OF RORγ AND THE TREATEMENT OF DISEASE |
| US9127069B1 (en) * | 2014-06-11 | 2015-09-08 | Antecip Bioventures LLC | Compositions comprising rank/rankl antagonists and related compounds for treating pain |
| CN104086538B (zh) * | 2014-06-13 | 2016-07-06 | 南京药石科技股份有限公司 | 一种pi3k激酶抑制剂的中间体及其制备方法与应用 |
| WO2016059220A1 (en) | 2014-10-16 | 2016-04-21 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Tcr-activating agents for use in the treatment of t-all |
| CA2975997A1 (en) | 2015-02-11 | 2016-08-18 | Merck Sharp & Dohme Corp. | Substituted pyrazole compounds as rorgammat inhibitors and uses thereof |
| WO2016179343A1 (en) | 2015-05-05 | 2016-11-10 | Lycera Corporation | DIHYDRO-2H-BENZO[b][1,4]OXAZINE SULFONAMIDE AND RELATED COMPOUNDS FOR USE AS AGONISTS OF RORy AND THE TREATMENT OF DISEASE |
| GB201509492D0 (en) * | 2015-06-02 | 2015-07-15 | Glaxosmithkline Ip Dev Ltd | Novel processes |
| CN107980042B (zh) | 2015-06-11 | 2021-10-08 | 莱斯拉公司 | 用作RORγ激动剂和用于治疗疾病的芳基二氢-2H-苯并[b][1,4]噁嗪磺酰胺和相关化合物 |
| EP3368516B1 (en) | 2015-10-27 | 2020-07-15 | Merck Sharp & Dohme Corp. | SUBSTITUTED BICYCLIC PYRAZOLE COMPOUNDS AS RORgammaT INHIBITORS AND USES THEREOF |
| JP2018531958A (ja) | 2015-10-27 | 2018-11-01 | メルク・シャープ・アンド・ドーム・コーポレーションMerck Sharp & Dohme Corp. | RORγT阻害薬としてのヘテロアリール置換安息香酸及びその使用 |
| US10287272B2 (en) | 2015-10-27 | 2019-05-14 | Merck Sharp & Dohme Corp. | Substituted indazole compounds as RORgammaT inhibitors and uses thereof |
| US10196396B2 (en) * | 2016-01-14 | 2019-02-05 | Handok Inc. | Compounds antagonizing A3 adenosine receptor, method for preparing them, and medical-use thereof |
| US10376406B2 (en) | 2016-07-27 | 2019-08-13 | Purewick Corporation | Male urine collection device using wicking material |
| EP3497100A1 (en) * | 2016-08-08 | 2019-06-19 | GlaxoSmithKline Intellectual Property Development Limited | Chemical compounds |
| CN110612075B (zh) | 2017-01-31 | 2022-09-09 | 普利维克公司 | 用于接收排出的尿液的装置和方法 |
| US12575961B2 (en) | 2018-05-01 | 2026-03-17 | Purewick Corporation | Fluid collection devices, systems, and methods |
| US11944740B2 (en) | 2018-05-01 | 2024-04-02 | Purewick Corporation | Fluid collection devices, related systems, and related methods |
| AU2019262945B2 (en) | 2018-05-01 | 2022-08-25 | Purewick Corporation | Fluid collection devices and methods of using the same |
| JP7072084B2 (ja) | 2018-05-01 | 2022-05-19 | ピュアウィック コーポレイション | 流体収集装置、関連システム、及び関連方法 |
| EP4084746B1 (en) | 2020-01-03 | 2025-04-02 | Purewick Corporation | Urine collection devices having a relatively wide portion and an elongated portion and related methods cross-reference to related applications |
| WO2021155206A1 (en) | 2020-01-30 | 2021-08-05 | Purewick Corporation | Fluid collection assemblies including a skirt cross-reference to related applications |
| US12589022B2 (en) | 2020-03-19 | 2026-03-31 | Purewick Corporation | Fluid collection assemblies including one or more movement enhancing features |
| WO2021195384A1 (en) | 2020-03-26 | 2021-09-30 | Purewick Corporation | Multi-layered urine capture device and related methods |
| US12465514B2 (en) | 2020-04-17 | 2025-11-11 | Purewick Corporation | Fluid collection devices, systems, and methods securing a protruding portion in position for use |
| US12472090B2 (en) | 2020-04-17 | 2025-11-18 | Purewick Corporation | Female external catheter devices having a urethral cup, and related systems and methods |
| US12447042B2 (en) | 2020-04-17 | 2025-10-21 | Purewick Corporation | Fluid collection assemblies including a fluid impermeable barrier having a sump and a base |
| WO2021216422A1 (en) | 2020-04-20 | 2021-10-28 | Purewick Corporation | Fluid collection devices adjustable between a vacuum- based orientation and a gravity-based orientation, and related systems and methods |
| US12048643B2 (en) | 2020-05-27 | 2024-07-30 | Purewick Corporation | Fluid collection assemblies including at least one inflation device and methods and systems of using the same |
| WO2022031943A1 (en) | 2020-08-06 | 2022-02-10 | Purewick Corporation | A fluid collection system including a garment and a fluid collection device |
| US20220047410A1 (en) | 2020-08-11 | 2022-02-17 | Purewick Corporation | Fluid collection assemblies defining waist and leg openings |
