DK1663298T3 - Anvendelse af prolinspecifikke endoproteaser til hydrolyse af peptider og proteiner - Google Patents

Anvendelse af prolinspecifikke endoproteaser til hydrolyse af peptider og proteiner Download PDF

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Publication number
DK1663298T3
DK1663298T3 DK04765616.0T DK04765616T DK1663298T3 DK 1663298 T3 DK1663298 T3 DK 1663298T3 DK 04765616 T DK04765616 T DK 04765616T DK 1663298 T3 DK1663298 T3 DK 1663298T3
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Denmark
Prior art keywords
endoproteas
hydrolyse
proline
peptides
proteins
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DK04765616.0T
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English (en)
Inventor
Melissa Harvey
Luppo Edens
Der Hoeven Robertus Antonius Mijndert Van
Roos Andre Leonardus De
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Dsm Ip Assets Bv
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    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00Preparation of peptides or proteins
    • C12P21/06Preparation of peptides or proteins produced by the hydrolysis of a peptide bond, e.g. hydrolysate products
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23JPROTEIN COMPOSITIONS FOR FOODSTUFFS; WORKING-UP PROTEINS FOR FOODSTUFFS; PHOSPHATIDE COMPOSITIONS FOR FOODSTUFFS
    • A23J3/00Working-up of proteins for foodstuffs
    • A23J3/30Working-up of proteins for foodstuffs by hydrolysis
    • A23J3/32Working-up of proteins for foodstuffs by hydrolysis using chemical agents
    • A23J3/34Working-up of proteins for foodstuffs by hydrolysis using chemical agents using enzymes
    • A23J3/346Working-up of proteins for foodstuffs by hydrolysis using chemical agents using enzymes of vegetable proteins
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46Hydrolases (3)
    • A61K38/48Hydrolases (3) acting on peptide bonds (3.4)
    • A61K38/482Serine endopeptidases (3.4.21)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/12Antidiarrhoeals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/04Drugs for skeletal disorders for non-specific disorders of the connective tissue
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/18Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/24Antidepressants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/02Nutrients, e.g. vitamins, minerals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/06Immunosuppressants, e.g. drugs for graft rejection
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00Drugs for disorders of the endocrine system
    • A61P5/14Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Immunology (AREA)
  • Diabetes (AREA)
  • Nutrition Science (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Epidemiology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Endocrinology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Polymers & Plastics (AREA)
  • Food Science & Technology (AREA)
  • Psychiatry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Emergency Medicine (AREA)
  • Transplantation (AREA)
DK04765616.0T 2003-09-23 2004-09-23 Anvendelse af prolinspecifikke endoproteaser til hydrolyse af peptider og proteiner DK1663298T3 (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP03078012 2003-09-23
EP03078496 2003-11-06
PCT/EP2004/010782 WO2005027953A2 (en) 2003-09-23 2004-09-23 Use of proline specific endoproteases to hydrolyse peptides and proteins

Publications (1)

Publication Number Publication Date
DK1663298T3 true DK1663298T3 (da) 2019-10-14

Family

ID=34379381

Family Applications (1)

Application Number Title Priority Date Filing Date
DK04765616.0T DK1663298T3 (da) 2003-09-23 2004-09-23 Anvendelse af prolinspecifikke endoproteaser til hydrolyse af peptider og proteiner

Country Status (8)

Country Link
US (3) US8524225B2 (da)
EP (1) EP1663298B1 (da)
JP (2) JP5328100B2 (da)
DK (1) DK1663298T3 (da)
ES (1) ES2746173T3 (da)
HU (1) HUE044812T2 (da)
RU (1) RU2370279C2 (da)
WO (1) WO2005027953A2 (da)

