JP2012514602A5 - - Google Patents
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- JP2012514602A5 JP2012514602A5 JP2011544675A JP2011544675A JP2012514602A5 JP 2012514602 A5 JP2012514602 A5 JP 2012514602A5 JP 2011544675 A JP2011544675 A JP 2011544675A JP 2011544675 A JP2011544675 A JP 2011544675A JP 2012514602 A5 JP2012514602 A5 JP 2012514602A5
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- pharmaceutical composition
- wound
- protease
- staphylococcus aureus
- lipase
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- 102000004190 Enzymes Human genes 0.000 claims description 27
- 108090000790 Enzymes Proteins 0.000 claims description 27
- 229940110715 ENZYMES FOR TREATMENT OF WOUNDS AND ULCERS Drugs 0.000 claims description 24
- 229940114721 Enzymes FOR DISORDERS OF THE MUSCULO-SKELETAL SYSTEM Drugs 0.000 claims description 24
- 229940093738 Enzymes for ALIMENTARY TRACT AND METABOLISM Drugs 0.000 claims description 24
- 229940019336 antithrombotic Enzymes Drugs 0.000 claims description 24
- 229940020899 hematological Enzymes Drugs 0.000 claims description 24
- 229940083249 peripheral vasodilators Enzymes Drugs 0.000 claims description 24
- 239000008194 pharmaceutical composition Substances 0.000 claims description 24
- 230000001079 digestive Effects 0.000 claims description 20
- 239000004365 Protease Substances 0.000 claims description 19
- 108091005771 Peptidases Proteins 0.000 claims description 17
- 239000004367 Lipase Substances 0.000 claims description 15
- 102000004882 lipase Human genes 0.000 claims description 15
- 108090001060 lipase Proteins 0.000 claims description 15
- 235000019421 lipase Nutrition 0.000 claims description 15
- 102000033147 ERVK-25 Human genes 0.000 claims description 12
- 241000191967 Staphylococcus aureus Species 0.000 claims description 11
- 229940076185 Staphylococcus aureus Drugs 0.000 claims description 11
- 239000000203 mixture Substances 0.000 claims description 11
- 229940040461 Lipase Drugs 0.000 claims description 10
- 102000013142 Amylases Human genes 0.000 claims description 9
- 108010065511 Amylases Proteins 0.000 claims description 9
- 235000019418 amylase Nutrition 0.000 claims description 9
- 241000124008 Mammalia Species 0.000 claims description 8
- 200000000019 wound Diseases 0.000 claims description 8
- 210000003491 Skin Anatomy 0.000 claims description 7
- 239000004382 Amylase Substances 0.000 claims description 5
- 102000035443 Peptidases Human genes 0.000 claims description 5
- 230000000844 anti-bacterial Effects 0.000 claims description 5