| WO2022035745A1 (en) | 2020-08-11 | 2022-02-17 | Purewick Corporation | Fluid collection devices and methods of manufacturing same cross-reference to related applications |
| WO2022055957A1 (en) | 2020-09-09 | 2022-03-17 | Purewick Corporation | Fluid collection devices, systems, and methods |
| US11801186B2 (en) | 2020-09-10 | 2023-10-31 | Purewick Corporation | Urine storage container handle and lid accessories |
| AU2021341508A1 (en) | 2020-09-10 | 2023-05-25 | Precirix N.V. | Antibody fragment against fap |
| US12042423B2 (en) | 2020-10-07 | 2024-07-23 | Purewick Corporation | Fluid collection systems including at least one tensioning element |
| US12569365B2 (en) | 2020-10-21 | 2026-03-10 | Purewick Corporation | Fluid collection assemblies including at least one shape memory material disposed in the conduit |
| US12440370B2 (en) | 2020-10-21 | 2025-10-14 | Purewick Corporation | Apparatus with compressible casing for receiving discharged urine |
| US12257174B2 (en) | 2020-10-21 | 2025-03-25 | Purewick Corporation | Fluid collection assemblies including at least one of a protrusion or at least one expandable material |
| US12208031B2 (en) | 2020-10-21 | 2025-01-28 | Purewick Corporation | Adapters for fluid collection devices |
| US12048644B2 (en) | 2020-11-03 | 2024-07-30 | Purewick Corporation | Apparatus for receiving discharged urine |
| US12599495B2 (en) | 2021-01-05 | 2026-04-14 | Purewick Corporation | Male external catheter with attachment interface configured to bias against penis |
| US12268627B2 (en) | 2021-01-06 | 2025-04-08 | Purewick Corporation | Fluid collection assemblies including at least one securement body |
| CN116940312A (zh) | 2021-01-07 | 2023-10-24 | 普利维克公司 | 轮椅固定的尿液收集系统和相关方法 |
| ES2975761T3 (es) | 2021-01-19 | 2024-07-15 | Purewick Corp | Dispositivo de recogida de líquido de ajuste variable |
| JP2023553620A (ja) | 2021-02-26 | 2023-12-25 | ピュアウィック コーポレイション | 管開口とバリアとの間に排水受けを有する流体収集装置、ならびに関連するシステムおよび方法 |
| US12551385B2 (en) | 2021-03-05 | 2026-02-17 | Purewick Corporation | Fluid collection assembly including a tube having porous wicking material for improved fluid transport |
| US12029677B2 (en) | 2021-04-06 | 2024-07-09 | Purewick Corporation | Fluid collection devices having a collection bag, and related systems and methods |
| US12251333B2 (en) | 2021-05-21 | 2025-03-18 | Purewick Corporation | Fluid collection assemblies including at least one inflation device and methods and systems of using the same |
| US12324767B2 (en) | 2021-05-24 | 2025-06-10 | Purewick Corporation | Fluid collection assembly including a customizable external support and related methods |
| US12150885B2 (en) | 2021-05-26 | 2024-11-26 | Purewick Corporation | Fluid collection system including a cleaning system and methods |
| US12575960B2 (en) | 2021-06-24 | 2026-03-17 | Purewick Corporation | Urine collection systems having one or more of volume, pressure, or flow indicators, and related methods |
| US12551366B2 (en) | 2021-08-02 | 2026-02-17 | Purewick Corporation | Fluid collection devices having multiple fluid collection regions, and related systems and methods |
| US12594062B2 (en) | 2021-09-08 | 2026-04-07 | Purewick Corporation | Fluid collection assemblies including an extension |
| CN118748993A (zh) | 2021-12-28 | 2024-10-08 | 日本新药株式会社 | 吲唑化合物和药物 |
| WO2023147603A2 (en) * | 2022-01-31 | 2023-08-03 | Intra-Cellular Therapies, Inc. | Salt crystals |
| WO2023203135A1 (en) | 2022-04-22 | 2023-10-26 | Precirix N.V. | Improved radiolabelled antibody |
| AU2023264245A1 (en) | 2022-05-02 | 2024-12-19 | Precirix N.V. | Pre-targeting |
Family Cites Families (152)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9127376D0 (en) | 1991-12-24 | 1992-02-19 | Wellcome Found | Amidino derivatives |
| FI944549L (fi) | 1992-04-02 | 1994-11-30 | Smithkline Beecham Corp | Allergisten ja tulehdussairauksien hoidossa käyttökelpoiset yhdisteet |
| EP0957087B1 (en) | 1994-06-15 | 2002-12-04 | The Wellcome Foundation Limited | Intermediates useful in the preparation of enzyme inhibitors |
| DE69622166T2 (de) | 1995-04-14 | 2003-04-03 | Smithkline Beecham Corp., Philadelphia | Dosierinhalator für albuterol |
| US5821243A (en) | 1996-07-22 | 1998-10-13 | Viropharma Incorporated | Compounds compositions and methods for treating influenza |