Families Citing this family (67)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6632429B1 (en) 1999-12-17 2003-10-14 Joan M. Fallon Methods for treating pervasive development disorders
US20070053895A1 (en) * 2000-08-14 2007-03-08 Fallon Joan M Method of treating and diagnosing parkinsons disease and related dysautonomic disorders
US8030002B2 (en) 2000-11-16 2011-10-04 Curemark Llc Methods for diagnosing pervasive development disorders, dysautonomia and other neurological conditions
NZ530165A (en) 2001-07-18 2004-08-27 Dsm Ip Assets B Process for the hydrolysis of milk proteins
EP1612558A1 (en) * 2004-06-30 2006-01-04 Academisch Ziekenhuis Leiden Method for detecting gluten
US20060198838A1 (en) * 2004-09-28 2006-09-07 Fallon Joan M Combination enzyme for cystic fibrosis
WO2006097949A1 (en) * 2005-03-16 2006-09-21 Actial Farmacêutica, Lda. Mixture of at least 6 species of lactic acid bacteria and/or bifidobacteria in the manufacture of sourdough
US20080058282A1 (en) 2005-08-30 2008-03-06 Fallon Joan M Use of lactulose in the treatment of autism
US20070116695A1 (en) * 2005-09-21 2007-05-24 Fallon Joan M Pharmaceutical preparations for attention deficit disorder, attention deficit hyperactivity disorder and other associated disorders
CN101511211A (zh) * 2006-02-02 2009-08-19 帝斯曼知识产权资产管理有限公司 包含脯氨酸特异性蛋白酶的食物产品
EP3868855A1 (en) 2006-07-13 2021-08-25 DSM IP Assets B.V. Improved brewing process
US8827133B2 (en) 2007-01-11 2014-09-09 Ethicon Endo-Surgery, Inc. Surgical stapling device having supports for a flexible drive mechanism
MX2009009780A (es) * 2007-03-16 2010-05-20 Univ Leland Stanford Junior Terapia de enzima de combinacion para la digestion de gluten dietetico.
JP5855828B2 (ja) * 2007-08-13 2016-02-09 コモンウェルス サイエンティフィック アンド インダストリアル リサーチ オーガナイゼーション 低レベルのホルデインを有するオオムギ
JP2010538981A (ja) * 2007-09-11 2010-12-16 モンドバイオテック ラボラトリーズ アクチエンゲゼルシャフト 単独でまたはペプチドGly−Arg−Gly−Asp−Asn−Pro−OHと組み合わせて用いる、治療剤としてのペプチドHis−Ser−Leu−Gly−Lys−Trp−Leu−Gly−His−Pro−Asp−Lys−Pheの使用
US20100322912A1 (en) * 2007-12-10 2010-12-23 Chaitan Khosla Combination Enzyme Therapy for Gastric Digestion of Dietary Gluten in Celiac Sprue Patients
US8658163B2 (en) 2008-03-13 2014-02-25 Curemark Llc Compositions and use thereof for treating symptoms of preeclampsia
US8084025B2 (en) 2008-04-18 2011-12-27 Curemark Llc Method for the treatment of the symptoms of drug and alcohol addiction
TW201000634A (en) * 2008-05-30 2010-01-01 Dsm Ip Assets Bv Proline-specific protease
US9320780B2 (en) * 2008-06-26 2016-04-26 Curemark Llc Methods and compositions for the treatment of symptoms of Williams Syndrome
US20090324730A1 (en) * 2008-06-26 2009-12-31 Fallon Joan M Methods and compositions for the treatment of symptoms of complex regional pain syndrome
EP2318035B1 (en) * 2008-07-01 2019-06-12 Curemark, Llc Methods and compositions for the treatment of symptoms of neurological and mental health disorders
US10776453B2 (en) * 2008-08-04 2020-09-15 Galenagen, Llc Systems and methods employing remote data gathering and monitoring for diagnosing, staging, and treatment of Parkinsons disease, movement and neurological disorders, and chronic pain
US20100092447A1 (en) * 2008-10-03 2010-04-15 Fallon Joan M Methods and compositions for the treatment of symptoms of prion diseases
ES2668909T3 (es) 2009-01-06 2018-05-23 Galenagen, Llc Composiciones que comprenden proteasa, amilasa y lipasa para su uso en el tratamiento de infecciones por Staphylococcus aureus
US9084784B2 (en) 2009-01-06 2015-07-21 Curelon Llc Compositions and methods for the treatment or the prevention of E. coli infections and for the eradication or reduction of E. coli surfaces
US9056050B2 (en) * 2009-04-13 2015-06-16 Curemark Llc Enzyme delivery systems and methods of preparation and use
WO2011000773A1 (en) 2009-07-02 2011-01-06 Dsm Ip Assets B.V. Testing efficacy for celiac disease
US9511125B2 (en) 2009-10-21 2016-12-06 Curemark Llc Methods and compositions for the treatment of influenza
CN102858795A (zh) 2010-02-02 2013-01-02 天野酶制品美国有限公司 蛋白酶针对谷蛋白不耐受的用途