- 230000003385 bacteriostatic Effects 0.000 claims description 5
- 230000000249 desinfective Effects 0.000 claims description 5
- 201000009910 diseases by infectious agent Diseases 0.000 claims description 5
- 241000271566 Aves Species 0.000 claims description 4
- 206010072170 Skin wound Diseases 0.000 claims description 4
- 210000001519 tissues Anatomy 0.000 claims description 4
- 108090000317 Chymotrypsin Proteins 0.000 claims description 3
- 229940088598 Enzyme Drugs 0.000 claims description 3
- 108090000631 Trypsin Proteins 0.000 claims description 3
- 102000004142 Trypsin Human genes 0.000 claims description 3
- 229960002376 chymotrypsin Drugs 0.000 claims description 3
- 235000019833 protease Nutrition 0.000 claims description 3
- 229960001322 trypsin Drugs 0.000 claims description 3
- 239000012588 trypsin Substances 0.000 claims description 3
- 101700023572 AGL Proteins 0.000 claims description 2
- 101710012512 CPM1 Proteins 0.000 claims description 2
- 101700010794 MAL12 Proteins 0.000 claims description 2
- 101700025925 MAL32 Proteins 0.000 claims description 2
- 101700012066 MAL62 Proteins 0.000 claims description 2
- 101710026950 MGAM Proteins 0.000 claims description 2
- 102100008175 MGAM Human genes 0.000 claims description 2
- 101710011129 Mal-B1 Proteins 0.000 claims description 2
- 210000000496 Pancreas Anatomy 0.000 claims description 2
- 229940055729 Papain Drugs 0.000 claims description 2
- 108090000526 Papain Proteins 0.000 claims description 2
- 102100000672 SMPX Human genes 0.000 claims description 2
- 108060007673 SMPX Proteins 0.000 claims description 2
- 108010084040 Sucrase Proteins 0.000 claims description 2
- 102400000472 Sucrase Human genes 0.000 claims description 2
- 208000002847 Surgical Wound Diseases 0.000 claims description 2
- 239000000443 aerosol Substances 0.000 claims description 2
- 101700023638 aglA Proteins 0.000 claims description 2
- 239000003242 anti bacterial agent Substances 0.000 claims description 2
- 239000003782 beta lactam antibiotic agent Substances 0.000 claims description 2
- 230000003115 biocidal Effects 0.000 claims description 2
- 239000007894 caplet Substances 0.000 claims description 2
- 239000002775 capsule Substances 0.000 claims description 2
- 239000006071 cream Substances 0.000 claims description 2
- 239000000839 emulsion Substances 0.000 claims description 2
- 238000009472 formulation Methods 0.000 claims description 2
- 230000002538 fungal Effects 0.000 claims description 2