| MY117948A (en) | 1997-01-13 | 2004-08-30 | Glaxo Group Ltd | Nitride oxide synthase inhibitors. |
| DE19723722A1 (de) | 1997-05-30 | 1998-12-10 | Schering Ag | Nichtsteroidale Gestagene |
| TW533865U (en) | 1997-06-10 | 2003-05-21 | Glaxo Group Ltd | Dispenser for dispensing medicament and actuation indicating device |
| WO1999016766A1 (en) | 1997-10-01 | 1999-04-08 | Kyowa Hakko Kogyo Co., Ltd. | Benzodioxole derivatives |
| US6506766B1 (en) | 1998-02-13 | 2003-01-14 | Abbott Laboratories | Glucocortiocoid-selective antinflammatory agents |
| SI1070056T1 (en) | 1998-03-14 | 2004-12-31 | Altana Pharma Ag | Phthalazinone pde iii/iv inhibitors |
| GB9811599D0 (en) | 1998-05-30 | 1998-07-29 | Glaxo Group Ltd | Nitric oxide synthase inhibitors |
| US6119853A (en) | 1998-12-18 | 2000-09-19 | Glaxo Wellcome Inc. | Method and package for storing a pressurized container containing a drug |
| US6315112B1 (en) | 1998-12-18 | 2001-11-13 | Smithkline Beecham Corporation | Method and package for storing a pressurized container containing a drug |
| US6390291B1 (en) | 1998-12-18 | 2002-05-21 | Smithkline Beecham Corporation | Method and package for storing a pressurized container containing a drug |
| US6352152B1 (en) | 1998-12-18 | 2002-03-05 | Smithkline Beecham Corporation | Method and package for storing a pressurized container containing a drug |
| AU4501800A (en) | 1999-05-04 | 2000-11-17 | American Home Products Corporation | Tetracyclic progesterone receptor modulator compounds and methods |
| ES2165768B1 (es) | 1999-07-14 | 2003-04-01 | Almirall Prodesfarma Sa | Nuevos derivados de quinuclidina y composiciones farmaceuticas que los contienen. |
| CO5180649A1 (es) | 1999-09-01 | 2002-07-30 | Abbott Lab | Antagonistas de los receptores de los glucocorticoides para el tratamiento de la diabetes para el tratamiento de la diabetes |
| OA11558A (en) | 1999-12-08 | 2004-06-03 | Advanced Medicine Inc | Beta 2-adrenergic receptor agonists. |
| CA2417826A1 (en) | 2000-08-05 | 2002-02-14 | Glaxo Group Limited | 17.beta.-carbothioate 17.alpha.-arylcarbonyloxyloxy androstane derivative as anti-inflammatory agents |
| AR035205A1 (es) | 2000-09-29 | 2004-05-05 | Glaxo Group Ltd | Compuestos utiles en el tratamiento de enfermedades inflamatorias, proceso para su preparacion, intermediarios y composiciones farmaceuticas |
| GB0031179D0 (en) | 2000-12-21 | 2001-01-31 | Glaxo Group Ltd | Nitric oxide synthase inhibitors |
| US6484903B2 (en) | 2001-01-09 | 2002-11-26 | Riverwood International Corporation | Carton with an improved dispensing feature in combination with a unique handle |
| GB0103630D0 (en) | 2001-02-14 | 2001-03-28 | Glaxo Group Ltd | Chemical compounds |
| WO2002067683A1 (en) | 2001-02-26 | 2002-09-06 | Merck & Co., Inc. | Hiv protease inhibitors supported on cation exchange resins for oral administration |
| JP2004526720A (ja) | 2001-03-08 | 2004-09-02 | グラクソ グループ リミテッド | βアドレナリン受容体のアゴニスト |
| ATE381537T1 (de) | 2001-03-22 | 2008-01-15 | Glaxo Group Ltd | Formanilid-derivative als beta2-adrenorezeptor- agonisten |
| CZ20032829A3 (cs) | 2001-04-16 | 2005-03-16 | Tanabe Seiyaku Co., Ltd. | Heterocyklické sloučeniny |
| AR033290A1 (es) | 2001-04-30 | 2003-12-10 | Glaxo Group Ltd | Derivados antiinflamatorios de androstano |
| EP1395604B1 (en) | 2001-06-12 | 2008-06-25 | Glaxo Group Limited | Novel anti inflammatory 17.alpha.-heterocyclic-esters of 17.beta.-carbothioate androstane derivatives |
| WO2003000257A1 (en) | 2001-06-26 | 2003-01-03 | Takeda Chemical Industries, Ltd. | TGF-ß SUPERFAMILY PRODUCTION/SECRETION PROMOTER |
| ES2438985T3 (es) | 2001-09-14 | 2014-01-21 | Glaxo Group Limited | Formulación de inhalación que comprende derivados de fenetanolamina para el tratamiento de enfermedades respiratorias |
| US6653323B2 (en) | 2001-11-13 | 2003-11-25 | Theravance, Inc. | Aryl aniline β2 adrenergic receptor agonists |
| AU2002353186A1 (en) | 2001-12-19 | 2003-06-30 | Smithkline Beecham P.L.C. | (1-h-indazol-3-yl) -amide derivatives as gsk-3 inhibitors |
| EP1467982B8 (en) | 2002-01-14 | 2007-04-11 | Boehringer Ingelheim Pharmaceuticals Inc. | Glucocorticoid mimetics, methods of making them, pharmaceutical formulations containing them, and uses thereof |