US20120244362A1 (en) 2011-03-22 2012-09-27 Pramanik Pranabes K Multi-layer sheet structure
CN106310242B (zh) 2011-04-21 2020-02-28 柯尔马克有限责任公司 用于治疗神经精神障碍的化合物
WO2012174127A1 (en) * 2011-06-17 2012-12-20 Alvine Pharmaceuticals, Inc. Proteases for degrading gluten
WO2013047082A1 (ja) * 2011-09-29 2013-04-04 天野エンザイム株式会社 外因性オピオイドペプチド分解酵素剤
EA028228B1 (ru) 2011-12-06 2017-10-31 Фондацьоне Иституто Инсубрико Ди Ричерка Пер Ла Вита Гидролизующая глютеновые олигопептиды эндопептидазная композиция, способ ее получения и применение
US10350278B2 (en) 2012-05-30 2019-07-16 Curemark, Llc Methods of treating Celiac disease
US20130344042A1 (en) * 2012-06-20 2013-12-26 Gretchen Tanbonliong Dietary management of celiac disease and food allergy
BR102013003182B1 (pt) * 2013-02-08 2019-03-19 Vitor Carlos Veit Processo de fabricação de cerveja sem glúten
US9345741B2 (en) 2013-03-15 2016-05-24 Mead Johnson Nutrition Company Nutritional composition containing a peptide component with adiponectin simulating properties and uses thereof
US9138455B2 (en) 2013-03-15 2015-09-22 Mead Johnson Nutrition Company Activating adiponectin by casein hydrolysate
US9345727B2 (en) * 2013-03-15 2016-05-24 Mead Johnson Nutrition Company Nutritional compositions containing a peptide component and uses thereof
US8889633B2 (en) 2013-03-15 2014-11-18 Mead Johnson Nutrition Company Nutritional compositions containing a peptide component with anti-inflammatory properties and uses thereof
US9289461B2 (en) 2013-03-15 2016-03-22 Mead Johnson Nutrition Company Reducing the risk of autoimmune disease
US9352020B2 (en) 2013-03-15 2016-05-31 Mead Johnson Nutrition Company Reducing proinflammatory response
RU2015155833A (ru) * 2013-05-31 2017-07-06 ДСМ АйПи АССЕТС Б.В. Иммобилизованная пролинспецифичная эндопротеаза
EP3008161A4 (en) 2013-06-13 2017-02-22 Commonwealth Scientific and Industrial Research Organisation Barley with very low levels of hordeins
ES2743194T3 (es) * 2013-07-12 2020-02-18 A2 Milk Co Ltd Beta-caseína A2 y reducción o prevención de síntomas de intolerancia a lactosa
EP2883458A1 (en) * 2013-12-11 2015-06-17 DSM IP Assets B.V. Medicament and method for treating innate immune response diseases
WO2015177153A1 (en) 2014-05-19 2015-11-26 Dsm Ip Assets B.V. Proline-specific endoprotease
WO2015177152A1 (en) 2014-05-19 2015-11-26 Dsm Ip Assets B.V. Proline-specific endoprotease
EA034253B1 (ru) 2014-05-19 2020-01-22 ДСМ АйПи АССЕТС Б.В. Пролин-специфическая эндопротеаза
JP6244601B2 (ja) * 2014-07-01 2017-12-13 ディーエスエム アイピー アセッツ ビー.ブイ. 低グルテン酵母加水分解産物
JP6739767B2 (ja) * 2015-03-04 2020-08-12 学校法人日本大学 タンパク質シート及びタンパク質シートの製造方法
FR3035664B1 (fr) * 2015-04-29 2020-02-21 Malteries Soufflet Utilisation de cysteine endoprotease pour diminuer le trouble de boissons
JP6616198B2 (ja) * 2016-01-21 2019-12-04 オリエンタル酵母工業株式会社 パン類の品質改良剤及びパン類の製造方法
WO2018191233A1 (en) 2017-04-10 2018-10-18 Curemark, Llc Compositions for treating addiction
CN107814836A (zh) * 2017-12-01 2018-03-20 浙江熊猫乳业集团股份有限公司 一种生物活性多肽fpgpipns及其制备方法和应用
US20210315238A1 (en) * 2018-07-31 2021-10-14 Dupont Nutrition Biosciences Aps Proline specific endopeptidases
CA3117480A1 (en) * 2018-10-29 2020-05-07 The A2 Milk Company Limited Beta-casein analysis of milk and milk products
JP2023515120A (ja) * 2020-02-19 2023-04-12 パーフェクト・デイ・インコーポレイテッド 低アレルギー性組換え乳タンパク質およびこれを含む組成物
US11541009B2 (en) 2020-09-10 2023-01-03 Curemark, Llc Methods of prophylaxis of coronavirus infection and treatment of coronaviruses
JP2022135015A (ja) * 2021-03-04 2022-09-15 国立大学法人東京工業大学 オピオイド受容体作動剤
CN118043454A (zh) 2021-06-18 2024-05-14 国际N&H丹麦有限公司 用于啤酒浑浊减少的蛋白酶
EP4687490A1 (en) 2023-03-27 2026-02-11 DSM IP Assets B.V. Enzyme composition and beer brewing process
EP4437856A1 (en) 2023-03-31 2024-10-02 DSM IP Assets B.V. Novel enzyme composition and novel beer brewing process
WO2025012442A1 (en) * 2023-07-13 2025-01-16 Dsm Ip Assets B.V. Rapeseed protein hydrolysate
WO2026013293A1 (en) * 2024-07-12 2026-01-15 Dsm Ip Assets B.V. Composition comprising rapeseed protein hydrolysate and use thereof