- 239000000499 gel Substances 0.000 claims description 2
- 235000011073 invertase Nutrition 0.000 claims description 2
- 239000006210 lotion Substances 0.000 claims description 2
- 101700009216 malA Proteins 0.000 claims description 2
- 230000000813 microbial Effects 0.000 claims description 2
- 235000019834 papain Nutrition 0.000 claims description 2
- ISWSIDIOOBJBQZ-UHFFFAOYSA-N phenol Chemical compound OC1=CC=CC=C1 ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 claims description 2
- 239000006187 pill Substances 0.000 claims description 2
- 239000000843 powder Substances 0.000 claims description 2
- 230000001737 promoting Effects 0.000 claims description 2
- 238000011012 sanitization Methods 0.000 claims description 2
- 230000037390 scarring Effects 0.000 claims description 2
- 239000000243 solution Substances 0.000 claims description 2
- -1 sprinkles Substances 0.000 claims description 2
- 239000003826 tablet Substances 0.000 claims description 2
- 230000000699 topical Effects 0.000 claims description 2
- 230000029663 wound healing Effects 0.000 claims description 2
- 239000002132 β-lactam antibiotic Substances 0.000 claims description 2
- 229940025131 Amylases Drugs 0.000 claims 4
- 230000029087 digestion Effects 0.000 claims 2
- 229940106157 CELLULASE Drugs 0.000 claims 1
- 108010059892 Cellulase Proteins 0.000 claims 1
- 239000000645 desinfectant Substances 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
- 241000272525 Anas platyrhynchos Species 0.000 description 1
- 241000272814 Anser sp. Species 0.000 description 1
- 229940064005 Antibiotic throat preparations Drugs 0.000 description 1
- 229940083879 Antibiotics FOR TREATMENT OF HEMORRHOIDS AND ANAL FISSURES FOR TOPICAL USE Drugs 0.000 description 1
- 229940042052 Antibiotics for systemic use Drugs 0.000 description 1
- 229940042786 Antitubercular Antibiotics Drugs 0.000 description 1
- 241000283690 Bos taurus Species 0.000 description 1
- 241000282472 Canis lupus familiaris Species 0.000 description 1
- 241000283707 Capra Species 0.000 description 1
- 241000282693 Cercopithecidae Species 0.000 description 1
- 241000283073 Equus caballus Species 0.000 description 1
- 241000588724 Escherichia coli Species 0.000 description 1
- 241000282326 Felis catus Species 0.000 description 1
- 241000287828 Gallus gallus Species 0.000 description 1
- 229940093922 Gynecological Antibiotics Drugs 0.000 description 1
- 241000282414 Homo sapiens Species 0.000 description 1
- 241000699666 Mus <mouse, genus> Species 0.000 description 1