| CA2473886C (en) | 2002-01-22 | 2012-08-21 | The Regents Of The University Of California | Non-steroidal ligands for the glucocorticoid receptor, compositions and uses thereof |
| TW200306819A (en) | 2002-01-25 | 2003-12-01 | Vertex Pharma | Indazole compounds useful as protein kinase inhibitors |
| GB0204719D0 (en) | 2002-02-28 | 2002-04-17 | Glaxo Group Ltd | Medicinal compounds |
| FR2836915B1 (fr) | 2002-03-11 | 2008-01-11 | Aventis Pharma Sa | Derives d'aminoindazoles, procede de preparation et intermediaires de ce procede a titre de medicaments et compositions pharmaceutiques les renfermant |
| JP4324480B2 (ja) | 2002-03-26 | 2009-09-02 | ベーリンガー インゲルハイム ファーマシューティカルズ インコーポレイテッド | グルココルチコイドミメティクス、その製法、医薬組成物、及び使用 |
| EP1490317A1 (en) | 2002-03-26 | 2004-12-29 | Boehringer Ingelheim Pharmaceuticals Inc. | Glucocorticoid mimetics, methods of making them, pharmaceutical compositions, and uses thereof |
| DE10215316C1 (de) | 2002-04-02 | 2003-12-18 | Schering Ag | Chinolin- und Isochinolin-Derivate, ein pharmazeutisches Mittel und ihre Verwendung als Entzündungshemmer |
| WO2003086294A2 (en) | 2002-04-11 | 2003-10-23 | Merck & Co., Inc. | 1h-benzo[f]indazol-5-yl derivatives as selective glucocorticoid receptor modulators |
| ATE381535T1 (de) | 2002-04-25 | 2008-01-15 | Glaxo Group Ltd | Phenethanolaminderivate |
| US7186864B2 (en) | 2002-05-29 | 2007-03-06 | Boehringer Ingelheim Pharmaceuticals, Inc. | Glucocorticoid mimetics, methods of making them, pharmaceutical compositions, and uses thereof |
| US7074806B2 (en) | 2002-06-06 | 2006-07-11 | Boehringer Ingelheim Pharmaceuticals, Inc. | Glucocorticoid mimetics, methods of making them, pharmaceutical compositions, and uses thereof |
| JP2006500325A (ja) | 2002-06-27 | 2006-01-05 | ノボ ノルディスク アクティーゼルスカブ | 新規なグルカゴンアンタゴニスト |
| WO2004005229A1 (en) | 2002-07-08 | 2004-01-15 | Pfizer Products Inc. | Modulators of the glucocorticoid receptor |
| JP2006508042A (ja) | 2002-07-18 | 2006-03-09 | ブリストル−マイヤーズ スクイブ カンパニー | グルココルチコイド受容体の修飾物質および方法 |
| GB0217225D0 (en) | 2002-07-25 | 2002-09-04 | Glaxo Group Ltd | Medicinal compounds |
| WO2004014881A2 (en) | 2002-08-09 | 2004-02-19 | Astra Zeneca Ab | '1,2,4'oxadiazoles as modulators of metabotropic glutamate receptor-5 |
| CN1691944A (zh) | 2002-08-09 | 2005-11-02 | 阿斯利康(瑞典)有限公司 | 作为代谢型谷氨酸受体-5调节剂的噁二唑 |
| AU2003264018A1 (en) | 2002-08-09 | 2004-02-25 | Astrazeneca Ab | Compounds having an activity at metabotropic glutamate receptors |
| US20040224986A1 (en) | 2002-08-16 | 2004-11-11 | Bart De Corte | Piperidinyl targeting compounds that selectively bind integrins |
| CA2496175A1 (en) | 2002-08-21 | 2004-03-04 | Boehringer Ingelheim Pharmaceuticals, Inc. | Substituted hihydroquinolines as glucocorticoid mimetics, methods of making them, pharmaceutical compositions, and uses thereof |
| GB0220730D0 (en) | 2002-09-06 | 2002-10-16 | Glaxo Group Ltd | Medicinal compounds |
| BR0314392A (pt) | 2002-09-16 | 2005-07-12 | Glaxo Group Ltd | Composto ou um sal do mesmo, composição farmacêutica, uso de um composto, método de tratamento e/ou profilaxia de uma doença inflamatória e/ou alérgica ou deficiência cognitiva em um mamìfero, e, combinação |
| GB0230045D0 (en) | 2002-12-23 | 2003-01-29 | Glaxo Group Ltd | Compounds |
| AU2003270783C1 (en) | 2002-09-20 | 2010-05-20 | Merck Sharp & Dohme Corp. | Octahydro-2-H-naphtho[1,2-F] indole-4-carboxamide derivatives as selective glucocorticoid receptor modulators |
| WO2004029055A1 (en) * | 2002-09-30 | 2004-04-08 | Bayer Pharmaceuticals Corporation | Fused azole-pyrimidine derivatives |
| GB0224084D0 (en) | 2002-10-16 | 2002-11-27 | Glaxo Group Ltd | Novel compounds |
| AU2003298094A1 (en) | 2002-10-22 | 2004-05-13 | Glaxo Group Limited | Medicinal arylethanolamine compounds |
| GB0225030D0 (en) | 2002-10-28 | 2002-12-04 | Glaxo Group Ltd | Medicinal compounds |
| DE60320007T2 (de) | 2002-10-28 | 2009-06-18 | Glaxo Group Ltd., Greenford | Phenthanolamin-Derivate zur Behandlung von Atemwegserkrankungen |
| GB0225540D0 (en) | 2002-11-01 | 2002-12-11 | Glaxo Group Ltd | Medicinal compounds |
| GB0225535D0 (en) | 2002-11-01 | 2002-12-11 | Glaxo Group Ltd | Medicinal compounds |
| US7202257B2 (en) | 2003-12-24 | 2007-04-10 | Deciphera Pharmaceuticals, Llc | Anti-inflammatory medicaments |