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1490723A (en) 1973-10-31 1977-11-02 Phelan J Detoxification of gluten
DD262999A1 (de) 1987-07-27 1988-12-21 Adw Ddr Verfahren zur herstellung eines diaetetikums fuer zoeliakie- und spruekranke
ATE237689T1 (de) 1991-07-24 2003-05-15 Novartis Pharma Gmbh Dna kodierend für propylendopeptidase und dessen verwendung
US6251391B1 (en) * 1999-10-01 2001-06-26 Klaire Laboratories, Inc. Compositions containing dipepitidyl peptidase IV and tyrosinase or phenylalaninase for reducing opioid-related symptons
AU1142001A (en) 2000-10-19 2002-04-29 Dsm N.V. Protein hydrolysates
KR20030085112A (ko) 2000-12-07 2003-11-03 디에스엠 아이피 어셋츠 비.브이. 카르복시 말단 프롤린 잔기를 갖는 펩티드가 풍부한단백질 가수분해물
EP1326957B1 (en) 2000-12-07 2004-05-06 DSM IP Assets B.V. Method for the prevention or reduction of haze in beverages
EP1224869B1 (en) 2001-01-12 2004-09-22 Campina B.V. Method for producing a gluten-free peptide preparation and preparation thus obtained
CN100582226C (zh) 2001-02-23 2010-01-20 Dsmip资产有限公司 编码新蛋白水解酶的新基因
NZ530165A (en) * 2001-07-18 2004-08-27 Dsm Ip Assets B Process for the hydrolysis of milk proteins
NO318426B1 (no) * 2001-10-02 2005-04-18 Neurozym Biotech As Et materiale for a senke konsentrasjonen av patogene tarmpeptider
US8143210B2 (en) * 2002-02-14 2012-03-27 The Board Of Trustees Of The Leland Stanford Junior University Enzyme treatment of foodstuffs for celiac sprue
ATE505201T1 (de) 2002-02-14 2011-04-15 Univ Leland Stanford Junior Enzymbehandlung von nahrungsmitteln für zöliakie- sprue
AU2003236689A1 (en) 2002-06-04 2003-12-19 Dsm Ip Assets B.V. Protein hydrolysate rich in tripeptides
ES2525873T3 (es) 2002-06-07 2014-12-30 Dsm Ip Assets B.V. Método mejorado para la prevención o reducción del enturbiamiento en bebidas
JP4719465B2 (ja) 2002-09-04 2011-07-06 ディーエスエム アイピー アセッツ ビー.ブイ. インスリン感受性増強剤およびペプチド画分を含む栄養補給用および治療用組成物
NZ552140A (en) 2004-07-12 2009-02-28 Dsm Ip Assets Bv Blood pressure lowering protein hydrolysates
JP5106117B2 (ja) 2004-12-22 2012-12-26 ディーエスエム アイピー アセッツ ビー.ブイ. 単一の酵素工程における血圧降下ペプチド
WO2012174127A1 (en) * 2011-06-17 2012-12-20 Alvine Pharmaceuticals, Inc. Proteases for degrading gluten

Also Published As

Publication number Publication date
US8524225B2 (en) 2013-09-03
RU2006113586A (ru) 2006-08-10
JP2011120601A (ja) 2011-06-23
HUE044812T2 (hu) 2019-11-28
EP1663298B1 (en) 2019-07-17
US20110142987A1 (en) 2011-06-16
US20070031399A1 (en) 2007-02-08
RU2370279C2 (ru) 2009-10-20
WO2005027953A3 (en) 2005-06-16
JP2007505639A (ja) 2007-03-15
ES2746173T3 (es) 2020-03-05
US20140206036A1 (en) 2014-07-24
EP1663298A2 (en) 2006-06-07
JP5328100B2 (ja) 2013-10-30
WO2005027953A2 (en) 2005-03-31

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