- 241000283898 Ovis Species 0.000 description 1
- 206010036790 Productive cough Diseases 0.000 description 1
- 241000700159 Rattus Species 0.000 description 1
- 210000003802 Sputum Anatomy 0.000 description 1
- 241000282898 Sus scrofa Species 0.000 description 1
- 229940024982 Topical Antifungal Antibiotics Drugs 0.000 description 1
- 239000001913 cellulose Substances 0.000 description 1
- 229920002678 cellulose Polymers 0.000 description 1
- 235000010980 cellulose Nutrition 0.000 description 1
- 230000001747 exhibiting Effects 0.000 description 1
- 239000012212 insulator Substances 0.000 description 1
- 229940079866 intestinal antibiotics Drugs 0.000 description 1
- 229940005935 ophthalmologic Antibiotics Drugs 0.000 description 1
- 230000002335 preservative Effects 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- 239000000523 sample Substances 0.000 description 1
- 239000004094 surface-active agent Substances 0.000 description 1
Description
1つまたは複数の本発明の態様の詳細を添付の図面および以下の説明において示す。特許、特許出願、明細書、本、論文、科学出版物などの本明細書において開示される参考文献は全て、その全体が参照により組み入れられる。本発明の他の特徴、目的、および利点は、説明および図面ならびに特許請求の範囲から明らかであろう。
[本発明1001]
鳥または哺乳動物における黄色ブドウ球菌(S.aureus)感染を治療または予防するための方法であって、1種類または複数の種類の消化酵素を含む治療的有効量の薬学的組成物を鳥または哺乳動物に投与する工程を含む、方法。
[本発明1002]
1種類または複数の種類の消化酵素が、プロテアーゼ、アミラーゼ、セルロース、スクラーゼ、マルターゼ、パパイン、およびリパーゼからなる群より選択される1種類または複数の種類の酵素を含む、本発明1001の方法。
[本発明1003]
1種類または複数の種類の消化酵素が1種類または複数の種類の膵臓酵素を含む、本発明1001の方法。
[本発明1004]
1種類または複数の種類の消化酵素がブタ酵素を含む、本発明1001の方法。
[本発明1005]
プロテアーゼがキモトリプシンおよびトリプシンを含む、本発明1002の方法。
[本発明1006]
1種類または複数の種類の消化酵素が、独立して、動物供給源、微生物供給源、植物供給源、真菌供給源に由来するか、または合成により調製される、本発明1001の方法。
[本発明1007]
哺乳動物が、ブタ、ウマ、ウシ、イヌ、ネコ、サル、ラット、マウス、ヒツジ、ヤギ、もしくはヒトであるか、または鳥が、ニワトリ、アヒル、シチメンチョウ、もしくはガチョウである、本発明1001の方法。
[本発明1008]
動物供給源がブタ膵臓である、本発明1006の方法。
[本発明1009]
薬学的組成物が、少なくとも1種類のアミラーゼと、キモトリプシンおよびトリプシンを含むプロテアーゼの混合物と、少なくとも1種類のリパーゼとを含む、本発明1001の方法。
[本発明1010]
薬学的組成物が、少なくとも1種類のプロテアーゼおよび少なくとも1種類のリパーゼを含み、全プロテアーゼと全リパーゼとの比(USP単位)が約1:1〜約20:1である、本発明1001の方法。
[本発明1011]
プロテアーゼとリパーゼとの比が約4:1〜約10:1である、本発明1011の方法。
[本発明1012]
薬学的組成物が、丸剤、錠剤、カプセル剤、カプレット、スプリンクル、クリーム、ローション剤、エアロゾル剤、エマルジョン、散剤、液剤、ゲル、およびそれらの任意の組み合わせからなる群より選択される投与製剤である、本発明1001の方法。
[本発明1013]
薬学的組成物が経口投与用に処方される、本発明1001の方法。
[本発明1014]
薬学的組成物が局部投与用に処方される、本発明1001の方法。
[本発明1015]
薬学的組成物が経粘膜投与用に処方される、本発明1001の方法。
[本発明1016]
薬学的組成物が創傷への適用用に処方される、本発明1001の方法。
[本発明1017]
黄色ブドウ球菌感染の1つまたは複数の症状を示す哺乳動物または鳥を治療する方法であって、1種類または複数の種類の消化酵素を含む治療的有効量の組成物を哺乳動物または鳥に投与する工程を含む、方法。
[本発明1018]
βラクタム抗生物質を哺乳動物または鳥に投与する工程をさらに含む、本発明1001または1017の方法。
[本発明1019]
創傷治癒を促進するための、および/または創傷を有する個体における瘢痕化を低減するための方法であって、1種類または複数の種類の消化酵素を含む薬学的組成物を個体に投与する工程を含む、方法。