| AR044519A1 (es) * | 2003-05-02 | 2005-09-14 | Novartis Ag | Derivados de piridin-tiazol amina y de pirimidin-tiazol amina |
| TWI328009B (en) | 2003-05-21 | 2010-08-01 | Glaxo Group Ltd | Quinoline derivatives as phosphodiesterase inhibitors |
| CA2528938A1 (en) | 2003-06-13 | 2005-02-24 | Zentaris Gmbh | Compounds having inhibitive activity of phosphatidylinositol 3-kinase and methods of use thereof |
| GB0316290D0 (en) | 2003-07-11 | 2003-08-13 | Glaxo Group Ltd | Novel compounds |
| US20050090529A1 (en) | 2003-07-31 | 2005-04-28 | Pfizer Inc | 3,5 Disubstituted indazole compounds with nitrogen-bearing 5-membered heterocycles, pharmaceutical compositions, and methods for mediating or inhibiting cell proliferation |
| GB0320197D0 (en) * | 2003-08-28 | 2003-10-01 | Novartis Ag | Organic compounds |
| CN101230061A (zh) | 2003-10-14 | 2008-07-30 | 葛兰素集团有限公司 | 蕈毒碱性乙酰胆碱受体拮抗剂 |
| TWI344961B (en) * | 2003-10-15 | 2011-07-11 | Ube Industries | Novel indazole derivative |
| BRPI0416128B8 (pt) | 2003-11-03 | 2021-06-22 | Glaxo Group Ltd | dispositivo de dispensação de fluido |
| TW200524577A (en) | 2003-11-04 | 2005-08-01 | Glaxo Group Ltd | Muscarinic acetylcholine receptor antagonists |
| CA2557004A1 (en) | 2003-12-19 | 2005-06-30 | Glaxo Group Limited | Pyrazolo [3,4-b] pyridine compounds, and their use as phosphodiesterase inhibitors |
| WO2005077345A1 (en) | 2004-02-03 | 2005-08-25 | Astrazeneca Ab | Compounds for the treatment of gastro-esophageal reflux disease |
| WO2005077373A2 (en) | 2004-02-03 | 2005-08-25 | Astrazeneca Ab | Treatment of gastro-esophageal reflux disease (gerd) |
| WO2005077368A2 (en) | 2004-02-03 | 2005-08-25 | Astrazeneca Ab | Treatment of gastro-esophageal reflux disease (gerd) |
| AU2005210039B2 (en) | 2004-02-04 | 2010-09-02 | Neurosearch A/S | Diazabicyclic aryl derivatives as nicotinic acetylcholine receptor ligands |
| GB0405937D0 (en) | 2004-03-16 | 2004-04-21 | Glaxo Group Ltd | Compounds |
| GB0405933D0 (en) | 2004-03-16 | 2004-04-21 | Glaxo Group Ltd | Compounds |
| WO2005090354A1 (en) | 2004-03-16 | 2005-09-29 | Glaxo Group Limited | PYRAZOLO[3,4-b] PYRIDINE COMPOUNDS, AND THEIR USE AS PDE4 INHIBITORS |
| AR050902A1 (es) | 2004-04-27 | 2006-12-06 | Glaxo Group Ltd | Compuesto de quinuclidina, composicion farmaceutica que lo comprende y su usopara preparar dicha composicion |
| WO2006012226A2 (en) | 2004-06-24 | 2006-02-02 | Incyte Corporation | N-substituted piperidines and their use as pharmaceuticals |
| WO2006000398A1 (en) | 2004-06-28 | 2006-01-05 | Glaxo Group Limited | 2,3-benzoxazin derivatives as non-steroidal glucocorticoid receptor modulators |
| WO2006000401A1 (en) | 2004-06-28 | 2006-01-05 | Glaxo Group Limited | Substituted oxazines as glucocorticoid receptor modulators |
| US20060013540A1 (en) * | 2004-07-19 | 2006-01-19 | Chao Zhang | Single fiber optical transceiver module |
| WO2006135383A2 (en) | 2004-08-04 | 2006-12-21 | Myriad Genetics, Inc. | Indazoles |
| GB0418045D0 (en) | 2004-08-12 | 2004-09-15 | Glaxo Group Ltd | Compounds |
| BRPI0518222A (pt) | 2004-10-19 | 2008-11-04 | Hoffmann La Roche | composto, processo para a sua manufatura, composições farmacêuticas que os compreendem, método para o tratamento e/ou prevenção de enfermidades que estão associadas com a modulação de receptores de h3 e utilização dos mesmos |
| CN101103016A (zh) | 2004-11-18 | 2008-01-09 | 因塞特公司 | 11-β羟基类固醇脱氢酶1型抑制剂及其使用方法 |
| AU2005311826A1 (en) | 2004-11-30 | 2006-06-08 | Plexxikon, Inc. | Indole derivatives for use as PPAR active compounds |
| JP5281291B2 (ja) | 2005-01-10 | 2013-09-04 | グラクソ グループ リミテッド | 新規化合物 |
| US20090124588A1 (en) | 2005-01-10 | 2009-05-14 | Glaxo Group Limited | Androstane 17-Alpha-Carbonate for Use in the Treatment of Inflammatory and Allergic Conditions |
| US7728009B1 (en) | 2005-02-18 | 2010-06-01 | Neurogen Corporation | Thiazole amides, imidazole amides and related analogues |
| BRPI0609485A2 (pt) | 2005-03-31 | 2010-04-13 | Ronen Kahana | criação de aves domésticas e outros animais resistentes a doenças virais |
| US20060264433A1 (en) | 2005-05-23 | 2006-11-23 | Backes Bradley J | Pharmaceutical compositions as inhibitors of dipeptidyl peptidase-IV (DPP-IV) |