[本発明1020]
薬学的組成物が個体の創傷に適用される、本発明1019の方法。
[本発明1021]
創傷が手術創である、本発明1019の方法。
[本発明1022]
表面上にいる黄色ブドウ球菌の量を減らすために、または表面上にいる黄色ブドウ球菌を根絶するために表面を衛生化または消毒するための方法であって、1種類または複数の種類の消化酵素を含む組成物を該表面に適用する工程を含む、方法。
[本発明1023]
表面が非生物的表面または無生物表面である、本発明1022の方法。
[本発明1024]
表面が医療機器の表面である、本発明1023の方法。
[本発明1025]
医療機器が、メス、ナイフ、ハサミ、スパチュラ、エキスパンダー、クリップ、ピンセット、鏡、開創器、縫合糸、手術用メッシュ、チゼル、ドリル、水準器、ラスプ、ノコギリ、副子、キャリパー、クランプ、鉗子、フック、ランセット、針、カニューレ、キューレット、圧抵器、拡張器、挺子、咬合器、抽出器、プローブ、ステープル、カテーテル、ステント、チューブ、ボウル、トレー、スポンジ、スネア、匙、注射器、ペースメーカー、ねじ、プレート、およびピンより選択される、本発明1024の方法。
[本発明1026]
哺乳動物または鳥の皮膚領域、皮膚組織、または皮膚創傷に存在する黄色ブドウ球菌の量を減らすための方法であって、該皮膚領域、該皮膚組織、または該皮膚創傷に、1種類または複数の種類の消化酵素を含む組成物を適用する工程を含む、方法。
[本発明1027]
黄色ブドウ球菌または大腸菌(E.coli)に対して>1〜約20のフェノール係数を有する、1種類または複数の種類の消化酵素を含む消毒剤。
[本発明1028]
黄色ブドウ球菌に対して殺菌性および/または静菌性である、1種類または複数の種類の消化酵素を含む抗生物質。
[本発明1029]
黄色ブドウ球菌に対して殺菌性および/または静菌性である、1種類または複数の種類の消化酵素を含む界面活性剤。
[本発明1030]
黄色ブドウ球菌に対して殺菌性および/または静菌性である、1種類または複数の種類の消化酵素を含む防腐剤。
[本発明1031]
黄色ブドウ球菌に対して殺菌性および/または静菌性である、1種類または複数の種類の消化酵素を含む消毒剤。
[本発明1001]
鳥または哺乳動物における黄色ブドウ球菌(S.aureus)感染を治療または予防するための方法であって、1種類または複数の種類の消化酵素を含む治療的有効量の薬学的組成物を鳥または哺乳動物に投与する工程を含む、方法。
[本発明1002]
1種類または複数の種類の消化酵素が、プロテアーゼ、アミラーゼ、セルロース、スクラーゼ、マルターゼ、パパイン、およびリパーゼからなる群より選択される1種類または複数の種類の酵素を含む、本発明1001の方法。
[本発明1003]
1種類または複数の種類の消化酵素が1種類または複数の種類の膵臓酵素を含む、本発明1001の方法。
[本発明1004]
1種類または複数の種類の消化酵素がブタ酵素を含む、本発明1001の方法。
[本発明1005]
プロテアーゼがキモトリプシンおよびトリプシンを含む、本発明1002の方法。
[本発明1006]
1種類または複数の種類の消化酵素が、独立して、動物供給源、微生物供給源、植物供給源、真菌供給源に由来するか、または合成により調製される、本発明1001の方法。
[本発明1007]
哺乳動物が、ブタ、ウマ、ウシ、イヌ、ネコ、サル、ラット、マウス、ヒツジ、ヤギ、もしくはヒトであるか、または鳥が、ニワトリ、アヒル、シチメンチョウ、もしくはガチョウである、本発明1001の方法。
[本発明1008]
動物供給源がブタ膵臓である、本発明1006の方法。
[本発明1009]
薬学的組成物が、少なくとも1種類のアミラーゼと、キモトリプシンおよびトリプシンを含むプロテアーゼの混合物と、少なくとも1種類のリパーゼとを含む、本発明1001の方法。
[本発明1010]
薬学的組成物が、少なくとも1種類のプロテアーゼおよび少なくとも1種類のリパーゼを含み、全プロテアーゼと全リパーゼとの比(USP単位)が約1:1〜約20:1である、本発明1001の方法。
[本発明1011]
プロテアーゼとリパーゼとの比が約4:1〜約10:1である、本発明1011の方法。
[本発明1012]
薬学的組成物が、丸剤、錠剤、カプセル剤、カプレット、スプリンクル、クリーム、ローション剤、エアロゾル剤、エマルジョン、散剤、液剤、ゲル、およびそれらの任意の組み合わせからなる群より選択される投与製剤である、本発明1001の方法。
[本発明1013]
薬学的組成物が経口投与用に処方される、本発明1001の方法。
[本発明1014]
薬学的組成物が局部投与用に処方される、本発明1001の方法。
[本発明1015]
薬学的組成物が経粘膜投与用に処方される、本発明1001の方法。
[本発明1016]
薬学的組成物が創傷への適用用に処方される、本発明1001の方法。
[本発明1017]
黄色ブドウ球菌感染の1つまたは複数の症状を示す哺乳動物または鳥を治療する方法であって、1種類または複数の種類の消化酵素を含む治療的有効量の組成物を哺乳動物または鳥に投与する工程を含む、方法。
[本発明1018]
βラクタム抗生物質を哺乳動物または鳥に投与する工程をさらに含む、本発明1001または1017の方法。
[本発明1019]
創傷治癒を促進するための、および/または創傷を有する個体における瘢痕化を低減するための方法であって、1種類または複数の種類の消化酵素を含む薬学的組成物を個体に投与する工程を含む、方法。
[本発明1020]
薬学的組成物が個体の創傷に適用される、本発明1019の方法。
[本発明1021]
創傷が手術創である、本発明1019の方法。
[本発明1022]
表面上にいる黄色ブドウ球菌の量を減らすために、または表面上にいる黄色ブドウ球菌を根絶するために表面を衛生化または消毒するための方法であって、1種類または複数の種類の消化酵素を含む組成物を該表面に適用する工程を含む、方法。
[本発明1023]
表面が非生物的表面または無生物表面である、本発明1022の方法。
[本発明1024]
表面が医療機器の表面である、本発明1023の方法。
[本発明1025]
医療機器が、メス、ナイフ、ハサミ、スパチュラ、エキスパンダー、クリップ、ピンセット、鏡、開創器、縫合糸、手術用メッシュ、チゼル、ドリル、水準器、ラスプ、ノコギリ、副子、キャリパー、クランプ、鉗子、フック、ランセット、針、カニューレ、キューレット、圧抵器、拡張器、挺子、咬合器、抽出器、プローブ、ステープル、カテーテル、ステント、チューブ、ボウル、トレー、スポンジ、スネア、匙、注射器、ペースメーカー、ねじ、プレート、およびピンより選択される、本発明1024の方法。
[本発明1026]
哺乳動物または鳥の皮膚領域、皮膚組織、または皮膚創傷に存在する黄色ブドウ球菌の量を減らすための方法であって、該皮膚領域、該皮膚組織、または該皮膚創傷に、1種類または複数の種類の消化酵素を含む組成物を適用する工程を含む、方法。
[本発明1027]
黄色ブドウ球菌または大腸菌(E.coli)に対して>1〜約20のフェノール係数を有する、1種類または複数の種類の消化酵素を含む消毒剤。
[本発明1028]
黄色ブドウ球菌に対して殺菌性および/または静菌性である、1種類または複数の種類の消化酵素を含む抗生物質。
[本発明1029]
黄色ブドウ球菌に対して殺菌性および/または静菌性である、1種類または複数の種類の消化酵素を含む界面活性剤。
[本発明1030]
黄色ブドウ球菌に対して殺菌性および/または静菌性である、1種類または複数の種類の消化酵素を含む防腐剤。
[本発明1031]
黄色ブドウ球菌に対して殺菌性および/または静菌性である、1種類または複数の種類の消化酵素を含む消毒剤。
Claims (17)
- 鳥または哺乳動物における黄色ブドウ球菌(S.aureus)感染の治療または予防に使用するための、プロテアーゼ、アミラーゼ、およびリパーゼを含む消化酵素を含む、薬学的組成物。
- 消化酵素が、セルラーゼ、スクラーゼ、マルターゼ、およびパパインからなる群より選択される1種類または複数の種類の酵素をさらに含む、請求項1記載の使用のための薬学的組成物。
- プロテアーゼがキモトリプシンおよびトリプシンを含む、請求項1記載の使用のための薬学的組成物。
- 消化酵素が、独立して、動物供給源、微生物供給源、植物供給源、真菌供給源に由来するか、または合成により調製され、任意で動物供給源がブタ膵臓である、請求項1記載の使用のための薬学的組成物。
- 少なくとも1種類のプロテアーゼおよび少なくとも1種類のリパーゼを含み、全プロテアーゼと全リパーゼとの比(USP単位)が約1:1〜約20:1であり、任意でプロテアーゼとリパーゼとの比が約4:1〜約10:1である、請求項1記載の使用のための薬学的組成物。
- 丸剤、錠剤、カプセル剤、カプレット、スプリンクル、クリーム、ローション剤、エアロゾル剤、エマルジョン、散剤、液剤、ゲル、およびそれらの任意の組み合わせからなる群より選択される投与製剤である、請求項1記載の使用のための薬学的組成物。
- 経口投与用、局部投与用、経粘膜投与用、または創傷への適用用に処方される、請求項1記載の使用のための薬学的組成物。
- 黄色ブドウ球菌感染の1つまたは複数の症状を示す哺乳動物または鳥の治療に使用するための、プロテアーゼ、アミラーゼ、およびリパーゼを含む消化酵素の治療的有効量を含む、薬学的組成物。
- βラクタム抗生物質をさらに含む、請求項1または8記載の使用のための薬学的組成物。
- 創傷治癒の促進および/または創傷を有する個体における瘢痕化の低減に使用するための、プロテアーゼ、アミラーゼ、およびリパーゼを含む消化酵素を含む、薬学的組成物。
- 個体の創傷に適用される、請求項10記載の使用のための薬学的組成物。
- 創傷が手術創である、請求項10記載の薬学的組成物。
- 表面上にいる黄色ブドウ球菌の量を減らすために、または表面上にいる黄色ブドウ球菌を根絶するために表面を衛生化または消毒するための方法であって、プロテアーゼ、アミラーゼ、およびリパーゼを含む消化酵素を含む組成物を該表面に適用する工程を含む、方法。
- 表面が非生物的表面または無生物表面であり、任意で表面が医療機器の表面であり、任意で医療機器が、メス、ナイフ、ハサミ、スパチュラ、エキスパンダー、クリップ、ピンセット、鏡、開創器、縫合糸、手術用メッシュ、チゼル、ドリル、水準器、ラスプ、ノコギリ、副子、キャリパー、クランプ、鉗子、フック、ランセット、針、カニューレ、キューレット、圧抵器、拡張器、挺子、咬合器、抽出器、プローブ、ステープル、カテーテル、ステント、チューブ、ボウル、トレー、スポンジ、スネア、匙、注射器、ペースメーカー、ねじ、プレート、およびピンより選択される、請求項13記載の方法。
- 哺乳動物または鳥の皮膚領域、皮膚組織、または皮膚創傷に存在する黄色ブドウ球菌の量を減らすことによって、動物における黄色ブドウ球菌感染を治療または予防するための薬学的組成物であって、該皮膚領域、該皮膚組織、または該皮膚創傷に適用するために処方され、プロテアーゼ、アミラーゼ、およびリパーゼを含む消化酵素を含む、薬学的組成物。
- 黄色ブドウ球菌に対して>1〜約20のフェノール係数を有し、プロテアーゼ、アミラーゼ、およびリパーゼを含む消化酵素を含む、消毒剤。
- プロテアーゼ、アミラーゼ、およびリパーゼを含む消化酵素を含む組成物であって、黄色ブドウ球菌に対して殺菌性および/または静菌性であり、抗生物質である、組成物。
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