| TW200800946A (en) | 2005-08-15 | 2008-01-01 | Astrazeneca Ab | Substituted piperazines as metabotropic glutamate receptor antagonists |
| JP2009504769A (ja) | 2005-08-16 | 2009-02-05 | ジェンザイム・コーポレーション | ケモカイン受容体結合化合物 |
| RU2008140144A (ru) | 2006-03-10 | 2010-04-20 | Оно Фармасьютикал Ко., Лтд. (Jp) | Азотосодержащее гетероциклическое производное и фармацевтическое средство, включающее такое производное в качестве активного ингредиента |
| US20100273776A1 (en) | 2006-03-29 | 2010-10-28 | FOLDRx PHARMACEUTICALS, INC | Inhibition of alpha-synuclein toxicity |
| US8008481B2 (en) | 2006-03-31 | 2011-08-30 | Ericsson Anna M | Indazole compounds |
| KR20150038395A (ko) * | 2006-04-04 | 2015-04-08 | 더 리젠트스 오브 더 유니이버시티 오브 캘리포니아 | 키나제 길항물질 |
| GB0608820D0 (en) | 2006-05-04 | 2006-06-14 | Piramed Ltd | Pharmaceutical compounds |
| US8492378B2 (en) | 2006-08-03 | 2013-07-23 | Takeda Pharmaceutical Company Limited | GSK-3β inhibitor |
| WO2008020229A2 (en) | 2006-08-17 | 2008-02-21 | Astrazeneca Ab | Antibacterial pyrrolecarboxamides |
| CA2661898A1 (en) | 2006-08-25 | 2008-02-28 | Abbott Laboratories | Indazole derivatives that inhibit trpv1 and uses thereof |
| US7948877B2 (en) * | 2006-09-07 | 2011-05-24 | Via Technologies, Inc. | Systems and methods for packet forward control |
| AU2007301607A1 (en) | 2006-09-25 | 2008-04-03 | Mutabilis Sa | Substituted heterocyclylcarbonylamino-acetic-acid-derivatives as inhibitors of bacterial heptose synthesis, methods for their preparation and biological applications of said inhibitors |
| JP2010504933A (ja) | 2006-09-29 | 2010-02-18 | ノバルティス アーゲー | Pi3k脂質キナーゼ阻害剤としてのピラゾロピリミジン |
| TWI405763B (zh) | 2006-11-02 | 2013-08-21 | Targacept Inc | 菸鹼乙醯膽鹼受體亞型選擇性之二氮雜雙環烷類醯胺 |
| GB0701426D0 (en) | 2007-01-25 | 2007-03-07 | Univ Sheffield | Compounds and their use |
| US8450348B2 (en) | 2007-02-21 | 2013-05-28 | Forma Tm, Llc | Derivatives of squaric acid with anti-proliferative activity |
| JP2010116389A (ja) | 2008-10-17 | 2010-05-27 | Bayer Cropscience Ag | 殺虫性アリールピロリジン類 |
| GB0709031D0 (en) | 2007-05-10 | 2007-06-20 | Sareum Ltd | Pharmaceutical compounds |
| US8648069B2 (en) | 2007-06-08 | 2014-02-11 | Abbvie Inc. | 5-substituted indazoles as kinase inhibitors |
| JP5588339B2 (ja) | 2007-06-25 | 2014-09-10 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | 新規化学化合物 |
| JP5451611B2 (ja) | 2007-07-26 | 2014-03-26 | ヴァイティー ファーマシューティカルズ,インコーポレイテッド | 11β−ヒドロキシステロイドデヒドロゲナーゼ1のサイクリックインヒビター |
| CN101932587A (zh) | 2007-09-24 | 2010-12-29 | 吉宁特有限公司 | 噻唑并嘧啶pi3k抑制剂化合物及使用方法 |
| JP2009127226A (ja) * | 2007-11-21 | 2009-06-11 | Seiji Ohara | 温水プールに雪を落し込む手段を持つ融雪装置 |
| CA2723032A1 (en) * | 2008-05-01 | 2009-11-05 | Vitae Pharmaceuticals, Inc. | Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1 |
| EP2291370B1 (en) | 2008-05-01 | 2013-11-27 | Vitae Pharmaceuticals, Inc. | Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1 |
| KR20110002492A (ko) * | 2008-05-01 | 2011-01-07 | 비타이 파마슈티컬즈, 인코포레이티드 | 11베타-하이드록시스테로이드 탈수소효소 1의 고리형 억제제 |
| TW201004945A (en) | 2008-05-01 | 2010-02-01 | Vitae Pharmaceuticals Inc | Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1 |
| JP5502076B2 (ja) | 2008-06-05 | 2014-05-28 | グラクソ グループ リミテッド | 新規化合物 |
| EP2280946B1 (en) * | 2008-06-05 | 2016-02-10 | Glaxo Group Limited | 4-carboxamide indazole derivatives useful as inhibitors of p13-kinases |
| WO2009147188A1 (en) | 2008-06-05 | 2009-12-10 | Glaxo Group Limited | Benzpyrazol derivatives as inhibitors of pi3 kinases |
| WO2009147190A1 (en) | 2008-06-05 | 2009-12-10 | Glaxo Group Limited | Novel compounds |
| US10322469B2 (en) * | 2008-06-11 | 2019-06-18 | Hamamatsu Photonics K.K. | Fusion bonding process for glass |
| WO2010011314A1 (en) | 2008-07-25 | 2010-01-28 | Boehringer Ingelheim International Gmbh | Cyclic inhibitors of 11 beta-hydroxysteroid dehydrogenase 1 |
| US8245111B2 (en) * | 2008-12-09 | 2012-08-14 | Intel Corporation | Performing multi-bit error correction on a cache line |
| WO2010068287A2 (en) | 2008-12-11 | 2010-06-17 | Angion Biomedica Corp. | Small molecule modulators of hepatocyte growth factor (scatter factor) activity |
| WO2010083163A1 (en) | 2009-01-13 | 2010-07-22 | Philadelphia Health And Education Corporation | The role of p110 delta signaling in morbidity and lung pathology induced by influenza virus infection |
| US8524751B2 (en) | 2009-03-09 | 2013-09-03 | GlaxoSmithKline Intellecutual Property Development | 4-oxadiazol-2-YL-indazoles as inhibitors of P13 kinases |
| KR20120061771A (ko) | 2009-04-30 | 2012-06-13 | 비타이 파마슈티컬즈, 인코포레이티드 | 11베타-하이드록시스테로이드 탈수소효소 1의 고리형 억제제 |
| CA2759482A1 (en) | 2009-04-30 | 2010-11-04 | Abbott Gmbh & Co. Kg | N-phenyl-(piperazinyl or homopiperazinyl)-benzenesulfonamide or benzenesulfonyl-phenyl-(piperazine or homopiperazine) compounds suitable for treating disorders that respond to modulation of the serotonin 5-ht6 receptor |
| RS53830B1 (sr) | 2009-04-30 | 2015-06-30 | Glaxo Group Limited | Indazoli supstituisani oksazolom kao inhibitori pi3-kinaze |
| US8343959B2 (en) * | 2009-04-30 | 2013-01-01 | Abbott Gmbh & Co. Kg | N-phenyl-(piperazinyl or homopiperazinyl)-benzenesulfonamide or benzenesulfonyl-phenyl-(piperazine or homopiperazine) compounds suitable for treating disorders that respond to modulation of the serotonin 5-HT6 receptor |
| UA109255C2 (ru) * | 2009-04-30 | 2015-08-10 | Берінгер Інгельхайм Інтернешнл Гмбх | Циклические ингибиторы 11бета-гидроксистероиддегидрогеназы 1 |
| BRPI1014641A2 (pt) * | 2009-04-30 | 2019-09-24 | Bayer Cropscience Ag | arilpirrolidinas pesticidas |
| WO2011067365A1 (en) | 2009-12-03 | 2011-06-09 | Glaxo Group Limited | Benzpyrazole derivatives as inhibitors of p13 kinases |
| EP2507231A1 (en) * | 2009-12-03 | 2012-10-10 | Glaxo Group Limited | Indazole derivatives as pi 3 - kinase inhibitors |
| WO2011067364A1 (en) | 2009-12-03 | 2011-06-09 | Glaxo Group Limited | Novel compounds |
| HRP20151017T1 (hr) | 2010-09-08 | 2015-10-23 | Glaxosmithkline Intellectual Property Development Limited | Polimorfi i soli n-[5-[4-(5-{[(2r,6s)-2,6-dimetil-4-morfolinil]metil}-1,3-oksazol-2-il)-1h-indazol-6-il]-2-(metiloksi)-3-piridinil]metansulfonamida |
| EP2613781B1 (en) | 2010-09-08 | 2016-08-24 | GlaxoSmithKline Intellectual Property Development Limited | Indazole derivatives for use in the treatment of influenza virus infection |
| US9102668B2 (en) | 2010-09-08 | 2015-08-11 | Glaxo Group Limited | Polymorphs and salts |
| GB201018124D0 (en) | 2010-10-27 | 2010-12-08 | Glaxo Group Ltd | Polymorphs and salts |
| US10642898B1 (en) * | 2017-04-11 | 2020-05-05 | Northrop Grumman Systems Corporation | Three-dimensional graph |
-
2010
- 2010-04-28 RS RS20150107A patent/RS53830B1/sr unknown
- 2010-04-28 RS RS20171020A patent/RS56433B1/sr unknown
- 2010-04-28 SI SI201030873T patent/SI2424864T1/sl unknown
- 2010-04-28 EA EA201190227A patent/EA021056B1/ru not_active IP Right Cessation
- 2010-04-28 EP EP17182412.1A patent/EP3260453B1/en active Active
- 2010-04-28 AR ARP100101429A patent/AR076435A1/es active IP Right Grant
- 2010-04-28 SG SG2011077989A patent/SG175782A1/en unknown
- 2010-04-28 DK DK10714892.6T patent/DK2424864T3/en active
- 2010-04-28 KR KR1020167032300A patent/KR101771193B1/ko not_active Expired - Fee Related
- 2010-04-28 TW TW99113559A patent/TWI466884B/zh not_active IP Right Cessation
- 2010-04-28 ME MEP-2015-22A patent/ME02053B/me unknown
- 2010-04-28 CA CA2759476A patent/CA2759476C/en active Active
- 2010-04-28 ES ES17182412T patent/ES2876933T3/es active Active
- 2010-04-28 AU AU2010243613A patent/AU2010243613B2/en not_active Ceased
- 2010-04-28 SI SI201031548T patent/SI2899191T1/sl unknown
- 2010-04-28 CN CN201080030329.2A patent/CN102459253B/zh not_active Expired - Fee Related
- 2010-04-28 US US12/768,777 patent/US8580797B2/en not_active Expired - Fee Related
- 2010-04-28 PE PE2011001881A patent/PE20120321A1/es active IP Right Grant
- 2010-04-28 TW TW103127990A patent/TWI516487B/zh not_active IP Right Cessation
- 2010-04-28 ES ES10714892T patent/ES2531274T3/es active Active
- 2010-04-28 PT PT141948661T patent/PT2899191T/pt unknown
- 2010-04-28 MY MYPI2011005217A patent/MY160454A/en unknown
- 2010-04-28 US US13/266,254 patent/US20120046286A1/en not_active Abandoned
- 2010-04-28 ME MEP-2017-242A patent/ME02900B/me unknown
- 2010-04-28 LT LTEP14194866.1T patent/LT2899191T/lt unknown
- 2010-04-28 EP EP14194866.1A patent/EP2899191B1/en active Active
- 2010-04-28 ES ES14194866.1T patent/ES2644724T3/es active Active
- 2010-04-28 UA UAA201112776A patent/UA101098C2/uk unknown
- 2010-04-28 TW TW104135940A patent/TWI562992B/zh not_active IP Right Cessation
- 2010-04-28 JO JOP/2010/0132A patent/JO3025B1/ar active
- 2010-04-28 NZ NZ596071A patent/NZ596071A/en not_active IP Right Cessation
- 2010-04-28 MA MA34398A patent/MA33304B1/fr unknown
- 2010-04-28 SM SM20170481T patent/SMT201700481T1/it unknown
- 2010-04-28 DK DK14194866.1T patent/DK2899191T3/da active
- 2010-04-28 JP JP2012507720A patent/JP5570589B2/ja not_active Expired - Fee Related
- 2010-04-28 PT PT107148926T patent/PT2424864E/pt unknown
- 2010-04-28 US US12/768,775 patent/US8575162B2/en not_active Expired - Fee Related
- 2010-04-28 KR KR1020117028746A patent/KR101679642B1/ko not_active Expired - Fee Related
- 2010-04-28 BR BRPI1016219A patent/BRPI1016219B8/pt not_active IP Right Cessation
- 2010-04-28 PL PL14194866T patent/PL2899191T3/pl unknown
- 2010-04-28 HU HUE14194866A patent/HUE034724T2/hu unknown
- 2010-04-28 SG SG10201401881QA patent/SG10201401881QA/en unknown
- 2010-04-28 UY UY0001032585A patent/UY32585A/es not_active Application Discontinuation
- 2010-04-28 HR HRP20150173TT patent/HRP20150173T1/hr unknown
- 2010-04-28 MX MX2011011534A patent/MX2011011534A/es active IP Right Grant
- 2010-04-28 WO PCT/EP2010/055666 patent/WO2010125082A1/en not_active Ceased
- 2010-04-28 EP EP10714892.6A patent/EP2424864B1/en active Active
- 2010-04-28 PL PL10714892T patent/PL2424864T3/pl unknown
-
2011
- 2011-10-21 CO CO11141673A patent/CO6390057A2/es active IP Right Grant
- 2011-10-23 IL IL215803A patent/IL215803A/en active IP Right Grant
- 2011-10-26 DO DO2011000328A patent/DOP2011000328A/es unknown
- 2011-10-27 ZA ZA2011/07878A patent/ZA201107878B/en unknown
- 2011-10-28 CL CL2011002706A patent/CL2011002706A1/es unknown
- 2011-11-15 CR CR20110603A patent/CR20110603A/es unknown
-
2012
- 2012-10-02 US US13/633,348 patent/US8586583B2/en not_active Expired - Fee Related
- 2012-10-02 US US13/633,230 patent/US8609657B2/en not_active Expired - Fee Related
- 2012-10-02 US US13/633,320 patent/US8586590B2/en not_active Expired - Fee Related
-
2013
- 2013-11-25 US US14/088,505 patent/US20140080830A1/en not_active Abandoned
-
2015
- 2015-02-19 SM SM201500043T patent/SMT201500043B/xx unknown
- 2015-05-27 US US14/722,176 patent/US20150328226A1/en not_active Abandoned
-
2016
- 2016-08-02 US US15/225,962 patent/US20170015656A1/en not_active Abandoned
-
2017
- 2017-02-15 US US15/433,010 patent/US20170157136A1/en not_active Abandoned
- 2017-05-05 AR ARP170101175A patent/AR108388A2/es unknown
- 2017-09-27 HR HRP20171450TT patent/HRP20171450T1/hr unknown
- 2017-10-11 CY CY20171101063T patent/CY1119515T1/el unknown
-
2018
- 2018-05-16 US US15/980,778 patent/US20180325911A1/en not_active Abandoned
-
2019
- 2019-02-20 US US16/280,094 patent/US10383879B2/en active Active
- 2019-07-09 US US16/505,769 patent/US10624898B2/en active Active
-
2020
- 2020-03-12 US US16/816,311 patent/US10946025B2/en active Active
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ME02053B (me) | Oksazol supstituisani indazoli kao inhibitori pi3-kinaze | |
| CN107624111B (zh) | 作为激酶抑制剂的杂环酰胺 | |
| CA2934137C (en) | Novel carboxamides, method for the production thereof, pharmaceutical preparations comprising them, and use thereof for producing medicaments | |
| CA2849169C (en) | Pyrazole carboxamides as janus kinase inhibitors | |
| RU2019132212A (ru) | Селективные ингибиторы hdac6 | |
| JP2024521618A5 (enExample) | ||
| JP2016512488A5 (enExample) | ||
| JP2018512381A5 (enExample) | ||
| JP6500010B2 (ja) | 新規ピリジン誘導体 | |
| JP2007510689A5 (enExample) | ||
| US8367679B2 (en) | Biaryl carboxamides | |
| RU2016102137A (ru) | Первичные карбоксамиды в качестве ингибиторов bik | |
| EP3541813A1 (en) | Heterocyclic amides as kinase inhibitors | |
| JP2016523911A5 (enExample) | ||
| KR20170042595A (ko) | 의약으로서의 rip1 키나제 억제제로서의 헤테로시클릭 아미드 | |
| JP2010504280A5 (enExample) | ||
| JP2019519484A5 (enExample) | ||
| JP2013510859A5 (enExample) | ||
| AU2008253311A1 (en) | Inhibitors of hypoxia inducible factor (HIF) useful for treating hyper-proliferative disorders and diseases associated with angiogenesis | |
| JP2017538750A5 (enExample) | ||
| JP2010533158A5 (enExample) | ||
| JP2014531465A5 (enExample) | ||
| EP2489663A1 (en) | Compounds as syk kinase inhibitors | |
| JP2020520354A5 (enExample) | ||
| JP5602230B2 (ja) | スフィンゴシン−1−リン酸受容体アゴニスト |